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biochemistry & molecular biology (16) 16
amino acid sequence (11) 11
ankyrin repeat (11) 11
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Drug Discovery Today, ISSN 1359-6446, 2008, Volume 13, Issue 15, pp. 695 - 701
Journal Article
Nature Biotechnology, ISSN 1087-0156, 05/2004, Volume 22, Issue 5, pp. 575 - 582
We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity target binding. Using a consensus design strategy, we... 
ANTIBODIES | EVOLUTION | RECOGNITION | STRUCTURAL BASIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RIBOSOME DISPLAY | DIVERSITY | SCAFFOLDS | BINDING-SITES | AFFIBODY | PROGRAM | Molecular Sequence Data | Amino Acid Sequence | Protein Conformation | Ankyrin Repeat | Enzyme-Linked Immunosorbent Assay
Journal Article
Journal Article
Current Opinion in Biotechnology, ISSN 0958-1669, 2005, Volume 16, Issue 4, pp. 459 - 469
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2008, Volume 376, Issue 1, pp. 241 - 257
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2003, Volume 100, Issue 4, pp. 1700 - 1705
Journal Article
Angiogenesis, ISSN 0969-6970, 1/2013, Volume 16, Issue 1, pp. 101 - 111
The next-generation ophthalmic anti-VEGF therapeutics must aim at being superior to the currently available agents with regard to potency and improved drug... 
Binding protein | Repeat protein | Biomedicine | DARPin | VEGF | Cancer Research | Oncology | Ophthalmology | Cardiology | Biomedicine general | Cell Biology | ANKYRIN REPEAT PROTEIN | MACULAR DEGENERATION | VASCULAR-PERMEABILITY | CHOROIDAL NEOVASCULARIZATION | RETINAL NEOVASCULARIZATION | LIBRARIES | IN-VITRO | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | SELECTION | EXPRESSION | Recombinant Proteins - therapeutic use | Eye - pathology | Ophthalmic Solutions - pharmacology | Blood Vessels - growth & development | Eye - blood supply | Human Umbilical Vein Endothelial Cells - metabolism | Intravitreal Injections | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Rats, Inbred BN | Angiogenesis Inhibitors - administration & dosage | Choroidal Neovascularization - drug therapy | Choroidal Neovascularization - pathology | Protein Binding - drug effects | Angiogenesis Inhibitors - therapeutic use | Eye - drug effects | Drug Evaluation, Preclinical | Disease Models, Animal | Rabbits | Human Umbilical Vein Endothelial Cells - drug effects | Ophthalmic Solutions - therapeutic use | Angiogenesis Inhibitors - pharmacology | Rats | Ankyrin Repeat | Recombinant Proteins - pharmacology | Recombinant Proteins - administration & dosage | Animals | Blood Vessels - drug effects | Mice | Administration, Topical | Original Paper
Journal Article