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1. Full Text Myeloid Cell Prostaglandin E2 Receptor EP4 Modulates Cytokine Production but Not Atherogenesis in a Mouse Model of Type 1 Diabetes
by Vallerie, Sara N and Kramer, Farah and Barnhart, Shelley and Kanter, Jenny E and Breyer, Richard M and Andreasson, Katrin I and Bornfeldt, Karin E
PLOS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0158316
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2. Full Text Atherosclerosis: Successes, Surprises, and Future Challenges
by Libby, Peter and Bornfeldt, Karin E and Tall, Alan R
Circulation Research, ISSN 0009-7330, 02/2016, Volume 118, Issue 4, pp. 531 - 534
atherosclerosis | clinical trial | smooth muscle cells | epidemiology | endothelial cells | pharmacology | leukocytes | Editorials | vascular cell biology | CARDIAC & CARDIOVASCULAR SYSTEMS | ACUTE CORONARY SYNDROMES | PATHOGENESIS | TRIAL | HEART-DISEASE | GENETIC RISK | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Atherosclerosis - blood | Animals | Prognosis | Atherosclerosis - therapy | Humans | Lipids - blood | Risk Factors | Atherosclerosis - diagnosis | Biomarkers - blood | Atherosclerosis - epidemiology
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3. Full Text Growing evidence for a role for acyl‐CoA synthetase 1 in immunometabolism
by Bornfeldt, Karin E
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2019, Volume 106, Issue 4, pp. 787 - 790
Discussion on the role of acyl‐CoA synthetase 1 in immunometabolism. 
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4. Full Text ATVB Named Lecture Review - Insight into Author
by Bornfeldt, Karin E
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2017, Volume 37, Issue 2, pp. 181 - 182
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5. Full Text Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics
by Rune, Ida and Rolin, Bidda and Lykkesfeldt, Jens and Nielsen, Dennis Sandris and Krych, Łukasz and Kanter, Jenny E and Bornfeldt, Karin E and Kihl, Pernille and Buschard, Karsten and Josefsen, Knud and Fels, Johannes Josef and Mortensen, Alan and Christoffersen, Berit and Kirk, Rikke Kaae and Hansen, Axel Kornerup
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5416 - 12
In the apolipoprotein E-deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present... 
SPRAGUE-DAWLEY RATS | DIABETES INCIDENCE | BODY-WEIGHT | CHYLOMICRON REMNANTS | NOD MICE | GLUTEN-FREE | MULTIDISCIPLINARY SCIENCES | ANIMAL-MODEL | GUT MICROBIOTA | KNOCKOUT MICE | INDUCED OBESITY | Lipoproteins (low density) | Oxidative stress | Nutrient deficiency | Diabetes mellitus | Thorax | Apolipoproteins | Low density lipoprotein | High fat diet | Microbiota | Diet | Apolipoprotein E | Arteriosclerosis | Rodents | Low fat diet | Atherosclerosis | Aorta | Diabetes mellitus (non-insulin dependent) | Gluten
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6. Full Text Uncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture
by Bornfeldt, Karin E and Bornfeldt, Karin E
Diabetes, ISSN 0012-1797, 08/2015, Volume 64, Issue 8, pp. 2689 - 2697
The risk of cardiovascular events in humans increases in the presence of type 1 or type 2 diabetes mellitus, in large part due to exacerbated atherosclerosis.... 
HEART-DISEASE | PLAQUE REGRESSION | INSULIN-RESISTANCE | ADVANCED GLYCATION ENDPRODUCTS | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | OF-FUNCTION MUTATIONS | ACCELERATES ATHEROSCLEROSIS | END-PRODUCTS RAGE | SCIENTIFIC STATEMENT | POTENTIAL ROLE | Diabetic Angiopathies - metabolism | Animals | Diabetic Angiopathies - pathology | Humans | Awards and Prizes | Diabetes Mellitus, Experimental - pathology | Diabetes Mellitus, Experimental - complications | Mice | Diabetes Mellitus, Type 2 - metabolism | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Type 2 - complications | Complications and side effects | Blood circulation disorders | Diabetes | Risk factors | s in Diabetes
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7. Full Text Highlighting Residual Atherosclerotic Cardiovascular Disease Risk
by Matsuura, Yunosuke and Kanter, Jenny E and Bornfeldt, Karin E
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 01/2019, Volume 39, Issue 1, pp. e1 - e9
simvastatin | diabetes mellitus | triglycerides | statin | inflammation | lipoproteins | ENDOTHELIAL LIPASE | ESTER TRANSFER PROTEIN | MYOCARDIAL-INFARCTION | OF-FUNCTION MUTATIONS | NLRP3 INFLAMMASOME | PARTICLE NUMBER | DENSITY-LIPOPROTEIN CHOLESTEROL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | CORONARY-ARTERY-DISEASE | APOLIPOPROTEIN-A-I
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8. Full Text Insulin Resistance, Hyperglycemia, and Atherosclerosis
by Bornfeldt, Karin E and Tabas, Ira
Cell Metabolism, ISSN 1550-4131, 11/2011, Volume 14, Issue 5, pp. 575 - 585
Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by the epidemic of type 2 diabetes. Further advances in this area demand... 
SMOOTH-MUSCLE | GLUCOSE CONTROL | CLINICAL-TRIAL | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | GENE-EXPRESSION | RECEPTOR | ENDOPLASMIC-RETICULUM STRESS | ACCELERATES ATHEROSCLEROSIS | DIABETIC ATHEROSCLEROSIS | GLYCATION END-PRODUCTS | CELL BIOLOGY | Apolipoproteins B - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Hyperglycemia - complications | Diabetes Mellitus, Type 2 - metabolism | Coronary Artery Disease - pathology | Hyperglycemia - pathology | Diabetes Mellitus, Type 2 - complications | Atherosclerosis - pathology | Signal Transduction | Endothelial Cells - metabolism | Coronary Artery Disease - metabolism | Risk Factors | Insulin Resistance | Atherosclerosis - complications | Apolipoproteins B - genetics | Macrophages - cytology | Muscle, Smooth, Vascular - cytology | Atherosclerosis - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Insulin - metabolism | Macrophages - metabolism | Animals | Endothelial Cells - cytology | Coronary Artery Disease - complications | Receptor, Insulin - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Blood Glucose - metabolism | Type 2 diabetes | Insulin resistance | Hyperglycemia | Coronary heart disease | Atherosclerosis
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9. Full Text 2013 Russell Ross Memorial Lecture in Vascular Biology: Cellular and Molecular Mechanisms of Diabetes Mellitus–Accelerated Atherosclerosis
by Bornfeldt, Karin E
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2014, Volume 34, Issue 4, pp. 705 - 714
Adults with diabetes mellitus are much more likely to have cardiovascular disease than those without diabetes mellitus. Genetically engineered mouse models... 
atherosclerosis | endothelial cells | macrophages | diabetes mellitus | mice | CARTILAGINOUS METAPLASIA | SMOOTH-MUSCLE-CELL | APOLIPOPROTEIN-E | LIPOPROTEIN METABOLISM | COA SYNTHETASE 1 | GENE-EXPRESSION | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | BLOOD-GLUCOSE CONTROL | ALDOSE REDUCTASE | Diabetic Angiopathies - metabolism | Atherosclerosis - pathology | Genetic Predisposition to Disease | Signal Transduction | Atherosclerosis - genetics | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Risk Factors | Insulin Resistance | Diabetic Angiopathies - etiology | Mice, Transgenic | Atherosclerosis - metabolism | Disease Progression | Atherosclerosis - etiology | Phenotype | Animals | Diabetic Angiopathies - pathology | Time Factors | Mice | Blood Glucose - metabolism | Diabetic Angiopathies - genetics | Disease Models, Animal
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10. Full Text Myeloid cell prostaglandin E2 receptor EP4 modulates cytokine production but not atherogenesis in a mouse model of type 1 diabetes
by Vallerie, Sara N and Kramer, Farah and Barnhart, Shelley and Kanter, Jenny E and Breyer, Richard M and Andreasson, Katrin I and Bornfeldt, Karin E
PLoS ONE, 06/2016, Volume 11, Issue 6, p. e0158316
Type 1 diabetes mellitus (T1DM) is associated with cardiovascular complications induced by atherosclerosis. Prostaglandin E2 (PGE2) is often raised in states... 
Receptors, Prostaglandin E, EP4 Subtype - genetics | Tumor Necrosis Factor-alpha - metabolism | Mice, Inbred C57BL | Tumor Necrosis Factor-alpha - genetics | Cells, Cultured | Receptors, CCR7 - genetics | Diabetes Mellitus, Type 1 - metabolism | Diabetes Mellitus, Type 1 - complications | Atherosclerosis - metabolism | Interleukins - metabolism | Dinoprostone - metabolism | Atherosclerosis - etiology | Interleukins - genetics | Macrophages - metabolism | Animals | Receptors, CCR7 - metabolism | Receptors, Prostaglandin E, EP4 Subtype - deficiency | Myeloid Cells - metabolism | Mice | Receptors, Prostaglandin E, EP4 Subtype - metabolism | CC chemokine receptors | Atherogenesis | Prostaglandin E2 | Cardiovascular disease | Interleukin 23 | Diabetes mellitus (insulin dependent) | mRNA | Kinases | Macrophages | Accumulation | Interleukin 6 | Rodents | Atherosclerosis | Interleukin 1 | Fibroblasts | Bone marrow | Tumor necrosis factor-TNF | Prostaglandin E | Myeloid cells | Cytokines | Complications | CCR7 protein | Diabetes mellitus | Inflammation | Tumor necrosis factor-α | Gene expression | Insulin | Medicine | Signaling | Arteriosclerosis | Diabetes | Laboratory animals | Peritoneum
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11. Full Text Macrophage Phenotype and Function in Different Stages of Atherosclerosis
by Tabas, Ira and Bornfeldt, Karin E
Circulation Research, ISSN 0009-7330, 02/2016, Volume 118, Issue 4, pp. 653 - 667
The remarkable plasticity and plethora of biological functions performed by macrophages have enticed scientists to study these cells in relation to... 
atherosclerosis | foam cells | phenotype | cholesterol | macrophage | CARDIAC & CARDIOVASCULAR SYSTEMS | LOW-DENSITY-LIPOPROTEIN | ENDOPLASMIC-RETICULUM STRESS | BINDING CASSETTE TRANSPORTERS | RECEPTOR-DEFICIENT MICE | FOAM CELL-FORMATION | IN-VIVO | TOLL-LIKE RECEPTORS | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | CORONARY-ARTERY-DISEASE | PROMOTES ATHEROSCLEROSIS | Atherosclerosis - pathology | Atherosclerosis - immunology | Macrophages - pathology | Signal Transduction | Humans | Arteries - immunology | Cellular Microenvironment | Arteries - pathology | Cholesterol - metabolism | Plaque, Atherosclerotic | Atherosclerosis - metabolism | Arteries - metabolism | Macrophages - metabolism | Phenotype | Animals | Inflammation Mediators - metabolism | Cell Differentiation | Foam Cells - metabolism | Macrophages - immunology | Cholesterol | Foam cells | Atherosclerosis | Cytokine | Macrophage
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12. Full Text Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
by Guo, R and Hua, YN and Ren, J and Bornfeldt, KE and Nair, S
CELL DEATH & DISEASE, ISSN 2041-4889, 06/2018, Volume 9, Issue 6, pp. 692 - 14
The lysosomal cysteine protease Cathepsin K is elevated in humans and animal models of heart failure. Our recent studies show that whole-body deletion of... 
CARDIAC CONTRACTILE DYSFUNCTION | STEM-CELLS | MICE LACKING DESMIN | INDUCED APOPTOSIS | PYRROLIDINE DITHIOCARBAMATE | HEART-FAILURE | CARDIOVASCULAR-DISEASE | DILATED CARDIOMYOPATHY | MYOCARDIAL DYSFUNCTION | CYSTEINE PROTEASES | CELL BIOLOGY | NF-κB protein | Animal models | Calcium (intracellular) | Cathepsin K | Cysteine proteinase | Contractility | Homeostasis | Cardiomyocytes | mRNA | Doxorubicin | Muscle contraction | Coronary artery disease | Energy balance | Clonal deletion | Microfilaments | Rodents | Myosin | Heart diseases | Calcium homeostasis | Apoptosis | Structure-function relationships
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13. Full Text A Long Road Ahead for Discovering New HDL Metrics That Reflect Cardiovascular Disease Risk.sup.
by Heinecke, Jay W and Bornfeldt, Karin E
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2017, Volume 70, Issue 2, p. 179
Display Omitted 
Cardiovascular diseases
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14. Full Text Uncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture: Figure 1
by Bornfeldt, Karin E
Diabetes, ISSN 0012-1797, 08/2015, Volume 64, Issue 8, pp. 2689 - 2697
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15. Full Text 2013 Russell Ross Memorial Lecture in Vascular Biology: Cellular and Molecular Mechanisms of Diabetes-Accelerated Atherosclerosis
by Bornfeldt, Karin E
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 4/2014, Volume 34, Issue 4, pp. 705 - 714
Adults with diabetes are much more likely to suffer from cardiovascular disease than those without diabetes. Genetically engineered mouse models have started... 
atherosclerosis | mouse | macrophage | diabetes mellitus | endothelial cell
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16. Full Text Myeloid Cell Prostaglandin E.sub.2 Receptor EP4 Modulates Cytokine Production but Not Atherogenesis in a Mouse Model of Type 1 Diabetes
by Vallerie, Sara N and Kramer, Farah and Barnhart, Shelley and Kanter, Jenny E and Breyer, Richard M and Andreasson, Katrin I and Bornfeldt, Karin E
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6
Complications and side effects | Cytokines | Type 1 diabetes | Atherosclerosis | Physiological aspects | Synthetic prostaglandins E | Models | Research | Diagnosis | Risk factors
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17. Full Text Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein
by He, Yi and Song, Hyun D and Anantharamaiah, G.M and Palgunachari, M.N and Bornfeldt, Karin E and Segrest, Jere P and Heinecke, Jay W
Molecular and Cellular Proteomics, ISSN 1535-9476, 05/2019, Volume 18, Issue 5, pp. 854 - 864
Apolipoprotein A1 (APOA1), the major protein of highdensity lipoprotein (HDL), contains 10 helical repeats that play key roles in protein-protein and... 
HETEROGENEITY | HDL | LINKING | MOLECULAR-DYNAMICS | CHOLESTEROL | FUNCTIONALITY | STABILITY | BIOCHEMICAL RESEARCH METHODS | CROSS-LINKED PEPTIDES | MASS-SPECTROMETRY | LECITHIN
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18. Full Text Does Elevated Glucose Promote Atherosclerosis? Pros and Cons
by Bornfeldt, Karin E
Circulation Research, ISSN 0009-7330, 07/2016, Volume 119, Issue 2, pp. 190 - 193
The quote above, by the Roman poet Publius Ovidius Naso (43 BC to 17 AD), has been an inspiration to me since childhood. It reminds me that accumulating pieces... 
atherosclerosis | glucose | macrophages | diabetes mellitus | inflammation | CARDIAC & CARDIOVASCULAR SYSTEMS | FLUX | LESIONS | HYPERGLYCEMIA | MYELOPOIESIS | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | HEMATOLOGY | Glucose | Diabetes Mellitus | HbA1c | Atherosclerosis
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19. Full Text Abstract 414: Local Artery Wall Inflammation Overrides Systemic Inflammation in Diabetes-Accelerated Atherosclerosis
by Kanter, Jenny E and Kramer, Farah and Barnhart, Shelley and Rahman, Karishma and Amengual, Jaume and Wei, Xiaochao and Bergsbaken, Tessa and Chait, Alan and Fink, Pamela J and Winer, Daniel A and Fisher, Edward A and Goldberg, Ira J and Semenkovich, Clay F and Bornfeldt, Karin E
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2018, Volume 38, Issue Suppl_1
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20. Full Text HDL Function in Cardiovascular Disease and Diabetes
by He, Yi and Kothari, Vishal and Bornfeldt, Karin E
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 2/2018, Volume 38, Issue 2, pp. e10 - e16
HDL function | Cardiovascular disease | HDL composition
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