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biochemistry & molecular biology (13) 13
humans (12) 12
molecular sequence data (12) 12
models, molecular (10) 10
protein conformation (10) 10
amino acid sequence (9) 9
research (9) 9
cell biology (8) 8
physiological aspects (6) 6
protein structure, tertiary (6) 6
receptors, ldl - metabolism (6) 6
biophysics (5) 5
crystallography, x-ray (5) 5
ligands (5) 5
mutation (5) 5
receptors, ldl - chemistry (5) 5
animals (4) 4
base sequence (4) 4
basic biological sciences (4) 4
density-lipoprotein receptor (4) 4
index medicus (4) 4
protein folding (4) 4
structure (4) 4
3-dimensional structure (3) 3
amino acid motifs (3) 3
binding sites (3) 3
biochemistry (3) 3
cellular signal transduction (3) 3
chromatography, high pressure liquid (3) 3
cysteine-rich repeat (3) 3
domain (3) 3
drosophila (3) 3
escherichia coli - genetics (3) 3
familial hypercholesterolemia (3) 3
gene mutations (3) 3
genetic aspects (3) 3
hyperlipoproteinemia type ii - genetics (3) 3
ldl receptor (3) 3
models, biological (3) 3
multidisciplinary sciences (3) 3
nuclear magnetic resonance, biomolecular (3) 3
peptides - chemistry (3) 3
protein (3) 3
protein binding (3) 3
protein structure, secondary (3) 3
receptors, ldl - genetics (3) 3
repetitive sequences, amino acid (3) 3
sequence alignment (3) 3
acute lymphoblastic-leukemia (2) 2
amino acids (2) 2
article (2) 2
biological sciences (2) 2
calcium - metabolism (2) 2
calcium-binding (2) 2
cell line, tumor (2) 2
cloning, molecular (2) 2
conserved sequence (2) 2
crystal-structure (2) 2
crystallography (2) 2
cysteine - metabolism (2) 2
different proteins (2) 2
enhancer (2) 2
enzymes (2) 2
epidermal growth factor - chemistry (2) 2
epitopes - chemistry (2) 2
escherichia coli - metabolism (2) 2
expression (2) 2
gene (2) 2
genes, reporter (2) 2
genetics & heredity (2) 2
glycoprotein (2) 2
glycoproteins (2) 2
health aspects (2) 2
hydrogen-ion concentration (2) 2
immunoglobulin j recombination signal sequence-binding protein - metabolism (2) 2
influenza hemagglutinin (2) 2
kinetics (2) 2
leukemia (2) 2
lipoproteins (2) 2
membrane glycoproteins - chemistry (2) 2
membrane proteins (2) 2
mice (2) 2
molecular biology (2) 2
mutagenesis, site-directed (2) 2
nmr (2) 2
nmr solution structure (2) 2
peptide fragments - chemistry (2) 2
peptide fragments - metabolism (2) 2
plasmids (2) 2
precursor t-cell lymphoblastic leukemia-lymphoma - genetics (2) 2
precursor t-cell lymphoblastic leukemia-lymphoma - metabolism (2) 2
pseudorevertants (2) 2
receptor, notch1 - metabolism (2) 2
receptors, virus - chemistry (2) 2
receptors, virus - metabolism (2) 2
recombinant proteins - chemistry (2) 2
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1. Full Text Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies
by Bernasconi-Elias, P and Hu, T and Jenkins, D and Firestone, B and Gans, S and Kurth, E and Capodieci, P and Deplazes-Lauber, J and Petropoulos, K and Thiel, P and Ponsel, D and Hee Choi, S and Lemotte, P and London, A and Goetcshkes, M and Nolin, E and Jones, M.D and Slocum, K and Kluk, M.J and Weinstock, D.M and Christodoulou, A and Weinberg, O and Jaehrling, J and Ettenberg, S.A and Buckler, A and Blacklow, S.C and Aster, J.C and Fryer, C.J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Oncogene, ISSN 0950-9232, 11/2016, Volume 35, Issue 47, pp. 6077 - 6086
Notch receptors have been implicated as oncogenic drivers in several cancers, the most notable example being NOTCH1 in T-cell acute lymphoblastic leukemia... 
ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | REGULATORY REGION | MICE | MATURATION | NEGATIVE BREAST-CANCER | INSIGHTS | CELL BIOLOGY | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Humans | Epitopes - immunology | Codon | Receptor, Notch3 - antagonists & inhibitors | Female | Receptor, Notch3 - genetics | Antineoplastic Agents - pharmacology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Disease Models, Animal | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Receptor, Notch3 - metabolism | Antibodies, Monoclonal - pharmacology | Models, Molecular | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Protein Conformation | Epitopes - chemistry | Mice | Mutation | Amino Acid Substitution | Receptor, Notch3 - chemistry | Development and progression | Cellular signal transduction | Genetic aspects | Acute lymphocytic leukemia | Gene mutations | Health aspects | Monoclonal antibodies | Lymphomas | Inhibitor drugs | Leukemia | Cells | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | NOTCH3 | inhibitory antibody | Notch signaling | T-ALL
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2. Full Text A trimeric structural domain of the HIV-1 transmembrane glycoprotein
by Lu, Min and Blacklow, Stephen C and Kim, Peter S
Nature Structural Biology, ISSN 1072-8368, 12/1995, Volume 2, Issue 12, pp. 1075 - 1082
Infection with HIV-1 is initiated by fusion of cellular and viral membranes. The gp41 subunit of the HIV-1 envelope plays a major role in this process, but the... 
MEMBRANE-FUSION | HTLV-III/LAV | SOLUBLE CD4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | OLIGOMERIC STRUCTURE | ENVELOPE GLYCOPROTEIN | RECEPTOR-MEDIATED ACTIVATION | HUMAN-IMMUNODEFICIENCY-VIRUS | COILED-COIL | INFLUENZA HEMAGGLUTININ | GCN4 LEUCINE-ZIPPER | CELL BIOLOGY | Amino Acid Sequence | Giant Cells - chemistry | Molecular Weight | Peptides - chemistry | Membrane Glycoproteins - chemistry | Molecular Sequence Data | Recombinant Proteins - chemistry | Viral Envelope Proteins - ultrastructure | HIV Envelope Protein gp120 - ultrastructure | Proline - chemistry | HIV-1 - ultrastructure | Endopeptidases - chemistry | Membrane Glycoproteins - ultrastructure | HIV-1 - chemistry | Viral Envelope Proteins - chemistry | Cloning, Molecular | Protein Conformation | HIV Envelope Protein gp120 - chemistry
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3. Full Text Structural features of the low-density lipoprotein receptor facilitating ligand binding and release
by Beglova, N and Jeon, H and Fisher, C and Blacklow, S.C
Biochemical Society Transactions, ISSN 0300-5127, 11/2004, Volume 32, Issue 5, pp. 721 - 723
The LDLR (low-density lipoprotein receptor) is a modular protein built from several distinct structural units: LA (LDLR type-A), epidermal growth factor-like... 
Ligand binding | NMR | Lipoprotein | Interdomain linkers | Structure | Conformational change | BACKBONE DYNAMICS | FAMILIAL HYPERCHOLESTEROLEMIA | DOMAIN | lipoprotein | LDL RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN APOLIPOPROTEIN-E | interdomain linkers | conformational change | structure | MODULES | CONCATEMER | NMR STRUCTURE | ligand binding | PAIR | Protein Structure, Tertiary | Humans | Receptors, LDL - metabolism | Crystallography, X-Ray | Receptors, LDL - chemistry | Animals | Models, Biological | Epidermal Growth Factor - chemistry | Protein Binding | Ligands | Cell Membrane - metabolism | Green Fluorescent Proteins - chemistry | Hydrogen-Ion Concentration
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4. Full Text Trimeric Subdomain of the Simian Immunodeficiency Virus Envelope Glycoprotein
by Blacklow, Stephen C and Lu, Min and Kim, Peter S
Biochemistry, ISSN 0006-2960, 11/1995, Volume 34, Issue 46, pp. 14955 - 14962
Previous attempts to define the oligomeric state of the HIV and SIV envelope glycoproteins have yielded conflicting results. We have produced in Escherichia... 
Amino Acid Sequence | Peptide Fragments - metabolism | Protein Structure, Secondary | Membrane Glycoproteins - chemistry | Molecular Sequence Data | Recombinant Proteins - chemistry | Chromatography, High Pressure Liquid | Hot Temperature | Simian Immunodeficiency Virus - chemistry | Protein Folding | Macromolecular Substances | Peptide Fragments - chemistry | Endopeptidase K | HIV - chemistry | Viral Envelope Proteins - chemistry | Retroviridae Proteins - chemistry | Serine Endopeptidases - metabolism | Circular Dichroism | Hydrogen-Ion Concentration | Simian immunodeficiency virus | Glycoproteins | Research
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5. Full Text Folding Determinants of LDL Receptor Type A Modules
by Koduri, Vidyasagar and Blacklow, Stephen C
Biochemistry, ISSN 0006-2960, 10/2001, Volume 40, Issue 43, pp. 12801 - 12807
To investigate how three disulfide bonds and coordination of a calcium ion cooperate to specify the structure of an LDL-A module, we studied the... 
3-DIMENSIONAL STRUCTURE | FAMILIAL HYPERCHOLESTEROLEMIA | NMR SOLUTION STRUCTURE | CYSTEINE-RICH REPEAT | MOLTEN GLOBULE | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING DOMAIN | INTERMEDIATE | PANCREATIC TRYPSIN-INHIBITOR | DENSITY-LIPOPROTEIN RECEPTOR | Amino Acid Sequence | Mutagenesis, Site-Directed | Magnetic Resonance Spectroscopy | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Molecular Sequence Data | Chromatography, High Pressure Liquid | Cysteine - chemistry | Recombinant Fusion Proteins - chemistry | Receptors, LDL - chemistry | Protein Folding | Dose-Response Relationship, Drug | Sequence Homology, Amino Acid | Time Factors | Disulfides - chemistry | Escherichia coli - metabolism | Protein Binding | Ligands | Protein Conformation | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Research | Calcium-binding proteins | Protein folding | Analysis | Low density lipoproteins | Structure-activity relationships (Biochemistry)
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6. Full Text Two Functionally Distinct Forms of a Retroviral Receptor Explain the Nonreciprocal Receptor Interference among Subgroups B, D, and E Avian Leukosis Viruses
by Heather B. Adkins and Stephen C. Blacklow and John A. T. Young
Journal of Virology, ISSN 0022-538X, 04/2001, Volume 75, Issue 8, pp. 3520 - 3526
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
APOPTOSIS | CYTOTOXIC LIGAND TRAIL | VIROLOGY | CELL-SURFACE RECEPTOR | SUPERINFECTION | MURINE LEUKEMIA VIRUSES | DEATH RECEPTOR-5 | GLYCOPROTEIN | SARCOMA-VIRUSES | IDENTIFICATION | VIRAL ENTRY | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Avian Leukosis Virus - pathogenicity | Receptors, Virus - metabolism | Humans | Cytopathogenic Effect, Viral | Molecular Sequence Data | Substrate Specificity | Avian Leukosis Virus - metabolism | Glycosylation | Receptors, Virus - genetics | Precipitin Tests | Cysteine - genetics | Flow Cytometry | Receptors, Virus - chemistry | Transfection | Models, Biological | Avian Leukosis Virus - genetics | Cysteine - metabolism | Receptors, Virus - antagonists & inhibitors | Superinfection - virology | Avian Leukosis Virus - classification | Virus-Cell Interactions
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7. Full Text Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor
by Blacklow, Stephen C and Kim, Peter S
Nature Structural Biology, ISSN 1072-8368, 09/1996, Volume 3, Issue 9, pp. 758 - 762
3-DIMENSIONAL STRUCTURE | DOMAIN | CYSTEINE-RICH REPEAT | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE-PROTEIN | GLYCOPROTEIN | EPIDERMAL GROWTH-FACTOR | EXPRESSION | DENSITY-LIPOPROTEIN RECEPTOR | APOLIPOPROTEIN-E | CELL BIOLOGY | Hyperlipoproteinemia Type II - metabolism | Amino Acid Sequence | Point Mutation | Receptors, LDL - genetics | Calcium - metabolism | Humans | Molecular Sequence Data | Receptors, LDL - metabolism | Receptors, LDL - chemistry | Protein Folding | Hyperlipoproteinemia Type II - genetics
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8. Full Text A Simplified Reconstitution of mRNA-Directed Peptide Synthesis: Activity of the Epsilon Enhancer and an Unnatural Amino Acid
by Forster, Anthony C and Weissbach, Herbert and Blacklow, Stephen C
Analytical Biochemistry, ISSN 0003-2697, 10/2001, Volume 297, Issue 1, pp. 60 - 70
The study of the early events in translation would be greatly facilitated by reconstitution with easily purified components. Here, Escherichia coli... 
reconstitution | epsilon | enhancer | peptide | tRNA | elongation factor | biotin | translation | ribosome | unnatural amino acid | E. coli | initiation factor | Initiation factor | Translation | Ribosome | Enhancer | Unnatural amino acid | TRNA | Epsilon | Elongation factor | Biotin | Reconstitution | Peptide | CHEMISTRY, ANALYTICAL | PROTEIN | ESCHERICHIA-COLI | TRANSLATION INITIATION | IN-VITRO SYNTHESIS | ELONGATION-FACTOR-TU | BETA-GALACTOSIDASE | GENE-EXPRESSION | FACTOR-II | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | INITIATION-FACTOR IF3 | DOWNSTREAM BOX | Peptide Elongation Factors - metabolism | Amino Acids - chemistry | Ribosomes - metabolism | Chromatography, High Pressure Liquid | Histidine - metabolism | RNA, Messenger - metabolism | Threonine - metabolism | Recombinant Fusion Proteins - metabolism | Amino Acids - metabolism | Peptide Biosynthesis | Peptides - metabolism | Time Factors | Base Sequence | Escherichia coli - metabolism | Lysine - metabolism | Lysine - analogs & derivatives | Peptide Chain Initiation, Translational - genetics | Bacteriophage T7 - genetics | Peptides - chemistry | RNA, Messenger - genetics | Valine - analogs & derivatives | Mutation - genetics | Regulatory Sequences, Nucleic Acid - genetics | Threonine - analogs & derivatives | Peptide Initiation Factors - metabolism | Valine - metabolism | Escherichia coli - genetics
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9. Full Text Backbone Dynamics of a Module Pair from the Ligand-Binding Domain of the LDL Receptor
by Beglova, Natalia and North, Christopher L and Blacklow, Stephen C
Biochemistry, ISSN 0006-2960, 03/2001, Volume 40, Issue 9, pp. 2808 - 2815
The ligand-binding domain of the LDL receptor consists of seven contiguous LDL-A modules. The fifth of these ligand-binding modules is absolutely required for... 
3-DIMENSIONAL STRUCTURE | CYSTEINE-RICH REPEAT | NMR SOLUTION STRUCTURE | DIFFERENT PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAMILIAL HYPERCHOLESTEROLEMIA MUTATIONS | CALCIUM-BINDING | GENE FAMILY | MONOCLONAL-ANTIBODIES | DENSITY-LIPOPROTEIN RECEPTOR | VLDL RECEPTOR | Protein Structure, Tertiary | Amino Acid Sequence | Peptide Fragments - metabolism | Humans | Molecular Sequence Data | Receptors, LDL - metabolism | Nitrogen Isotopes | Receptors, LDL - chemistry | Amino Acid Motifs | Thermodynamics | Peptide Fragments - chemistry | Repetitive Sequences, Amino Acid | Solutions | Nuclear Magnetic Resonance, Biomolecular | Ligands | Protein Conformation | Lipoproteins | Biochemistry | Research
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10. Full Text Evidence that Familial Hypercholesterolemia Mutations of the LDL Receptor Cause Limited Local Misfolding in an LDL-A Module Pair
by North, Christopher L and Blacklow, Stephen C
Biochemistry, ISSN 0006-2960, 10/2000, Volume 39, Issue 43, pp. 13127 - 13135
Mutations at conserved sites within the ligand-binding LDL-A modules of the LDL receptor cause the genetic disease familial hypercholesterolemia (FH), and... 
EGF-LIKE DOMAIN | DIFFERENT PROTEINS | STRUCTURAL INTEGRITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MARFAN-SYNDROME | FACTOR-LIKE DOMAINS | CALCIUM-BINDING | GROWTH-FACTOR PRECURSOR | CULTURED HUMAN FIBROBLASTS | DENSITY-LIPOPROTEIN RECEPTOR | CYSTEINE-RICH | Calcium-Binding Proteins - metabolism | Amino Acid Sequence | Receptors, LDL - genetics | Mutagenesis, Site-Directed | Calcium - metabolism | Humans | Molecular Sequence Data | Receptors, LDL - metabolism | Spectrometry, Fluorescence | Protein Folding | Nuclear Magnetic Resonance, Biomolecular | Protein Conformation | Amino Acid Motifs - genetics | Calcium-Binding Proteins - genetics | Hyperlipoproteinemia Type II - genetics | Lipoproteins | Gene mutations | Physiological aspects | Amino acids | Ligands | Biochemistry | Research | Membrane proteins
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11. Full Text Quantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism
by Goldhaber, S.Z and Goldhaber, Samuel Z and Simons, Grant R and Simons, G.R and Elliott, C. Gregory and Elliott, C.G and Haire, W.D and Haire, William D and Toltzis, Robert and Toltzis, R and Blacklow, Stephen C and Blacklow, S.C and Doolittle, Marc H and Doolittle, M.H and Weinberg, David S and Weinberg, D.S
Journal of the American Medical Association, ISSN 0098-7484, 12/1993, Volume 270, Issue 23, pp. 2819 - 2822
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12. Full Text Searching Sequence Space by Definably Random Mutagenesis: Improving the Catalytic Potency of an Enzyme
by Jeffrey D. Hermes and Stephen C. Blacklow and Jeremy R. Knowles
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/1990, Volume 87, Issue 2, pp. 696 - 700
How easy is it to improve the catalytic power of an enzyme? To address this question, the gene encoding a sluggish mutant triose-phosphate isomerase... 
Phosphates | Enzymes | Mutagenesis | Active sites | Plasmids | Oligonucleotides | Amino acids | Catalytic activity | Biochemistry | Genetic mutation | Evolution | triase-phosphate isomerase | Pseudorevertants | Spiked oligonucleotides | Triose-phosphate isomerase | MULTIDISCIPLINARY SCIENCES | Genes, Bacterial | Oligonucleotide Probes | Escherichia coli - enzymology | Models, Molecular | Aspartic Acid | Glutamic Acid | Triose-Phosphate Isomerase - genetics | Escherichia coli - genetics | Triose-Phosphate Isomerase - metabolism | Protein Conformation | Kinetics | Mutation | Glutamates | Carbohydrate Epimerases - genetics
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13. Full Text A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers
by Hermes, Jeffrey D and Parekh, Shirish M and Blacklow, Stephen C and Koster, Hubert and Knowles, Jeremy R
Gene, ISSN 0378-1119, 1989, Volume 84, Issue 1, pp. 143 - 151
A new procedure for the production of a defined library of random mutants is described. Long spiked oligodeoxyribonucleotides (oligos), in which a... 
incorporation of mismatching bases | pseudorevertants | on-line mixing | automated DNA synthesis | Recombinant DNA | triosephosphate isomerase | phagemid vectors | GENETICS & HEREDITY | Gene Library | Escherichia coli - genetics | Plasmids | Base Sequence | Cloning, Molecular | Molecular Sequence Data | Templates, Genetic | Mutation | Oligonucleotide Probes - chemical synthesis
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14. The development of enzyme catalytic efficiency: An experimental approach
by Hermes, J.D and Blacklow, S.C and Knowles, J.R
Cold Spring Harbor Symposia on Quantitative Biology, ISSN 0091-7451, 1987, Volume 52, pp. 597 - 602
Biological Evolution | Models, Theoretical | Thermodynamics | Triose-Phosphate Isomerase - metabolism | Models, Molecular | Protein Conformation | Catalysis | Kinetics | Mutation | Binding Sites | Enzymes - metabolism
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15. Full Text Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
by Kopan, Raphael and McArthur, Debbie G and Hass, Matthew and Aster, Jon C and Blacklow, Stephen C and Ilagan, Ma Xenia G and Arnett, Kelly L
Nature Structural & Molecular Biology, ISSN 1545-9993, 11/2010, Volume 17, Issue 11, pp. 1312 - 1317
Ligand-induced proteolysis of Notch produces an intracellular effector domain that transduces essential signals by regulating the transcription of target... 
PRESENILIN | ACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROSOPHILA | CELL BIOLOGY | BIOPHYSICS | DNA | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENES | LIGAND | CSL | MASTERMIND | Transcription Factor HES-1 | Transcription Factors - chemistry | Homeodomain Proteins - metabolism | Humans | Receptor, Notch1 - chemistry | Molecular Sequence Data | Crystallography, X-Ray | DNA-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Base Sequence | Conserved Sequence | Binding Sites | Dimerization | Immunoglobulin J Recombination Signal Sequence-Binding Protein - chemistry | Protein Structure, Tertiary | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Promoter Regions, Genetic | Repressor Proteins - chemistry | Models, Molecular | Receptor, Notch1 - metabolism | Homeodomain Proteins - chemistry | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Mice | Basic Helix-Loop-Helix Transcription Factors - chemistry | Promoters (Genetics) | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Genetic transcription | Membrane proteins | Signal transduction | Molecular structure | Molecular biology | Deoxyribonucleic acid--DNA | Binding sites
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16. Full Text Structural basis for autoinhibition of Notch
by Vardar-Ulu, Didem and Sanchez-Irizarry, Cheryll and Histen, Gavin and Aster, Jon C and Blacklow, Stephen C and Gordon, Wendy R
Nature Structural & Molecular Biology, ISSN 1545-9993, 04/2007, Volume 14, Issue 4, pp. 295 - 300
Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an... 
UBIQUITIN LIGASE | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEOLYTIC ACTIVATION | MIND-BOMB | SEA DOMAIN | DROSOPHILA | CELL BIOLOGY | SIGNAL-TRANSDUCTION | LIGAND ENDOCYTOSIS | CAENORHABDITIS-ELEGANS | BIOPHYSICS | IN-VIVO | Protein Structure, Tertiary | Receptor, Notch2 - antagonists & inhibitors | Protein Structure, Secondary | Humans | Models, Molecular | Protein Binding | Crystallography, X-Ray | Structure-Activity Relationship | Receptor, Notch2 - chemistry | Genes, Reporter | Cell receptors | Control | Physiological aspects | Cellular signal transduction | Glycoproteins | Research | Structure | Molecular biology | Leukemia | Mutation
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17. Full Text Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia
by Yumi Yashiro-Ohtani and Hongfang Wang and Chongzhi Zang and Kelly L. Arnett and Will Bailis and Yugong Ho and Birgit Knoechel and Claudia Lanauze and Lumena Louis and Katherine S. Forsyth and Sujun Chen and Yoonjie Chung and Jonathan Schug and Gerd A. Blobel and Stephen A. Liebhaber and Bradley E. Bernstein and Stephen C. Blacklow and Xiaole Shirley Liu and Jon C. Aster and Warren S. Pear
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. E4946 - E4953
Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical... 
Chromatin | Enhancer | Transcription | Gene regulation | Brd4 | TARGET | enhancer | transcription | MULTIDISCIPLINARY SCIENCES | COMPLEXES | C-MYC | chromatin | GENOME | SUPER-ENHANCERS | gene regulation | ACUTE LYMPHOBLASTIC-LEUKEMIA | MARGINAL ZONE LYMPHOMA | EXPRESSION | Humans | Molecular Sequence Data | Genes, myc | Neoplasm Proteins - metabolism | Promoter Regions, Genetic - genetics | Gene Expression Regulation, Leukemic - genetics | Chromatin Immunoprecipitation | Base Sequence | Transcription, Genetic | Neoplasm Proteins - genetics | Genes, Reporter | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Genome-Wide Association Study | Models, Molecular | Transcription Factors - antagonists & inhibitors | Receptor, Notch1 - metabolism | Sequence Homology, Nucleic Acid | Sequence Alignment | Animals | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Enhancer Elements, Genetic - genetics | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Biological Sciences | PNAS Plus
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18. Full Text Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
by Takagi, Junichi and Beglova, Natalia and Blacklow, Stephen C and Springer, Timothy A
Nature Structural Biology, ISSN 1072-8368, 04/2002, Volume 9, Issue 4, pp. 282 - 287
Cysteine-rich repeats in the integrin β subunit stalk region relay activation signals to the ligand-binding headpiece. The NMR solution structure and disulfide... 
DOMAIN | LIGAND-BINDING | LDL RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCLONAL-ANTIBODY | CRYSTALLOGRAPHY | CELL BIOLOGY | PROTEIN STRUCTURES | NMR | EPITOPE | BIOPHYSICS | CALCIUM | INFLUENZA HEMAGGLUTININ | Disulfides - metabolism | Amino Acid Sequence | Protein Subunits | Epitopes - metabolism | Humans | Models, Molecular | Molecular Sequence Data | CD18 Antigens - chemistry | Structure-Activity Relationship | Amino Acid Motifs | CD18 Antigens - metabolism | Repetitive Sequences, Amino Acid | Sequence Alignment | Models, Biological | Nuclear Magnetic Resonance, Biomolecular | Protein Conformation | Cysteine - metabolism | Epitopes - chemistry | Physiological aspects | Cysteine | Genetic aspects | Research | Gene expression | Integrins
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