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radiotherapy (12) 12
index medicus (10) 10
oncology (10) 10
animals (8) 8
humans (8) 8
cancer (6) 6
tumors (6) 6
mice (5) 5
radiology, nuclear medicine & medical imaging (5) 5
cell line, tumor (4) 4
hematology, oncology and palliative medicine (4) 4
hypoxia (4) 4
inhibition (4) 4
positron-emission tomography (4) 4
activated prodrug th-302 (3) 3
disease models, animal (3) 3
expression (3) 3
fractionated-irradiation (3) 3
hematology (3) 3
immunotherapy (3) 3
multidisciplinary sciences (3) 3
radiation (3) 3
radiology nuclear medicine and imaging (3) 3
rats (3) 3
renal-cell carcinoma (3) 3
th-302 (3) 3
tumor hypoxia (3) 3
abscopal effect (2) 2
analysis (2) 2
antineoplastic agents - pharmacology (2) 2
biochemistry (2) 2
biology and life sciences (2) 2
biotechnology (2) 2
ca-ix (2) 2
cancer therapies (2) 2
cancer treatment (2) 2
carbonic anhydrase inhibitors - pharmacology (2) 2
carbonic anhydrase ix (2) 2
carbonic-anhydrase-ix (2) 2
cell biology (2) 2
cell lines (2) 2
cell proliferation - drug effects (2) 2
cell survival (2) 2
cell survival - radiation effects (2) 2
damage (2) 2
dna (2) 2
dose-painting (2) 2
dose-response relationship, radiation (2) 2
enzymes (2) 2
enzymology (2) 2
female (2) 2
gene expression (2) 2
glutathione (2) 2
growth (2) 2
growth delay (2) 2
head (2) 2
health aspects (2) 2
hx4 pet (2) 2
hypoxia-activated prodrug (2) 2
in-vitro (2) 2
inhibitors (2) 2
male (2) 2
medicine (2) 2
medicine and health sciences (2) 2
memory effect (2) 2
metabolism (2) 2
metastasis (2) 2
mice, nude (2) 2
neoplasms - diagnosis (2) 2
neoplasms - metabolism (2) 2
neoplasms - radiotherapy (2) 2
nitroimidazoles - pharmacology (2) 2
nitroimidazoles - therapeutic use (2) 2
original research (2) 2
phosphoramide mustards - therapeutic use (2) 2
physiological aspects (2) 2
proteins (2) 2
radiation dosage (2) 2
radiation therapy (2) 2
rat rhabdomyosarcoma (2) 2
research article (2) 2
rhabdomyosarcoma - radiotherapy (2) 2
safety (2) 2
science (2) 2
toxicology (2) 2
treatment outcome (2) 2
tumor cells, cultured (2) 2
tumour (2) 2
xenograft model antitumor assays (2) 2
5-nitroimidazole (1) 1
abscopal effect; immunotherapy; l19-il2; memory effect; radiotherapy; tumour (1) 1
abscopal regression (1) 1
acidification (1) 1
activation (1) 1
adenocarcinoma (1) 1
angiogenesis (1) 1
animal models (1) 1
antibiotics, antineoplastic - pharmacology (1) 1
antibodies - immunology (1) 1
antigens, neoplasm - analysis (1) 1
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1. Full Text Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress
by van Gisbergen, Marike W and Voets, An M and Biemans, Rianne and Hoffmann, Roland F and ttij-Reijnders, Marie-Jose and Haenen, Guido R. M. M and Heijink, Irene H and Rouschop, Kasper M. A and Dubois, Ludwig J and Lambin, Philippe
Plos one, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182508
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that... 
METFORMIN | METABOLISM | GLUTATHIONE | MULTIDISCIPLINARY SCIENCES | TUMOR RESPONSE | RESISTANCE | GENERATION | RADIOSENSITIVITY | MITOCHONDRIAL-DNA | IONIZING-RADIATION | CELL-DEATH | Sequence Deletion | DNA, Mitochondrial - genetics | Reactive Oxygen Species - metabolism | Humans | Cell Line, Tumor | Oxidative Stress - radiation effects | DNA Damage | In Vitro Techniques | Cell Survival - radiation effects | DNA - radiation effects | Cell Proliferation - radiation effects | Oxidative stress | Care and treatment | DNA damage | Physiological aspects | Mitochondrial DNA | Research | Radiotherapy | Health aspects | Cancer | Drugs | Cell culture | Biotechnology | Radiosensitivity | Copy number | Radiation | Oncology | Genomes | Dosage | Cancer therapies | Antioxidants | Mitochondria | Toxicology | Stress response | Damage | Deoxyribonucleic acid--DNA | Glutathione | Medical research | Cell survival | Developmental biology | Radiation therapy | Metabolism | Depletion | Cell lines | Irradiation | Mutation | In vitro methods and tests | Deoxyribonucleic acid | DNA
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2. Full Text A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the “Low Drug Uptake Volume”
by Yaromina, Ala and Granzier, Marlies and Biemans, Rianne and Lieuwes, Natasja and van Elmpt, Wouter and Shakirin, Georgy and Dubois, Ludwig and Lambin, Philippe
Radiotherapy and Oncology, ISSN 0167-8140, 2017, Volume 124, Issue 3, pp. 513 - 520
Abstract Background and purpose We tested a novel treatment approach combining (1) targeting radioresistant hypoxic tumour cells with the hypoxia-activated... 
Hematology, Oncology and Palliative Medicine | Hypoxia-activated prodrug | HX4 PET | Rat rhabdomyosarcoma | Dose-painting | Growth delay | Radiotherapy | TH-302
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3. Full Text Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity
by Spiegelberg, Linda and van Hoof, Stefan J and Biemans, Rianne and Lieuwes, Natasja G and Marcus, Damiënne and Niemans, Raymon and Theys, Jan and Yaromina, Ala and Lambin, Philippe and Verhaegen, Frank and Dubois, Ludwig J
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, ISSN 0167-8140, 08/2019
Esophageal cancer incidence is increasing and is rarely curable. Hypoxic tumor areas cause resistance to conventional therapies, making them susceptible for... 
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4. Full Text In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity
by Panth, Kranthi Marella and van den Beucken, Twan and Biemans, Rianne and Lieuwes, Natasja G and Weber, Marcel and Losen, Mario and Yaromina, Ala and Dubois, Ludwig J and Lambin, Philippe
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 22198 - 22198
Matrix metalloproteinase-2 (MMP2) is important in tumorigenesis, angiogenesis and tumor invasion. In this study, we investigated if the Cy5-tagged small immuno... 
ACTIVATION | INVASION | METASTASIS | INHIBITION | INCREASED EXPRESSION | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | GELATINASE-A MMP-2 | MATRIX METALLOPROTEINASE-2 MMP-2 | CANCER | Neoplasms - metabolism | Gene Expression | Reproducibility of Results | Matrix Metalloproteinase 2 - metabolism | Tumor Microenvironment | Molecular Imaging - methods | Neoplasms - diagnosis | Integrin alphaVbeta3 - metabolism | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Animals | Heterografts | Integrin alphaVbeta3 - genetics | Neoplasms - genetics | Antibodies - immunology | Cell Line, Tumor | Mice | Enzyme Activation | Matrix Metalloproteinase 2 - immunology | Optical Imaging - methods | Disease Models, Animal | Lysates | Angiogenesis | Animal models | Gelatin | Tumorigenesis | Metalloproteinase | Matrix metalloproteinase | Tumors | Gelatinase A | Index Medicus
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5. Full Text The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy
by van Kuijk, Simon J. A and Gieling, Roben G and Niemans, Raymon and Lieuwes, Natasja G and Biemans, Rianne and Telfer, Brian A and Haenen, Guido R. M. M and Yaromina, Ala and Lambin, Philippe and Dubois, Ludwig J and Williams, Kaye J
PLoS One, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0161040
Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX... 
Carbonic Anhydrase IX - antagonists & inhibitors | Cell Hypoxia - drug effects | Antibiotics, Antineoplastic - pharmacology | Humans | Carbonic Anhydrase Inhibitors - pharmacology | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | HT29 Cells | Xenograft Model Antitumor Assays | Breast Neoplasms - enzymology | Animals | Breast Neoplasms - pathology | Mice, Nude | Female | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Doxorubicin - pharmacology | BREAST-CANCER | CARBONIC-ANHYDRASE-IX | IN-VITRO | CHEMOTHERAPEUTIC-AGENTS | TUMOR HYPOXIA | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | MARKERS | FRACTIONATED-IRRADIATION | EXPRESSION | Treatment outcome | Usage | Analysis | Carbonic anhydrase inhibitors | Dosage and administration | Drug therapy, Combination | Drug therapy | Doxorubicin | Tumors | Biotechnology | Effectiveness | Carbon dioxide | Acidification | Breast cancer | Metastasis | Radiation therapy | Metabolism | Gene expression | pH effects | Cancer therapies | Proteins | Chemotherapy | Inhibitors | Carbonic anhydrase | Cell lines | Xenografts | Hypoxia | Vascular endothelial growth factor | Viability
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6. Full Text A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the "Low Drug Uptake Volume"
by Yaromina, A and Granzier, M and Biemans, R and Lieuwes, N and van Elmpt, W and Shakirin, G and Dubois, L and Lambin, P
RADIOTHERAPY AND ONCOLOGY, ISSN 0167-8140, 09/2017, Volume 124, Issue 3, pp. 513 - 520
Background and purpose: We tested a novel treatment approach combining (1) targeting radioresistant hypoxic tumour cells with the hypoxia-activated prodrug... 
NECK-CANCER PATIENTS | Hypoxia-activated prodrug | NUDE-MICE | Rat rhabdomyosarcoma | Growth delay | Radiotherapy | PROGNOSTIC VALUE | LUNG-CANCER | HX4 PET | ONCOLOGY | PHASE-I TRIAL | Dose-painting | ACTIVATED PRODRUG TH-302 | SQUAMOUS-CELL CARCINOMA | INTERNATIONAL MULTICENTER | LOCAL-CONTROL | FRACTIONATED-IRRADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | TH-302 | Radiotherapy Dosage | Humans | Rats | Rhabdomyosarcoma - pathology | Male | Tumor Burden | Rhabdomyosarcoma - diagnostic imaging | Positron Emission Tomography Computed Tomography | Rhabdomyosarcoma - radiotherapy | Animals | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - therapeutic use | Radiotherapy Planning, Computer-Assisted | Radiation | Tumors | Pets | Tracers (Biology)
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7. Full Text TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [F-18]HX4 Hypoxia PET Imaging
by Peeters, Sarah G. J. A and Zegers, Catharina M. L and Biemans, Rianne and Lieuwes, Natasja G and van Stiphout, Ruud G. P. M and Yaromina, Ala and Sun, Jessica D and Hart, Charles P and Windhorst, Albert D and van Elmpt, Wouter and Dubois, Ludwig J and Lambin, Philippe
Clinical Cancer Research, ISSN 1078-0432, 07/2015, Volume 21, Issue 13, pp. 2984 - 2992
Purpose: Conventional anticancer treatments are often impaired by the presence of hypoxia. TH-302 selectively targets hypoxic tumor regions, where it is... 
TRIAL | FRACTION | TUMOR HYPOXIA | PHARMACOKINETICS | ONCOLOGY | SAFETY | ACTIVATED PRODRUG TH-302 | CARBOGEN | PHASE-I | CANCER | SOFT-TISSUE SARCOMA | Nitroimidazoles - pharmacology | Phosphoramide Mustards - pharmacology | Rats | Treatment Outcome | Antineoplastic Agents - therapeutic use | Lung Neoplasms - therapy | Positron-Emission Tomography | Chemoradiotherapy | Cell Hypoxia | Xenograft Model Antitumor Assays | Carcinoma, Non-Small-Cell Lung - therapy | Animals | Imidazoles | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - therapeutic use | Triazoles | Lung Neoplasms - diagnostic imaging | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Radiopharmaceuticals
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8. Full Text Synthesis and in Vivo Biological Evaluation of 68Ga-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography
by Sneddon, Deborah and Niemans, Raymon and Bauwens, Matthias and Yaromina, Ala and Van Kuijk, Simon J. A and Lieuwes, Natasja G and Biemans, Rianne and Pooters, Ivo and Pellegrini, Paul A and Lengkeek, Nigel A and Greguric, Ivan and Tonissen, Kathryn F and Supuran, Claudiu T and Lambin, Philippe and Dubois, Ludwig and Poulsen, Sally-Ann
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 13, pp. 6431 - 6443
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9. Full Text Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs
by Dubois, Ludwig and Peeters, Sarah G.J.A and van Kuijk, Simon J.A and Yaromina, Ala and Lieuwes, Natasja G and Saraya, Ruchi and Biemans, Rianne and Rami, Marouan and Parvathaneni, Nanda Kumar and Vullo, Daniela and Vooijs, Marc and Supuran, Claudiu T and Winum, Jean-Yves and Lambin, Philippe
Radiotherapy and Oncology, ISSN 0167-8140, 2013, Volume 108, Issue 3, pp. 523 - 528
Abstract Background and purpose Carbonic anhydrase IX (CAIX) plays an important role in pH regulation processes critical for tumor cell growth and metastasis.... 
Hematology, Oncology and Palliative Medicine | Sulfamide | Carbonic anhydrase IX (CAIX) | 5-Nitroimidazole | Radiotherapy | Dual targeting | VITRO | HEAD | HYPOXIA | NIMORAZOLE | CANCER | INHIBITION | ONCOLOGY | IN-VIVO | GROWTH | PH | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Carbonic Anhydrases - physiology | Animals | Nitroimidazoles - pharmacology | Antigens, Neoplasm - physiology | Humans | Radiation-Sensitizing Agents - pharmacology | Colorectal Neoplasms - radiotherapy | Cell Line, Tumor | Mice | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase IX | Health aspects | Tumors
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10. Full Text Synthesis and in Vivo Biological Evaluation of Ga-68-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography
by Sneddon, Deborah and Niemans, Raymon and Bauwens, Matthias and Yaromina, Ala and van Kuijk, Simon J. A and Lieuwes, Natasja G and Biemans, Rianne and Pooters, I and Pellegrini, Paul A and Lengkeek, Nigel A and Greguric, Ivan and Tonissen, Kathryn F and Supuran, Claudiu T and Lambin, Philippe and Dubois, Ludwig and Poulsen, Sally-Ann
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 13, pp. 6431 - 6443
Tumor hypoxia contributes resistance to chemo- and radiotherapy, while oxygenated tumors are sensitive to these treatments. The indirect detection of hypoxic... 
CA-IX | DESIGN | CHEMISTRY, MEDICINAL | TUMOR HYPOXIA | CONTRAST AGENTS | TRANSMEMBRANE | PET/CT | INHIBITORS | EXPRESSION | RENAL-CELL CARCINOMA | CANCER-THERAPY
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11. Full Text Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer
by Meijer, Tineke W.H and Peeters, Wenny J.M and Dubois, Ludwig J and van Gisbergen, Marike W and Biemans, Rianne and Venhuizen, Jan-Hendrik and Span, Paul N and Bussink, Johan
Lung Cancer, ISSN 0169-5002, 12/2018, Volume 126, pp. 32 - 40
Metabolic inhibition might sensitize tumors to irradiation. Here, we examined the effect of lonidamine (several metabolic effects, inhibiting hexokinase... 
Glycolysis | Radiotherapy | Metabolic inhibition | Glutamine metabolism | Non-small cell lung cancer | MITOCHONDRIAL | ADENOCARCINOMA | SENSITIVITY | CLASSIFICATION | DEPENDENCIES | INHIBITION | ONCOLOGY | GLUTATHIONE | RESPIRATORY SYSTEM | EXPRESSION | LONIDAMINE | Glucose metabolism | Squamous cell carcinoma | Radiation | Physiological aspects | Lung cancer, Small cell | Glucose | Lung cancer, Non-small cell | Cells | Dextrose | Glutamine
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12. Full Text Preclinical Assessment of Efficacy of Radiation Dose Painting Based on Intratumoral FDG-PET Uptake
by Trani, Daniela and Yaromina, Ala and Dubois, Ludwig and Granzier, Marlies and Peeters, Sarah G. J. A and Biemans, Rianne and Nalbantov, Georgi and Lieuwes, Natasja and Reniers, Brigitte and Troost, Esther E. G. C and Verhaegen, Frank and Lambin, Philippe
Clinical Cancer Research, ISSN 1078-0432, 12/2015, Volume 21, Issue 24, pp. 5511 - 5518
Purpose: We tested therapeutic efficacy of two dose painting strategies of applying higher radiation dose to tumor subvolumes with high FDG uptake (biologic... 
CELL LUNG-CANCER | HETEROGENEITY | TUMOR-MODEL | HEAD | NSCLC | ONCOLOGY | FRACTIONATED-IRRADIATION | RADIOTHERAPY | HYPOXIA | NECK-CANCER | ESCALATION | Neoplasms - metabolism | Rhabdomyosarcoma - diagnosis | Tumor Burden - radiation effects | Humans | Fluorodeoxyglucose F18 - metabolism | Rats | Male | Neoplasms - diagnosis | Positron-Emission Tomography | Radiation Dosage | Rhabdomyosarcoma - radiotherapy | Animals | Neoplasms - radiotherapy | Dose-Response Relationship, Radiation | Disease Models, Animal
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13. Full Text New ways to image and target tumour hypoxia and its molecular responses
by Dubois, Ludwig J and Niemans, Raymon and van Kuijk, Simon J.A and Panth, Kranthi M and Parvathaneni, Nanda-Kumar and Peeters, Sarah G.J.A and Zegers, Catharina M.L and Rekers, Nicolle H and van Gisbergen, Marike W and Biemans, Rianne and Lieuwes, Natasja G and Spiegelberg, Linda and Yaromina, Ala and Winum, Jean-Yves and Vooijs, Marc and Lambin, Philippe
Radiotherapy and Oncology, ISSN 0167-8140, 2015, Volume 116, Issue 3, pp. 352 - 357
Abstract Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive... 
Hematology, Oncology and Palliative Medicine | Therapy | Hypoxia | Carbonic anhydrase IX | Window-of-opportunity trial | Imaging | CARBONIC-ANHYDRASE-IX | CANCER | RENAL-CELL CARCINOMA | CA-IX | IN-VITRO | POSITRON-EMISSION-TOMOGRAPHY | INHIBITION | ONCOLOGY | ACTIVATED PRODRUG TH-302 | RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | Hypoxia - physiopathology | Positron-Emission Tomography | Neoplasms - physiopathology | Hypoxia - diagnostic imaging | Neoplasms - diagnostic imaging | Humans | Tumors
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14. Full Text Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model
by Rekers, Nicolle H and Zegers, Catharina M.L and Yaromina, Ala and Lieuwes, Natasja G and Biemans, Rianne and Senden-Gijsbers, Birgit L.M.G and Losen, Mario and Van Limbergen, Evert J and Germeraad, Wilfred T.V and Neri, Dario and Dubois, Ludwig and Lambin, Philippe
Radiotherapy and Oncology, ISSN 0167-8140, 2015, Volume 116, Issue 3, pp. 438 - 442
Abstract Background and purpose Recently, we have shown that radiotherapy (RT) combined with the immunocytokine L19-IL2 can induce long-lasting antitumour... 
Hematology, Oncology and Palliative Medicine | ED-B | MHCI | Immunotherapy | Cancer | F9 | INTERLEUKIN-2 | ONCOLOGY | MEDIATED ERADICATION | METASTASES | FIBRONECTIN | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | DELIVERY | Drug Administration Schedule | Recombinant Fusion Proteins - pharmacology | Combined Modality Therapy | Antineoplastic Agents - administration & dosage | Mice, Inbred Strains | Fibronectins - metabolism | Histocompatibility Antigens Class I - metabolism | Immunity, Cellular - immunology | Animals | Neoplasms - immunology | Killer Cells, Natural - immunology | Radioimmunotherapy - methods | Neoplasms - radiotherapy | Antineoplastic Agents - pharmacology | Mice | Recombinant Fusion Proteins - administration & dosage | Disease Models, Animal | Killer cells | Radiotherapy | Analysis | Tumors
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15. Full Text The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses
by Rekers, Nicolle H and Olivo Pimentel, Veronica and Yaromina, Ala and Lieuwes, Natasja G and Biemans, Rianne and Zegers, Catharina M. L and Germeraad, Wilfred T. V and Van Limbergen, Evert J and Neri, Dario and Dubois, Ludwig J and Lambin, Philippe
OncoImmunology, ISSN 2162-4011, 04/2018, Volume 7, Issue 4, p. e1414119
Recently, we have shown that the administration of the tumour-targeted antibody-based immunocytokine L19-IL2 after radiotherapy (RT) resulted in synergistic... 
L19-IL2 | abscopal effect | Radiotherapy | memory effect | tumour | immunotherapy | CTLA-4 BLOCKADE | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | RENAL-CELL CARCINOMA | LOCAL RADIOTHERAPY | RADIATION-THERAPY | METASTATIC MELANOMA | SELECTIVE EXPRESSION | ONCOLOGY | ED-B DOMAIN | ABSCOPAL REGRESSION | T-CELLS
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16. Full Text High dose rate and flattening filter free irradiation can be safely implemented in clinical practice
by Dubois, Ludwig and Biemans, Rianne and Reniers, Brigitte and Bosmans, Geert and Trani, Daniela and Podesta, Mark and Kollaard, Robert and Rouschop, Kasper ma and Theys, Jan and Vooijs, Marc and Pruschy, Martin and Verhaegen, Frank and Lambin, Philippe
International Journal of Radiation Biology, ISSN 0955-3002, 10/2015, Volume 91, Issue 10, pp. 778 - 785
Purpose: We hypothesize that flattening filter free (FFF) high dose rate irradiation will decrease cell survival in normal and cancer cells with more... 
cell survival | High dose rate irradiation | DNA repair | flattening filter free (FFF) | fl attening fi lter free (FFF) | BODY RADIATION-THERAPY | CELL-SURVIVAL | DAMAGE | ELECTRON FLUENCE | REPAIR | NUCLEAR SCIENCE & TECHNOLOGY | LINEAR-ACCELERATOR | DNA | BIOLOGY | FREE PHOTON BEAMS | MONTE-CARLO-SIMULATION | RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Clone Cells - cytology | Homologous Recombination - radiation effects | Clone Cells - radiation effects | Humans | Cell Line, Tumor | DNA Repair - radiation effects | Radiation Dosage | Relative Biological Effectiveness | Safety | Cell Survival - radiation effects | Dose-Response Relationship, Radiation | Index Medicus | Space life sciences
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17. Full Text The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses
by Rekers, Nicolle H and Olivo Pimentel, Veronica and Yaromina, Ala and Lieuwes, Natasja G and Biemans, Rianne and Zegers, Catharina M L and Germeraad, Wilfred T V and Van Limbergen, Evert J and Neri, Dario and Dubois, Ludwig J and Lambin, Philippe
Oncoimmunology, ISSN 2162-4011, 2018, Volume 7, Issue 4, p. e1414119
Recently, we have shown that the administration of the tumour-targeted antibody-based immunocytokine L19-IL2 after radiotherapy (RT) resulted in synergistic... 
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