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1. Full Text Altered tumor-cell glycosylation promotes metastasis
by Häuselmann, Irina and Borsig, Lubor
Frontiers in Oncology, ISSN 2234-943X, 2014, Volume 4, p. 28
Malignant transformation of cells is associated with aberrant glycosylation presented on the cell-surface. Commonly observed changes in glycan structures... 
Mucins | Glycan ligands | Selectins | Galectins | Glycosylation | Siglecs | Metastasis | Cancer | metastasis
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2. Full Text Cancer cell adhesion and metastasis: Selectins, integrins, and the inhibitory potential of heparins
by Bendas, Gerd and Borsig, Lubor
International Journal of Cell Biology, ISSN 1687-8876, 2012, Volume 2012, pp. 1 - 10
Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the... 
Review
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3. Full Text Selectins in cancer immunity
by Borsig, Lubor
Glycobiology, ISSN 0959-6658, 2018, Volume 28, Issue 9, pp. 648 - 655
Selectins are vascular adhesion molecules that mediate physiological responses such as inflammation, immunity and hemostasis. During cancer progression,... 
Selectin | Myeloid cells | Immune response | Cancer glycosylation | Cell signaling | myeloid cells | HUMAN NEUTROPHILS | selectin | BIOCHEMISTRY & MOLECULAR BIOLOGY | cancer glycosylation | NECROSIS-FACTOR-ALPHA | TUMOR-CELLS | CD8(+) T-CELLS | COLON-CARCINOMA CELLS | GLYCOPROTEIN LIGAND-1 | immune response | cell signaling | IN-VIVO | P-SELECTIN | LEUKOCYTE ADHESION | HIGH ENDOTHELIAL VENULES | Animals | Neoplasms - pathology | Neoplasms - immunology | Immunity | Humans | Selectins - immunology
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4. Full Text The role of platelet activation in tumor metastasis
by Borsig, Lubor
Expert Review of Anticancer Therapy, ISSN 1473-7140, 08/2008, Volume 8, Issue 8, pp. 1247 - 1255
Platelets are highly reactive components of the circulatory system, which exert not only haemostatic activity but also contribute to the modulation of various... 
thrombosis | Trousseau's syndrome | metastasis | adhesion molecule | selectin ligand | tumor emboli | platelet | P-selectin | Platelet | Tumor emboli | Adhesion molecule | Selectin ligand | Metastasis | Thrombosis | MECHANISTIC CONNECTIONS | VON-WILLEBRAND-FACTOR | LUNG METASTASIS | BREAST-CANCER CELLS | ONCOLOGY | HEMATOGENOUS METASTASIS | MOLECULAR-WEIGHT HEPARIN | ENDOTHELIAL-CELLS | TISSUE FACTOR | CARCINOMA METASTASIS | Platelet Aggregation | Neoplasm Metastasis | Hemostasis | Platelet Activation | Humans | Neoplasms - pathology | Neoplasms - drug therapy | Care and treatment | Cytokines | Development and progression | Health aspects | Cancer | Integrins
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5. Full Text Antimetastatic activities of heparins and modified heparins. Experimental evidence
by Borsig, Lubor
Thrombosis Research, ISSN 0049-3848, 2010, Volume 125, pp. S66 - S71
Abstract Heparin is commonly used for prevention or treatment of cancer-associated thromboembolism. Recent clinical evidence indicates that heparin, and... 
Hematology, Oncology and Palliative Medicine | Selectin ligands | Heparin | Metastasis | P-selectin | HEPARANASE ACTIVITY | SIALYL-LEWIS-X | LUNG METASTASIS | MURINE MAMMARY-TUMOR | CANCER METASTASIS | MOLECULAR-WEIGHT HEPARIN | IN-VIVO | PROSTATE-CANCER | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CARCINOMA METASTASIS | Heparin, Low-Molecular-Weight - pharmacology | Humans | Anticoagulants - therapeutic use | Heparin - therapeutic use | Antineoplastic Agents - therapeutic use | Heparin, Low-Molecular-Weight - therapeutic use | Neoplasms - drug therapy | Animals | Neoplasm Metastasis - drug therapy | Anticoagulants - pharmacology | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Heparin - pharmacology
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6. Breastfed at Tiffany's
by Thierry Hennet and Lubor Borsig
Trends in Biochemical Sciences, ISSN 0968-0004, 06/2016, Volume 41, Issue 6, p. 508
  The importance of breast milk for the growing infant is undisputed; breastfeeding decreases infantile mortality by tenfold and decreases the incidence of... 
Carbohydrates | Immunoglobulins | Breastfeeding & lactation | Infectious diseases | Infant mortality
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7. Full Text VWF fibers induce thrombosis during cancer
by Borsig, Lubor
Blood, ISSN 0006-4971, 05/2015, Volume 125, Issue 20, pp. 3042 - 3043
In this issue of Blood, Bauer et al(1) provide an explanation for the formation of luminal von Willebrand factor (VWF) fibers observed in cancer patients,... 
HEPARIN | HEMATOLOGY | MECHANISMS | Melanoma - metabolism | Platelet Aggregation | Animals | Humans | von Willebrand Factor - metabolism
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8. Full Text Heparin as an Inhibitor of Cancer Progression
by Borsig, Lubor
2010, Progress in Molecular Biology and Translational Science, ISBN 9780123812827, Volume 93, Issue C, 15
Heparin is frequently used in the treatment of cancer-associated thromboembolism. Accumulating clinical evidence indicates that cancer patients treated with... 
Carcinoma | Heparanase | L-selectin | Heparin | Metastasis | Platelets | Adhesion | P-selectin | CELL LUNG-CANCER | HEPARANASE ACTIVITY | VENOUS THROMBOEMBOLISM | NON-ANTICOAGULANT HEPARINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR-WEIGHT HEPARIN | TUMOR-METASTASIS | IN-VIVO | P-SELECTIN | SIALYL-LEWIS-X | ATTENUATES METASTASIS | Anticoagulants - therapeutic use | Heparin - therapeutic use | Neoplasms - pathology | Humans | Disease Progression | Neoplasms - drug therapy
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9. Full Text Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
by Laubli, H and Borsig, L
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 09/2019, Volume 10
Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic... 
L-SELECTIN | Siglec | selectin | immunity | IMMUNOLOGY | BREAST-CANCER | LUNG METASTASIS | LIGANDS | sialic acid | EXTRAVASATION | P-SELECTIN | SIGLECS | tumor microenvironment | integrin | TUMOR-GROWTH | TENASCIN-C | Cell interaction | Analysis | Cell adhesion | Development and progression | Research | Metastasis | Risk factors
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10. Full Text Breastfed at Tiffany's
by Hennet, Thierry and Borsig, Lubor
Trends in Biochemical Sciences, ISSN 0968-0004, 06/2016, Volume 41, Issue 6, pp. 508 - 518
The importance of breast milk for the growing infant is undisputed; breastfeeding decreases infantile mortality by tenfold and decreases the incidence of... 
microbiota | oligosaccharide | breast milk | IgA | lactose | lactase | Lactose | Microbiota | Lactase | Oligosaccharide | Breast milk | CAMPYLOBACTER-JEJUNI | INFLAMMATORY-BOWEL-DISEASE | EPITHELIAL-CELLS | INTESTINAL MICROBIOTA | LACTOFERRIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-LACTALBUMIN | FATTY-ACIDS | HUMAN-MILK OLIGOSACCHARIDES | LACTATION | LACTOSE SYNTHETASE | Carbohydrate Sequence | Immunoglobulin A - biosynthesis | Humans | Lactalbumin - genetics | Breast Feeding | Gene Expression Regulation | Infant | Lactalbumin - immunology | Lipopolysaccharide Receptors - immunology | Galactosyltransferases - genetics | Milk, Human - chemistry | Oligosaccharides - biosynthesis | Immunity | Galactosyltransferases - immunology | Sodium-Glucose Transporter 1 - genetics | Oligosaccharides - immunology | Lipopolysaccharide Receptors - genetics | Female | Sodium-Glucose Transporter 1 - immunology | Gastrointestinal Microbiome - immunology | Milk, Human - immunology | Cytokines - genetics | Cytokines - immunology | Infants | Immunoglobulin A | Breast feeding | Patient outcomes
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11. Full Text Antimetastatic Activities of Modified Heparins: Selectin Inhibition by Heparin Attenuates Metastasis
by Borsig, Lubor
Seminars in Thrombosis and Hemostasis, ISSN 0094-6176, 7/2007, Volume 33, Issue 5, pp. 540 - 546
ABSTRACT Heparin, which is traditionally used as an anticoagulant but has a variety of additional biological activities, was shown in several retrospective and... 
Heparanase | Selectin | Anticoagulation | Heparin | Metastasis | selectin | ANGIOGENESIS | anticoagulation | heparanase | heparin | SIALYL LEWIS(X) | VENOUS THROMBOEMBOLISM | metastasis | CANCER METASTASIS | MOLECULAR-WEIGHT HEPARIN | TUMOR-METASTASIS | P-SELECTIN | PERIPHERAL VASCULAR DISEASE | ADVANCED MALIGNANCY | HEMATOLOGY | CARCINOMA METASTASIS | Heparin - metabolism | Anticoagulants - metabolism | P-Selectin - metabolism | Humans | Heparin Lyase - administration & dosage | Neoplasms - enzymology | Anticoagulants - therapeutic use | Heparin - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | L-Selectin - metabolism | Neoplasms - drug therapy | Disease-Free Survival | Thrombosis - metabolism | Animals | Heparin - analogs & derivatives | Neoplasm Metastasis - drug therapy | Blood Platelets - metabolism | Heparin Lyase - metabolism
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12. Full Text P-selectin mediates metastatic progression through binding to sulfatides on tumor cells
by Garcia, Josep and Callewaert, Nico and Borsig, Lubor
Glycobiology, ISSN 0959-6658, 02/2007, Volume 17, Issue 2, pp. 185 - 196
Hematogenous carcinoma metastasis is associated with tumor cell emboli formation, which is now known to be facilitated by selectins. P-selectin-mediated... 
glycolipids | MALDI-TOF | selectin | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBOHYDRATE | LEWIS LUNG-CARCINOMA | ABERRANT GLYCOSYLATION | ADHESION | OVARIAN-TUMORS | GLYCOSPHINGOLIPIDS | LIGANDS | metastasis | CANCER METASTASIS | carbohydrate sulfation | EXPRESSION | Sulfoglycosphingolipids - analysis | P-Selectin - metabolism | Humans | Cell Communication | Disease Progression | Carcinoma - chemistry | Neoplasm Metastasis | Animals | Ligands | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Carcinoma - metabolism | Sulfoglycosphingolipids - metabolism | Tumor Cells, Cultured | Carcinoma - pathology
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13. Full Text Selectins as Mediators of Lung Metastasis
by Läubli, Heinz and Borsig, Lubor
Cancer Microenvironment, ISSN 1875-2292, 12/2010, Volume 3, Issue 1, pp. 97 - 105
Lung metastasis remains the major cause of cancer related mortality in patients with breast, gastrointestinal, sarcoma, melanoma and kidney cancer. Here we... 
Biochemistry, general | Carcinomas | Tumor microenvironment | Oncology | Metastasis | Biomedicine general | Cell Biology | Endothelium | Metastatic microenvironment | Biomedicine | Immunology | Selectins | Cancer Research | Sarcoma | Analysis | Melanoma | Tumors
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14. CCL2-CCR2 signaling in disease pathogenesis
by O’Connor, Tracy and Borsig, Lubor and Heikenwalder, Mathias
Endocrine, Metabolic and Immune Disorders - Drug Targets, ISSN 1871-5303, 06/2015, Volume 15, Issue 2, pp. 105 - 118
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years.... 
Chemokine | MCP-1 | Autoimmune disease | CCL2 | CNS | Metastasis | Cancer | CCR2 | chemokine | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | COLONY-STIMULATING FACTOR | FOCAL CEREBRAL-ISCHEMIA | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | MICROVASCULAR ENDOTHELIAL-CELLS | AMYOTROPHIC-LATERAL-SCLEROSIS | CHEMOKINE RECEPTOR CCR2 | IMMUNOLOGY | ACUTE EXCITOTOXIC INJURY | metastasis | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGY & PHARMACY | cancer | CENTRAL-NERVOUS-SYSTEM | TRANSGENIC MOUSE MODEL
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15. Full Text Selectins Facilitate Carcinoma Metastasis and Heparin Can Prevent Them
by Borsig, Lubor
News in Physiological Sciences, ISSN 0886-1714, 02/2004, Volume 19, Issue 1, pp. 16 - 21
Selectins are cell adhesion molecules mediating attachment of leukocytes to activated endothelium, as well as the adhesion reaction of tumors during... 
MUCINS | CELLS | LEUKOCYTES | LIGANDS | PLATELETS | TUMOR-METASTASIS | P-SELECTIN | TROUSSEAU-SYNDROME | CANCER | Heparin - therapeutic use | Selectins - metabolism | Antineoplastic Agents - therapeutic use | Neoplasm Metastasis - prevention & control | Humans | Neoplasm Metastasis - physiopathology
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16. Full Text Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+cells through TLR4
by Ekaterina Kurakevich and Thierry Hennet and Martin Hausmann and Gerhard Rogler and Lubor Borsig
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17444 - 17449
Breast milk oligosaccharides shape the intestinal environment by affecting mucosal immunity and bacterial colonization. To clarify the role of milk... 
T lymphocytes | Inflammatory bowel diseases | Dendritic cells | Cytokines | Mice | Inflammation | Oligosaccharides | Colitis | Leukocytes | Neutrophil infiltration | Carbohydrate | Mouse innate immunity | Glycan | Prebiotics | CAMPYLOBACTER-JEJUNI | mouse innate immunity | TGF-BETA | DENDRITIC CELLS | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | SIALIC-ACID | carbohydrate | ENTEROCOLITIS | glycan | INFLAMMATORY-BOWEL-DISEASE | prebiotics | DIFFERENTIATION | POLARIZATION | T-CELLS | Immunity, Mucosal - immunology | Milk - chemistry | Lactose - immunology | Colitis - genetics | Dendritic Cells - immunology | Lactose - analogs & derivatives | Sialyltransferases - immunology | Male | Intestines - metabolism | CD11c Antigen - immunology | Gastrointestinal Tract - pathology | Intestines - immunology | CD11c Antigen - metabolism | Gastrointestinal Tract - immunology | Bacteria - immunology | Flow Cytometry | Lactose - metabolism | Gene Expression - immunology | Bacteria - classification | Female | Milk - immunology | Colitis - immunology | Sialic Acids - immunology | Cytokines - genetics | Immunity, Mucosal - genetics | Dendritic Cells - metabolism | Cytokines - immunology | Animals, Newborn | Lactation - immunology | Interleukin-10 - deficiency | Cytokines - metabolism | Mice, Inbred C57BL | Sialyltransferases - deficiency | Cells, Cultured | Sialic Acids - metabolism | Sialyltransferases - genetics | Gastrointestinal Tract - microbiology | Toll-Like Receptor 4 - immunology | Reverse Transcriptase Polymerase Chain Reaction | Bacteria - genetics | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Animals | Interleukin-10 - genetics | Colitis - metabolism | Interleukin-10 - immunology | Intestines - cytology | Biological Sciences
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17. Full Text Selectins promote tumor metastasis
by Läubli, Heinz and Borsig, Lubor
Seminars in Cancer Biology, ISSN 1044-579X, 2010, Volume 20, Issue 3, pp. 169 - 177
Abstract Cancer metastasis is facilitated by cell–cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell... 
Hematology, Oncology and Palliative Medicine | Carcinomas | Metastatic microenvironment | Selectin | Mucin | Metastasis | ACTIVATED PROTEIN-KINASE | MULTIPLE ORGAN FAILURE | DEFICIENT MICE | MAJOR E-SELECTIN | COLON-CARCINOMA CELLS | BREAST-CANCER | ENDOTHELIAL P-SELECTIN | ONCOLOGY | DEPENDENT LEUKOCYTE RECRUITMENT | CANCER METASTASIS | IN-VIVO | Cell Adhesion - genetics | Selectins - physiology | Humans | Selectins - genetics | Disease Progression | Neoplasm Metastasis - genetics | Selectins - metabolism | Animals | Neoplastic Stem Cells - metabolism | Cell Adhesion - physiology | Models, Biological | Neoplasm Metastasis - pathology | Stem Cell Niche - metabolism | Neoplastic Stem Cells - pathology | Ligands | Stem Cell Niche - pathology | Endothelium | Integrins
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