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Journal of Pathology, ISSN 0022-3417, 09/2015
Pancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to treat. Five-year survival rate of PDA patients is 7%, and PDA is... 
Journal Article
The Journal of Pathology, ISSN 0022-3417, 01/2016, Volume 238, Issue 2, pp. 197 - 204
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2016
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
Journal Article
Journal of Cystic Fibrosis, ISSN 1569-1993, 07/2018, Volume 17, Issue 4, pp. 441 - 443
The European Cystic Fibrosis Society (ECFS) Basic Science Working Group (BSWG) organized a session on the topic “ ”, within the 15th ECFS Basic Science... 
Cystic Fibrosis Basic Science | Meeting report | Basic Science Working Group | Pancreas | Intestine | Kidney | STEM-CELLS | RESPIRATORY SYSTEM | EXPANSION | INTESTINAL ORGANOIDS | Cystic fibrosis | Conferences and conventions
Journal Article
PLoS genetics, ISSN 1553-7390, 2010, Volume 6, Issue 5, p. e1000970
Journal Article
Cell, ISSN 0092-8674, 01/2015, Volume 160, Issue 1-2, pp. 324 - 338
Journal Article
Diabetes, ISSN 0012-1797, 05/2009, Volume 58, Issue 5, pp. 1245 - 1253
Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans Sylvia F. Boj 1 , Joan Marc... 
NETWORK | ELEMENT | EVOLUTION | EMBRYONIC STEM-CELLS | MOUSE | REGIONS | ENDOCRINOLOGY & METABOLISM | MUTATIONS | FACTOR-BINDING SITES | GENOME-WIDE ASSOCIATION | ALPHA-GENE | Original
Journal Article
EMBO Journal, ISSN 0261-4189, 2013, Volume 32, Issue 20, pp. 2708 - 2721
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 494, Issue 7436, pp. 247 - 250
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2010, Volume 6, Issue 5
The transcription of individual genes is determined by combinatorial interactions between DNA-binding transcription factors. The current challenge is to... 
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2010, Volume 6, Issue 5
  The transcription of individual genes is determined by combinatorial interactions between DNA-binding transcription factors. The current challenge is to... 
Studies | Genotype & phenotype | Rodents | Genetics | Mutation | Diabetes | Gene expression | Experiments
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 60 - 68
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
MEDICINE, RESEARCH & EXPERIMENTAL | RNF43 | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CANCER | CELL BIOLOGY | ESSENTIAL GENES | INHIBITION | GROWTH | MUTATIONAL LANDSCAPE | WNT | RECEPTORS | Frizzled Receptors - antagonists & inhibitors | Neoplasm Transplantation | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Colorectal Neoplasms - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Flow Cytometry | Organoids - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Cycle Checkpoints - drug effects | Fluorescent Antibody Technique | Organoids - drug effects | Cell Line, Tumor | Mice | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genotype | Genetic engineering | Cellular signal transduction | Genetic aspects | Health aspects | Proteins | Viral antibodies | Genomics | Colorectal cancer | Antibodies | Genomes | Genetic screening | Cell proliferation | Adenocarcinoma | CRISPR | Therapy | Immunoglobulins | Wnt protein | Frizzled protein | Xenotransplantation | Colorectal carcinoma | Cell surface | Signaling | Receptors | Organoids | Xenografts | Inhibition | Mutation | Pancreas | Cancer | Tumors | Recombinant
Journal Article
Cell, ISSN 0092-8674, 12/2012, Volume 151, Issue 7, pp. 1595 - 1607
Most studies on TCF7L2 SNP variants in the pathogenesis of type 2 diabetes (T2D) focus on a role of the encoded transcription factor TCF4 in beta cells. Here,... 
Journal Article