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10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
The New England Journal of Medicine, ISSN 0028-4793, 10/2016, Volume 375, Issue 15, pp. 1415 - 1424
In the ProtecT trial, over 1600 men with PSA-detected localized prostate cancer were assigned to active monitoring, prostatectomy, or radiotherapy. Although...
CLUSTER RANDOMIZED-TRIAL | MORTALITY | RATES | MEDICINE, GENERAL & INTERNAL | DESIGN | SCREENING TRIAL | CONFORMAL RADIOTHERAPY | RADICAL PROSTATECTOMY | DEATH | ACTIVE-SURVEILLANCE | RT01 TRIAL | Prostatic Neoplasms - radiotherapy | Age Factors | Follow-Up Studies | Outcome Assessment (Health Care) | Prostatic Neoplasms - surgery | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Disease Progression | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Prostatic Neoplasms - therapy | Neoplasm Metastasis | Comparative Effectiveness Research | Prostatectomy | Watchful Waiting | Aged | Care and treatment | Usage | Patient outcomes | Surgery | Research | Radiotherapy | Prostate cancer | Patients | Health aspects | Prostate-specific antigen | Mortality | Comparative studies | Radiation therapy | Prostate | Clinical outcomes | Cancer surgery | Metastases
CLUSTER RANDOMIZED-TRIAL | MORTALITY | RATES | MEDICINE, GENERAL & INTERNAL | DESIGN | SCREENING TRIAL | CONFORMAL RADIOTHERAPY | RADICAL PROSTATECTOMY | DEATH | ACTIVE-SURVEILLANCE | RT01 TRIAL | Prostatic Neoplasms - radiotherapy | Age Factors | Follow-Up Studies | Outcome Assessment (Health Care) | Prostatic Neoplasms - surgery | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Disease Progression | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Prostatic Neoplasms - therapy | Neoplasm Metastasis | Comparative Effectiveness Research | Prostatectomy | Watchful Waiting | Aged | Care and treatment | Usage | Patient outcomes | Surgery | Research | Radiotherapy | Prostate cancer | Patients | Health aspects | Prostate-specific antigen | Mortality | Comparative studies | Radiation therapy | Prostate | Clinical outcomes | Cancer surgery | Metastases
Journal Article
Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, 11/2016, Volume 418, pp. 137 - 142
We have employed Verwey transition as a probe to check phase purity of nanocrystalline Fe O films grown at different substrate temperatures ( ) by means of...
Verwey transition | Easy magnetization axis of Fe3O4 | Wet H2 reduction | Easy magnetization axis of Fe | reduction | Wet H | MAGNETORESISTANCE | ROOM-TEMPERATURE | PHYSICS, CONDENSED MATTER | TRANSPORT-PROPERTIES | DEPOSITION | MATERIALS SCIENCE, MULTIDISCIPLINARY | MAGNETIC-PROPERTIES | Wet H-2 reduction
Verwey transition | Easy magnetization axis of Fe3O4 | Wet H2 reduction | Easy magnetization axis of Fe | reduction | Wet H | MAGNETORESISTANCE | ROOM-TEMPERATURE | PHYSICS, CONDENSED MATTER | TRANSPORT-PROPERTIES | DEPOSITION | MATERIALS SCIENCE, MULTIDISCIPLINARY | MAGNETIC-PROPERTIES | Wet H-2 reduction
Journal Article
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Full Text
Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
The New England Journal of Medicine, ISSN 0028-4793, 10/2016, Volume 375, Issue 15, pp. 1425 - 1437
The choice of treatment for PSA-detected, localized prostate cancer is influenced by effects of the interventions on quality of life. In the ProtecT trial,...
MORTALITY | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | ACTIVE SURVEILLANCE | MEN | VALIDATION | RADICAL PROSTATECTOMY | QUALITY-OF-LIFE | RANDOMIZED CONTROLLED-TRIAL | INTERVENTION | URINARY-INCONTINENCE | Erectile Dysfunction | Prostatic Neoplasms - radiotherapy | Outcome Assessment (Health Care) | Prostatic Neoplasms - surgery | Humans | Middle Aged | Digestive System Diseases | Male | Treatment Outcome | Prostatic Neoplasms - mortality | Prostatic Neoplasms - therapy | Intention to Treat Analysis | Quality of Life | Urologic Diseases | Prostatectomy | Surveys and Questionnaires | Watchful Waiting | Aged | Health Status | Care and treatment | Usage | Patient outcomes | Surgery | Analysis | Research | Radiotherapy | Prostate cancer | Patients | Health aspects | Quality of life | Clinical trials | Data processing | Radiation therapy | Mental depression | Clinical outcomes | Cancer surgery | Motivation | Intestine | Comparative studies | Anxiety | Prostate
MORTALITY | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | ACTIVE SURVEILLANCE | MEN | VALIDATION | RADICAL PROSTATECTOMY | QUALITY-OF-LIFE | RANDOMIZED CONTROLLED-TRIAL | INTERVENTION | URINARY-INCONTINENCE | Erectile Dysfunction | Prostatic Neoplasms - radiotherapy | Outcome Assessment (Health Care) | Prostatic Neoplasms - surgery | Humans | Middle Aged | Digestive System Diseases | Male | Treatment Outcome | Prostatic Neoplasms - mortality | Prostatic Neoplasms - therapy | Intention to Treat Analysis | Quality of Life | Urologic Diseases | Prostatectomy | Surveys and Questionnaires | Watchful Waiting | Aged | Health Status | Care and treatment | Usage | Patient outcomes | Surgery | Analysis | Research | Radiotherapy | Prostate cancer | Patients | Health aspects | Quality of life | Clinical trials | Data processing | Radiation therapy | Mental depression | Clinical outcomes | Cancer surgery | Motivation | Intestine | Comparative studies | Anxiety | Prostate
Journal Article
BJU International, ISSN 1464-4096, 03/2019, Volume 123, Issue 3, pp. 429 - 438
Objectives To report outcomes from a multiparametric (mp) magnetic resonance imaging (MRI)‐based active surveillance programme that did not include performing...
prostate biopsy | prostate cancer | MRI scan | active surveillance | PRIAS | KINETICS | PROSTATE-CANCER | MEN | UROLOGY & NEPHROLOGY | Magnetic resonance imaging | Prostate cancer | Nuclear magnetic resonance--NMR | Surveillance | Biopsy | Prostate
prostate biopsy | prostate cancer | MRI scan | active surveillance | PRIAS | KINETICS | PROSTATE-CANCER | MEN | UROLOGY & NEPHROLOGY | Magnetic resonance imaging | Prostate cancer | Nuclear magnetic resonance--NMR | Surveillance | Biopsy | Prostate
Journal Article
Journal of Clinical Epidemiology, ISSN 0895-4356, 2008, Volume 62, Issue 1, pp. 29 - 36
Abstract Objective Multicenter randomized trials are required for pragmatic evaluations of health care interventions, but recruitment is difficult. Systematic...
Internal Medicine | Qualitative research methods | Randomization | ProtecT study | Randomized controlled trial | Prostate cancer | Recruitment | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | QUALITY | CLINICAL-TRIALS | CANCER | PARTICIPATION | PROTECT | Outcome Assessment (Health Care) - methods | Humans | Middle Aged | Medical Audit | Male | United Kingdom | Random Allocation | Disclosure | Patient Selection | Prostatic Neoplasms - therapy | Informed Consent | Aged | Qualitative Research | Informed consent (Medical law)
Internal Medicine | Qualitative research methods | Randomization | ProtecT study | Randomized controlled trial | Prostate cancer | Recruitment | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | QUALITY | CLINICAL-TRIALS | CANCER | PARTICIPATION | PROTECT | Outcome Assessment (Health Care) - methods | Humans | Middle Aged | Medical Audit | Male | United Kingdom | Random Allocation | Disclosure | Patient Selection | Prostatic Neoplasms - therapy | Informed Consent | Aged | Qualitative Research | Informed consent (Medical law)
Journal Article
The Journal of Urology, ISSN 0022-5347, 04/2018, Volume 199, Issue 4, pp. e996 - e996
Journal Article
Journal of Clinical Epidemiology, ISSN 0895-4356, 2019, Volume 113, pp. 200 - 213
AbstractObjectivesRecruitment to pragmatic trials is often difficult, and little is known about factors associated with key participation and treatment...
Internal Medicine | Research participation | Randomization | Randomized trial | Comprehensive cohort | Preferences | Recruitment | SURGERY | DESIGN | LOCALIZED PROSTATE-CANCER | VALIDATION | RADICAL PROSTATECTOMY | CHALLENGES | IMPACT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | QUALITY-OF-LIFE | RADIOTHERAPY | EQUIPOISE | Clinical trials | Research | Prostate cancer | Analysis | Oncology, Experimental | Cancer | Signs and symptoms | Risk groups | Medical services | Health risks | Decisions | Risk | Family medical history | Radiation therapy | Cancer therapies | Patients | Design | Biopsy | Prostate | Sociodemographics | Tumors
Internal Medicine | Research participation | Randomization | Randomized trial | Comprehensive cohort | Preferences | Recruitment | SURGERY | DESIGN | LOCALIZED PROSTATE-CANCER | VALIDATION | RADICAL PROSTATECTOMY | CHALLENGES | IMPACT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | QUALITY-OF-LIFE | RADIOTHERAPY | EQUIPOISE | Clinical trials | Research | Prostate cancer | Analysis | Oncology, Experimental | Cancer | Signs and symptoms | Risk groups | Medical services | Health risks | Decisions | Risk | Family medical history | Radiation therapy | Cancer therapies | Patients | Design | Biopsy | Prostate | Sociodemographics | Tumors
Journal Article
Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, 11/2016, Volume 418, p. 137
We have employed Verwey transition as a probe to check phase purity of nanocrystalline Fe.sub.3O.sub.4 films grown at different substrate temperatures...
Thin films | Magnetization | Anisotropy | Dielectric films | Iron oxides
Thin films | Magnetization | Anisotropy | Dielectric films | Iron oxides
Journal Article
Journal of Clinical Epidemiology, ISSN 0895-4356, 04/2018, Volume 96, pp. 35 - 46
Randomized controlled trials (RCTs) deliver robust internally valid evidence but generalizability is often neglected. Design features built into the Prostate...
Clinical trial | External validity | Randomized | Comprehensive cohort | Generalizability | Prostate cancer | RANDOMIZED CONTROLLED-TRIALS | RECRUITMENT | PRECIS-2 | FOLLOW-UP | RADICAL PROSTATECTOMY | INFORMED-CONSENT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CLINICAL-TRIALS | HEALTH CARE SCIENCES & SERVICES | RADIOTHERAPY | INTERVENTION | Medical research | Antigens | Prostate-specific antigen | Decision making | Feasibility studies | Clinical trials | Population studies | Radiation therapy | Medical screening | Cancer therapies | Patients | Quality of life | Design | Occupation | Mens health | Randomization | Judgments | Surgery | Men | Data collection | Clinical medicine | Prostate | Cancer
Clinical trial | External validity | Randomized | Comprehensive cohort | Generalizability | Prostate cancer | RANDOMIZED CONTROLLED-TRIALS | RECRUITMENT | PRECIS-2 | FOLLOW-UP | RADICAL PROSTATECTOMY | INFORMED-CONSENT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CLINICAL-TRIALS | HEALTH CARE SCIENCES & SERVICES | RADIOTHERAPY | INTERVENTION | Medical research | Antigens | Prostate-specific antigen | Decision making | Feasibility studies | Clinical trials | Population studies | Radiation therapy | Medical screening | Cancer therapies | Patients | Quality of life | Design | Occupation | Mens health | Randomization | Judgments | Surgery | Men | Data collection | Clinical medicine | Prostate | Cancer
Journal Article
The Journal of Sexual Medicine, ISSN 1743-6095, 08/2016, Volume 13, Issue 8, pp. 1245 - 1245
Journal Article
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 03/2018, Volume 319, Issue 9, pp. 883 - 895
IMPORTANCE Prostate cancer screening remains controversial because potential mortality or quality-of-life benefits may be outweighed by harms from...
INVITATION | MEDICINE, GENERAL & INTERNAL | DESIGN | REDUCTION | GENERAL-PRACTICE | OVERDIAGNOSIS | ERSPC | ROTTERDAM | SECTION | ANTIGEN TESTING RATES | ACCURACY | Age Distribution | Follow-Up Studies | Early Detection of Cancer | Humans | Middle Aged | Male | Prostatic Neoplasms - diagnosis | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Social Class | Mass Screening | Prostatic Neoplasms - blood | Aged | Primary Health Care | United Kingdom - epidemiology | Treatment outcome | Care and treatment | Usage | Prostate-specific antigen | Analysis | Clinical trials | Diagnosis | Prostate cancer | Health care | Intervention | Risk groups | Mortality | Health risks | Medical screening | Screening | Randomization | Biopsy | Quality | Men | Fatalities | Diagnostic systems | Prostate | Cancer | Tumors | Original Investigation | Research
INVITATION | MEDICINE, GENERAL & INTERNAL | DESIGN | REDUCTION | GENERAL-PRACTICE | OVERDIAGNOSIS | ERSPC | ROTTERDAM | SECTION | ANTIGEN TESTING RATES | ACCURACY | Age Distribution | Follow-Up Studies | Early Detection of Cancer | Humans | Middle Aged | Male | Prostatic Neoplasms - diagnosis | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Social Class | Mass Screening | Prostatic Neoplasms - blood | Aged | Primary Health Care | United Kingdom - epidemiology | Treatment outcome | Care and treatment | Usage | Prostate-specific antigen | Analysis | Clinical trials | Diagnosis | Prostate cancer | Health care | Intervention | Risk groups | Mortality | Health risks | Medical screening | Screening | Randomization | Biopsy | Quality | Men | Fatalities | Diagnostic systems | Prostate | Cancer | Tumors | Original Investigation | Research
Journal Article
Trials, ISSN 1745-6215, 05/2014, Volume 15, Issue 1, pp. 183 - 183
Background: Men who undergo surgery for prostate cancer frequently experience significant side-effects including urinary and sexual dysfunction. These...
Intervention | Psychological | Sexual | Adjustment | Couple | Relationship | Prostate cancer | Counselling | Communication | Functioning | Quality of life | MEDICINE, RESEARCH & EXPERIMENTAL | PSYCHOSOCIAL ADJUSTMENT | 1ST YEAR | COMPLEX INTERVENTIONS | PARTNERS | FAMILY | RADICAL RETROPUBIC PROSTATECTOMY | MEN | PSYCHOLOGICAL DISTRESS | QUALITY-OF-LIFE | SEXUAL DYSFUNCTION | Sexual Dysfunctions, Psychological - therapy | Sexual Dysfunction, Physiological - therapy | Humans | Clinical Protocols | Male | Scotland | Feasibility Studies | Sexual Dysfunctions, Psychological - diagnosis | Couples Therapy - economics | Prostatic Neoplasms - economics | Sexual Dysfunction, Physiological - psychology | Sexual Dysfunctions, Psychological - etiology | Time Factors | Sexual Dysfunctions, Psychological - economics | Urologic Surgical Procedures, Male - adverse effects | Urologic Surgical Procedures, Male - economics | Female | Sexual Behavior | Prostatic Neoplasms - surgery | Treatment Outcome | Sexual Dysfunction, Physiological - economics | Spouses - psychology | Health Care Costs | Pilot Projects | Sexual Dysfunction, Physiological - etiology | Cost-Benefit Analysis | Research Design | Sexual Partners - psychology | Sexual Dysfunction, Physiological - diagnosis | Research | Surgery | Analysis
Intervention | Psychological | Sexual | Adjustment | Couple | Relationship | Prostate cancer | Counselling | Communication | Functioning | Quality of life | MEDICINE, RESEARCH & EXPERIMENTAL | PSYCHOSOCIAL ADJUSTMENT | 1ST YEAR | COMPLEX INTERVENTIONS | PARTNERS | FAMILY | RADICAL RETROPUBIC PROSTATECTOMY | MEN | PSYCHOLOGICAL DISTRESS | QUALITY-OF-LIFE | SEXUAL DYSFUNCTION | Sexual Dysfunctions, Psychological - therapy | Sexual Dysfunction, Physiological - therapy | Humans | Clinical Protocols | Male | Scotland | Feasibility Studies | Sexual Dysfunctions, Psychological - diagnosis | Couples Therapy - economics | Prostatic Neoplasms - economics | Sexual Dysfunction, Physiological - psychology | Sexual Dysfunctions, Psychological - etiology | Time Factors | Sexual Dysfunctions, Psychological - economics | Urologic Surgical Procedures, Male - adverse effects | Urologic Surgical Procedures, Male - economics | Female | Sexual Behavior | Prostatic Neoplasms - surgery | Treatment Outcome | Sexual Dysfunction, Physiological - economics | Spouses - psychology | Health Care Costs | Pilot Projects | Sexual Dysfunction, Physiological - etiology | Cost-Benefit Analysis | Research Design | Sexual Partners - psychology | Sexual Dysfunction, Physiological - diagnosis | Research | Surgery | Analysis
Journal Article
European Urology, ISSN 0302-2838, 2016, Volume 71, Issue 3, pp. 381 - 388
Abstract Background Early detection and treatment of asymptomatic men with advanced and high-risk prostate cancer (PCa) may improve survival rates. Objective...
Urology | Prostate cancer | Survival | Prostate-specific antigen screening | ANDROGEN-DEPRIVATION THERAPY | TESTING RATES | PHASE-3 TRIAL | UROLOGY & NEPHROLOGY | GENERAL-PRACTICE | FOLLOW-UP | RADICAL PROSTATECTOMY | RADIOTHERAPY | ENGLAND | Prostatic Neoplasms - pathology | Prostatectomy - methods | Early Detection of Cancer | Humans | Middle Aged | Mortality | Male | United Kingdom | Antibodies, Monoclonal | Prostatic Neoplasms - diagnosis | Cause of Death | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Prostatic Neoplasms - therapy | Randomized Controlled Trials as Topic | Neoplasm Metastasis | Antineoplastic Agents, Hormonal - therapeutic use | Radiotherapy - methods | Aged | Kallikreins - blood | Eligibility Determination | Cohort Studies | Medical colleges | Hospitals | Oncology, Experimental | Research | Research institutes | Epidemiology | Cancer | Analysis | Platinum Priority – Prostate Cancer
Urology | Prostate cancer | Survival | Prostate-specific antigen screening | ANDROGEN-DEPRIVATION THERAPY | TESTING RATES | PHASE-3 TRIAL | UROLOGY & NEPHROLOGY | GENERAL-PRACTICE | FOLLOW-UP | RADICAL PROSTATECTOMY | RADIOTHERAPY | ENGLAND | Prostatic Neoplasms - pathology | Prostatectomy - methods | Early Detection of Cancer | Humans | Middle Aged | Mortality | Male | United Kingdom | Antibodies, Monoclonal | Prostatic Neoplasms - diagnosis | Cause of Death | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Prostatic Neoplasms - therapy | Randomized Controlled Trials as Topic | Neoplasm Metastasis | Antineoplastic Agents, Hormonal - therapeutic use | Radiotherapy - methods | Aged | Kallikreins - blood | Eligibility Determination | Cohort Studies | Medical colleges | Hospitals | Oncology, Experimental | Research | Research institutes | Epidemiology | Cancer | Analysis | Platinum Priority – Prostate Cancer
Journal Article