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index medicus (87) 87
ophthalmology (81) 81
humans (79) 79
female (55) 55
male (55) 55
middle aged (48) 48
macular degeneration (42) 42
adult (38) 38
aged (38) 38
fluorescein angiography (28) 28
tomography, optical coherence (28) 28
eye diseases (25) 25
retina (25) 25
mutation (23) 23
optical coherence tomography (22) 22
retrospective studies (21) 21
visual acuity - physiology (20) 20
genetic aspects (17) 17
macular degeneration - genetics (17) 17
phenotype (17) 17
central serous chorioretinopathy (16) 16
electroretinography (16) 16
genetic structures (16) 16
mutations (15) 15
photodynamic therapy (15) 15
sense organs (15) 15
aged, 80 and over (14) 14
central serous chorioretinopathy - diagnosis (14) 14
retinitis-pigmentosa (14) 14
update (14) 14
adolescent (13) 13
medical imaging (13) 13
medical research (13) 13
risk factors (13) 13
analysis (12) 12
child (12) 12
disease (12) 12
genes (12) 12
genetics (12) 12
genotype (12) 12
pedigree (12) 12
research (12) 12
visual acuity (12) 12
age (11) 11
chronic central serous chorioretinopathy (11) 11
chronic disease (11) 11
genetic predisposition to disease (11) 11
macular degeneration - diagnosis (11) 11
medicine, experimental (11) 11
ophthalmoscopy (11) 11
patients (11) 11
photochemotherapy (11) 11
polymorphism, single nucleotide (11) 11
abridged index medicus (10) 10
cancer (10) 10
care and treatment (10) 10
diabetic retinopathy (10) 10
dna mutational analysis (10) 10
eye proteins - genetics (10) 10
fundus oculi (10) 10
genetics & heredity (10) 10
variants (10) 10
complement factor h - genetics (9) 9
cone-rod dystrophy (9) 9
degeneration (9) 9
electrooculography (9) 9
follow-up studies (9) 9
photoreceptors (9) 9
prospective studies (9) 9
proteins (9) 9
retina - pathology (9) 9
retinal degeneration (9) 9
young adult (9) 9
age of onset (8) 8
child, preschool (8) 8
complement factor-h (8) 8
eye (8) 8
fluorescein (8) 8
health aspects (8) 8
maculopathy (8) 8
pathophysiology (8) 8
retinal-pigment epithelium (8) 8
subretinal fluid (8) 8
verteporfin (8) 8
age-related maculopathy (7) 7
association (7) 7
case-control studies (7) 7
central serous chorioretinopathy - drug therapy (7) 7
chloride channels - genetics (7) 7
choroidal neovascularization (7) 7
diagnosis (7) 7
genotype & phenotype (7) 7
nerve tissue proteins - genetics (7) 7
physiological aspects (7) 7
prevalence (7) 7
retinal diseases - diagnosis (7) 7
retinal diseases - genetics (7) 7
retinitis pigmentosa (7) 7
retinopathy (7) 7
acuity (6) 6
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1. Full Text Retinal Gene Therapy
: Methods and Protocols
2018, Methods in Molecular Biology, ISBN 1493975218, Volume 1715
Human Genetics | Biomedicine
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2. Full Text Correspondence
by Bronkhorst, Inge H. G and Marinkovic, Marina and Dijkman, Greet and Boon, Camiel J. F
Retina, ISSN 0275-004X, 08/2015, Volume 35, Issue 8, pp. e52 - e54
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3. Full Text Correspondence
by Bronkhorst, Inge H. G and Marinkovic, Marina and Dijkman, Greet and Boon, Camiel J. F
Retina, ISSN 0275-004X, 08/2015, Volume 35, Issue 8, pp. e52 - e54
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4. Full Text LONG-TERM FOLLOW-UP OF PATIENTS WITH CHOROIDEREMIA WITH SCLERAL PITS AND TUNNELS AS A NOVEL OBSERVATION
by van Schuppen, Sanne M and Talib, Mays and Bergen, Arthur A and Ten Brink, Jacoline B and Florijn, Ralph J and Boon, Camiel J F and van Schooneveld, Mary J
Retina, ISSN 0275-004X, 2017
PURPOSE: To evaluate the long-term clinical course and visual outcome of patients with choroideremia. METHODS: Clinical examination, a social questionnaire,... 
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5. Full Text Measuring central retinal sensitivity using microperimetry
by Talib, Mays and Jolly, Jasleen K and Boon, Camiel J. F
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1715, pp. 339 - 349
Microperimetry is an increasingly often used method of assessing the sensitivity of the central macula, analyzing fixation capabilities and loci, and... 
Retinal sensitivity | Microperimetry | MAIA | Macula Lutea - metabolism | Retina - metabolism | Contrast Sensitivity - physiology | Tomography, Optical Coherence - methods | Humans | Index Medicus
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6. Full Text Recording and analysis of goldmann kinetic visual fields
by Talib, Mays and Dagnelie, Gislin and Boon, Camiel J. F
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1715, pp. 327 - 338
Goldmann kinetic perimetry is a commonly used method of evaluating the peripheral visual field. Ongoing gene therapy trials have targeted the central retina,... 
Peripheral visual field | Goldmann visual field | Kinetic perimetry | Quantitative visual field analysis | Visual Field Tests - methods | Retina - metabolism | Software | Kinetics | Visual Fields | Humans | Index Medicus
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7. Full Text OCT Angiography Compared to Fluorescein and Indocyanine Green Angiography in Chronic Central Serous Chorioretinopathy
by Teussink, M.M and Breukink, M.B and Grinsven, M.J.J.P. van and Hoyng, C.B and Klevering, B.J and Boon, C.J.F and Jong, E.K and Theelen, T
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2015, Volume 56, Issue 9, pp. 5229 - 5237
PURPOSE: Abnormal choroidal blood flow is considered important in the pathogenesis of chronic central serous chorioretinopathy (CSC). Optical coherence... 
Split-spectrum amplitude decorrelation angiography | OCT angiography | Choriocapillary flow | Optical coherence tomography | Chronic central serous chorioretinopathy | SSADA | PHOTODYNAMIC THERAPY | VARIANTS | optical coherence tomography | VIDEOANGIOGRAPHY | MACULAR DEGENERATION | CHOROIDAL NEOVASCULARIZATION | chronic central serous chorioretinopathy | PATHOPHYSIOLOGY | FEATURES | choriocapillary flow | split-spectrum amplitude decorrelation angiography | OPHTHALMOLOGY | UPDATE | SELECTIVE RETINA THERAPY | Reproducibility of Results | Follow-Up Studies | Fluorescein Angiography - methods | Coloring Agents | Humans | Middle Aged | Indocyanine Green | Male | Tomography, Optical Coherence - methods | Visual Acuity | Contrast Media | Central Serous Chorioretinopathy - diagnosis | Fluorescein | Adult | Female | Aged | Retrospective Studies | Choroid - pathology | Chronic Disease | Fundus Oculi | Index Medicus
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8. Full Text A functional variant in the CFI gene confers a high risk of age-related macular degeneration
by Ven, J.P.H. van de and Nilsson, S.C and Tan, P.L and Buitendijk, G.H and Ristau, T and Mohlin, F.C and Nabuurs, S.B and Schoenmaker-Koller, F.E and Smailhodzic, D and Campochiaro, P.A and Zack, D.J and Duvvari, M.R and Bakker, B and Paun, C.C and Boon, C.J.F and Uitterlinden, A.G and Liakopoulos, S and Klevering, B.J and Fauser, S and Daha, M.R and Katsanis, N and Klaver, C.C and Blom, A.M and Hoyng, C.B and Hollander, A.I. den and Lund University and Protein Chemistry, Malmö and Lunds universitet and Proteinkemi, Malmö
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 7, pp. 813 - 817
Up to half of the heritability of age-related macular degeneration (AMD) is explained by common variants. Here, we report the identification of a rare, highly... 
COMPLEMENT FACTOR-I | C4B-BINDING PROTEIN | MACULOPATHY | DRUSEN | HEMOLYTIC-UREMIC SYNDROME | ZEBRAFISH | ANGIOGENESIS | DISEASE | GENETICS & HEREDITY | MUTATIONS | PREVALENCE | Genetic Predisposition to Disease | Retina - metabolism | Animals, Genetically Modified | Complement Factor I - physiology | Humans | Risk Factors | Models, Molecular | Complement Factor I - genetics | Zebrafish | Retina - embryology | Mutation, Missense - physiology | Animals | Macular Degeneration - genetics | Base Sequence | Embryo, Nonmammalian | HEK293 Cells | Models, Genetic | Retina - pathology | Amino Acid Substitution | Macular Degeneration - pathology | Macular degeneration | Genetic variation | Genetic aspects | Aged | Research | Health aspects | Risk factors | Proteins | Plasma | Mutation | Index Medicus | Basic Medicine | Other Basic Medicine | Andra medicinska och farmaceutiska grundvetenskaper | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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9. Full Text Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy
by Van Rijssen, Thomas J and Mohabati, Danial and Dijkman, Greet and Theelen, Thomas and De Jong, Eiko K and Van Dijk, Elon H. C and Boon, Camiel J. F
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, pp. e0202549 - e0202549
Purpose To assess parameters on optical coherence tomography (OCT), and their correlation with best-corrected visual acuity (BCVA) in patients with... 
DENSITY | SEGMENT | FOVEAL PHOTORECEPTOR LAYER | MULTIDISCIPLINARY SCIENCES | THICKNESS | Treatment outcome | Usage | Care and treatment | Analysis | Eye diseases | Diagnosis | Photochemotherapy | Coherence (Optics) | Cancer | Correlation | Retinopathy | Statistical analysis | Photodynamic therapy | Parameters | Diabetes mellitus | Retina | Visual acuity | Patients | Constraining | Acuity | Macular degeneration | Thickness | Optical Coherence Tomography | Tomography | Photoreceptors | Integrity | Index Medicus
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10. Full Text Increased Fundus Autofluorescence Related to Outer Retinal Disruption
by Freund, K. Bailey and Mrejen, Sarah and Jung, Jesse and Yannuzzi, Lawrence A and Boon, Camiel J. F
JAMA Ophthalmology, ISSN 2168-6165, 12/2013, Volume 131, Issue 12, pp. 1645 - 1649
Retinal Pigments - metabolism | Retinal Diseases - diagnosis | Tomography, Optical Coherence | Coloring Agents | Humans | Middle Aged | Indocyanine Green | Retinal Photoreceptor Cell Outer Segment - metabolism | Fluorescence | Male | Retinal Diseases - metabolism | Retinal Photoreceptor Cell Outer Segment - pathology | Choroiditis - diagnosis | Central Serous Chorioretinopathy - diagnosis | Adult | Female | Central Serous Chorioretinopathy - metabolism | Fundus Oculi | Choroiditis - metabolism | Fluorescein Angiography | Physiological aspects | Research | Retinal diseases | Fundus oculi | Index Medicus | Abridged Index Medicus
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11. Full Text AAV serotype testing on cultured human donor retinal explants
by Buck, Thilo M and Pellissier, Lucie P and Vos, Rogier M and van Dijk, Elon H. C and Boon, Camiel J. F and Wijnholds, Jan
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1715, pp. 275 - 288
This protocol details on a screening method for infectivity and tropism of different serotypes of adeno-associated viruses (AAVs) on human retinal explants... 
Human | Adeno-Associated Virus (AAV) | Organotypic | Potency assays | Neural retina tissue culture | Postmortem | Explant | Photoreceptors | Retinal Müller glial cell | Dependovirus - genetics | Green Fluorescent Proteins - metabolism | Organ Culture Techniques - methods | Retina - metabolism | Transduction, Genetic | Humans | Photoreceptor Cells - metabolism | Serogroup | Dependovirus - immunology | Injections, Intraocular - methods | Genetic Vectors | Transgenes | Index Medicus
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12. Full Text A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration
by Helgason, H and Sulem, P and Duvvari, M.R and Luo, H and Thorleifsson, G and Stefansson, H and Jonsdottir, I and Masson, G and Gudbjartsson, D.F and Walters, G.B and Magnusson, O.T and Kong, A and Rafnar, T and Kiemeney, L.A.L.M and Schoenmaker-Koller, F.E and Zhao, L and Boon, C.J.F and Song, Y and Fauser, S and Pei, M and Ristau, T and Patel, S and Liakopoulos, S and Ven, J.P.H. van de and Hoyng, C.B and Ferreyra, H and Duan, Y and Bernstein, P.S and Geirsdottir, A and Helgadottir, G and Stefansson, E and Hollander, A.I. den and Zhang, K and Jonasson, F and Sigurdsson, H and Thorsteinsdottir, U and Stefansson, K
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 11, pp. 1371 - 1374
Through whole-genome sequencing of 2,230 Icelanders, we detected a rare nonsynonymous SNP (minor allele frequency = 0.55%) in the C3 gene encoding a... 
MACULOPATHY | IMPUTATION | DISEASES | CFH | GENETICS & HEREDITY | FRAMEWORK | LOCI | GENOME-WIDE ASSOCIATION | Complement Factor H - immunology | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Genotype | Risk | Sequence Analysis, DNA | Iceland | Genetic Variation | Complement Activation - genetics | Complement C3b - metabolism | Complement Factor H - metabolism | Macular Degeneration - genetics | Base Sequence | Polymorphism, Single Nucleotide | Complement C3 - genetics | Amino Acid Substitution | Complement C3b - immunology | Haplotypes | Confidence intervals | Genotype & phenotype | Vegetables | Genomes | Chromosomes | Methods | Logistics | Index Medicus
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13. Full Text The ocular phenotype in primary hyperoxaluria type 1
by Birtel, Johannes and Herrmann, Philipp and Garrelfs, Sander F and Dulz, Simon and Atiskova, Yevgeniya and Diederen, Roselie M and Gliem, Martin and Brinkert, Florian and Holz, Frank G and Boon, Camiel J F and Hoppe, Bernd and Issa, Peter Charbel
American journal of ophthalmology, ISSN 0002-9394, 05/2019, Volume 206, pp. 184 - 191
To investigate ophthalmic features in a large group of patients with primary hyperoxaluria type 1 (PH1), and to determine the relation between ocular... 
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14. Full Text Correspondence
by Bronkhorst, Inge H G and Marinkovic, Marina and Dijkman, Greet and Boon, Camiel J F
Retina (Philadelphia, Pa.), 08/2015, Volume 35, Issue 8, p. e52
Antibodies, Monoclonal, Humanized - therapeutic use | Receptors, Vascular Endothelial Growth Factor - therapeutic use | Retinal Vein Occlusion - drug therapy | Humans | Recombinant Fusion Proteins - therapeutic use | Macular Edema - drug therapy | Angiogenesis Inhibitors - therapeutic use | Female | Male | Vascular Endothelial Growth Factor A - antagonists & inhibitors
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15. Full Text Clinical characteristics of chronic central serous chorioretinopathy patients with insufficient response to reduced-settings photodynamic therapy
by van Rijssen, Thomas J and van Dijk, Elon H. C and Dijkman, Greet and Boon, Camiel J. F
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN 0721-832X, 8/2018, Volume 256, Issue 8, pp. 1395 - 1402
To identify characteristics of Caucasian chronic central serous chorioretinopathy (cCSC) patients without a complete resolution of subretinal fluid (SRF) after... 
Photodynamic therapy | Medicine & Public Health | Optical coherence tomography | Subretinal fluid | Treatment response | Ophthalmology | Chronic central serous chorioretinopathy | Resolution | EFFICACY | VERTEPORFIN | OPHTHALMOLOGY | UPDATE | OUTCOMES | INDOCYANINE GREEN ANGIOGRAPHY | ASSOCIATION | HALF-TIME | Diabetic retinopathy | Care and treatment | Photochemotherapy | Cancer | Leakage | Retinopathy | Medical imaging | Angiography | Diabetes mellitus | Fluorescein | Males | Patients | Age | Acuity | Index Medicus | Retinal Disorders
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16. Full Text Autosomal recessive bestrophinopathy: differential diagnosis and treatment options
by Boon, Camiel J. F and van den Born, L. Ingeborgh and Visser, Linda and Keunen, Jan E. E and Bergen, Arthur A. B and Booij, Judith C and Riemslag, Frans C and Florijn, Ralph J and van Schooneveld, Mary J
Ophthalmology, ISSN 0161-6420, 2013, Volume 120, Issue 4, pp. 809 - 820
To describe the clinical and genetic characteristics of patients with autosomal recessive bestrophinopathy (ARB). Retrospective case series. Ten patients with... 
GENE-MUTATIONS | CARBONIC-ANHYDRASE-XIV | BEST-DISEASE | CLINICAL-EVALUATION | OPHTHALMOLOGY | CANINE MULTIFOCAL RETINOPATHY | VITELLIFORM MACULAR DYSTROPHY | TOPICAL DORZOLAMIDE | RETINITIS-PIGMENTOSA | MULLER CELLS | RETINAL-PIGMENT EPITHELIUM | Electrooculography | Retinal Diseases - genetics | Humans | Middle Aged | Retinal Diseases - therapy | Child, Preschool | Eye Diseases, Hereditary - diagnosis | Male | Chloride Channels - genetics | Young Adult | Bestrophins | DNA Mutational Analysis | Adult | Female | Retrospective Studies | Eye Proteins - genetics | Child | Fluorescein Angiography | Electroretinography | Diagnosis, Differential | Retinal Diseases - diagnosis | Genetic Association Studies | Tomography, Optical Coherence | Retina - physiopathology | Visual Acuity | Eye Diseases, Hereditary - genetics | DNA - genetics | Phenotype | Pedigree | Adolescent | Eye Diseases, Hereditary - therapy | Mutation | Fundus Oculi | Retina - pathology | Genetic Therapy - methods | Index Medicus
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17. Full Text Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration
by Saksens, N.T.M and Lechanteur, Y.T.E and Verbakel, S.K and Groenewoud, J.M.M and Daha, M.R and Schick, T and Fauser, S and Boon, C.J.F and Hoyng, C.B and Hollander, A.I. den
Plos One, ISSN 1932-6203, 2016, Volume 11, Issue 6, pp. e0144367 - e0144367
AIMS: Age-related macular degeneration (AMD) is a multifactorial disease, in which complement-mediated inflammation plays a pivotal role. A positive family... 
METAANALYSIS | FACTOR-B | GENE | CFH | MULTIDISCIPLINARY SCIENCES | FACTOR-H POLYMORPHISM | CHOROIDAL NEOVASCULARIZATION | ASSOCIATION | VARIANT | AGGREGATION | COMPONENT 3 | Complement C3 - analysis | Complement C3d - analysis | Genetic Predisposition to Disease | Complement Activation | Gene Frequency | Humans | Middle Aged | Risk Factors | Genotype | Male | Macular Degeneration - blood | Proteins - genetics | Macular Degeneration - genetics | Alleles | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Retrospective Studies | Databases, Factual | Allelomorphism | Macular degeneration | Analysis | Genetic aspects | Single nucleotide polymorphisms | Research | Health aspects | Risk factors | Complement component C3d | Disease | Genes | Families & family life | Complement | Single-nucleotide polymorphism | Family medical history | Data bases | Body mass index | Prediction models | Genetics | Degeneration | Age | Siblings | Risk analysis | Patients | Genetic variance | Complement activation | Complement component C3 | Mutation | Health risk assessment | Smoking | Index Medicus
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18. Full Text Systemic complement activation in central serous chorioretinopathy
by van Dijk, Elon H. C and Tsonaka, Roula and Klar-Mohamad, Ngaisah and Wouters, Diana and de Vries, Aiko P. J and de Jong, Eiko K and van Kooten, Cees and Boon, Camiel J. F
PLoS ONE, ISSN 1932-6203, 2017, Volume 12, Issue 7, pp. e0180312 - e0180312
A clear link between several variants in genes involved in the complement system and chronic central serous chorioretinopathy (CSC) has been described. In... 
VARIANTS | GENE | PERSPECTIVE | MULTIDISCIPLINARY SCIENCES | MACULAR DEGENERATION | LUPUS-ERYTHEMATOSUS | RISK | FACTOR-H | POLYMORPHISM | CORTICOSTEROIDS | PATHOPHYSIOLOGY | Prospective Studies | Humans | Middle Aged | Central Serous Chorioretinopathy - immunology | Adult | Female | Male | Complement Activation - immunology | Case-Control Studies | Eye diseases | Genetic aspects | Research | Nephrology | Disease | Control methods | Pathogenesis | Complement component C5a | Genes | Control systems | Activation | Complement | Mannose | Assaying | Risk factors | Macular degeneration | Body mass index | Mannose-binding lectin | Degeneration | Inhibition | Age | Activation analysis | Immune system | Lupus | Medical imaging | Permeability | Risk analysis | Patients | Complement activation | Body mass | Complement component C3 | Smoking | Index Medicus
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19. Full Text Exome sequencing in patients with chronic central serous chorioretinopathy
by Schellevis, RL and Breukink, MB and Gilissen, C and Boon, CJF and Hoyng, CB and de Jong, EK and den Hollander, AI
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 6598 - 7
Chronic central serous chorioretinopathy (cCSC) is a multifactorial eye disease characterized by subretinal fluid accumulation that leads to vision loss.... 
GENE-EXPRESSION | SUPPORT | VARIANTS | ASSOCIATION | MULTIDISCIPLINARY SCIENCES | Proteins | Genes | Sex | Eye diseases | Genomes | Genetic factors | Females | Males
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20. Full Text Photodynamic therapy in chronic central serous chorioretinopathy with subretinal fluid outside the fovea
by van Dijk, Elon H. C and Dijkman, Greet and Boon, Camiel J. F
Graefe s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, ISSN 0721-832X, 2017, Volume 255, Issue 10, pp. 2029 - 2035
To assess the efficacy of photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC), in whom subretinal fluid (SRF) was... 
Photodynamic therapy | Medicine & Public Health | Extrafoveal | Subretinal fluid | Visual complaints | Choroidal thickness | Ophthalmology | Chronic central serous chorioretinopathy | Resolution | VERTEPORFIN | PROTOCOL | OPHTHALMOLOGY | PATHOPHYSIOLOGY | DEGENERATION | Porphyrins - administration & dosage | Injections, Intravenous | Fluorescein Angiography - methods | Photochemotherapy - methods | Humans | Middle Aged | Subretinal Fluid - diagnostic imaging | Fovea Centralis - pathology | Central Serous Chorioretinopathy - drug therapy | Male | Treatment Outcome | Tomography, Optical Coherence - methods | Visual Acuity | Dose-Response Relationship, Drug | Photosensitizing Agents - administration & dosage | Central Serous Chorioretinopathy - diagnosis | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Chronic Disease | Fundus Oculi | Fluorescence | Diabetic retinopathy | Photochemotherapy | Fluorescein | Cancer | Eye | Photography | Retinopathy | Medical imaging | Angiography | Diabetes mellitus | Retinal degeneration | Retina | Acuity | Index Medicus | Medical Ophthalmology
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