Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (49) 49
life sciences & biomedicine (47) 47
toxicology (35) 35
animals (23) 23
biochemie (23) 23
biochemistry (23) 23
magnetic resonance spectroscopy (20) 20
pharmacology & pharmacy (20) 20
rats (18) 18
humans (17) 17
biochemistry & molecular biology (16) 16
chromatography, high pressure liquid (16) 16
chemistry (14) 14
physical sciences (14) 14
biological and medical sciences (13) 13
kinetics (13) 13
leerstoelgroep toxicologie (13) 13
sub-department of toxicology (13) 13
toxicologie (13) 13
chemistry, medicinal (12) 12
cytochrome p-450 enzyme system - metabolism (12) 12
chemistry, multidisciplinary (11) 11
microsomes, liver - enzymology (11) 11
vlag (11) 11
biotransformation (9) 9
male (9) 9
medical sciences (9) 9
microsomes, liver - metabolism (9) 9
oxidation-reduction (9) 9
hydrogen-ion concentration (8) 8
hydroxylation (8) 8
models, biological (8) 8
aniline compounds - metabolism (7) 7
female (7) 7
metabolism (7) 7
peroxidases - metabolism (7) 7
phenols - metabolism (7) 7
quercetin - chemistry (7) 7
quercetin - metabolism (7) 7
safrole (7) 7
structure-activity relationship (7) 7
substrate specificity (7) 7
aniline compounds - chemistry (6) 6
biodegradation, environmental (6) 6
flavonoids - chemistry (6) 6
fundamental and applied biological sciences. psychology (6) 6
glutathione - metabolism (6) 6
in vitro (6) 6
mass spectrometry (6) 6
metabolites (6) 6
microbiology (6) 6
quinones - chemistry (6) 6
rats, wistar (6) 6
analytical, structural and metabolic biochemistry (5) 5
carcinogens - pharmacokinetics (5) 5
dietary flavonoids (5) 5
dose-response relationship, drug (5) 5
eugenol - analogs & derivatives (5) 5
glutathione - chemistry (5) 5
hydrogen peroxide - metabolism (5) 5
indolequinones (5) 5
models, chemical (5) 5
oxidation (5) 5
peroxidase (5) 5
quercetin - analogs & derivatives (5) 5
rat (5) 5
1'-hydroxyestragole (4) 4
analysis (4) 4
antioxidants - chemistry (4) 4
benzoquinones - chemistry (4) 4
bioactivation (4) 4
biodegradation (4) 4
carcinogens - metabolism (4) 4
cytochrome p450 (4) 4
detoxification (4) 4
dna-adducts (4) 4
enzymes (4) 4
enzymes and enzyme inhibitors (4) 4
estragole bioactivation (4) 4
flavonoids (4) 4
flavonoids - pharmacology (4) 4
flavoring agents - metabolism (4) 4
in vitro techniques (4) 4
indoles - chemistry (4) 4
molecular structure (4) 4
oxidoreductases (4) 4
phenol hydroxylase (4) 4
phenols (4) 4
post-labeling analysis (4) 4
quercetin (4) 4
research (4) 4
rhodococcus (4) 4
rhodococcus - growth & development (4) 4
rhodococcus - metabolism (4) 4
species specificity (4) 4
allylbenzene analogs (3) 3
anisoles - metabolism (3) 3
anisoles - pharmacokinetics (3) 3
antioxidant activity (3) 3
bacteria (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Beneficial Effects of Whole Body Vibration on Brain Functions in Mice and Humans
by Boerema, Ate S and Heesterbeek, Marelle and Boersma, Selma A and Schoemaker, Regien and de Vries, Erik F. J and van Heuvelen, Marieke J. G and Van der Zee, Eddy A
Dose-response, ISSN 1559-3258, 12/2018, Volume 16, Issue 4, pp. 1559325818811756 - 1559325818811756
brain glucose metabolism | motor performance | executive functions | behavioral arousal | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats
by Punt, Ans and Paini, Alicia and Boersma, Marelle G and Freidig, Andreas P and Delatour, Thierry and Scholz, Gabriele and Schilter, Benoît and Bladeren, Peter J. van and Rietjens, Ivonne M. C. M
Toxicological sciences, ISSN 1096-6080, 8/2009, Volume 110, Issue 2, pp. 255 - 269
Human | Metabolism | Estragole | In vitro | Species differences | PBBK | Life Sciences & Biomedicine | Toxicology | Science & Technology | Inactivation, Metabolic | Reproducibility of Results | Glucuronides - pharmacokinetics | Species Specificity | Humans | Microsomes, Liver - metabolism | Rats | Male | Anisoles - pharmacokinetics | Carcinogens - toxicity | Kidney - metabolism | Animals | Anisoles - toxicity | Models, Biological | Biotransformation | Female | Carcinogens - pharmacokinetics | Lung - metabolism | Intestine, Small - metabolism | Toxicity Tests | Index Medicus | Biotransformation and Toxicokinetics | in vitro | species differences | metabolism | human | estragole
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples
by Brand, W and Boersma, M.G and Bik, H and Hoek-van den Hil, E.F and Vervoort, J.J.M and Barron, D and Meinl, W and Glatt, H and Williamson, G and Bladeren, van, P.J and Rietjens, I
Drug metabolism and disposition, ISSN 0090-9556, 2010, Volume 38, Issue 4, pp. 617 - 625
orange juice | tc7 cells | identification | expression | bioavailability | caco-2 cell monolayers | conjugated metabolites | messenger-rna | gastrointestinal-tract | flavanones | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Humans | Insecta | Microsomes, Liver - metabolism | DNA, Complementary - genetics | Male | Chromatography, High Pressure Liquid | Cytosol - enzymology | Transfection | Biotransformation | DNA, Complementary - biosynthesis | Sulfotransferases - metabolism | Microsomes, Liver - enzymology | Cell Line | Sulfates - metabolism | Magnetic Resonance Spectroscopy | Liver - metabolism | Rats | Glucosides - metabolism | Rats, Sprague-Dawley | Colon - metabolism | Animals | Glucuronosyltransferase - metabolism | Cytosol - metabolism | Intestine, Small - metabolism | Kinetics | In Vitro Techniques | Hesperidin - pharmacokinetics | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Beneficial effects of whole body vibration on brain functions in mice and humans
by Boerema, Ate S and Heesterbeek, Marelle and Boersma, Selma A and Schoemaker, Regina G and de Vries, Erik F. J and van Heuvelen, Marieke J.G and van der Zee, Eddy A
Dose-response, ISSN 1559-3258, 12/2018, Volume 16, Issue 4, pp. 1 - 10
IMPROVE | PERFORMANCE | BEHAVIOR | VOLUNTARY EXERCISE | behavioral arousal | BALANCE | MILD | brain glucose metabolism | executive functions | GLUCOSE | DISEASE | F-18-FDG | motor performance
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Identification of 14 Quercetin Phase II Mono- and Mixed Conjugates and Their Formation by Rat and Human Phase II in Vitro Model Systems
by van der Woude, Hester and Boersma, Marelle G and Vervoort, Jacques and Rietjens, Ivonne M. C. M
Chemical research in toxicology, ISSN 0893-228X, 11/2004, Volume 17, Issue 11, pp. 1520 - 1530
regioselectivity | derivatives | antioxidant | catechol-o-methyltransferase | bioavailability | induced lipid-peroxidation | low-density-lipoprotein | plasma metabolites | potentially anticarcinogenic flavonoids | dietary flavonoids | Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Intestines - drug effects | Cell Survival - drug effects | Quercetin - analogs & derivatives | Magnetic Resonance Spectroscopy | Humans | Microsomes, Liver - metabolism | Rats | Intestines - metabolism | Chromatography, High Pressure Liquid | Hepatocytes - metabolism | Animals | Quercetin - toxicity | Spectrometry, Mass, Electrospray Ionization | Microsomes, Liver - drug effects | Models, Biological | Cell Line, Tumor | Subcellular Fractions | Hepatocytes - drug effects | Quercetin - metabolism | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat
by Al-Subeihi, Ala' A.A and Spenkelink, Bert and Punt, Ans and Boersma, Marelle G and van Bladeren, Peter J and Rietjens, Ivonne M.C.M
Toxicology and applied pharmacology, ISSN 0041-008X, 05/2012, Volume 260, Issue 3, pp. 271 - 284
Human | PBK | Methyleugenol | Metabolism | In vitro | Species differences | genotoxicity | derivatives | human liver-microsomes | methyl eugenol | fischer-344 rat | dna-adducts | allylbenzene | metabolism | safrole | estragole bioactivation | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Species Specificity | Administration, Oral | Eugenol - toxicity | Humans | Microsomes, Liver - metabolism | Eugenol - analogs & derivatives | Rats | Male | DNA Adducts - metabolism | Dose-Response Relationship, Drug | Animals | Models, Biological | Computer Simulation | Eugenol - pharmacokinetics | Eugenol - administration & dosage | Female | Phosphates | Purines | Niacinamide | Metabolites | Body weight | Models | Comparative analysis | Mass spectrometry | Chromatography | Index Medicus | DETOXIFICATION | BIOLOGICAL PATHWAYS | DMSO | CARCINOGENS | RATS | ADDUCTS | MASS SPECTROSCOPY | PROPANE | URIDINE | 60 APPLIED LIFE SCIENCES | EXTRAPOLATION | FLAVOR MODEL | DOSES | DNA | IN VITRO | LIQUID COLUMN CHROMATOGRAPHY | GLYCOLS | LIVER | NADP | OXIDES | GAS CHROMATOGRAPHY | FLAVOR | FOOD
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Physiologically Based Biokinetic (PBBK) Modeling of Safrole Bioactivation and Detoxification in Humans as Compared With Rats
by Martati, E and Boersma, M.G and Spenkelink, A and Khadka, D.B and Bladeren, van, P.J and Rietjens, I and Punt, A
Toxicological sciences, ISSN 1096-6080, 2012, Volume 128, Issue 2, pp. 301 - 316
human cytochrome-p450 enzymes | carcinogen 1'-hydroxysafrole | mouse | oral-cancer | alkenylbenzene methyleugenol | dna-adducts | metabolism | allylbenzene analogs | estragole bioactivation | risk-assessment | Safrole | Physiologically based biokinetic (PBBK) or physiologically based pharmacokinetic (PBPK) | In vitro | Bioactivation | Humans | Detoxification | Life Sciences & Biomedicine | Toxicology | Science & Technology | Animals | Safrole - pharmacokinetics | Biotransformation | Models, Molecular | Rats | Male | Chromatography, High Pressure Liquid | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat
by Punt, Ans and Freidig, Andreas P and Delatour, Thierry and Scholz, Gabriele and Boersma, Marelle G and Schilter, Benoît and van Bladeren, Peter J and Rietjens, Ivonne M.C.M
Toxicology and applied pharmacology, ISSN 0041-008X, 2008, Volume 231, Issue 2, pp. 248 - 259
PBPK | Rat | Estragole | In vitro | Bioactivation | Detoxification | post-labeling analysis | organic-chemicals | 1'-hydroxyestragole | species-differences | in-vitro | naturally-occurring alkenylbenzenes | mouse-liver | metabolism | allylbenzene analogs | mice | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Plant poisons toxicology | Biological and medical sciences | Medical sciences | Inactivation, Metabolic | Rats, Wistar | Rats | Sulfones - metabolism | Anisoles - metabolism | Male | Phenols - metabolism | Rats, Sprague-Dawley | Anisoles - pharmacokinetics | Carcinogens - administration & dosage | Dose-Response Relationship, Drug | Tissue Distribution | Kidney - metabolism | Animals | Glucuronides - metabolism | Anisoles - administration & dosage | Models, Biological | Allyl Compounds - metabolism | Female | Carcinogens - pharmacokinetics | Lung - metabolism | Metabolites | Index Medicus | DETOXIFICATION | BIOLOGICAL PATHWAYS | METABOLITES | DMSO | LUNGS | RATS | URIDINE | 60 APPLIED LIFE SCIENCES | KIDNEYS | FLAVOR MODEL | DOSES | IN VITRO | LIVER | PERFUSED TISSUES | NADP | OXIDES | BLOOD | FLAVOR | FOOD
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Safety evaluation of neem ( Azadirachta indica) derived pesticides
by Boeke, Sara J and Boersma, Marelle G and Alink, Gerrit M and van Loon, Joop J.A and van Huis, Arnold and Dicke, Marcel and Rietjens, Ivonne M.C.M
2004, Volume 94, Issue 1, 17
Neem-derived pesticides | Health evaluation | Toxicity | Oral administration | NOAEL | toxicity | gastric carcinogenesis | male-rats | praneem | nitro-n-nitrosoguanidine | blood-constituents | oil | seed extract | buccal pouch carcinogenesis | leaf extracts | erythrocyte sedimentation rate | 7,12-dimethylbenz[α]anthracene (carcinogenic agent) | ESR | ADI | DMBA | CNS | acceptable daily intake | central nervous system | body weight | medium effective dose | GGT | ESD | estimated safe dose | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Dose-Response Relationship, Drug | Animals | Plant Extracts - toxicity | Risk Assessment | Administration, Oral | Pesticides - toxicity | Humans | Plant Oils - toxicity | Lethal Dose 50 | Azadirachta | Index Medicus
Book Review
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Flavonoids and alkenylbenzenes: New concepts in bioactivation studies
by Rietjens, Ivonne M.C.M and Huseiny, Wasma Al and Boersma, Marelle G
Chemico-biological interactions, ISSN 0009-2797, 2011, Volume 192, Issue 1, pp. 87 - 95
Sulfotransferases | Physiologically based kinetic modeling | Flavonoids | Matrix effect | Alkenylbenzenes | Electrophile responsive element | safety assessment | mediated gene-expression | rat-liver | intestinal-absorption | metabolic stability | quercetin quinone methide | dna-adducts | human liver | anticancer properties | estragole bioactivation | Benzene - pharmacokinetics | Flavonoids - pharmacology | Gene Expression - drug effects | Models, Biological | Flavonoids - pharmacokinetics | Biotransformation | Gene expression | Analysis | Quinone | Isoflavones | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Regioselectivity of Phase II Metabolism of Luteolin and Quercetin by UDP-Glucuronosyl Transferases
by Boersma, Marelle G and van der Woude, Hester and Bogaards, Jan and Boeren, Sjef and Vervoort, Jacques and Cnubben, Nicole H. P and van Iersel, Marlou L. P. S and van Bladeren, Peter J and Rietjens, Ivonne M. C. M
Chemical research in toxicology, ISSN 0893-228X, 05/2002, Volume 15, Issue 5, pp. 662 - 670
Toxicologie | Toxicology |