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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 22, pp. 9434 - 9439
Genome-wide linkage studies have defined a broad susceptibility region for late-onset Alzheimer's disease on chromosome 12, which contains the Low-Density... 
Haplotypes | Nervous system diseases | HEK293 cells | Neurodegenerative diseases | Neurons | Genes | Cell lines | Predisposing factors | Alzheimers disease | Chromosomes | Single-nucleotide polymorphism | APOE | Wnt | Neurodegenerative | LRP-6 | WNT SIGNALING PATHWAY | CHROMOSOME 12 | MULTIDISCIPLINARY SCIENCES | SEQUENCE VARIANTS | AMYLOID PRECURSOR PROTEIN | HIPPOCAMPAL-NEURONS | APOLIPOPROTEIN-E | GLYCOGEN-SYNTHASE KINASE-3-BETA | neurodegenerative | RECEPTOR-RELATED PROTEIN-5 | ALPHA-T-CATENIN | single-nucleotide polymorphism | FAMILY-BASED TESTS | LDL-Receptor Related Proteins - metabolism | Humans | Molecular Sequence Data | LDL-Receptor Related Proteins - genetics | Aging - genetics | Conserved Sequence | Chromosomes, Human, Pair 12 - genetics | Amino Acid Sequence | Cell Line | Low Density Lipoprotein Receptor-Related Protein-6 | Cells, Cultured | Gene Expression Regulation | Genes, Reporter - genetics | beta Catenin - metabolism | beta Catenin - genetics | Hippocampus - metabolism | Sequence Alignment | Animals | Valine - metabolism | LDL-Receptor Related Proteins - chemistry | Age of Onset | Alleles | Alzheimer Disease - metabolism | Polymorphism, Single Nucleotide - genetics | Valine - genetics | Alzheimer Disease - genetics | Genetic aspects | Research | Single nucleotide polymorphisms | Alzheimer's disease | Low density lipoproteins | Genetic research | Low density lipoprotein | Genomics | Index Medicus | Biological Sciences
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 06/2011, Volume 36, Issue 7, pp. 1397 - 1411
Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting similar to 2% of the worldwide population, for which the etiological basis,... 
lithium | AKT | depression | TCF/LEF | behavior | mania | MOLECULAR-MECHANISM | ACTIVATION | PSYCHIATRY | GLYCOGEN-SYNTHASE KINASE-3 | BIPOLAR DISORDER | NEUROSCIENCES | IN-VIVO | PHARMACOLOGY & PHARMACY | DOPAMINE-RECEPTORS | UP-REGULATION | SIGNALING CASCADE | RODENT MODEL | Gene Expression Regulation, Enzymologic - drug effects | Mood Disorders - drug therapy | Humans | Glycogen Synthase Kinase 3 beta | Male | Corpus Striatum - metabolism | Proto-Oncogene Proteins c-akt - genetics | Drug Interactions | Transfection - methods | Lithium Chloride - pharmacology | Mice, Inbred DBA | Disease Models, Animal | Mood Disorders - chemically induced | Drug Administration Routes | Antimanic Agents - therapeutic use | Lithium Chloride - therapeutic use | Antimanic Agents - pharmacology | Drug Administration Schedule | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Amphetamine - adverse effects | Signal Transduction - genetics | Glycogen Synthase Kinase 3 - metabolism | Hippocampus - cytology | Animals | Analysis of Variance | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - drug effects | Corpus Striatum - drug effects | Mice | Cell Line, Transformed | Index Medicus | animal models | mood | stress disorders | LEF | LEF response | anxiety | TCF | neuropharmacology | mood-related behavior | psychiatry and behavioral sciences | Original
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 136, Issue 6, pp. 1017 - 1031
The D i S 1 ( ) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scottish family with a high incidence of major depression,... 
HUMDISEASE | MOLNEURO | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | MICE | BETA-CATENIN | DISC1 | LITHIUM | HIPPOCAMPAL NEUROGENESIS | EXPRESSION | BRAIN | DISRUPTED-IN-SCHIZOPHRENIA-1 | CELL BIOLOGY
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. LB-066 - LB-066
Journal Article
Cell Cycle, ISSN 1538-4101, 10/2012, Volume 11, Issue 20, pp. 3724 - 3730
The limitations of revolutionary new mutation-specific inhibitors of BRAF V600E include the universal recurrence seen in melanoma patients treated with this... 
apoptosis | melanoma | MEK | BRAF | wnt | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Wnt | Melanoma | Apoptosis | AXIN | STABILITY | MALIGNANT-MELANOMA | BETA-CATENIN | NEGATIVE REGULATOR | BRAF(V600E) | CELL BIOLOGY | WNT PATHWAY | NEURAL CREST | EXPRESSION | EXON 3 | RNA, Small Interfering - genetics | Axin Protein - genetics | Apoptosis - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Axin Protein - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Axin Protein - metabolism | Wnt3A Protein - pharmacology | Melanoma - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Melanoma - metabolism | beta Catenin - agonists | Melanoma - pathology | Sulfonamides - pharmacology | beta Catenin - metabolism | beta Catenin - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Melanoma - drug therapy | Cell Line, Tumor | Benzimidazoles - pharmacology | Mutation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27460 - e27460
Hypoxia Inducible Factor (HIF) signaling pathway is important for tumor cells with limited oxygen supplies, as it is shown to be involved in the process of... 
HSP90 | DEVELOPING MOUSE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | HUMAN PAPILLOMAVIRUSES | TUMOR ANGIOGENESIS | HIF-1-ALPHA | DIFFERENTIATION | HIPPEL-LINDAU PROTEIN | ENDOTHELIAL GROWTH-FACTOR | Oxygen - pharmacology | Repetitive Sequences, Nucleic Acid - genetics | Transcription, Genetic - drug effects | Cell Hypoxia - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | RNA, Messenger - genetics | Genes, Reporter - genetics | Lactams, Macrocyclic - pharmacology | RNA, Messenger - metabolism | Benzoquinones - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Binding - drug effects | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | HSP90 Heat-Shock Proteins - genetics | Gene Expression Regulation, Neoplastic - drug effects | Cell Hypoxia - genetics | Heat shock proteins | Development and progression | Health aspects | Cervical cancer | Cancer | Biotechnology | Hsp90 protein | Transcription factors | Biochemistry | Genomes | Biology | Kinases | Cancer therapies | Proteins | Angiogenesis | Signal transduction | Repressors | Fibroblasts | Tumorigenesis | Vascular endothelial growth factor | Nucleotide sequence | Tumor cells | Tumor cell lines | Cervix | Gene expression | Medicine | Signaling | Cell lines | Stem cells | Hypoxia | VHL protein | Binding sites | Apoptosis | Index Medicus
Journal Article
Journal Article