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Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Lung Neoplasms - secretion | Melanoma - secretion | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - secretion | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
Journal Article
Cancer Research, ISSN 0008-5472, 06/2007, Volume 67, Issue 12, pp. 5649 - 5657
Despite an extensive body of evidence linking UV radiation and melanoma tumorigenesis, a clear mechanistic understanding of this process is still lacking.... 
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 11/2012, Volume 491, Issue 7424, pp. 449 - 453
Journal Article
by Akbani, Rehan and Akdemir, Kadir C and Aksoy, B. Arman and Albert, Monique and Ally, Adrian and Amin, Samirkumar B and Arachchi, Harindra and Arora, Arshi and Auman, J. Todd and Ayala, Brenda and Baboud, Julien and Balasundaram, Miruna and Balu, Saianand and Barnabas, Nandita and Bartlett, John and Bartlett, Pam and Bastian, Boris C and Baylin, Stephen B and Behera, Madhusmita and Belyaev, Dmitry and Benz, Christopher and Bernard, Brady and Beroukhim, Rameen and Bir, Natalie and Black, Aaron D and Bodenheimer, Tom and Boice, Lori and Boland, Genevieve M and Bono, Riccardo and Bootwalla, Moiz S and Bosenberg, Marcus and Bowen, Jay and Bowlby, Reanne and Bristow, Christopher A and Brockway-Lunardi, Laura and Brooks, Denise and Brzezinski, Jakub and Bshara, Wiam and Buda, Elizabeth and Burns, William R and Butterfield, Yaron S.N and Button, Michael and Calderone, Tiffany and Cappellini, Giancarlo Antonini and Carter, Candace and Carter, Scott L and Cherney, Lynn and Cherniack, Andrew D and Chevalier, Aaron and Chin, Lynda and Cho, Juok and Cho, Raymond J and Choi, Yoon-La and Chu, Andy and Chudamani, Sudha and Cibulskis, Kristian and Ciriello, Giovanni and Clarke, Amanda and Coons, Stephen and Cope, Leslie and Crain, Daniel and Curley, Erin and Danilova, Ludmila and D’Atri, Stefania and Davidsen, Tanja and Davies, Michael A and Delman, Keith A and Demchok, John A and Deng, Qixia A and Deribe, Yonathan Lissanu and Dhalla, Noreen and Dhir, Rajiv and DiCara, Daniel and Dinikin, Michael and Dubina, Michael and Ebrom, J. Stephen and Egea, Sophie and Eley, Greg and Engel, Jay and Eschbacher, Jennifer M and Fedosenko, Konstantin V and Felau, Ina and Fennell, Timothy and Ferguson, Martin L and Fisher, Sheila and Flaherty, Keith T and Frazer, Scott and Frick, Jessica and Fulidou, Victoria and Gabriel, Stacey B and Gao, Jianjiong and Gardner, Johanna and Garraway, Levi A and Gastier-Foster, Julie M and Gaudioso, Carmelo and Gehlenborg, Nils and Genovese, Giannicola and Gerken, Mark and Gershenwald, Jeffrey E and Getz, Gad and ... and Canc Genome Atlas Network and Cancer Genome Atlas Network
Cell, ISSN 0092-8674, 06/2015, Volume 161, Issue 7, pp. 1681 - 1696
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 6, pp. E536 - E545
Journal Article
Immunity, ISSN 1074-7613, 05/2016, Volume 44, Issue 5, pp. 1190 - 1203
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2013, Volume 110, Issue 45, pp. 18226 - 18231
Inhibitors of BRAF protein kinase, such as Vemurafenib and Dabrafenib, have shown remarkable antitumor activity in patients with BRAF mutant melanoma. However,... 
Vemurafenib | LKB1 | Biological Sciences
Journal Article
Cancer Discovery, ISSN 2159-8274, 02/2016, Volume 6, Issue 2, pp. 202 - 216
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2012, Volume 44, Issue 9, pp. 1006 - 1014
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