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Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer
Journal Article
Journal Article
LEUKEMIA, ISSN 0887-6924, 01/2020, Volume 34, Issue 1, pp. 50 - 62
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the malignant transformation of myeloid progenitors. Despite intensive... 
GENE-MUTATIONS | JMJD3 | ONCOLOGY | UTX | SPECTRUM | DAUNORUBICIN | ENHANCERS | HEMATOLOGY | DEMETHYLASES | Chemotherapy | Mutation | Drug resistance | Myeloid leukemia | Acute myeloid leukemia | Leukemia | Cancer therapeutic resistance | Acute myeloid leukaemia
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 69 - 78
In acute myeloid leukemia (AML), therapy resistance frequently occurs, leading to high mortality among patients. However, the mechanisms that render leukemic... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | SOMATIC MUTATIONS | CELL BIOLOGY | THERAPY | GENE EZH2 | DIFFERENTIATION | INHIBITOR | EXPRESSION | Immunohistochemistry | CDC2 Protein Kinase | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Cyclin-Dependent Kinases - metabolism | Cytarabine - pharmacology | Immunoprecipitation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bortezomib - pharmacology | Gene Knockdown Techniques | Young Adult | Flow Cytometry | Mass Spectrometry | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Blotting, Western | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors | Animals | Proteomics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Mice | Protein Processing, Post-Translational | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Pyridones - pharmacology | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Methyltransferases | Drug resistance | Health aspects | Antimitotic agents | Prognosis | Mortality | Heat shock proteins | Histones | Drug therapy | Antineoplastic agents | Gene expression | Drugs | Therapy | Hsp90 protein | Phosphorylation | Leukemia | Chemoresistance | Cytotoxicity | Kinases | Degradation | Proteins | Cytarabine | Restoration | Histone methyltransferase | HOX gene | Protein-tyrosine kinase | Tyrosine | Bortezomib | Myeloid leukemia | Patients | Sensitivity | Inhibitors | Derepression | Proteasomes | Blast resistance | Methylation | Acute myeloid leukemia | Heat shock
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2006, Volume 44, Issue 5, pp. 984 - 993
A tightly controlled balance between cell division and cell death is a basic feature for the development and maintenance of liver homeostasis. Disturbances of... 
PROGRAMMED CELL-DEATH | MITOCHONDRIAL PERMEABILITY TRANSITION | RAT HEPATOCYTES | BILE-DUCT LIGATION | CHRONIC HEPATITIS-C | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | CASPASE ACTIVATION | MEDIATED HEPATOCYTE APOPTOSIS | ANTI-FAS ANTIBODY | FACTOR-ALPHA | Liver - pathology | Animals | Apoptosis - physiology | Humans | Liver Diseases - pathology | Necrosis | Apoptosis
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5378 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120925
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2009, Volume 15, Issue 47, pp. 5924 - 5935
AIM:To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors,in combination with the death receptor ligand tumor necrosis factor-related... 
RNA干扰 | 细胞凋亡基因 | TRAIL | 流式细胞仪 | 受体激酶 | PD98059 | 酶抑制剂 | 肿瘤坏死因子相关凋亡诱导配体 | 5-fluorouracil | c-Jun N-terminal kinase | BCL-xL | MCL-1 | Sorafenib | Phosphoinositol-3-kinase | Hepatocellular carcinoma | Tumor necrosis factor-related apoptosis inducing ligand | Doxorubicin | (Mitogen-activated protein kinase)/(extracellular signal regulated kinase) kinase | Apoptosis | BCL-XL | 3-KINASE/AKT PATHWAY | MEDIATED APOPTOSIS | RAF/MEK/ERK PATHWAY | CANCER-THERAPY | PROTEIN-KINASE CASCADE | CLINICAL-TRIALS | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Doxorubicin - therapeutic use | Humans | Liver Neoplasms - drug therapy | bcl-X Protein - genetics | Antineoplastic Agents - therapeutic use | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Enzyme Inhibitors - therapeutic use | Fluorouracil - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Carcinoma, Hepatocellular - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Liver Neoplasms - pathology | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Apoptosis - physiology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Carcinoma, Hepatocellular - metabolism | Mitogen-activated protein kinase | (extracellular signal regulated kinase) kinase | Original
Journal Article
Journal Article