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Nature genetics, ISSN 1061-4036, 09/2019, Volume 51, Issue 9, pp. 1399 - 1410I
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodeling complexes are highly abundant in human cancers.... 
Chromatin | Lethal mutation | Development and progression | Genetic aspects | Research | Gene expression | Cancer | Incorporation | BRG1 protein | Transcription factors | Genomes | Chromatin remodeling | Proteins | Cell lines | Stem cells | Mutation | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2014, Volume 6, Issue 12, pp. 1525 - 1541
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/2008, Volume 180, Issue 4, pp. 803 - 812
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2019, Volume 15, Issue 7, pp. 672 - 680
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 08/2019, Volume 15, Issue 8, pp. 822 - 822
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is... 
DESIGN | PROTEIN | ASSAY | CHROMATIN | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING | Cell proliferation | Myeloid leukemia | Leukemia | Lung cancer | Breast cancer | Myc protein | Gene expression | Domains | Organic chemistry | Lysine | Chromosome 8 | Breast | Acute myeloid leukemia | Viability | Binding sites
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4462 - 4475
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 22, pp. 10147 - 10162
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2003, Volume 278, Issue 52, pp. 52689 - 52699
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2016, Volume 15, Issue 10, pp. 2388 - 2398
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2000, Volume 19, Issue 19, pp. 5092 - 5104
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 1919 - 1919
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2014, Volume 6, Issue 12, pp. 1525 - 1541
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1... 
Ubiquitin | Cell culture | Laboratories | Tumor cells | Epithelial cells | Colorectal carcinoma | Colorectal cancer | Myc protein | Gene expression | Experiments | Carcinogenesis | Proteins | Gene silencing | Signal transduction | Molecular modelling | Colon cancer | Transcription activation | Stem cells | Xenografts | Tumorigenesis | Ubiquitin-protein ligase | Huwe1 protein
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. 1080 - 1080
Journal Article
Genes and Cancer, ISSN 1947-6019, 2010, Volume 1, Issue 2, pp. 101 - 114
Increasing evidence suggests that processes termed epithelial-mesenchymal transitions (EMTs) play a key role in therapeutic resistance, tumor recurrence, and... 
Epithelial-mesenchymal transition | NF-κB | IKK2 | Metastasis | Chemical inhibitor | epithelial-mesenchymal transition | chemical inhibitor | metastasis | Original
Journal Article