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1. Full Text Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study
by Leiter, L. A and Lundman, P and da Silva, P. M and xel, H and Jünger, C and Gitt, A. K and Absenger, Guun and Albrich, Ernst and Allinger, Berndt and Allinger, Stephan and Anacher, Gerald and Angermayr, Gertraud and Angermeier, Hermann and Anzengruber, Aneas and Archimanitis, Gabriele and Arnsteiner, Patricia and Auberger, Wolfgang and Azhary, Mawaheb and Barfuss, Michael and Bauer, Christian and Bauer, Birgit Elisabeth and Beclin, Thomas and Binder, Thomas and Binder, Gabriele and Böhler, Dietmar and Brändle, Johann and Breslmair, Jörg and Brettlecker, Marlis and Bürger, Michael and Calvi, Inge and Dorfinger, Werner and Doringer-Schnepf, Elisabeth and Eer, Anton and Eckmayr, Christine and Eder, Franz and Egermann, Margit and Erath, Michael and Etzinger, Michael and Etzinger, Claudia and Fiedler, Lothar and Filip, Wolfgang and Filip, Michaela and Föchterle, Johann and Fodor, Anita and Frieden, Thomas and Gareiss, Mertens and Gföllner, Peter and Ghamarian, Thomas and Goritschan, Michael and Haar, Klaus and Habeler, Gerhard and Hadjiivanov, Valery and Haiböck, Christian and Hammer, Regina and Hartmann, Siegfried and Haschkovitz, Herbert and Hauer, Walter and Hauer, Josef and Haunschmidt, Christian and Heimayr, Christine and Hengl, Wolfgang and Hengl, Gunter and Hermann, Rudolf and Herrmann, Rainer and Hillebrand, Roswitha and Hintersteininger, Otto and Hirsch, Michael and Hitzinger, Martin and Hochegger, Tanja and Hockl, Wolfgang and Hoi, Michael and Hörmann, Jan and Hudler, Brigitte and Imb, Gerhard and Joichl, Anea and Jungbauer, Karl and Kapl, Gerlinde and Kerschbaum, Margit and Kienesberger, Franz and Killinger, Gerhard and Kitzler, Gerhard and Klein, Franz and Kleinbichler, Dietmar and Kohr, Anton and Kopetzky, Michael and Korthals, Christian and Kortschak, Werner and Koschutnik, Martin and Kraus, Werner A and Kurzemann, Susanne and Lavicka, Claus and Lehner, Guido and Lenz, Jürgen and Lepuschütz, Sabine and Lichtenwallner, Michael and Lober, Reinhard and Loidl, Christine and Lopatka, Eduard and Ludwig, Rudolf and Maca, Thomas and ... and DYSIS Investigators and DYSIS investigators
Diabetic medicine, ISSN 0742-3071, 2011, Volume 28, Issue 11, pp. 1343 - 1351
To assess the prevalence of persistent lipid abnormalities in statin-treated patients with diabetes with and without the metabolic syndrome. This was a... 
metabolic syndrome | cardiovascular disease | diabetes mellitus | dyslipidaemia | statins | Cardiovascular disease | Dyslipidaemia | Metabolic syndrome | Diabetes mellitus | Statins | METAANALYSIS | GUIDELINES | PREVENTION | DENSITY-LIPOPROTEIN CHOLESTEROL | THERAPY | REDUCTION | ENDOCRINOLOGY & METABOLISM | CORONARY-HEART-DISEASE | CLINICAL-PRACTICE | CARDIOVASCULAR RISK | LOW HDL-CHOLESTEROL | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Humans | Diabetic Angiopathies - etiology | Male | Metabolic Syndrome - drug therapy | Diabetes Mellitus, Type 2 - epidemiology | Metabolic Syndrome - blood | Canada - epidemiology | Cardiovascular Diseases - epidemiology | Cholesterol, LDL - blood | Female | Dyslipidemias - etiology | Diabetes Mellitus, Type 2 - complications | Metabolic Syndrome - epidemiology | Cardiovascular Diseases - etiology | Diabetic Angiopathies - chemically induced | Cross-Sectional Studies | Cholesterol, HDL - drug effects | Europe - epidemiology | Cholesterol, LDL - drug effects | Diabetic Angiopathies - blood | Anticholesteremic Agents - adverse effects | Metabolic Syndrome - complications | Diabetes Mellitus, Type 2 - blood | Dyslipidemias - epidemiology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Anticholesteremic Agents - administration & dosage | Dyslipidemias - chemically induced | Cholesterol, HDL - blood | Diabetic Angiopathies - epidemiology | Aged | Cardiovascular Diseases - chemically induced | Diabetes Mellitus, Type 2 - drug therapy | Diabetics | Blood cholesterol | Simvastatin | Low density lipoproteins | Triglycerides | Diabetes | Risk factors | Trans fatty acids | Index Medicus
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2. Full Text Small Molecule Obatoclax (GX15-070) Antagonizes MCL-1 and Overcomes MCL-1-Mediated Resistance to Apoptosis
by Mai Nguyen and Richard C. Marcellus and Anne Roulston and Mark Watson and Lucile Serfass and S. R. Murthy Madiraju and Daniel Goulet and Jean Viallet and Laurent Bélec and Xavier Billot and Stephane Acoca and Enrico Purisima and Adrian Wiegmans and Leonie Cluse and Ricky W. Johnstone and Pierre Beauparlant and Gordon C. Shore
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 49, pp. 19512 - 19517
Elevated expression of members of the BCL-2 pro-survival family of proteins can confer resistance to apoptosis in cancer cells. Small molecule obatoclax... 
Molecules | Yeasts | Mitochondria | Epithelial cells | Cell lines | Small interfering RNA | Antibodies | Cell membranes | Annexins | Apoptosis | Bcl-2 | Bax | Caspase | Bak | Melanoma | MULTIPLE-MYELOMA | MANTLE-CELL LYMPHOMA | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | melanoma | MEDIATED APOPTOSIS | BH3-ONLY LIGANDS | BORTEZOMIB | BH3 MIMETIC ABT-737 | caspase | IN-VIVO | BCL-2 PROTEINS | INHIBITORS | Melanoma - metabolism | Bortezomib | Apoptosis - drug effects | Humans | bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Pyrroles - pharmacology | Animals | Cysteine Proteinase Inhibitors - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Mice | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Drug resistance | Antagonist drugs | Cancer | Index Medicus | Biological Sciences
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3. Full Text Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
by Myburgh, John A and Finfer, Simon and Bellomo, Rinaldo and Billot, Laurent and Cass, Alan and Gattas, David and Glass, Parisa and Lipman, Jeffrey and Liu, Bette and McArthur, Colin and McGuinness, Shay and Rajbhandari, Dorrilyn and Taylor, Colman B and Webb, Steven A.R and CHEST Investigators and Australian New Zealand Intensive and Australian and New Zealand Intensive Care Society Clinical Trials Group
The New England Journal of Medicine, ISSN 0028-4793, 11/2012, Volume 367, Issue 20, pp. 1901 - 1911
In a study of fluid resuscitation, patients received 6% hydroxyethyl starch (HES; 130/0.4) or saline until ICU discharge or death or for 90 days. There was no... 
TRIAL | REPLACEMENT | ACUTE KIDNEY INJURY | MEDICINE, GENERAL & INTERNAL | MULTICENTER | THERAPY | RENAL-FUNCTION | CRITICALLY-ILL PATIENTS | UNITS | SEVERE SEPSIS | Intensive Care Units | Resuscitation - methods | Hospital Mortality | Humans | Middle Aged | Male | Creatinine - urine | Fluid Therapy - adverse effects | Sodium Chloride - therapeutic use | Critical Illness - mortality | Fluid Therapy - methods | Intention to Treat Analysis | Creatinine - blood | Critical Illness - therapy | Hydroxyethyl Starch Derivatives - therapeutic use | Adult | Critical Care | Female | Aged | Kidney Diseases - etiology | Hydroxyethyl Starch Derivatives - adverse effects | Care and treatment | Usage | Kidney failure | Critically ill | Patient outcomes | Physiologic salines | Health aspects | Risk factors | Resuscitation | Methods | Ethics | Intensive care | Renal function | Starch | Mortality | Fluid | Renal failure | Clinical trials | Hydroxyethyl starch | Sodium chloride | Patients | Molecular weight | Index Medicus | Abridged Index Medicus
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4. Full Text Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
by Venkatesh, Balasubramanian and Finfer, Simon and Cohen, Jeremy and Rajbhandari, Dorrilyn and Arabi, Yaseen and Bellomo, Rinaldo and Billot, Laurent and Correa, Maryam and Glass, Parisa and Harward, Meg and Joyce, Christopher and Li, Qiang and McArthur, Colin and Perner, Anders and Rhodes, Andrew and Thompson, Kelly and Webb, Steve and Myburgh, John and ADRENAL Trial Investigators and Australian-New Zealand Intensive C and ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group
The New England Journal of Medicine, ISSN 0028-4793, 03/2018, Volume 378, Issue 9, pp. 797 - 808
Whether hydrocortisone reduces mortality among patients with septic shock is unclear. Patients with septic shock undergoing mechanical ventilation were... 
TRIAL | MORTALITY | DEFINITIONS | MEDICINE, GENERAL & INTERNAL | CORTICOTROPIN TEST | GUIDELINES | ADULTS | CRITICALLY-ILL PATIENTS | CORTICOSTEROID TREATMENT | HYDROCORTISONE | SEVERE SEPSIS | Recurrence | Double-Blind Method | Fungemia - etiology | Humans | Middle Aged | Renal Replacement Therapy | Shock, Septic - complications | Hydrocortisone - therapeutic use | Male | Survival Rate | Treatment Outcome | Shock, Septic - mortality | Respiration, Artificial | Shock, Septic - therapy | Hydrocortisone - adverse effects | Anti-Inflammatory Agents - adverse effects | Shock, Septic - drug therapy | Anti-Inflammatory Agents - therapeutic use | Bacteremia - etiology | Female | Aged | Chemotherapy, Adjuvant | Infusions, Intravenous | APACHE | Septic shock | Dosage and administration | Corticosteroids | Safety and security measures | Diagnosis | Health care | Shock | Ventilators | Intensive care | Statistical analysis | Glucocorticoids | Mortality | Preventive medicine | Hydrocortisone | Blood transfusion | Bacteremia | Design | Hospitals | Fungemia | Pharmacy | Ventilation | Sepsis | Clinical medicine | Renal replacement therapy | Drug dosages | Index Medicus | Abridged Index Medicus
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