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Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7500, pp. 361 - 365
T cells discriminate between foreign and host molecules by recognizing distinct microbial molecules, predominantly peptides and lipids(1-4). Riboflavin... 
RIBOFLAVIN | SYNTHASE | DESIGN | RECOGNITION | VITAMIN-B METABOLITES | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | SALMONELLA-TYPHIMURIUM | RECEPTOR | MR1 | T-Lymphocyte Subsets - immunology | Immunity, Mucosal - immunology | Pyrimidines - immunology | Vitamin B Complex - immunology | Glyoxal - metabolism | T-Lymphocyte Subsets - cytology | Minor Histocompatibility Antigens | Humans | Molecular Conformation | Antigens, Bacterial - immunology | Amino Sugars - immunology | Pyrimidines - chemistry | Pyrimidines - metabolism | Histocompatibility Antigens Class I - metabolism | Pyruvaldehyde - metabolism | Lymphocyte Activation - immunology | Riboflavin - metabolism | Uracil - immunology | Uracil - chemistry | Riboflavin - biosynthesis | Antigens, Bacterial - chemistry | Glyoxal - chemistry | Histocompatibility Antigens Class I - immunology | Models, Molecular | Riboflavin - immunology | Antigen Presentation - immunology | Histocompatibility Antigens Class I - chemistry | Immunity, Innate - immunology | Metabolic Networks and Pathways | Mucous Membrane - immunology | Amino Sugars - metabolism | Schiff Bases - chemistry | Ligands | Uracil - metabolism | Amino Sugars - chemistry | Pyruvaldehyde - chemistry | Vitamin B Complex - metabolism | Antigens, Bacterial - metabolism | Uracil - analogs & derivatives | Antigens | Immune response | Physiological aspects | Physiological research | Research | T cells | Properties | T cell receptors | Mutation | Metabolites | Bacteriology | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2017, Volume 18, Issue 4, pp. 402 - 411
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2385 - 10
Venetoclax is a first-in-class cancer therapy that interacts with the cellular apoptotic machinery promoting apoptosis. Treatment of patients suffering chronic... 
Therapy | Chronic lymphatic leukemia | Bcl-2 protein | Leukemia | Mutation | Binding sites | Crystal structure | Apoptosis | Index Medicus
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 2, pp. 177 - 185
T cells autoreactive to the antigen-presenting molecule CD1a are common in human blood and skin, but the search for natural autoantigens has been confounded by... 
NKT CELLS | REPERTOIRE | ACTIVATION | COMPLEX | HUMAN CD1D MOLECULES | GLYCOLIPID ANTIGENS | RECEPTOR | IMMUNOLOGY | SELF ANTIGEN | LIPIDS | LYMPHOCYTES | Membrane lipids | Physiological aspects | Autoantigens | Genetic aspects | Research | T cells | Health aspects | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2015, Volume 16, Issue 3, pp. 258 - 266
A central paradigm in αβ T cell-mediated immunity is the simultaneous co-recognition of antigens and antigen-presenting molecules by the αβ T cell antigen... 
Antigens, CD1 - immunology | Cell Line | Jurkat Cells | Humans | Lipids - immunology | Receptors, Antigen, T-Cell, alpha-beta - immunology | Antigen Presentation - immunology | Autoantigens - immunology | HEK293 Cells | Cell Line, Tumor | Protein Binding | Ligands | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 8, pp. 1585 - 1600
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 03/2015, Volume 16, Issue 3, pp. 258 - U215
A central paradigm in ab T cell-mediated immunity is the simultaneous co-recognition of antigens and antigen-presenting molecules by the ab T cell antigen... 
SYSTEM | HETEROGENEITY | REPERTOIRE | COMPLEX | I-LIKE MOLECULES | CRYSTAL-STRUCTURE | ANGSTROM | MHC | IMMUNOLOGY | TETRAMERS | LYMPHOCYTES
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2019, Volume 9, Issue 3, pp. 342 - 353
The BCL2 inhibitor venetoclax induces high rates of durable remission in patients with previously treated chronic lymphocytic leukemia (CLL). However, despite... 
APOPTOSIS | CLL | ONCOLOGY | RITUXIMAB | FAMILY PROTEINS | INHIBITOR | ABT-199
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2017, Volume 68, Issue 4, pp. 659 - 672.e9
Journal Article
Structure, ISSN 0969-2126, 10/2018, Volume 26, Issue 10, pp. 1346 - 1359.e5
BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requires its translocation from... 
apoptosis | BAX | translocation | allostery | CONFORMATIONAL ENTROPY | ACTIVATION | PROTEIN | PROAPOPTOTIC BAX | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | ALLOSTERY | BH3 DOMAINS | APOPTOTIC ACTIVITY | CELL BIOLOGY | BIOPHYSICS | CYTOSOL | Oligomers | Viral antibodies | Proteins | Analysis | Crystals | Antibodies | Structure
Journal Article