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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2805 - 2814
Unbound intrahepatic drug concentrations determine the interaction potential with intracellular targets related to toxicity, pharmacokinetics, or... 
passive diffusion/transport | human liver microsomes | disposition | biliary excretion | active transport | tissue partition | distribution | protein binding | hepatocytes | hepatic metabolism | Index Medicus
Journal Article
The FEBS Journal, ISSN 1742-464X, 11/2018, Volume 285, Issue 21, pp. 3993 - 4004
Journal Article
by Couch, Fergus and Kuchenbaecker, Karoline and Michailidou, Kyriaki and Mendoza-Fandino, Gustavo A and Nord, Silje and Lilyquist, Janna and Olswold, Curtis and Hallberg, Boubou and Agata, Simona and Ahsan, Habibul and Aittomäki, Kristiina and Ambrosone, Christine and Anulis, Irene and Anton-Culver, Hoda and Arndt, Volker and Arun, Banu and Arver, Brita Wasteson and Barile, Monica and Barkardottir, Rosa and Barrowdale, Daniel and Beckmann, Lars and Beckmann, Matthias and Benítez, Javier and Blank, Stephanie and Blomqvist, Carl and Bogdanova, Natalia and Bojesen, Stig and Bolla, Manjeet and Bonnani, Bernardo and Brauch, Hiltrud and Brenner, Hermann and Burwinkel, Barbara and Buys, Sauna S and Caldes, Trinidad and Caligo, Maria and Canzian, Federico and Carpenter, Aian and Chang-Claude, Jenny and Chanock, Stephen J and Chung, Wendy K and Claes, Kathleen B.M and Cox, Angela and Cross, Simon and Cunningham, Julie and Czene, Kamila and Daly, Mary B and Damiola, Francesca and Darabi, Hatef and Hoya, Miguel and Devilee, Peter and Díez, Orland and Ding, Yuan and Dolcetti, Riccardo and Domchek, Susan and Dorfling, Cecilia and Santos Silva, Isabel and Dumont, Martine and Dunning, Alison and Eccles, Diana and Ehrencrona, Hans and Ekici, Arif and Eliassen, Heather and Ellis, Steve and Fasching, Peter and Figueroa, Jonine and Flesch-Janys, Dieter and Försti, Asta and Fostira, Florentia and Foulkes, William and Friebel, Mark and Friedman, Eitan and Frost, Debra and Gabrielson, Marike and Gammon, Marilie and Ganz, Patricia A and Gapstur, Susan M and Garber, Judy and Gaudet, Mia and Gayther, Simon and Gerdes, Anne-Marie and Ghoussaini, Maya and Giles, Graham and Glendon, Gord and Godwin, Anew K and Goldberg, Mark and Goldgar, David and González-Neira, Anna and Greene, Mark H and Gronwald, Jacek and Guénel, Pascal and Gunter, Marc J and Haeberle, Lothar and Haiman, Christopher A and Hamann, Ute and Hansen, Thomas and Hart, Stewart and Healey, Sue and Heikkinen, Tuomas and Henderson, Brian and Herzog, Josef and ... and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Avdelningen för cellbiologi
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11375
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 06/2019, Volume 190, pp. 19 - 28
Oxysterols are cholesterol metabolites derived through either autoxidation or enzymatic processes. They consist of a large family of bioactive lipids that have... 
11beta-hydroxysteroid dehydrogenase | Epstein-Barr virus-induced gene 2 | Metabolism | 7-ketocholesterol | Cholesterol 25-hydroxylase | Oxysterol | Molecular modelling | Metabolites | Glucocorticoids | Hydroxylase | 11β-Hydroxysteroid dehydrogenase | Lipids | Oxidation | Cholesterol
Journal Article
by Bojesen, Stig E and Pooley, Karen A and Johnatty, Sharon E and Beesley, Jonathan and Michailidou, Kyriaki and Tyrer, Jonathan P and Edwards, Stacey L and Pickett, Hilda A and Shen, Howard C and Smart, Chanel E and Hillman, Kristine M and Mai, Phuong L and Lawrenson, Kate and Stutz, Michael D and Lu, Yi and Karevan, Rod and Woods, Nicholas and Johnston, Rebecca L and French, Juliet D and Chen, Xiaoqing and Weischer, Maren and Nielsen, Sune F and Maranian, Melanie J and Ghoussaini, Maya and Ahmed, Shahana and Baynes, Caroline and Bolla, Manjeet K and Wang, Qin and Dennis, Joe and McGuffog, Lesley and Barrowdale, Daniel and Lee, Anew and Healey, Sue and Lush, Michael and Tessier, Daniel C and Vincent, Daniel and Bacot, Françis and Vergote, Ignace and Lambrechts, Sanina and Despierre, Evelyn and Risch, Harvey A and González-Neira, Anna and Rossing, Mary Anne and Pita, Guillermo and Doherty, Jennifer A and Alvarez, Nuria and Larson, Melissa C and Fridley, Brooke L and Schoof, Nils and Chang-Claude, Jenny and Cicek, Mine S and Peto, Julian and Kalli, Kimberly R and Broeks, Annegien and Armasu, Sebastian M and Schmidt, Marjanka K and Braaf, Linde M and Winterhoff, Boris and Nevanlinna, Heli and Konecny, Gottfried E and Lambrechts, Diether and Rogmann, Lisa and Guénel, Pascal and Teoman, Attila and Milne, Roger L and Garcia, Joaquin J and Cox, Angela and Shridhar, Vijayalakshmi and Burwinkel, Barbara and Marme, Frederik and Hein, Rebecca and Sawyer, Elinor J and Haiman, Christopher A and Wang-Gohrke, Shan and Anulis, Irene L and Moysich, Kirsten B and Hopper, John L and Odunsi, Kunle and Lindblom, Annika and Giles, Graham G and Brenner, Hermann and Simard, Jacques and Lurie, Galina and Fasching, Peter A and Carney, Michael E and Radice, Paolo and Wilkens, Lynne R and Swerdlow, Anthony and Goodman, Marc T and Brauch, Hiltrud and Garcia-Closas, Montserrat and Hillemanns, Peter and Winqvist, Robert and Dürst, Matthias and Devilee, Peter and Runnebaum, Ingo and Jakubowska, Anna and Lubinski, Jan and Mannermaa, Arto and Butzow, Ralf and ... and Gene Environm Interactimi Breast and Kathleen Cuningham Fdn Consortium and Australian Ovarian Canc Study and Epidemiological Study BRCA1 and Hereditary Breast Ovarian Canc Res and Genetic Modifiers Canc Risk BRCA1 and Australian Canc Study and Swedish Breast Canc Study SWE-BRCA and The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO) and Gene Environment Interaction and Breast Cancer (GENICA) and Swedish Breast Cancer Study (SWE-BRCA) and Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE) and Australian Ovarian Cancer Study and Australian Cancer Study and Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) and Medicinska fakulteten and Umeå universitet and Institutionen för strålningsvetenskaper
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 4, pp. 371 - 384
Journal Article
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2805 - 2814
Unbound intrahepatic drug concentrations determine the interaction potential with intracellular targets related to toxicity, pharmacokinetics, or... 
Pharmaceutical Preparations - blood | Pharmaceutical Preparations - metabolism | Temperature | Lysosomes - metabolism | Models, Biological | Humans | Liver - metabolism | Cells, Cultured | Metabolic Clearance Rate | Hepatocytes - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36774
Background: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes... 
HEXOSE-6-PHOSPHATE DEHYDROGENASE | OXIDATIVE STRESS | TRANSCRIPTION FACTOR NRF2 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | TRANSFERASE A2 GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | RECEPTOR | INDUCTION | INDUCIBLE EXPRESSION | BASAL LEVEL | NF-E2-Related Factor 2 - antagonists & inhibitors | Receptors, Glucocorticoid - antagonists & inhibitors | Oligonucleotide Array Sequence Analysis | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Humans | Transcriptional Activation - drug effects | Male | Receptors, Glucocorticoid - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Transfection | Liver - drug effects | Glucocorticoids - metabolism | HEK293 Cells | Thiocyanates - pharmacology | Female | NF-E2-Related Factor 2 - genetics | Isothiocyanates | Genes, Reporter | Recombinant Proteins - metabolism | Liver - metabolism | Hydrogen Peroxide - pharmacology | Rats | Recombinant Proteins - genetics | Sex Characteristics | Down-Regulation - drug effects | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Glucocorticoids - pharmacology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Hydrocortisone - pharmacology | Liver - cytology | Oxidative stress | Hydrogen peroxide | Biomedical research | Dehydrogenases | Glucocorticoids | Adrenal glands | Oxidative metabolism | Liver | Genes | Glands | Alcohol | Dimorphism | Hormones | Gender | Antioxidants | Toxicology | Immunology | Rodents | 11β-Hydroxysteroid dehydrogenase | Drug metabolism | Fibroblasts | Physiology | Sexual dimorphism | Trends | Localization | Product safety | NRF2 protein | Pharmaceutical sciences | Enzymes | Liver diseases | Pharmacology | Gene expression | Metabolism | Cortisone | In vivo methods and tests
Journal Article
by Milne, Roger L and Kuchenbaecker, Karoline B and Michailidou, Kyriaki and Beesley, Jonathan and Kar, Siddhartha and Lindström, Sara and Hui, Shirley and Lemaçon, Auey and Soucy, Penny and Dennis, Joe and Jiang, Xia and Rostamianfar, Asha and Finucane, Hilary and Bolla, Manjeet K and McGuffog, Lesley and Wang, Qin and Aalfs, Cora M and Adams, Marcia and Adlard, Julian and Agata, Simona and Ahmed, Shahana and Ahsan, Habibul and Aittomäki, Kristiina and Al-Ejeh, Fares and Allen, Jamie and Ambrosone, Christine B and Amos, Christopher I and Anulis, Irene L and Anton-Culver, Hoda and Antonenkova, Natalia N and Arndt, Volker and Arnold, Norbert and Aronson, Kristan J and Auber, Bernd and Auer, Paul L and Ausems, Margreet G. E. M and Azzollini, Jacopo and Bacot, François and Balmaña, Judith and Barile, Monica and Barjhoux, Laure and Barkardottir, Rosa B and Barrdahl, Myrto and Barnes, Daniel and Barrowdale, Daniel and Baynes, Caroline and Beckmann, Matthias W and Benitez, Javier and Bermisheva, Marina and Bernstein, Leslie and Bignon, Yves-Jean and Blazer, Kathleen R and Blok, Marinus J and Blomqvist, Carl and Blot, William and Bobolis, Kristie and Boeckx, Bram and Bogdanova, Natalia V and Bojesen, Anders and Bojesen, Stig E and Bonanni, Bernardo and Børresen-Dale, Anne-Lise and Bozsik, Aniko and Bradbury, Angela R and Brand, Judith S and Brauch, Hiltrud and Brenner, Hermann and Bressac-de Paillerets, Brigitte and Brewer, Carole and Brinton, Louise and Broberg, Per and Brooks-Wilson, Angela and Brunet, Joan and Brüning, Thomas and Burwinkel, Barbara and Buys, Sauna S and Byun, Jinyoung and Cai, Qiuyin and Caldés, Trinidad and Caligo, Maria A and Campbell, Ian and Canzian, Federico and Caron, Olivier and Carracedo, Angel and Carter, Brian D and Castelao, J. Esteban and Castera, Laurent and Caux-Moncoutier, Virginie and Chan, Salina B and Chang-Claude, Jenny and Chanock, Stephen J and Chen, Xiaoqing and Cheng, Ting-Yuan David and Chiquette, Jocelyne and Christiansen, Hans and Claes, Kathleen B. M and Clarke, Christine L and Conner, Thomas and Conroy, Don M and Cook, Jackie and ... and ABCTB Investigators and HEBON and EMBRACE and GEMO Study Collaborators and kConFab AOCS Investigators and NBSC Collaborators and kConFab/AOCS Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik och genomik and Ortopedi and Uppsala universitet and Institutionen för kirurgiska vetenskaper
Nature genetics, ISSN 1061-4036, 2017, Volume 49, Issue 12, pp. 1767 - 1778
Journal Article
International Journal of Psychology, ISSN 0020-7594, 12/2017, Volume 52, Issue 6, pp. 425 - 435
Journal Article