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by Medema, Marnix H and Kottmann, Renzo and Yilmaz, Pelin and Cummings, Matthew and Biggins, John B and Blin, Kai and de Bruijn, Irene and Chooi, Yit Heng and Claesen, Jan and Coates, R Cameron and Cruz-Morales, Pablo and Duddela, Srikanth and Düsterhus, Stephanie and Edwards, Daniel J and Fewer, David P and Garg, Neha and Geiger, Christoph and Gomez-Escribano, Juan Pablo and Greule, Anja and Hadjithomas, Michalis and Haines, Anthony S and Helfrich, Eric J N and Hillwig, Matthew L and Ishida, Keishi and Jones, Adam C and Jones, Carla S and Jungmann, Katrin and Kegler, Carsten and Kim, Hyun Uk and Kötter, Peter and Krug, Daniel and Masschelein, Joleen and Melnik, Alexey V and Mantovani, Simone M and Monroe, Emily A and Moore, Marcus and Moss, Nathan and Nützmann, Hans-Wilhelm and Pan, Guohui and Pati, Amrita and Petras, Daniel and Reen, F Jerry and Rosconi, Federico and Rui, Zhe and Tian, Zhenhua and Tobias, Nicholas J and Tsunematsu, Yuta and Wiemann, Philipp and Wyckoff, Elizabeth and Yan, Xiaohui and Yim, Grace and Yu, Fengan and Xie, Yunchang and Aigle, Bertrand and Apel, Alexander K and Balibar, Carl J and Balskus, Emily P and Barona-Gómez, Francisco and Bechthold, Aneas and Bode, Helge B and Borriss, Rainer and Brady, Sean F and Brakhage, Axel A and Caffrey, Patrick and Cheng, Yi-Qiang and Clardy, Jon and Cox, Russell J and De Mot, René and Donadio, Stefano and Donia, Mohamed S and van der Donk, Wilfred A and Dorrestein, Pieter C and Doyle, Sean and essen, Arnold J M and Ehling-Schulz, Monika and Entian, Karl-Dieter and Fischbach, Michael A and Gerwick, Lena and Gerwick, William H and Gross, Harald and Gust, Bertolt and Hertweck, Christian and Höfte, Monica and Jensen, Susan E and Ju, Jianhua and Katz, Leonard and Kaysser, Leonard and Klassen, Jonathan L and Keller, Nancy P and Kormanec, Jan and Kuipers, Oscar P and Kuzuyama, Tomohisa and Kyrpides, Nikos C and Kwon, Hyung-Jin and Lautru, Sylvie and Lavigne, Rob and Lee, Chia Y and Linquan, Bai and Liu, Xinyu and Liu, Wen and ...
Nature Chemical Biology, ISSN 1552-4469, 08/2015, Volume 11, Issue 9, pp. 625 - 631
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4147 - 15
Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these... 
MYCOBACTERIUM-TUBERCULOSIS | ANSAMYCINS | STRUCTURAL BASIS | NATURAL-PRODUCTS | DNA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | TRANSCRIPTION | ALLOSTERIC MODULATION | RNA-POLYMERASE | RPOB MUTATIONS | DNA-Directed RNA Polymerases - antagonists & inhibitors | Rifampin - chemistry | Humans | Metagenomics - methods | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Antibiotics, Antitubercular - biosynthesis | Rifamycins - chemistry | Hydroxybenzoates - chemistry | Molecular Structure | Drug Resistance, Bacterial - drug effects | Drug Resistance, Bacterial - genetics | Mycobacterium tuberculosis - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacteria - metabolism | Soil Microbiology | Bacterial Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Antibiotics, Antitubercular - pharmacology | Bacteria - genetics | Antibiotics, Antitubercular - chemistry | Rifamycins - pharmacology | Aminobenzoates - chemistry | Tuberculosis - prevention & control | Bacterial Proteins - metabolism | Mutation | Rifampin - pharmacology | DNA-Directed RNA Polymerases - metabolism | Mycobacterium tuberculosis - genetics | Rifampin - metabolism | Phenotypes | Gene clusters | Congeners | Microbiomes | Biosynthesis | Rifamycin | Ribonucleic acid--RNA | Rifamycins | Substrates | Soil resistance | Tuberculosis | Antibiotics | Metabolites | Bacteria | Rifampin
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 3/2018, Volume 102, Issue 5, pp. 2337 - 2350
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2000, Volume 97, Issue 25, pp. 13537 - 13542
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2014, Volume 136, Issue 26, pp. 9484 - 9490
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 02/2011, Volume 133, Issue 6, pp. 1638 - 1641
Bacterial genome sequencing projects routinely uncover gene clusters that are predicted to encode the biosynthesis of uncharacterized small molecules. A subset... 
THAILANDENSIS | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | NATURAL-PRODUCTS | Genome, Bacterial - genetics | Gene Expression | Humans | Burkholderia pseudomallei - metabolism | HeLa Cells | Burkholderia pseudomallei - genetics | Operon - genetics | Physiological aspects | Burkholderia pseudomallei | Genetic aspects | Research | Phosphodiesterases
Journal Article
Organic Letters, ISSN 1523-7060, 03/2011, Volume 13, Issue 6, pp. 1536 - 1539
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2000, Volume 122, Issue 28, pp. 6803 - 6804
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2000, Volume 97, Issue 25, pp. 13537 - 13542
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 03/2010, Volume 5, Issue 3, pp. 313 - 320
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2006, Volume 335, pp. 83 - 92
Exploring the properties of molecules that cleave DNA (i.e., enzymatic nucleases, chemical footprinting agents, and naturally occurring DNA cleaving... 
Molecular Probes | Nucleic Acid Hybridization - methods | Molecular Probe Techniques | DNA Restriction Enzymes | DNA - analysis | DNA - metabolism | Fluorescent Dyes
Journal Article
Science (Washington), ISSN 0036-8075, 09/2003, Volume 301, Issue 5639, pp. 1537 - 1541
Antibiotic self-resistance mechanisms, which include drug elimination, drug modification, target modification, and drug sequestration, contribute substantially... 
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2000, Volume 122, Issue 28, pp. 6803 - 6804
Journal Article
Organic Letters, ISSN 1523-7060, 03/2003, Volume 5, Issue 6, pp. 933 - 936
In an effort to expand the scope of natural product in vitro glycorandomization (IVG), the substrate specificity of NovM was investigated. A test of four... 
NUCLEOTIDE | NUCLEOTIDYLYLTRANSFERASE | REPERTOIRE | DNA GYRASE | CHEMISTRY, ORGANIC | DRUG TARGET | SUGARS | CLOROBIOCIN | Streptomyces | Substrate Specificity | Anti-Bacterial Agents - biosynthesis | Novobiocin - biosynthesis | Glycosides - chemistry
Journal Article