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1. Full Text Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
by Venkatesh, Balasubramanian and Finfer, Simon and Cohen, Jeremy and Rajbhandari, Dorrilyn and Arabi, Yaseen and Bellomo, Rinaldo and Billot, Laurent and Correa, Maryam and Glass, Parisa and Harward, Meg and Joyce, Christopher and Li, Qiang and McArthur, Colin and Perner, Anders and Rhodes, Andrew and Thompson, Kelly and Webb, Steve and Myburgh, John and ADRENAL Trial Investigators and Australian-New Zealand Intensive C and ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group
The New England journal of medicine, ISSN 0028-4793, 03/2018, Volume 378, Issue 9, pp. 797 - 808
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Recurrence | Double-Blind Method | Fungemia - etiology | Humans | Middle Aged | Renal Replacement Therapy | Shock, Septic - complications | Hydrocortisone - therapeutic use | Male | Survival Rate | Treatment Outcome | Shock, Septic - mortality | Respiration, Artificial | Shock, Septic - therapy | Hydrocortisone - adverse effects | Anti-Inflammatory Agents - adverse effects | Shock, Septic - drug therapy | Anti-Inflammatory Agents - therapeutic use | Bacteremia - etiology | Female | Aged | Chemotherapy, Adjuvant | Infusions, Intravenous | APACHE | Septic shock | Dosage and administration | Corticosteroids | Safety and security measures | Diagnosis | Health care | Shock | Ventilators | Intensive care | Statistical analysis | Glucocorticoids | Mortality | Preventive medicine | Hydrocortisone | Blood transfusion | Bacteremia | Design | Hospitals | Fungemia | Pharmacy | Ventilation | Sepsis | Clinical medicine | Renal replacement therapy | Drug dosages | Index Medicus | Abridged Index Medicus
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2. Full Text Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
by Myburgh, John A and Finfer, Simon and Bellomo, Rinaldo and Billot, Laurent and Cass, Alan and Gattas, David and Glass, Parisa and Lipman, Jeffrey and Liu, Bette and McArthur, Colin and McGuinness, Shay and Rajbhandari, Dorrilyn and Taylor, Colman B and Webb, Steven A.R and CHEST Investigators and Australian New Zealand Intensive and Australian and New Zealand Intensive Care Society Clinical Trials Group
The New England journal of medicine, ISSN 0028-4793, 11/2012, Volume 367, Issue 20, pp. 1901 - 1911
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Intensive Care Units | Resuscitation - methods | Hospital Mortality | Humans | Middle Aged | Male | Creatinine - urine | Fluid Therapy - adverse effects | Sodium Chloride - therapeutic use | Critical Illness - mortality | Fluid Therapy - methods | Intention to Treat Analysis | Creatinine - blood | Critical Illness - therapy | Hydroxyethyl Starch Derivatives - therapeutic use | Adult | Critical Care | Female | Aged | Kidney Diseases - etiology | Hydroxyethyl Starch Derivatives - adverse effects | Care and treatment | Usage | Kidney failure | Critically ill | Patient outcomes | Physiologic salines | Health aspects | Risk factors | Resuscitation | Methods | Ethics | Intensive care | Fluids | Renal function | Starch | Mortality | Renal failure | Clinical trials | Hydroxyethyl starch | Sodium chloride | Patients | Molecular weight | Index Medicus | Abridged Index Medicus
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3. Full Text The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors
by Mark Watson and Anne Roulston and Laurent Bélec and Xavier Billot and Richard Marcellus and Dominique Bédard and Cynthia Bernier and Stéphane Branchaud and Helen Chan and Kenza Dairi and Karine Gilbert and Daniel Goulet and Michel-Olivier Gratton and Henady Isakau and Anne Jang and Abdelkrim Khadir and Elizabeth Koch and Manon Lavoie and Michael Lawless and Mai Nguyen and Denis Paquette and Émilie Turcotte and Alvin Berger and Matthew Mitchell and Gordon C. Shore and Pierre Beauparlant
Molecular and Cellular Biology, ISSN 0270-7306, 11/2009, Volume 29, Issue 21, pp. 5872 - 5888
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gene Expression Regulation, Enzymologic - drug effects | Humans | Guanidines - pharmacology | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Niacin - pharmacology | Niacin - administration & dosage | Nicotinamide Phosphoribosyltransferase - metabolism | NAD - biosynthesis | Cell Death - drug effects | Cyanides - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Ribose - metabolism | Cyanides - pharmacology | Models, Molecular | Neoplasms - enzymology | Nicotinamide Phosphoribosyltransferase - deficiency | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Nicotinamide Phosphoribosyltransferase - genetics | Animals | Substrate Specificity - drug effects | Models, Biological | Cell Line, Tumor | Mice | Guanidines - therapeutic use | Drug Resistance, Neoplasm - drug effects | Index Medicus
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4. Full Text CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea
by McEvoy, R. Doug and Antic, Nick A and Heeley, Emma and Luo, Yuanming and Ou, Qiong and Zhang, Xilong and Mediano, Olga and Chen, Guofang and Chen, Rui and Drager, Luciano F and Liu, Zhihong and Du, Baoliang and McArdle, Nigel and Mukherjee, Sutapa and Tripathi, Manjari and Billot, Laurent and Li, Qiang and Lorenzi-Filho, Geraldo and Barbe, Ferran and Redline, Susan and Wang, Jiguang and Arima, Hisatomi and Neal, Bruce and White, David P and Grunstein, Ron R and Zhong, Nanshan and Anderson, Craig S and SAVE Investigators Coordinators and SAVE Investigators and Coordinators
The New England journal of medicine, ISSN 0028-4793, 09/2016, Volume 375, Issue 10, pp. 919 - 931
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Continuous Positive Airway Pressure | Sleep Apnea, Obstructive - therapy | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Treatment Outcome | Hospitalization | Sleep Apnea, Obstructive - etiology | Cerebrovascular Disorders - complications | Coronary Artery Disease - complications | Intention to Treat Analysis | Cardiovascular Diseases - mortality | Female | Aged | Prevention | Usage | Sleep apnea syndromes | Diagnosis | Cardiovascular diseases | Continuous positive airway pressure | Myocardial infarction | Respiratory therapy | Cerebral infarction | Stroke | Transient ischemic attack | Daytime | Clinical trials | Cardiovascular disease | Sleep apnea | Angina | Quality of life | Respiratory tract | Sleep disorders | Airway management | Sleep | Apnea | Mood | Ischemia | Heart diseases | Sleep and wakefulness | Index Medicus | Abridged Index Medicus
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5. Full Text Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVD: The UMPIRE Randomized Clinical Trial
by Thom, Simon and Poulter, Neil and Field, Jane and Patel, Anushka and Prabhakaran, Dorairaj and Stanton, Alice and Grobbee, Diederick E and Bots, Michiel L and Reddy, K. Srinath and Cidambi, Raghu and Bompoint, Severine and Billot, Laurent and Rodgers, Anthony and UMPIRE Collaborative Grp and UMPIRE Collaborative Group
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 09/2013, Volume 310, Issue 9, pp. 918 - 929
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Public health. Hygiene-occupational medicine | Public health. Hygiene | Biological and medical sciences | General aspects | Medical sciences | Epidemiology | Medication Adherence - statistics & numerical data | Simvastatin - administration & dosage | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Risk Factors | Cholesterol, LDL - drug effects | Male | Treatment Outcome | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - adverse effects | Aspirin - administration & dosage | Anticholesteremic Agents - administration & dosage | Platelet Aggregation Inhibitors - administration & dosage | Cholesterol, LDL - blood | Female | Aged | Blood Pressure - drug effects | Atenolol - administration & dosage | Drug Combinations | Lisinopril - administration & dosage | Clinical trials | Cardiovascular disease | Blood pressure | Patients | Risk factors | Index Medicus | Abridged Index Medicus
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6. Full Text Long-Term Outcomes of the ADRENAL Trial
by Venkatesh, Balasubramanian and Cohen, Jeremy and Billot, Laurent and Finfer, Simon and Myburgh, John
The New England journal of medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 18, pp. 1744 - 1745
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Medical research | Statistical analysis | Councils | Mortality | Sepsis | Septic shock | Informed consent | Hydrocortisone | Index Medicus | Abridged Index Medicus
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7. Full Text Severe Hypoglycemia and Risks of Vascular Events and Death
by Zoungas, Sophia and Patel, Anushka and Chalmers, John and de Galan, Bastiaan E and Li, Qiang and Billot, Laurent and Woodward, Mark and Ninomiya, Toshiharu and Neal, Bruce and MacMahon, Stephen and Grobbee, Diederick E and Kengne, Andre Pascal and Marre, Michel and Heller, Simon and ADVANCE Collaborative Grp and ADVANCE Collaborative Group
The New England journal of medicine, ISSN 0028-4793, 10/2010, Volume 363, Issue 15, pp. 1410 - 1418
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Hypoglycemic Agents - therapeutic use | Follow-Up Studies | Vascular Diseases - etiology | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Vascular Diseases - epidemiology | Diabetes Mellitus, Type 2 - blood | Gliclazide - therapeutic use | Diabetes Mellitus, Type 2 - mortality | Cardiovascular Diseases - mortality | Hypoglycemia - complications | Microvessels | Female | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Gliclazide - adverse effects | Hypoglycemic Agents - adverse effects | Diabetes Mellitus, Type 2 - complications | Outcome and process assessment (Health Care) | Complications and side effects | Blood circulation disorders | Hypoglycemia | Risk factors | Diabetes | Glucose | Acute coronary syndromes | Mortality | Index Medicus | Abridged Index Medicus
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8. Full Text Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes
by Zoungas, Sophia and Chalmers, John and Neal, Bruce and Billot, Laurent and Li, Qiang and Hirakawa, Yoichiro and Arima, Hisatomi and Monaghan, Helen and Joshi, Rohina and Colagiuri, Stephen and Cooper, Mark E and Glasziou, Paul and Grobbee, Diederick and Hamet, Pavel and Harrap, Stephen and Heller, Simon and Lisheng, Liu and Mancia, Giuseppe and Marre, Michel and Matthews, David R and Mogensen, Carl E and Perkovic, Vlado and Poulter, Neil and Rodgers, Anthony and Williams, Bryan and MacMahon, Stephen and Patel, Anushka and Woodward, Mark and ADV-On Collaborative Grp and ADVANCE-ON Collaborative Group
The New England journal of medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 15, pp. 1392 - 1406
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Glycated Hemoglobin A - analysis | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Indapamide - therapeutic use | Blood Glucose | Hypertension - drug therapy | Male | Gliclazide - administration & dosage | Antihypertensive Agents - therapeutic use | Diabetes Mellitus, Type 2 - blood | Hypoglycemic Agents - administration & dosage | Diabetes Mellitus, Type 2 - mortality | Hypertension - complications | Female | Diabetes Mellitus, Type 2 - drug therapy | Perindopril - therapeutic use | Diabetes Mellitus, Type 2 - complications | Drug Combinations | Type 2 diabetes | Care and treatment | Blood pressure | Research | Patient outcomes | Indapamide | Diabetes mellitus | Mortality | Cardiovascular disease | Glucose | Confidence intervals | Ratios | Vascular diseases | Hemoglobin | Death | Diabetes | Kidney diseases | Diabetes mellitus (non-insulin dependent) | Drug dosages | Index Medicus | Abridged Index Medicus
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9. Full Text Trial of Pregabalin for Acute and Chronic Sciatica
by Mathieson, Stephanie and Maher, Christopher G and McLachlan, Andrew J and Latimer, Jane and Koes, Bart W and Hancock, Mark J and Harris, Ian and Day, Richard O and Billot, Laurent and Pik, Justin and Jan, Stephen and Lin, C.-W. Christine
The New England journal of medicine, ISSN 0028-4793, 03/2017, Volume 376, Issue 12, pp. 1111 - 1120
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Disability Evaluation | Analgesics - therapeutic use | Pregabalin - administration & dosage | Pregabalin - adverse effects | Back Pain - classification | Double-Blind Method | Pregabalin - therapeutic use | Humans | Middle Aged | Sciatica - classification | Dizziness - chemically induced | Analgesics - administration & dosage | Male | Sciatica - drug therapy | Treatment Failure | Quality of Life | Adult | Female | Aged | Pain Measurement | Analgesics - adverse effects | Complications and side effects | Treatment outcome | Patient outcomes | Placebos | Dosage and administration | Pregabalin | Drug therapy | Comparative analysis | Sciatica | Pain | Neurons | Pain management | Clinical trials | Neuropathy | Patients | Leg | Pharmaceuticals | Index Medicus | Abridged Index Medicus
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