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1. Full Text Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease
by Egan, Michael F and Kost, James and Voss, Tiffini and Mukai, Yuki and Aisen, Paul S and Cummings, Jeffrey L and Tariot, Pierre N and Vellas, Bruno and van Dyck, Christopher H and Boada, Merce and Zhang, Ying and Li, Wen and Furtek, Christine and Mahoney, Erin and Harper Mozley, Lyn and Mo, Yi and Sur, Cyrille and Michelson, David
The New England journal of medicine, ISSN 0028-4793, 04/2019, Volume 380, Issue 15, pp. 1408 - 1420
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Male | Positron-Emission Tomography | Prodromal Symptoms | Thiadiazines - adverse effects | Thiadiazines - therapeutic use | Alzheimer Disease - prevention & control | Treatment Failure | Female | Cognitive Dysfunction - drug therapy | Enzyme Inhibitors - adverse effects | Double-Blind Method | Organ Size | Hippocampus - pathology | Cognitive Dysfunction - pathology | Enzyme Inhibitors - therapeutic use | Disease Progression | Magnetic Resonance Imaging | Cyclic S-Oxides - therapeutic use | Plaque, Amyloid - diagnostic imaging | Intention to Treat Analysis | Amyloid beta-Peptides - analysis | Aged | Brain Chemistry | Amyloid beta-Protein Precursor - antagonists & inhibitors | Cyclic S-Oxides - adverse effects | Clinical trials | Usage | Safety and security measures | Drug therapy | Alzheimer's disease | Analysis | Enzymes | b-Site APP cleaving enzyme 1 | Nuclear magnetic resonance--NMR | Medical imaging | Memory | Oral administration | Cognition | Evidence-based medicine | Amyloid precursor protein | Cognition & reasoning | Dementia disorders | b-Site APP cleaving enzyme | Alzheimers disease | Dementia | Index Medicus | Abridged Index Medicus
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2. Genome-wide analysis of genetic loci associated with Alzheimer disease
by Seshadri, Sudha and Fitzpatrick, Annette L and Ikram, M. Arfan and DeStefano, Anita L and Gudnason, Vilmundur and Boada, Merce and Bis, Joshua C and Smith, Albert V and Carassquillo, Minerva M and Lambert, Jean Charles and Harold, Denise and Schrijvers, Elisabeth M. C and Ramirez-Lorca, Reposo and Debette, Stephanie and Longstreth Jr, W.T and Janssens, A. Cecile J. W and Pankratz, V. Shane and Dartigues, Jean François and Hollingworth, Paul and Aspelund, Thor and Hernandez, Isabel and Beiser, Alexa and Kuller, Lewis H and Koudstaal, Peter J and Dickson, Dennis W and Tzourio, Christophe and Abraham, Richard and Antunez, Carmen and Du, Yangchun and Rotter, Jerome I and Aulchenko, Yurii S and Harris, Tamara B and Petersen, Ronald C and Berr, Claudine and Owen, Michael J and Lopez-Arrieta, Jesus and Varadarajan, Badri N and Becker, James T and Rivadeneira, Fernando and Nalls, Michael A and Graff-Radford, Neill R and Campion, Dominique and Auerbach, Sanford and Rice, Kenneth and Hofman, Albert and Jonsson, Palmi V and Schmidt, Helena and Lathrop, Mark and Mosley, Thomas H and Au, Rhoda and Psaty, Bruce M and Uitterlinden, Andre G and Farrer, Lindsay A and Lumley, Thomas and Ruiz, Agustin and Williams, Julie and Amouyel, Philippe and Younkin, Steve G and Wolf, Philip A and Launer, Lenore J and Lopez, Oscar L and Van Duijn, Cornelia M and Breteler, Monique M. B and CHARGE GERAD1 EADI1 Consortia and EADI1 Consortium and CHARGE Consortium and GERAD1 Consortium
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 05/2010, Volume 303, Issue 18, pp. 1832 - 1840
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Age of Onset | Aged | Polymorphism, Single Nucleotide | Genetic Loci | Alzheimer Disease - genetics | Odds Ratio | Case-Control Studies | Gene loci | Alzheimers disease | Genomics | Genes
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3. Full Text Co-application of Se and a biostimulant at different wheat growth stages: Influence on grain development
by Xiao, Tingting and Boada, Roberto and Llugany, Mercè and Valiente, Manuel
Plant physiology and biochemistry, ISSN 0981-9428, 03/2021, Volume 160, pp. 184 - 192
Se speciation | Plant biostimulant | XAS | XRF | Wheat | Grain | Crop yields | Usage | Plant physiology | Growth | Physiological aspects | X-ray spectroscopy | Index Medicus
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4. Full Text Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials
by Vandenberghe, Rik and Rinne, Juha O and Boada, Mercè and Katayama, Sadao and Scheltens, Philip and Vellas, Bruno and Tuchman, Michael and Gass, Achim and Fiebach, Jochen B and Hill, Derek and Lobello, Kasia and Li, David and McRae, Tom and Lucas, Prisca and Evans, Iona and Booth, Kevin and Luscan, Gerald and Wyman, Bradley T and Hua, Lisa and Yang, Lingfeng and Brashear, H Robert and Black, Ronald S and Bapineuzumab 3000 Clinical Study and Bapineuzumab 3001 Clinical Study and Bapineuzumab 3000 and 3001 Clinical Study Investigators and for the Bapineuzumab 3000 and 3001 Clinical Study Investigators
Alzheimer's research & therapy, ISSN 1758-9193, 2016, Volume 8, Issue 1, pp. 18 - 18
Severity of Illness Index | Apolipoprotein E4 | Brain | Humans | Male | Treatment Outcome | Positron-Emission Tomography | Alzheimer Disease | Randomized Controlled Trial | tau Proteins | Journal Article | Neuropsychological Tests | Antibodies, Monoclonal, Humanized | Clinical Trial, Phase III | Research Support, Non-U.S. Gov't | Amyloid beta-Peptides | Biomarkers | Female | Multicenter Study | Aged | ARIA-E | Amyloid β | Immunotherapy | Clinical trial | Vasogenic edema | Alzheimer's disease | Bapineuzumab | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biomarkers - metabolism | Brain - diagnostic imaging | Antibodies, Monoclonal, Humanized - therapeutic use | Apolipoprotein E4 - genetics | Alzheimer Disease - drug therapy | tau Proteins - cerebrospinal fluid | Brain - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Alzheimer Disease - diagnostic imaging | Biomarkers - cerebrospinal fluid | Alzheimer Disease - genetics | Care and treatment | Research | Apolipoproteins | Health aspects | Neurodegenerative diseases | Index Medicus
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5. Full Text Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease
by Honig, Lawrence S and Vellas, Bruno and Woodward, Michael and Boada, Mercè and Bullock, Roger and Borrie, Michael and Hager, Klaus and Andreasen, Niels and Scarpini, Elio and Liu-Seifert, Hong and Case, Michael and Dean, Robert A and Hake, Ann and Sundell, Karen and Poole Hoffmann, Vicki and Carlson, Christopher and Khanna, Rashna and Mintun, Mark and DeMattos, Ronald and Selzler, Katherine J and Siemers, Eric
The New England journal of medicine, ISSN 0028-4793, 01/2018, Volume 378, Issue 4, pp. 321 - 330
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Peptide Fragments - cerebrospinal fluid | Double-Blind Method | Humans | Middle Aged | Alzheimer Disease - drug therapy | Male | Mental Status and Dementia Tests | Positron-Emission Tomography | Activities of Daily Living | Alzheimer Disease - diagnosis | Plaque, Amyloid - drug therapy | Immunotherapy | Treatment Failure | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Female | Aged | Biomarkers - cerebrospinal fluid | Infusions, Intravenous | Alzheimer Disease - psychology | Care and treatment | Solanezumab | Causes of | Dosage and administration | Research | Alzheimer's disease | Risk factors | Dementia | Neuroimaging | Edema | Neurodegenerative diseases | Effusion | Cognitive ability | Clinical trials | Cerebrospinal fluid | Patients | Proteins | Neurofibrillary tangles | Brain research | Magnetic resonance imaging | Monoclonal antibodies | Dementia disorders | Biomarkers | Alzheimers disease | Positron emission tomography | Plaques | Geriatrics | Index Medicus | Abridged Index Medicus
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6. Full Text A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease
by Ostrowitzki, Susanne and Lasser, Robert A and Dorflinger, Ernest and Scheltens, Philip and Barkhof, Frederik and Nikolcheva, Tania and Ashford, Elizabeth and Retout, Sylvie and Hofmann, Carsten and Delmar, Paul and Klein, Gregory and Andjelkovic, Mirjana and Dubois, Bruno and Boada, Mercè and Blennow, Kaj and Santarelli, Luca and Fontoura, Paulo and SCarlet RoAD Investigators and for the SCarlet RoAD Investigators and Sahlgrenska akademin and Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry and Sahlgrenska Academy
Alzheimer's research & therapy, ISSN 1758-9193, 12/2017, Volume 9, Issue 1, pp. 95 - 95
Cognitive Neuroscience | Neurology | Clinical Neurology | Alzheimer's disease | Gantenerumab | SCarlet RoAD | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Usage | Care and treatment | PET imaging | Analysis | Monoclonal antibodies | Clinical trials | Dosage and administration | Research | Index Medicus | Neurovetenskaper | Alzheimer’s disease
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7. Full Text A phase II trial of tideglusib in alzheimer's disease
by Lovestone, Simon and Boada, Mercè and Dubois, Bruno and Hüll, Michael and Rinne, Juha O and Huppertz, Hans-Jürgen and Calero, Miguel and Andrés, María V and Gómez-Carrillo, Belén and León, Teresa and Del Ser, Teodoro and ARGO Investigators and ARGO investigators and for the ARGO investigators
Journal of Alzheimer's disease, ISSN 1387-2877, 2015, Volume 45, Issue 1, pp. 75 - 88
pharmacological treatment | GSK-3 | randomized controlled clinical trial | Alzheimer's disease | tideglusib | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neuroprotective Agents - therapeutic use | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Follow-Up Studies | Humans | Middle Aged | Alzheimer Disease - drug therapy | Male | Alzheimer Disease - cerebrospinal fluid | Dose-Response Relationship, Drug | Psychiatric Status Rating Scales | Thiadiazoles - therapeutic use | Apolipoproteins E - genetics | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Female | Aged | Alzheimer Disease - genetics | Index Medicus | Life Sciences | Neurons and Cognition
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8. Full Text Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
by Vronskaya, Maria and van der Lee, Sven J and Bellenguez, Céline and Chouraki, Vincent and Chen, Yuning and Fitzpatrick, Annette L and Valladares, Otto and Smith, Albert V and Choi, Seung-Hoan and Adams, Hieab H and Dombroski, Beth A and Hofer, Edith and Sarnowski, Chloe and Kornhuber, Johannes and Barber, Robert C and Engelborghs, Sebastiaan and Mayhaus, Manuel and Gu, Wei and Squassina, Alessio and Orellana, Adelina and Rodriguez-Rodriguez, Eloy and Lovestone, Simon and Garcia, Melissa E and Munoz-Fernadez, Carmen and Lin, Honghuang and Maier, Wolfgang and Keene, C. Dirk and Koivisto, Anne Maria and Lynch, Aoibhinn and Tarraga, Lluís and Haapasalo, Annakaisa and Gill, Michael and Alvarez, Ignacio and Salani, Francesca and Ciaramella, Antonio and Boerwinkle, Eric and Hanon, Olivier and Royall, Donald R and Maletta, Raffaele Giovanni and Craig, David and Fratiglioni, Laura and Koutroumani, Maria and Panza, Francesco and Barnes, Lisa L and Barral, Sandra and Passmore, Peter and Bowen, James D and Burns, Jeffrey M and Bass, Nicholas J and Hardy, John and Allen, Mariet and Dick, Malcolm and Duara, Ranjan and Fardo, David W and Farlow, Martin R and Foroud, Tatiana M and Morris, John and Mayo, Kevin and Hamilton, Ronald L and Honig, Lawrence S and Jarvik, Gail P and Meggy, Alun and Karydas, Anna and Kim, Ronald and Lah, James J and Levey, Allan I and Martiniuk, Frank and Medway, Christopher and Nöthen, Markus M and Masliah, Eliezer and Hooper, Nigel M and Miller, Carol A and Shaw, Christopher E and Parisi, Joseph E and Paulson, Henry L and Collinge, John and Cribbs, David H and Rossor, Martin and Raskind, Murray and Reisberg, Barry and Clarke, Robert and Smith, A David and Warden, Donald and Bruni, Amalia Cecilia and Saykin, Andrew J and Pastor, Pau and Spina, Salvatore and Van Deerlin, Vivianna M and Saba, Yasaman and Pilotto, Alberto and Bennett, David and Warner, Nick and Gwilliam, Rhian and Goate, Alison M and Sanchez-Juan, Pascual and Launer, Lenore J and Ikram, M. Arfan and Nicolas, Gael and C. O’Donovan, Michael and Psaty, Bruce M and Cohorts Heart Aging Res Genomic Ep and Alzheimer Dis Genetics Consortium and European Alzheimers Dis Initiative and Genetic Environm Risk AD Defining and Alzheimer Disease Genetics Consortium (ADGC) and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) and European Alzheimer’s Disease Initiative (EADI) and Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) and The European Alzheimer’s Disease Initiative (EADI)
Nature genetics, ISSN 1061-4036, 03/2019, Volume 51, Issue 3, pp. 414 - 430
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease - genetics | Lipids - genetics | Humans | Genetic Loci - genetics | Male | Genetic Testing - methods | Case-Control Studies | Haplotypes - genetics | tau Proteins - genetics | Amyloid beta-Peptides - genetics | Female | Lipid Metabolism - genetics | Aged | Alzheimer Disease - genetics | Genome-Wide Association Study - methods | Immunity - genetics | Ontology | Genomics | Genes | Lipids | Mapping | Genomes | Family medical history | Immunity | Risk factors | Protein turnover | Datasets | Proteins | Consortia | Genetic analysis | Dementia disorders | Genetics | Lipid metabolism | Alzheimer's disease | Age | ADAMTS-1 protein | Neurodegenerative diseases | Health risks | Metabolism | Risk analysis | Amyloid precursor protein | Meta-analysis | White blood cells | Genetic variance | Tau protein | Histocompatibility antigen HLA | Gene loci | Gene mapping | Alzheimers disease | Secretase | Dementia | Index Medicus | Medicin och hälsovetenskap
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