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Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1412, pp. 149 - 156
The endocannabinoid 2-arachidonoylglycerol (2-AG) exerts its physiological action by binding to and functionally activating type-1 (CB1) and type-2 (CB2)... 
Thin-layer chromatography | 2-Arachidonoylglycerol | Radiometric assay | Diacylglycerol lipase | Endocannabinoids - biosynthesis | Enzyme Assays | Glycerides - biosynthesis | Radiometry - methods | Chromatography, Thin Layer | Lipoprotein Lipase - metabolism | Arachidonic Acids - biosynthesis
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 2, pp. 301 - 316
Journal Article
CNS and Neurological Disorders - Drug Targets, ISSN 1871-5273, 2010, Volume 9, Issue 5, pp. 564 - 573
The G-protein coupled receptors for Delta(9)-tetrahydrocannabinol, the major psychoactive principle of marijuana, are known as cannabinoid receptors of type 1... 
Amyotropic lateral sclerosis | Multiple sclerosis | Parkinson's disease | Huntington's chorea | Alzheimer's disease | Tetrahydrocannabinol | Cannabinoid receptors | Neuroinflammatory disorders | amyotropic lateral sclerosis | Delta-tetrahydrocannabinol | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | multiple sclerosis | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | HUNTINGTONS-DISEASE MICE | IN-SITU HYBRIDIZATION | AMYOTROPHIC-LATERAL-SCLEROSIS | GTP-BINDING PROTEINS | neuroinflammatory disorders | NEUROSCIENCES | MESSENGER-RNA LEVELS | LEVODOPA-INDUCED DYSKINESIA | ACID AMIDE HYDROLASE | PHARMACOLOGY & PHARMACY | cannabinoid receptors | TRANSGENIC MOUSE MODEL | Cannabinoid Receptor Antagonists | Brain - physiopathology | Humans | Receptors, Cannabinoid - physiology | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Central Nervous System Diseases - metabolism | Brain - drug effects | Brain - metabolism | Cannabinoid Receptor Agonists | Cannabinoid Receptor Modulators - physiology | Inflammation - metabolism | Animals | Neurodegenerative Diseases - physiopathology | Inflammation - drug therapy | Central Nervous System Diseases - drug therapy | Neuroglia - metabolism | Neurons - metabolism | Drug Delivery Systems - methods | Central Nervous System Diseases - physiopathology | Endocannabinoids | Inflammation - physiopathology | Enzymes | Neurotransmitter release | G protein-coupled receptors | Neurodegenerative diseases | Synaptic strength | Immunomodulation | Central nervous system | Amyotrophic lateral sclerosis | Inflammation | Cannabinoid CB1 receptors | Anandamide | Microglia | Neurological diseases | Lipophilic | Cannabis | Excitotoxicity | Cannabinoid CB2 receptors | Movement disorders
Journal Article
Journal Article
BioFactors, ISSN 0951-6433, 07/2014, Volume 40, Issue 4, pp. 373 - 380
Journal Article
Nature, ISSN 0028-0836, 08/2002, Volume 418, Issue 6897, pp. 530 - 534
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2003, Volume 163, Issue 3, pp. 463 - 468
Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme... 
COS cells | Enzymes | Brain | Receptors | Neurons | Purkinje cells | Antibodies | Reports | Fatty acids | Endocannabinoids | Cells | Axonal growth | Diacylglycerol lipase | CB1 receptor | Synaptic plasticity | Anandamide | PURKINJE-CELLS | SYSTEM | 2-ARACHIDONOYLGLYCEROL | ENDOGENOUS CANNABINOIDS | RELEASE | IDENTIFICATION | CELL BIOLOGY | axonal growth | RETROGRADE INHIBITION | ANIMAL-MODEL | synaptic plasticity | RECEPTORS | diacylglycerol lipase | anandamide | Cannabinoid Receptor Modulators - metabolism | Brain - embryology | Humans | Neurites - enzymology | DNA, Complementary - genetics | Brain - enzymology | Molecular Sequence Data | Arachidonic Acids - biosynthesis | Presynaptic Terminals - enzymology | Time Factors | Cloning, Molecular | Lipoprotein Lipase - isolation & purification | Cell Differentiation - physiology | Neurites - drug effects | DNA, Complementary - analysis | Brain - cytology | Lipoprotein Lipase - genetics | Enzyme Inhibitors - pharmacology | Rats | Glycerides - biosynthesis | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Sequence Homology, Nucleic Acid | Synaptic Membranes - enzymology | Sequence Homology, Amino Acid | Animals | Growth Substances - pharmacology | Dendrites - enzymology | Mice | COS Cells | Lipase | Research | 2-arachidonylglycerol | Report | diacylglycerol lipase; CB1 receptor; anandamide; axonal growth; synaptic plasticity
Journal Article
International Journal of Eating Disorders, ISSN 0276-3478, 11/2019, Volume 52, Issue 11, pp. 1251 - 1262
Objective Despite the growing knowledge on the functional relationship between an altered endocannabinoid (eCB) system and development of anorexia nervosa... 
endocannabinoid system | endocannabinoids | anorexia nervosa | activity‐based anorexia | anandamide | 2‐arachidonoylglycerol | Anorexia
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 784 - 793
Background and Purpose The development of potent and selective inhibitors of the biosynthesis of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) via DAG... 
inhibitor | anti‐obesity effects | cannabinoid | serine lipase | diacylglycerol | 2‐arachidonoylglycerol | anti-obesity effects | 2-arachidonoylglycerol | SYSTEM | HIGH-FAT DIET | HYDROLYSIS | OBESITY | PHARMACOLOGY & PHARMACY | ANTAGONISTS | RECEPTORS | PREFERENCE | Lipoprotein Lipase - antagonists & inhibitors | Obesity - drug therapy | Humans | Sterol Esterase - metabolism | Male | Anti-Obesity Agents - therapeutic use | Arachidonic Acids - metabolism | Liver - drug effects | Behavior, Animal - drug effects | Neurons - metabolism | Hypothalamus - drug effects | Lipoprotein Lipase - metabolism | Anti-Obesity Agents - administration & dosage | Organophosphonates - therapeutic use | Oleic Acids - therapeutic use | Liver - metabolism | Enzyme Inhibitors - pharmacology | Glycerophospholipids - therapeutic use | Rats | Recombinant Proteins - chemistry | Energy Intake - drug effects | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Arachidonic Acids - antagonists & inhibitors | Hypothalamus - metabolism | Neurons - enzymology | Hypothalamus - enzymology | Sterol Esterase - antagonists & inhibitors | Mice | Anti-Obesity Agents - pharmacology | Endocannabinoids - antagonists & inhibitors | Endocannabinoids - metabolism | Liver - enzymology | Glycerophospholipids - pharmacology | Cercopithecus aethiops | Glycerophospholipids - administration & dosage | Dose-Response Relationship, Drug | Oleic Acids - pharmacology | Neurons - drug effects | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Lipoprotein Lipase - genetics | Mice, Inbred C57BL | Nerve Tissue Proteins - genetics | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Organophosphonates - administration & dosage | Organophosphonates - pharmacology | Animals | Oleic Acids - administration & dosage | Glycerides - antagonists & inhibitors | Obesity - enzymology | Physiological aspects | Obesity | Amino acids | Chemical properties | Lipase | Fatty acids | Medical research | Biosynthesis | Rodents | Cannabinoids 2012, Part Two | Themed Section
Journal Article
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4503
There is robust evidence indicating that enhancing the endocannabinoid (eCB) tone has therapeutic potential in several brain disorders. The inhibition of eCBs... 
URB597 | TARGET | SELECTIVE FAAH INHIBITOR | patients' compliance | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCANNABINOID SYSTEM | endocannabinoid tone | CHEMISTRY, MULTIDISCIPLINARY | PF-04457845 | STRATEGIES | NEUROPATHIC PAIN | fatty acid amide hydrolase | intranasal drug delivery | BRAIN | CANNABINOIDS | patients’ compliance
Journal Article
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