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Current Topics in Medicinal Chemistry, ISSN 1568-0266, 10/2016, Volume 16, Issue 25, pp. 2753 - 2764
Heat shock proteins (HSPs) present as a double edged sword. While they play an important role in maintaining protein homeostasis in a normal cell, cancer cells... 
HSP90 | N-Terminal | Inhibitor | Chaperone | Cancer | FDG-PET | CO-CHAPERONES | COMPLEX | CHEMISTRY, MEDICINAL | HEAT-SHOCK-PROTEIN-90 | MOLECULAR CHAPERONES | POSTTRANSLATIONAL MODIFICATIONS | INHIBITOR NVP-AUY922 | PHASE-I | BINDING
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 397 - 401
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 10/2016, Volume 16, Issue 25, pp. 2829 - 2838
A toxic accumulation of proteins is the hallmark pathology of several neurodegenerative disorders. Protein accumulation is regularly prevented by the network... 
Hsp90 | Neurodegenerative disease | α -Synuclein | DNA | ANDROGEN RECEPTOR | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | MOLECULAR CHAPERONES | alpha -Synuclein | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | HEAT-SHOCK PROTEINS | ALPHA-SYNUCLEIN AGGREGATION | FAMILIAL PARKINSONS-DISEASE | SIGNALING COMPLEXES | CULTURE MODEL
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 1779 - 1790
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 10/2016, Volume 16, Issue 25, pp. 2753 - 2764
Heat shock proteins (HSPs) present as a double edged sword. While they play an important role in maintaining protein homeostasis in a normal cell, cancer cells... 
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4345 - 15
Journal Article
Molecular Imaging and Biology, ISSN 1536-1632, 6/2016, Volume 18, Issue 3, pp. 386 - 392
Journal Article
Nano letters, ISSN 1530-6984, 11/2017, Volume 17, Issue 11, pp. 7160 - 7168
Novel translational approaches based on clinical modular nanoplatforms are needed, in order to treat solid cancers according to their discrete molecular... 
molecular imaging | combination therapy | PSMA
Journal Article
Current topics in medicinal chemistry, 2016, Volume 16, Issue 25, p. 2753
Heat shock proteins (HSPs) present as a double edged sword. While they play an important role in maintaining protein homeostasis in a normal cell, cancer cells... 
Protein Binding | Heat-Shock Proteins - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Drug Discovery | Heat-Shock Proteins - metabolism | Humans
Journal Article
EJNMMI Research, ISSN 2191-219X, 12/2015, Volume 5, Issue 1, pp. 1 - 14
Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options... 
PARP1 | U251 MG | Glioblastoma | Oncology | SPECT | 131 I | Medicine & Public Health | Orthopedics | 124 I | Nuclear Medicine | Imaging / Radiology | Cardiology | U87 MG | PET | SURVIVAL | POLY(ADP-RIBOSE) POLYMERASE | GLIOMA | POOR | I-131 | I-124 | INHIBITOR | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Current topics in medicinal chemistry, 2016, Volume 16, Issue 25, p. 2829
A toxic accumulation of proteins is the hallmark pathology of several neurodegenerative disorders. Protein accumulation is regularly prevented by the network... 
HSP90 Heat-Shock Proteins - metabolism | tau Proteins - metabolism | Neurodegenerative Diseases - metabolism | Humans
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 9, pp. 3922 - 3943
Journal Article
Cold Spring Harbor perspectives in biology, 04/2019
Cancer is often associated with alterations in the chaperome, a collection of chaperones, cochaperones, and other cofactors. Changes in the expression levels... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2011, Volume 21, Issue 18, pp. 5610 - 5615
The glycogen synthase kinase 3 (GSK-3) is implicated in multiple cellular processes and has been linked to the pathogenesis of Alzheimer’s disease (AD). In the... 
Suzuki coupling | Microwave irradiation | Structure–activity relationship (SAR) | Glycogen synthase kinase 3 (GSK-3) | Alzheimer disease | Structure-activity relationship (SAR) | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC |