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Human Genetics, ISSN 0340-6717, 10/2018, Volume 137, Issue 10, pp. 847 - 862
Journal Article
Human Brain Mapping, ISSN 1065-9471, 11/2018, Volume 39, Issue 11, pp. 4290 - 4301
Increasing evidence shows that thinner retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), assessed on optical coherence tomography (OCT), are... 
magnetic resonance imaging | visual pathways | voxel‐based morphometry | brain | retina | population‐based study | voxel-based morphometry | population-based study | HUMAN BRAIN | OPTICAL COHERENCE TOMOGRAPHY | ALZHEIMERS-DISEASE | NEUROSCIENCES | NEUROIMAGING | LATERAL GENICULATE-NUCLEUS | TEMPORAL-LOBE | TRACT | GANGLION-CELLS | ROTTERDAM | GLAUCOMA | TRANSNEURONAL RETROGRADE DEGENERATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain - diagnostic imaging | Cross-Sectional Studies | Tomography, Optical Coherence | Humans | Organ Size | Male | Visual Pathways - diagnostic imaging | Retina - diagnostic imaging | Algorithms | Image Processing, Computer-Assisted | Brain - pathology | Female | Aged | Visual Pathways - pathology | Pattern Recognition, Automated | Retina - pathology | Cohort Studies | Medicine, Experimental | Medical research | Brain research | Anisotropy | Alzheimer's disease | Elderly people | Neuroimaging | Brain | Nuclear magnetic resonance--NMR | Segmentation | Image processing | Radiation | Retina | Population studies | Substantia grisea | Density | Atrophy | Regression models | Thalamus | Medical imaging | Neurodegenerative diseases | Cortex (visual) | Regression analysis | Substantia alba | Patients | Thickness | Image segmentation | Optical Coherence Tomography | Magnetic resonance imaging | Morphometry | Alzheimers disease | Elderly | Geriatrics
Journal Article
Journal Article
JAMA Neurology, ISSN 2168-6149, 10/2018, Volume 75, Issue 10, pp. 1256 - 1263
IMPORTANCE Retinal structures may serve as a biomarker for dementia, but longitudinal studies examining this link are lacking. OBJECTIVE To investigate the... 
NERVE-FIBER LAYER | RECOMMENDATIONS | ALZHEIMERS-DISEASE | MOUSE MODEL | RATS | ROTTERDAM | HEALTH | THICKNESS | CLINICAL NEUROLOGY | DEGENERATION | Online First | Original Investigation | Research
Journal Article
Journal Article
by Mauschitz, Matthias and Mauschitz, Matthias M and Bonnemaijer, Pieter W.M and Diers, Kersten and Rauscher, Franziska G and Rauscher, Franziska and Elze, Tobias and Engel, Christoph and Loeffler, Markus and Colijn, Johanna Maria and Colijn, Johanna and Ikram, M. Arfan and Vingerling, Johannes R and Williams, Katie M and Williams, Katie and Hammond, Christopher and Hammond, Christopher J and Creuzot-Garcher, Catherine and Bron, Alain and Bron, Alain M and Silva, Rufino and Nunes, Sandrina and Delcourt, Cécile and Cougnard-Grégoire, Audrey and Holz, Frank G and Holz, Frank and Klaver, Caroline C.W and Klaver, Caroline and Breteler, Monique M.B and Finger, Robert P and Finger, Robert and Acar, Niyazi and Anastosopoulos, Eleftherios and Azuara-Blanco, Augusto and Berendschot, Tos and Bergen, Arthur and Bertelsen, Geir and Binquet, Christine and Bird, Alan and Bobak, Martin and Larsen, Morten Bøgelund and Boon, Camiel and Bourne, Rupert and Brétillon, Lionel and Broe, Rebecca and Buitendijk, Gabrielle and Cachulo, Maria Luz and Capuano, Vittorio and Carrière, Isabelle and Chakravarthy, Usha and Chan, Michelle and Chang, Petrus and Cree, Angela and Cumberland, Phillippa and Cunha-Vaz, José and Daien, Vincent and De Jong, Eiko and Deak, Gabor and Delyfer, Marie-Noëlle and Hollander, Anneke den and Dietzel, Martha and Erke, Maja Gran and Faria, Pedro and Farinha, Claudia and Fauser, Sascha and Fletcher, Astrid and Foster, Paul and Founti, Panayiota and Gorgels, Theo and Grauslund, Jakob and Grus, Franz and Hense, Hans-Werner and Hermann, Manuel and Hoehn, René and Hogg, Ruth and Hoyng, Carel and Jansonius, Nomdo and Janssen, Sarah and Kersten, Eveline and Khawaja, Anthony and Korobelnik, Jean-François and Lamparter, Julia and Le Goff, Mélanie and Lechanteur, Yara and Lehtimäki, Terho and Leung, Irene and Lotery, Andrew and Meester, Magda and Merle, Bénédicte and Meyer zu Westrup, Verena and Midena, Edoardo and Miotto, Stefania and Mirshahi, Alireza and Mohan-Saïd, Sadek and Mueller, Michael and Muldrew, Alyson and Murta, Joaquim and Nickels, Stefan and Owen, Christopher and Peto, Tunde and ... and European Eye Epidemiology E3 and European Eye Epidemiology (E3) Consortium
Ophthalmology, ISSN 0161-6420, 10/2018, Volume 125, Issue 10, pp. 1526 - 1536
To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Cross-sectional... 
CONSORTIUM | AXIAL LENGTH | OPTICAL COHERENCE TOMOGRAPHY | ALZHEIMERS-DISEASE | ANYANG CHILDHOOD EYE | OPHTHALMOLOGY | DISC SIZE | INTRAOCULAR-PRESSURE | GLAUCOMA | GANGLION-CELL LAYER | ASSOCIATION | Epidemiology
Journal Article
Nature communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 155 - 155
Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article.... 
Association analysis | Eye diseases | Data processing | Cornea | Genomes
Journal Article
by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 07/2019, Volume 60, Issue 8, pp. 3142 - 3149
PURPOSE. To determine genetic correlations between common myopia and primary open-angle glaucoma (POAG). METHODS. We tested the association of myopia polygenic... 
COMMON VARIANTS | SUSCEPTIBILITY LOCI | RISK | INTRAOCULAR-PRESSURE | TRENDS | VISUAL-FIELD LOSS | GLOBAL PREVALENCE | primary open-angle glaucoma | PREDICT | OPHTHALMOLOGY | refractive error | genetic overlap | polygenic risk score | PROGRESSION | GENOME-WIDE ASSOCIATION
Journal Article