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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3070 - 15
Journal Article
Nature communications, ISSN 2041-1723, 08/2018, Volume 9, Issue 1, pp. 3540 - 1
The original version of this article incorrectly omitted an affiliation of Patricia A. J. Muller: 'Cancer Research UK Manchester Institute, The University of... 
Stability | p53 Protein | Cancer | Genomic instability
Journal Article
Journal Article
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6280, pp. 1463 - 1469
Journal Article
npj Breast Cancer, ISSN 2374-4677, 12/2018, Volume 4, Issue 1, pp. 16 - 4
The first genomic scar-based homologous recombination deficiency (HRD) measures were produced using SNP arrays. As array-based technology has been largely... 
Breast cancer
Journal Article
by Jamal-Hanjani, Mariam and Wilson, Gareth A and McGranahan, Nicholas and Birkbak, Nicolai J and Watkins, Thomas B.K and Veeriah, Selvaraju and Shafi, Seema and Johnson, Diana H and Mitter, Richard and Rosenthal, Rachel and Salm, Max and Horswell, Stuart and Escudero, Mickael and Matthews, Nik and Rowan, Andrew and Chambers, Tim and Moore, David A and Turajlic, Samra and Xu, Hang and Lee, Siow-Ming and Forster, Martin D and Ahmad, Tanya and Hiley, Crispin T and Abbosh, Christopher and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Shah, Rajesh and Joseph, Leena and Quinn, Anne M and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Dentro, Stefan and Taniere, Philippe and O’Sullivan, Brendan and Lowe, Helen L and Hartley, John A and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Shaw, Jacqui A and Herrero, Javier and Szallasi, Zoltan and Schwarz, Roland F and Stewart, Aengus and Quezada, Sergio A and Le Quesne, John and Van Loo, Peter and Dive, Caroline and Hackshaw, Allan and Swanton, Charles and TRACERx Consortium
The New England Journal of Medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 22, pp. 2109 - 2121
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 2027 - 2027
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, pp. 467 - 472
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is... 
BREAST-CANCER | MIGRATION | CELLS | ANEUPLOIDY | ACTIVATION | EVOLUTION | PROGNOSIS | PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | EXPRESSION | Breast Neoplasms - secondary | DNA, Neoplasm - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Brain Neoplasms - pathology | NF-kappa B - metabolism | Cytosol - enzymology | Brain Neoplasms - secondary | Inflammation - metabolism | Female | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Cell Line | Micronuclei, Chromosome-Defective | Chromosome Segregation | Brain Neoplasms - genetics | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Chromosomal Instability - genetics | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Inflammation - genetics | Cytosol - metabolism | Head and Neck Neoplasms - genetics | Mesoderm - metabolism | Mice | Complications and side effects | Development and progression | Genetic aspects | Metastasis | Chromosomal instability syndromes | Genetic suppression | Mitosis | Activation | Genomes | Cytosol | Metastases | Genomic instability | Stimulators | Signal transduction | Cyclic GMP | Chromosomes | Deoxyribonucleic acid--DNA | NF-κB protein | Stability | AMP | Organs | Breast cancer | Survival analysis | Signaling | Medical prognosis | Micronuclei | Interferon | Cancer | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2822 - 2822
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2017, Volume 49, Issue 12, pp. 1693 - 1704
A widespread approach to modern cancer therapy is to identify a single oncogenic driver gene and target its mutant-protein product (for example, EGFR-inhibitor... 
HETEROGENEITY | CELLS | ACTIVATION | CIRCULATING TUMOR DNA | MET AMPLIFICATION | GENETICS & HEREDITY | ACQUIRED-RESISTANCE | MUTATIONS | INHIBITOR | EXPRESSION | AZD9291 | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Kaplan-Meier Estimate | Lung Neoplasms - pathology | beta Catenin - genetics | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Cyclin-Dependent Kinases - genetics | Neoplasm Staging | Clonal Evolution | Care and treatment | Gene mutations | Lung cancer | Development and progression | Genetic aspects | Drug resistance | Health aspects | Therapy | Cell survival | Genomic analysis | Wnt protein | Epidermal growth factor receptors | Genes | Biological evolution | Genomes | Metastasis | Kinases | Patients | Cyclin-dependent kinase 4 | Clinical outcomes | Metastases | Datasets | Alterations | Inhibitors | Genetic testing | Deoxyribonucleic acid--DNA | Cancer | Fibroblast growth factor receptors | Tumors
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 02/2017, Volume 45, Issue 1, pp. 1 - 13
Next-generation deep genome sequencing has only recently allowed us to quantitatively dissect the extent of heterogeneity within a tumour, resolving patterns... 
GENOMIC INSTABILITY | BREAST-CANCER | ANALYSIS REVEALS | CONVERGENT EVOLUTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | GENETIC-HETEROGENEITY | CLONAL EVOLUTION | BRANCHED EVOLUTION | EXTREME CHROMOSOMAL INSTABILITY | TUMOR HETEROGENEITY | Genetic Predisposition to Disease - genetics |