Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 228 - 232
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths(1). Genome sequencing...
TRANSMISSION | VIRUS | EVOLUTION | DNA | MULTIDISCIPLINARY SCIENCES | SIERRA-LEONE | DYNAMICS | OUTBREAK | NANOPORE SEQUENCER | Ebolavirus - classification | Genome, Viral - genetics | Humans | Mutagenesis - genetics | Ebolavirus - pathogenicity | Mutation Rate | Disease Outbreaks - statistics & numerical data | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Sequence Analysis, DNA - instrumentation | Epidemiological Monitoring | Time Factors | Hemorrhagic Fever, Ebola - virology | Aircraft | Sequence Analysis, DNA - methods | Ebola virus | Distribution | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Prevalence studies (Epidemiology) | Electrical currents | Pathogens | Surveillance | Laboratories | Phylogenetics | Universal Serial Bus | Genomes | Bioinformatics | Deoxyribonucleic acid--DNA
TRANSMISSION | VIRUS | EVOLUTION | DNA | MULTIDISCIPLINARY SCIENCES | SIERRA-LEONE | DYNAMICS | OUTBREAK | NANOPORE SEQUENCER | Ebolavirus - classification | Genome, Viral - genetics | Humans | Mutagenesis - genetics | Ebolavirus - pathogenicity | Mutation Rate | Disease Outbreaks - statistics & numerical data | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Sequence Analysis, DNA - instrumentation | Epidemiological Monitoring | Time Factors | Hemorrhagic Fever, Ebola - virology | Aircraft | Sequence Analysis, DNA - methods | Ebola virus | Distribution | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Prevalence studies (Epidemiology) | Electrical currents | Pathogens | Surveillance | Laboratories | Phylogenetics | Universal Serial Bus | Genomes | Bioinformatics | Deoxyribonucleic acid--DNA
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 97 - 101
West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded(1-3). Until now, there have been 27,013 reported cases and...
MODEL | VP24 | INFERENCE | MULTIDISCIPLINARY SCIENCES | Sierra Leone - epidemiology | Humans | Molecular Sequence Data | Hemorrhagic Fever, Ebola - transmission | Male | Disease Outbreaks - statistics & numerical data | Phylogeny | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Mali - epidemiology | Ebolavirus - isolation & purification | Hemorrhagic Fever, Ebola - virology | Amino Acid Substitution - genetics | Female | Spatio-Temporal Analysis | High-Throughput Nucleotide Sequencing | Liberia - epidemiology | Evolution, Molecular | Ebola virus | Ebola virus infections | Distribution | Proteins | Epidemics | Phylogenetics | Evolution | Infections | Genomes | Epidemiology
MODEL | VP24 | INFERENCE | MULTIDISCIPLINARY SCIENCES | Sierra Leone - epidemiology | Humans | Molecular Sequence Data | Hemorrhagic Fever, Ebola - transmission | Male | Disease Outbreaks - statistics & numerical data | Phylogeny | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Mali - epidemiology | Ebolavirus - isolation & purification | Hemorrhagic Fever, Ebola - virology | Amino Acid Substitution - genetics | Female | Spatio-Temporal Analysis | High-Throughput Nucleotide Sequencing | Liberia - epidemiology | Evolution, Molecular | Ebola virus | Ebola virus infections | Distribution | Proteins | Epidemics | Phylogenetics | Evolution | Infections | Genomes | Epidemiology
Journal Article
PLoS Medicine, ISSN 1549-1277, 03/2016, Volume 13, Issue 3, p. e1001967
Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at...
VIRAL LOAD | MEDICINE, GENERAL & INTERNAL | HEMORRHAGIC-FEVER | PATIENT | INFECTION | T-705 FAVIPIRAVIR | OUTCOMES | CONVALESCENT PLASMA | OUTBREAK | SEVERE SEPSIS | FEATURES | Antiviral agents | Ebola virus infections | Drug therapy | Patient outcomes | Care and treatment | RNA | Mortality | Genomics | Clinical trials | Hostages | Biosafety | Oral medication | Ethical aspects | Non-governmental organizations | Ebola virus | Virus diseases | Analysis | Health aspects | Studies | Epidemics | Life Sciences | Social Anthropology and ethnology | Humanities and Social Sciences
VIRAL LOAD | MEDICINE, GENERAL & INTERNAL | HEMORRHAGIC-FEVER | PATIENT | INFECTION | T-705 FAVIPIRAVIR | OUTCOMES | CONVALESCENT PLASMA | OUTBREAK | SEVERE SEPSIS | FEATURES | Antiviral agents | Ebola virus infections | Drug therapy | Patient outcomes | Care and treatment | RNA | Mortality | Genomics | Clinical trials | Hostages | Biosafety | Oral medication | Ethical aspects | Non-governmental organizations | Ebola virus | Virus diseases | Analysis | Health aspects | Studies | Epidemics | Life Sciences | Social Anthropology and ethnology | Humanities and Social Sciences
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7601, pp. 100 - 104
Despite the magnitude of the Ebola virus disease (EVD) outbreak in West Africa, there is still a fundamental lack of knowledge about the pathophysiology of...
EFFECTOR | T-CELL RESPONSE | MULTIDISCIPLINARY SCIENCES | CTLA-4 | INFECTION | PATIENT | IDENTIFICATION | EXPRESSION | PROGRESSION | INSIGHTS | FEVER | Inflammation Mediators - immunology | Lymphocyte Activation | Humans | Patient Discharge | Survivors | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Male | Guinea - epidemiology | Ebolavirus - immunology | Viral Load | Flow Cytometry | T-Lymphocytes - metabolism | Hemorrhagic Fever, Ebola - mortality | Female | T-Lymphocytes - immunology | Hemorrhagic Fever, Ebola - immunology | Hemorrhagic Fever, Ebola - physiopathology | Longitudinal Studies | Physiological aspects | Medicine, Experimental | Medical research | Ebola virus infections | Immune response | Research | Ebola virus | Flow cytometry | Cytokines | Lymphocytes | Homeostasis | T cell receptors | Inflammation
EFFECTOR | T-CELL RESPONSE | MULTIDISCIPLINARY SCIENCES | CTLA-4 | INFECTION | PATIENT | IDENTIFICATION | EXPRESSION | PROGRESSION | INSIGHTS | FEVER | Inflammation Mediators - immunology | Lymphocyte Activation | Humans | Patient Discharge | Survivors | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Male | Guinea - epidemiology | Ebolavirus - immunology | Viral Load | Flow Cytometry | T-Lymphocytes - metabolism | Hemorrhagic Fever, Ebola - mortality | Female | T-Lymphocytes - immunology | Hemorrhagic Fever, Ebola - immunology | Hemorrhagic Fever, Ebola - physiopathology | Longitudinal Studies | Physiological aspects | Medicine, Experimental | Medical research | Ebola virus infections | Immune response | Research | Ebola virus | Flow cytometry | Cytokines | Lymphocytes | Homeostasis | T cell receptors | Inflammation
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 02/2017, Volume 64, Issue 4, pp. 513 - 516
A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory...
Ebola virus | Real-time sequencing | Asymptomatic carriage | Breast milk | Mother-to-child transmission | FLUIDS | INFECTIOUS DISEASES | real-time sequencing | breast milk | MICROBIOLOGY | IMMUNOLOGY | mother-to-child transmission | asymptomatic carriage | Humans | Hemorrhagic Fever, Ebola - transmission | Infant | Male | Infectious Disease Transmission, Vertical | Phylogeny | Milk, Human - virology | Sequence Analysis, DNA | Ebolavirus - isolation & purification | Sequence Homology | Young Adult | RNA, Viral - genetics | Adult | Female | Semen - virology | RNA, Viral - isolation & purification | Cluster Analysis | Disease transmission | RNA | Analysis | Patient outcomes | Ebola virus infections | Genetic aspects | Research | Health aspects | Epidemiology | Brief Report
Ebola virus | Real-time sequencing | Asymptomatic carriage | Breast milk | Mother-to-child transmission | FLUIDS | INFECTIOUS DISEASES | real-time sequencing | breast milk | MICROBIOLOGY | IMMUNOLOGY | mother-to-child transmission | asymptomatic carriage | Humans | Hemorrhagic Fever, Ebola - transmission | Infant | Male | Infectious Disease Transmission, Vertical | Phylogeny | Milk, Human - virology | Sequence Analysis, DNA | Ebolavirus - isolation & purification | Sequence Homology | Young Adult | RNA, Viral - genetics | Adult | Female | Semen - virology | RNA, Viral - isolation & purification | Cluster Analysis | Disease transmission | RNA | Analysis | Patient outcomes | Ebola virus infections | Genetic aspects | Research | Health aspects | Epidemiology | Brief Report
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 2015, Volume 61, Issue 5, pp. 669 - 675
Background. Reliable reverse transcription polymerase chain reaction (RT-PCR)-based diagnosis of Ebola virus infection currently requires a blood sample...
Ebola virus | Field diagnostic | Capillary blood | Ebola virus disease | INFECTIOUS DISEASES | WEST-AFRICA | SIERRA-LEONE | capillary blood | ANTIBODY | MICROBIOLOGY | IMMUNOLOGY | field diagnostic | HEMORRHAGIC-FEVER | DISEASE | REVERSE TRANSCRIPTION-PCR | OUTCOMES | EPIDEMIC | CONGO | ANTIGEN | Blood Specimen Collection - standards | Guinea | Humans | Middle Aged | Child, Preschool | Emergencies | Infant | Male | RNA, Viral - blood | Feasibility Studies | Young Adult | Hemorrhagic Fever, Ebola - diagnosis | Reverse Transcriptase Polymerase Chain Reaction - standards | Disease Outbreaks | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Adolescent | Aged, 80 and over | Adult | Female | Aged | Blood Specimen Collection - methods | Child | Polymerase chain reaction | Epidemics | Ebola virus infections | Control | Usage | Diagnosis | and Commentaries
Ebola virus | Field diagnostic | Capillary blood | Ebola virus disease | INFECTIOUS DISEASES | WEST-AFRICA | SIERRA-LEONE | capillary blood | ANTIBODY | MICROBIOLOGY | IMMUNOLOGY | field diagnostic | HEMORRHAGIC-FEVER | DISEASE | REVERSE TRANSCRIPTION-PCR | OUTCOMES | EPIDEMIC | CONGO | ANTIGEN | Blood Specimen Collection - standards | Guinea | Humans | Middle Aged | Child, Preschool | Emergencies | Infant | Male | RNA, Viral - blood | Feasibility Studies | Young Adult | Hemorrhagic Fever, Ebola - diagnosis | Reverse Transcriptase Polymerase Chain Reaction - standards | Disease Outbreaks | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Adolescent | Aged, 80 and over | Adult | Female | Aged | Blood Specimen Collection - methods | Child | Polymerase chain reaction | Epidemics | Ebola virus infections | Control | Usage | Diagnosis | and Commentaries
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 04/2016, Volume 62, Issue 7, pp. 903 - 905
We report 2 cases of Ebola viral disease (EVD) in pregnant women who survived, initially with intact pregnancies. Respectively 31-32 days after negativation of...
Ebola | EVD | pregnancy | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | Pregnancy | Young Adult | Fetal Blood - virology | Hemorrhagic Fever, Ebola | Humans | Stillbirth | Adult | Female | Pregnancy Complications, Infectious | Placenta - virology | Amniotic Fluid - virology | Ebola virus | Prognosis | Pregnant women | Dilemma | Health aspects | Analysis | Brief Reports
Ebola | EVD | pregnancy | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | Pregnancy | Young Adult | Fetal Blood - virology | Hemorrhagic Fever, Ebola | Humans | Stillbirth | Adult | Female | Pregnancy Complications, Infectious | Placenta - virology | Amniotic Fluid - virology | Ebola virus | Prognosis | Pregnant women | Dilemma | Health aspects | Analysis | Brief Reports
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2018, Volume 8, Issue 1, p. 11171
The family Arteriviridae harbors a rapidly expanding group of viruses known to infect a divergent group of mammals, including horses, pigs, possums, primates,...
IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | SIMIAN HEMORRHAGIC-FEVER | TOOL
IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | SIMIAN HEMORRHAGIC-FEVER | TOOL
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 02/2017, Volume 11, Issue 2, p. e0005389
Background In 2014-2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the...
EFFICACY | VIRUS INFECTION | DRUGS | ALDEHYDE OXIDASE | T-705 FAVIPIRAVIR | MODEL | PARASITOLOGY | TROPICAL MEDICINE | Antiviral Agents - pharmacokinetics | Guinea | Humans | Middle Aged | Pyrazines - administration & dosage | Child, Preschool | Male | Antiviral Agents - administration & dosage | Ebolavirus - drug effects | Young Adult | Hemorrhagic Fever, Ebola - virology | Pyrazines - pharmacokinetics | Adolescent | Amides - pharmacokinetics | Adult | Female | Aged | Ebolavirus - physiology | Amides - administration & dosage | Child | Hemorrhagic Fever, Ebola - drug therapy | Antiviral agents | Ebola virus infections | Models | Pharmacokinetics | Drug therapy | Patient outcomes | Ebola virus | Health care | Sepsis | Metabolism | Drug dosages | Patients | Public health | Ebolavirus | Hemorrhagic Fever, Ebola | Amides | Antiviral Agents | Virology | Pyrazines | Life Sciences | Microbiology and Parasitology
EFFICACY | VIRUS INFECTION | DRUGS | ALDEHYDE OXIDASE | T-705 FAVIPIRAVIR | MODEL | PARASITOLOGY | TROPICAL MEDICINE | Antiviral Agents - pharmacokinetics | Guinea | Humans | Middle Aged | Pyrazines - administration & dosage | Child, Preschool | Male | Antiviral Agents - administration & dosage | Ebolavirus - drug effects | Young Adult | Hemorrhagic Fever, Ebola - virology | Pyrazines - pharmacokinetics | Adolescent | Amides - pharmacokinetics | Adult | Female | Aged | Ebolavirus - physiology | Amides - administration & dosage | Child | Hemorrhagic Fever, Ebola - drug therapy | Antiviral agents | Ebola virus infections | Models | Pharmacokinetics | Drug therapy | Patient outcomes | Ebola virus | Health care | Sepsis | Metabolism | Drug dosages | Patients | Public health | Ebolavirus | Hemorrhagic Fever, Ebola | Amides | Antiviral Agents | Virology | Pyrazines | Life Sciences | Microbiology and Parasitology
Journal Article
10.
Full Text
DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency
The American Journal of Human Genetics, ISSN 0002-9297, 12/2018, Volume 103, Issue 6, pp. 1038 - 1044
During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations...
microcephaly | DNA replication | adrenal failure | cell cycle | polymerase epsilon | growth | immunodeficiency | IMAGe syndrome | DOMAIN | GROWTH-RETARDATION | ORIGIN RECOGNITION COMPLEX | GENETICS & HEREDITY | MUTATIONS | SHORT STATURE | INHIBITOR | REPLICATION STRESS | Polymerase chain reaction | Usage | Genetic disorders | Gene mutations | Cell cycle | Research | Risk factors | Report
microcephaly | DNA replication | adrenal failure | cell cycle | polymerase epsilon | growth | immunodeficiency | IMAGe syndrome | DOMAIN | GROWTH-RETARDATION | ORIGIN RECOGNITION COMPLEX | GENETICS & HEREDITY | MUTATIONS | SHORT STATURE | INHIBITOR | REPLICATION STRESS | Polymerase chain reaction | Usage | Genetic disorders | Gene mutations | Cell cycle | Research | Risk factors | Report
Journal Article
JOURNAL OF INFECTIOUS DISEASES, ISSN 0022-1899, 10/2016, Volume 214, pp. S250 - S257
Background. A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease ( EVD) treatment unit in Gueckedou, Guinea,...
VIRAL LOAD | INFECTIOUS DISEASES | Guinea | epidemic | SIERRA-LEONE | MICROBIOLOGY | IMMUNOLOGY | malaria | mobile laboratory | EBOLA-VIRUS DISEASE | Filovirus | OUTBREAK | Ebola virus disease
VIRAL LOAD | INFECTIOUS DISEASES | Guinea | epidemic | SIERRA-LEONE | MICROBIOLOGY | IMMUNOLOGY | malaria | mobile laboratory | EBOLA-VIRUS DISEASE | Filovirus | OUTBREAK | Ebola virus disease
Journal Article