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2011, ISBN 0123821983, xvi, 912
Book
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 369 - 383
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 15, pp. 3987 - 3992
Recessive Stargardt macular degeneration (STGD1) is caused by mutations in the gene for the ABCA4 transporter in photoreceptor outer segments. STGD1 patients... 
Recessive Stargardt macular degeneration | Bisretinoids | Complement system | Gene therapy | Retinal pigment epithelium | VISUAL CYCLE | CELLS | ACTIVATION | complement system | MULTIDISCIPLINARY SCIENCES | recessive Stargardt macular degeneration | gene therapy | MACULAR DEGENERATION | CHOROIDAL NEOVASCULARIZATION | RECEPTOR-OPSIN | RPE LIPOFUSCIN | MEMBRANE-ATTACK-COMPLEX | REGULATORY PROTEINS | retinal pigment epithelium | bisretinoids | GEOGRAPHIC ATROPHY | Dependovirus - genetics | Retinal Pigment Epithelium - metabolism | Retinoids - metabolism | Oxidative Stress | Complement C3 - metabolism | Gene Expression Regulation | Autophagy | Receptors, Complement - metabolism | Macular Degeneration - metabolism | Retinal Pigment Epithelium - pathology | Animals | Macular Degeneration - congenital | ATP-Binding Cassette Transporters - genetics | Mice, Mutant Strains | Receptors, Complement - genetics | Mice, Inbred BALB C | Photoreceptor Cells, Vertebrate - metabolism | Lipofuscin - metabolism | Photoreceptor Cells, Vertebrate - pathology | Injections, Intraocular | Disease Models, Animal | Macular Degeneration - pathology | Oxidative stress | Complement receptors | Complement component C3b | Retina | Viruses | Activation | Complement | Accumulation | Proteins | Macular degeneration | Genotype & phenotype | Etiology | Coding | Rodents | Modulation | Pigments | Degeneration | Recombinant | Crry protein | Therapeutic applications | Visual observation | Complement regulatory proteins | Gene expression | Epithelium | Complement activation | Complement component C3 | Retinal degeneration | Photoreceptors | Mice | Mutation | Transporter | Index Medicus | Biological Sciences
Journal Article
by Bok, D
Journal of Cell Science, ISSN 0021-9533, 1993, Volume 106, Issue 17, pp. 189 - 195
The retinal pigment epithelium (RPE) is a monolayer of cuboidal cells that lies in close association with the rod and cone photoreceptors. This epithelium has... 
Vitamin A | Na,K-Atpase | Retinoids | Phagocytosis | Retinal pigment epithelium | CELLS | LOCALIZATION | PHAGOCYTOSIS | POLARITY | RETINOIDS | NA,K-ATPASE | RAT RETINA | BINDING-PROTEIN | INTERPHOTORECEPTOR MATRIX | RECEPTOR | RETINAL PIGMENT EPITHELIUM | VITAMIN-A | CELL BIOLOGY | TRANSPORT | BOVINE | INFLUENZA-VIRUS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2007, Volume 104, Issue 32, pp. 13152 - 13157
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 47, pp. E11120 - E11127
Recessive Stargardt disease (STGD1) is an inherited blinding disorder caused by mutations in the Abca4 gene. ABCA4 is a flippase in photoreceptor outer... 
Lipofuscin | Stargardt disease | Bisretinoid | Retinal pigment epithelium | ABCA4 | CELLS | bisretinoid | PHOTORECEPTOR OUTER SEGMENTS | MULTIDISCIPLINARY SCIENCES | PHENOTYPE | KNOCKOUT MICE | RIM PROTEIN | DYSTROPHY | MOUSE MODEL | DISEASE | lipofuscin | retinal pigment epithelium | ACCUMULATION | Retinal Pigment Epithelium - metabolism | Cells, Cultured | Phagocytosis - immunology | Retinaldehyde - metabolism | Rhodopsin - metabolism | ATP-Binding Cassette Transporters - biosynthesis | Mice, Knockout | Animals | Lysosomes - metabolism | Macular Degeneration - congenital | ATP-Binding Cassette Transporters - genetics | Macular Degeneration - genetics | Photoreceptor Cells - metabolism | Mice | Mice, Inbred BALB C | Retinal Degeneration - pathology | Lipofuscin - metabolism | Retina - pathology | Disease Models, Animal | Macular Degeneration - pathology | c-Mer Tyrosine Kinase - genetics | Membranes | Pathogenesis | Immunoblotting | Retina | mRNA | Hybridization | Gene sequencing | Macular degeneration | Proteins | Proteolysis | Degeneration | Genetic modification | Photoreception | Phosphatidylethanolamine | Rhodopsin | Retinaldehyde | Epithelium | Ribonucleic acids | Blindness | Retinal degeneration | Hybridization analysis | Protein expression | Photoreceptors | Mutation | Immunofluorescence | Phagocytosis | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2002, Volume 99, Issue 23, pp. 14619 - 14621
  Proteome analysis has now been added to the armamentarium in the quest for insights into this important ocular disease. Bok comments on new insights and new... 
Drusen | Eyes | Life span | Commentaries | Retina | Photoreceptors | Eye diseases | Cell membranes | Digestion | Choroid membranes | MACULOPATHY | EYE | DRUSEN | BRUCHS MEMBRANE | PREVALENCE | MULTIDISCIPLINARY SCIENCES | Aging - physiology | Humans | Middle Aged | Proteome | Aged | Choroid - pathology | Retina - pathology | Macular Degeneration - pathology | Aging | Biochemistry | Disease | Eyes & eyesight | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0125921 - e0125921
Retinyl esters represent an insoluble storage form of vitamin A and are substrates for the retinoid isomerase (Rpe65) in cells of the retinal pigment... 
STORAGE | VISUAL CYCLE | 11-CIS-RETINOL | TRIACYLGLYCEROL SYNTHESIS | MULTIDISCIPLINARY SCIENCES | ISOMERASE | BINDING-PROTEIN | VITAMIN-A | MULLER CELLS | RPE65 | LECITHIN | Retinal Pigment Epithelium - metabolism | Retina - metabolism | Mice, Inbred C57BL | Cells, Cultured | Palmitoyl Coenzyme A - metabolism | Esters - metabolism | Acyltransferases - metabolism | Retinaldehyde - metabolism | Vitamin A - metabolism | Animals | Diacylglycerol O-Acyltransferase - genetics | Retina - cytology | Retina - ultrastructure | Retinal Pigment Epithelium - ultrastructure | Gene Deletion | cis-trans-Isomerases - metabolism | Mice, Inbred BALB C | Diacylglycerol O-Acyltransferase - metabolism | Retinal Pigment Epithelium - cytology | Diacylglycerol O-Acyltransferase - analysis | Vitamin A | Complications and side effects | Care and treatment | Transferases | Influence | Research | Health aspects | Retinal diseases | Neurosciences | Lecithin | Photopigments | Diacylglycerol | Visual pigments | Retina | Esters | Biochemistry | Biology | Glial cells | Isomers | Retinal pigment epithelium | Proteins | Diacylglycerol O-acyltransferase | Ultrastructure | Pigments | Coenzyme A | Catalysis | Chemical synthesis | Research & development--R&D | Epithelium | Substrates | Photoreceptors | Mice | Enzyme kinetics | Laboratory animals | Index Medicus | Research & development | R&D
Journal Article