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Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2019, Volume 26, Issue 10, pp. 854 - 857
The identification of the full target spectrum of active molecules, known as target deconvolution, has become an indispensable step during the drug discovery... 
Spectroscopy | Deconvolution | Target recognition | Epigenetics | Mass spectroscopy | Ions | Scientific imaging | Drug discovery | Mass spectrometry
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1528, pp. 97 - 119
Histone posttranslational modifications (hPTMs) play a key role in regulating chromatin dynamics and fine-tuning DNA-based processes. Mass spectrometry (MS)... 
Epigenetics | High-resolution mass spectrometry | SILAC | Ultrahigh-pressure liquid chromatography | SILAC spike-in | Histone posttranslational modifications | Isotope Labeling | Protein Processing, Post-Translational | Chromatography, High Pressure Liquid - methods | Histones - metabolism | Epigenomics - methods
Journal Article
PROTEOMICS, ISSN 1615-9853, 07/2016, Volume 16, Issue 14, pp. 1952 - 1954
Journal Article
PROTEOMICS, ISSN 1615-9853, 03/2019, Volume 19, Issue 5, pp. e1800300 - n/a
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 624 - 631
Cetuximab is a monoclonal antibody that is effective in the treatment of metastatic colorectal cancer (mCRC). Cetuximab blocks epidermal growth factor receptor... 
MEDICINE, RESEARCH & EXPERIMENTAL | 1ST-LINE TREATMENT | PLUS IRINOTECAN | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | METASTATIC COLORECTAL-CANCER | CELL BIOLOGY | CALRETICULIN EXPOSURE | COLON-CANCER | BRAF MUTATION | POOLED ANALYSIS | ENDOPLASMIC-RETICULUM | KRAS | Leucovorin - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Dendritic Cells - immunology | Humans | Cell Death - immunology | X-Box Binding Protein 1 - drug effects | Endoplasmic Reticulum Stress - immunology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Fluorouracil - administration & dosage | Calreticulin - drug effects | Calreticulin - metabolism | Camptothecin - administration & dosage | Dendritic Cells - drug effects | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Camptothecin - analogs & derivatives | Disease Models, Animal | Phagocytosis - drug effects | X-Box Binding Protein 1 - immunology | Endoplasmic Reticulum Stress - drug effects | Antibodies, Monoclonal - pharmacology | HCT116 Cells | Phagocytosis - immunology | Cetuximab - pharmacology | Sulfonamides - pharmacology | Unfolded Protein Response | HT29 Cells | Animals | Colorectal Neoplasms - immunology | Proto-Oncogene Proteins B-raf - genetics | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Mice | Pyridones - pharmacology | Physiological aspects | Genetic aspects | Immune response | Research | Drug therapy | Colorectal cancer | Care and treatment | Usage | Chemotherapy | Epidermal growth factor | Cell death | Analysis | Endoplasmic reticulum | Cancer | Monoclonal antibodies | Apoptosis | Immune system
Journal Article
Journal Article