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1. Full Text Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial
by Griffin, Simon J, Dr and Borch-Johnsen, Knut, Prof and Davies, Melanie J, Prof and Khunti, Kamlesh, Prof and Rutten, Guy EHM, PhD and Sandbæk, Annelli, Prof and Sharp, Stephen J, MSc and Simmons, Rebecca K, PhD and van den Donk, Maureen, PhD and Wareham, Nicholas J, Prof and Lauritzen, Torsten, Prof
Lancet, The, ISSN 0140-6736, 2011, Volume 378, Issue 9786, pp. 156 - 167
Summary Background Intensive treatment of multiple cardiovascular risk factors can halve mortality among people with established type 2 diabetes. We... 
Internal Medicine | MORTALITY | MEDICINE, GENERAL & INTERNAL | COST-EFFECTIVENESS | GLUCOSE | RISK | PEOPLE | CORONARY-HEART-DISEASE | MULTI-FACTORIAL | SIMVASTATIN | INTERVENTION | PROGRAM | Hypoglycemic Agents - therapeutic use | Outcome Assessment (Health Care) | Humans | Middle Aged | Netherlands - epidemiology | Risk Factors | Diabetic Angiopathies - mortality | Male | Diabetes Mellitus, Type 2 - diagnosis | Mass Screening | Diabetes Mellitus, Type 2 - mortality | Diabetes Mellitus, Type 2 - therapy | Intention to Treat Analysis | Denmark - epidemiology | Female | Aged | Diabetic Angiopathies - prevention & control | Diabetes Mellitus, Type 2 - drug therapy | United Kingdom - epidemiology | Cluster Analysis | Type 2 diabetes | Complications and side effects | Patient outcomes | Research | Diagnosis | Cardiovascular diseases | Risk factors | Medical research | Health sciences | Biomedical research | Heart attacks | Research & development--R&D | Health services | Meetings | Mortality | Health psychology | Biochemistry | Grants | Primary care | Trust departments | Councils | Risk assessment | Blood pressure | Diabetes
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2. Full Text Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
by Saxena, Richa and Hivert, Marie-France and Langenberg, Claudia and Tanaka, Toshiko and Pankow, James and Vollenweider, Peter and Lyssenko, Valeriya and Bouatia-Naji, Nabila and Dupuis, Josée and Jackson, Anne and Kao, Wen and Li, Man and Glazer, Nicole and Manning, Alisa and Anluan, Jian and Stringham, Heather and Prokopenko, Inga and Johnson, Toby and Grarup, Niels and Boesgaard, Trine and Lecoeur, Cécile and Shrader, Peter and O´Connell, J.R and Ingelsson, Erik and Couper, David and Rice, Kenneth and Song, Kijoung and Aneasen, Camilla and Dina, Christian and Köttgen, Anna and Bacquer, Olivier and Pattou, François and Taneera, Jalal and Steinthorsdottir, Valgerdur and Rybin, Denis and Ardlie, Kristin and Sampson, Michael and Qi, Lu and Hoek, Mandy and Weedon, Michael and Aulchenko, Yurii and Voight, Benjamin and Grallert, Harald and Balkau, Beverley and Bergman, Richard and Bielinski, Suzette and Bonnefond, Amélie and Bonnycastle, Lori and Borch-Johnsen, K and Böttcher, Yvonne and Brunner, Eric and Buchanan, Thomas and Bumpstead, Suzannah and Cavalcanti-Proença, Christine and Charpentier, Guillaume and Chen, Yii-Der Ida and Chines, Peter and Collins, Francis and Cornelis, Marilyn and Crawford, Gabe and Delplanque, Jerome and Doney, Alex and Egan, Josephine and Erdos, Michael and Firmann, Mathieu and Forouhi, Nita and Fox, Caroline and Goodarzi, Mark and Graessler, Jürgen and Hingorani, Aroon and Isomaa, Bo and Jørgensen, Torben and Kivimaki, Mika and Kovacs, Peter and Krohn, Knut and Kumari, Meena and Lauritzen, Torsten and Lévy-Marchal, Claire and Mayor, Vladimir and McAteer, Jarred and Meyre, David and Mitchell, Braxton and Mohlke, Karen and Morken, Mario and Narisu, Narisu and Palmer, Colin and Pakyz, Ruth and Pascoe, Laura and Payne, Felicity and Pearson, Daniel and Rathmann, Wolfgang and Sandbaek, Annelli and Sayer, A.A and Scott, Laura and Sharp, Stephen and Sijbrands, Eric and Singleton, Anew and Siscovick, David and Smith, Nicholas and Sparsø, Thomas and ... and GIANT Consortium and MAGIC Investigators and GIANT consortium and MAGIC investigators and the MAGIC investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 02/2010, Volume 42, Issue 2, pp. 142 - 148
textabstractGlucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report... 
FASTING PLASMA-GLUCOSE | GLUCAGON-LIKE PEPTIDE-1 | VARIANTS | GENETICS & HEREDITY | SENSITIVITY | RISK | RECEPTOR | GASTRIC-INHIBITORY POLYPEPTIDE | ASSOCIATION | EXPRESSION | BETA-CELL FUNCTION | Body Mass Index | Genome-Wide Association Study | Glucose Tolerance Test | Meta-Analysis as Topic | Diabetes Mellitus, Type 2 - genetics | Humans | RNA, Messenger - genetics | Gene Expression Regulation | Genetic Loci - genetics | Male | Gene Expression Profiling | RNA, Messenger - metabolism | Receptors, Gastrointestinal Hormone - metabolism | Incretins - genetics | Genetic Variation | Proteins - genetics | Insulin - metabolism | Receptors, Gastrointestinal Hormone - genetics | Denmark | Glucose - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Adenylyl Cyclases - genetics | Type 2 diabetes | Blood sugar | Genetic variation | Physiological aspects | Genetic aspects | Research | Diagnosis | Risk factors | Studies | Hyperglycemia | Diabetes | Meta-analysis | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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3. Full Text Age at initiation and frequency of screening to detect type 2 diabetes: a cost-effectiveness analysis
by Kahn, Richard, Dr and Alperin, Peter, MD and Eddy, David, MD and Borch-Johnsen, Knut, MD and Buse, John, MD and Feigelman, Justin and Gregg, Edward, PhD and Holman, Rury R, MD and Kirkman, M Sue, MD and Stern, Michael, MD and Tuomilehto, Jaakko, MD and Wareham, Nick J, Prof
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9723, pp. 1365 - 1374
Summary Background No clinical trials have assessed the effects or cost-effectiveness of sequential screening strategies to detect new cases of type 2... 
Internal Medicine | POPULATION | MEDICINE, GENERAL & INTERNAL | IMPACT | GLUCOSE | PREVENTION | ARCHIMEDES | ADULTS | HEALTH | MODEL | MELLITUS | STRATEGIES | Models, Theoretical | Quality-Adjusted Life Years | Stroke - prevention & control | Age Factors | Mass Screening - economics | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Stroke - complications | Diabetes Mellitus, Type 2 - economics | Models, Statistical | Hyperlipidemias - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Cardiovascular Diseases - complications | Cost-Benefit Analysis | Adult | Aged | Hypertension - diagnosis | Diabetes Mellitus, Type 2 - complications | Confidence intervals | Accuracy | Simulation | Prevention programs | Health services | Data collection | Cardiovascular disease | Mathematical models | Diabetes | Random variables
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4. Full Text A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: Baseline results Inter99 (1)
by Jørgensen, Torben and Jørgensen, Torben and Borch-Johnsen, Knut and Borch-John sen, Knut and Thomsen, Troels F and Thomsen, Troels F and Ibsen, Hans and Ibsen, Hans and Glümer, Charlotte and Glümer, Charlotte and Pisinger, Charlotta and Pisinger, Charlotta
European Journal of Cardiovascular Prevention and Rehabilitation, ISSN 1741-8267, 2003, Volume 10, Issue 5, pp. 377 - 386
Various strategies have been used to induce lifestyle changes to reduce ischaemic heart disease (IHD) with various successes. The aim of Inter99 is to assess... 
Intervention | Lifestyle | Population | Non-pharmacological | Ischaemic heart disease | Body Mass Index | Life Style | Humans | Middle Aged | Myocardial Ischemia - prevention & control | Male | Alcohol Drinking | Health Behavior | Exercise | Health Promotion | Diet | Counseling | Adult | Female | Research Design | Smoking Cessation
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5. Full Text Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort
by Janice A. Kolberg and Torben Jørgensen and Robert W. Gerwien and Sarah Hamren and Michael P. McKenna and Edward Moler and Michael W. Rowe and Mickey S. Urdea and Xiaomei M. Xu and Torben Hansen and Oluf Pedersen and Knut Borch-Johnsen
Diabetes Care, ISSN 0149-5992, 07/2009, Volume 32, Issue 7, pp. 1207 - 1212
Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort Janice A. Kolberg , PHD 1 , Torben Jørgensen , MD, DMSC 2... 
FASTING GLUCOSE | LIFE-STYLE INTERVENTION | DIAGNOSIS | ADIPONECTIN | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | ATHEROSCLEROSIS | MELLITUS | GLUCOSE-TOLERANCE | T-LYMPHOCYTES | PROGRESSION | Body Mass Index | Immunoassay | Risk Assessment | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Receptors, Interleukin-2 - blood | Risk Factors | Male | Biomarkers - blood | Insulin - blood | Case-Control Studies | Diabetes Mellitus, Type 2 - epidemiology | Adiponectin - blood | Diabetes Mellitus, Type 2 - blood | C-Reactive Protein - metabolism | Ferritins - blood | Denmark - epidemiology | Adult | Female | Blood Glucose - metabolism | Cohort Studies | Type 2 diabetes | Research | Biological markers | Risk assessment | Risk factors | Plasma | Nutrition | Biomarkers | Population | Statistical methods | Blood pressure | Diabetes | Apoptosis | Original Research
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6. Full Text Early detection and treatment of type 2 diabetes reduce cardiovascular morbidity and mortality : A simulation of the results of the Anglo-Danish-Dutch study of intensive treatment in people with screen-detected diabetes in primary care (ADDITION-Europe)
by Herman, William H and Ye, Wen and Griffin, Simon J and Simmons, Rebecca K and Davies, Melanie J and Khunti, Kamlesh and Rutten, Guy E. H. M and Sandbaek, Annelli and Lauritzen, Torsten and Borch-Johnsen, Knut and Brown, Morton B and Wareham, Nicholas J
Diabetes Care, ISSN 0149-5992, 08/2015, Volume 38, Issue 8, pp. 1449 - 1455
OBJECTIVE To estimate the benefits of screening and early treatment of type 2 diabetes compared with no screening and late treatment using a simulation model... 
COST-EFFECTIVENESS ANALYSIS | CLINICAL-DIAGNOSIS | ADULTS | Internal Medicine | RANDOMIZED CONTROLLED-TRIAL | Endocrinology, Diabetes and Metabolism | Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Multicenter Study | COHORT | OUTCOMES | Advanced and Specialised Nursing | ONSET | NIDDM | ENDOCRINOLOGY & METABOLISM | Cholesterol - blood | Humans | Middle Aged | Netherlands - epidemiology | Risk Factors | Diabetes Mellitus, Type 2 - prevention & control | Diabetic Angiopathies - mortality | Mass Screening - methods | Computer Simulation | Diabetes Mellitus, Type 2 - mortality | Denmark - epidemiology | Adult | Critical Care | Female | Aged | Blood Pressure - physiology | Primary Health Care | Diabetic Angiopathies - prevention & control | Blood Glucose - metabolism | Early Diagnosis | United Kingdom - epidemiology | Type 2 diabetes | Care and treatment | Primary health care | Mortality | Analysis | Management | Cardiovascular diseases | Risk factors | Epidemiology | Health Services Research
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7. Full Text Glycemic thresholds for diabetes-specific retinopathy: Implications for diagnostic criteria for diabetes
by Colagiuri, Stephen and Lee, Crystal M. Y and Wong, Tien Y and Balkau, Beverley and Shaw, Jonathan E and Borch-Johnsen, Knut and Detect-2 Collaboration Writing Grp and DETECT-2 Collaboration Writing Group and the DETECT-2 Collaboration Writing Group
Diabetes Care, ISSN 0149-5992, 2011, Volume 34, Issue 1, pp. 145 - 150
OBJECTIVE- To re-evaluate the relationship between glycemia and diabetic retinopathy. RESEARCH DESIGN AND METHODS- We conducted a data-pooling analysis of nine... 
HBA(1C) | US POPULATION | RISK-FACTORS | GLUCOSE | ENDOCRINOLOGY & METABOLISM | PEOPLE | PREVALENCE | Young Adult | Diabetic Retinopathy - blood | Diabetic Retinopathy - diagnosis | Blood Glucose - analysis | Fasting - blood | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Adult | Aged | Diabetic Retinopathy - metabolism | Diabetic retinopathy | Blood sugar | Physiological aspects | Glycosylated hemoglobin | Research | Diagnosis | Risk factors | Studies | Hyperglycemia | Sensitivity analysis | Atherosclerosis | Data collection | Air pollution | Statistical methods | Diabetes | Epidemiology | Original Research
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8. Full Text A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
by Moltke, Ida and Grarup, Niels and Jørgensen, Marit E and Bjerregaard, Peter and Treebak, Jonas T and Fumagalli, Matteo and Korneliussen, Thorfinn S and Andersen, Marianne A and Nielsen, Thomas S and Krarup, Nikolaj T and Gjesing, Anette P and Zierath, Juleen R and Linneberg, Allan and Wu, Xueli and Sun, Guangqing and Jin, Xin and Al-Aama, Jumana and Wang, Jun and Borch-Johnsen, Knut and Pedersen, Oluf and Nielsen, Rasmus and Albrechtsen, Anders and Hansen, Torben
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 190 - 193
The Greenlandic population, a small and historically isolated founder population comprising about 57,000 inhabitants, has experienced a dramatic increase in... 
POPULATION | GLUCOSE | MULTIDISCIPLINARY SCIENCES | MUTATION | GLYCEMIC TRAITS | FRAMEWORK | DISCOVERY | Genome-Wide Association Study | Blood Glucose - analysis | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Middle Aged | Genotype | Muscle, Skeletal - metabolism | Insulin - blood | Genetic Variation | Insulin Resistance - genetics | Adult | GTPase-Activating Proteins - genetics | Codon, Nonsense - genetics | Greenland | Type 2 diabetes | Glucose metabolism | Complications and side effects | Patient outcomes | Genomics | Muscles | Development and progression | Research | Risk factors | Insulin resistance | Diabetes | Glucose | Population genetics | Insulin | Genes
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9. Full Text Reply: Screening for type 2 diabetes and population mortality over 10 years
by Lauritzen, Torsten and Borch-Johnsen, Knut
The Lancet, ISSN 0140-6736, 2013, Volume 381, Issue 9870, p. 902
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10. Full Text Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
by Thorleifsson, G and Walters, G.B and Gudbjartsson, D.F and Steinthorsdottir, V and Sulem, P and Helgadottir, A and Styrkarsdottir, U and Gretarsdottir, S and Thorlacius, S and Jonsdottir, I and Jonsdottir, T and Olafsdottir, E.J and Olafsdottir, G.H and Jonsson, T and Jonsson, F and Borch-Johnsen, K and Hansen, T and Andersen, G and Jorgensen, T and Lauritzen, T and Aben, K.K.H and Verbeek, A.L.M and Roeleveld, N and Kampman, E and Yanek, L.R and Becker, L.C and Tryggvadottir, L and Rafnar, T and Becker, D.M and Gulcher, J and Kiemeney, L.A.L.M and Pedersen, O and Kong, A and Thorsteinsdottir, U and Stefansson, K
Nature Genetics, ISSN 1061-4036, 2009, Volume 41, Issue 1, pp. 18 - 24
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of... 
GENETIC-VARIATION | METABOLIC SYNDROME | ALPHA GENE | PROTEIN | METAANALYSIS | NEURITE OUTGROWTH | OVERWEIGHT | GENETICS & HEREDITY | BODY-MASS INDEX | POLYMORPHISM | WEIGHT | Body Mass Index | Genetic Predisposition to Disease | Genome-Wide Association Study | Quantitative Trait, Heritable | Obesity - complications | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Expression Regulation | Body Weight - genetics | Obesity - genetics | Genome, Human - genetics | Base Sequence | Polymorphism, Single Nucleotide - genetics | Diabetes Mellitus, Type 2 - complications | Quantitative Trait Loci - genetics | Obesity | Complications and side effects | Body mass index | Physiological aspects | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Medical research | Diabetes | Gene expression | Minority & ethnic groups | Quality control | metabolic syndrome | alpha gene | metaanalysis | protein | weight | polymorphism | neurite outgrowth | overweight | body-mass index | genetic-variation
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11. Full Text European guidelines on cardiovascular disease prevention in clinical practice: Executive summary - Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts)
by Graham, Ian and Atar, Dan and Borch-Johnsen, Knut and Boysen, Gudrun and Burell, Gunilla and Cifkova, Renata and Dallongeville, Jean and De Backer, Guy and Ebrahim, Shah and Gjelsvik, Bjørn and Herrmann-Lingen, Christoph and Hoes, Arno and Humphries, Steve and Knapton, Mike and Perk, Joep and Priori, Silvia G and Pyorala, Kalevi and Reiner, Zeljko and Ruilope, Luis and Sans-Menendez, Susana and Scholte Op Reimer, Wilma and Weissberg, Peter and Wood, David and Yarnell, John and Zamorano, Jose Luis and European Society of Cardiology (ESC) Committee for Practice Guidelines (CPG) and Document reviewers and Other experts who contributed to parts of the guidelines and Authors/Task Force Members
European Heart Journal, ISSN 0195-668X, 10/2007, Volume 28, Issue 19, pp. 2375 - 2414
Risk Assessment - methods | Life Style | Body Weight | Cardiovascular Diseases - prevention & control | Humans | Smoking Prevention | Exercise | Lipids - blood | Heart Rate - physiology | Blood Pressure - physiology | Nutritional Status | Diabetic Angiopathies - prevention & control | Health Policy | Cardiovascular Diseases - etiology | Cardiovascular Diseases - physiopathology | Europe | Biomarkers - blood | Evidence-Based Medicine | Cardiovascular Agents - therapeutic use | Diagnostic Imaging | Pedigree | Obesity - prevention & control | Sex Factors | Metabolic Syndrome - prevention & control | Evaluation Studies as Topic
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12. Full Text Albuminuria and Cardiovascular Risk in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study
by Kristian Wachtell and Hans Ibsen and Michael H. Olsen and Knut Borch-Johnsen and Lars H. Lindholm and Carl Erik Mogensen and Björn Dahlöf and Richard B. Devereux and Gareth Beevers and Ulf de Faire and Frej Fyhrquist and Stevo Julius and Sverre E. Kjeldsen and Krister Kristianson and Ole Lederballe-Pedersen and Markku S. Nieminen and Peter M. Okin and Per Omvik and Suzanne Oparil and Hans Wedel and Steven M. Snapinn and Peter Aurup
Annals of Internal Medicine, ISSN 0003-4819, 12/2003, Volume 139, Issue 11, pp. 901 - I26
Background: Several studies have shown that albuminuria is associated with increased risk for fatal and nonfatal cardiovascular events, independent of... 
MORTALITY | MEDICINE, GENERAL & INTERNAL | PREDICTOR | MORBIDITY | MICROALBUMINURIA | MASS | FOLLOW-UP | COHORT | INTERVENTION | VASCULAR-DISEASE | EXCRETION RATE | Cardiovascular Diseases - etiology | Hypertrophy, Left Ventricular - urine | Diabetes Complications | Prospective Studies | Humans | Middle Aged | Risk Factors | Male | Cause of Death | Hypertrophy, Left Ventricular - complications | Aged, 80 and over | Cardiovascular Diseases - mortality | Hypertension - complications | Female | Aged | Albuminuria - metabolism | Hypertension - urine | Hypertension | Stroke (Disease) | Cookery for hypertensives | Physiological aspects | Albuminuria | Health aspects | Heart attack | Risk factors | Cardiovascular disease | Risk | Diabetes | Patients
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