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administration, oral; adult; bupropion/administration & dosage; bupropion/blood; caffeine/administration & dosage; caffeine/blood; capsules; carbonated beverages; chromatography, high pressure liquid; chromatography, reverse-phase; coffee; cytochrome p-450 enzyme system/antagonists & inhibitors; cytochrome p-450 enzyme system/blood; dextromethorphan/administration & dosage; dextromethorphan/blood; dried blood spot testing; enzyme inhibitors/administration & dosage; feasibility studies; flurbiprofen/administration & dosage; flurbiprofen/blood; humans; isoenzymes; male; midazolam/administration & dosage; midazolam/blood; omeprazole/administration & dosage; omeprazole/blood; p-glycoprotein/antagonists & inhibitors; p-glycoprotein/blood; pharmaceutical preparations/administration & dosage; pharmaceutical preparations/blood; phenotype; pilot projects; predictive value of tests; spectrometry, mass, electrospray ionization; substrate specificity; tandem mass spectrometry; terfenadine/administration & dosage; terfenadine/analogs & derivatives; young adult (1) 1
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antineoplastic agents, phytogenic - adverse effects (1) 1
articles (1) 1
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atp binding cassette transporter, subfamily b - genetics (1) 1
atp-binding cassette, sub-family b, member 1 - antagonists & inhibitors (1) 1
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biochemical research methods (1) 1
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bupropion - metabolism (1) 1
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Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2015, Volume 37, Issue 8, pp. e134 - e134
  Case Presentation We report the case of a 21-year old African male patient who received vincristine 2 mg on 3 occasions (on 14.10, 30.10 and 06.11.14) for... 
Internal Medicine | Medical Education | Antimitotic agents | Antineoplastic agents | Cytochrome P-450 | Neurotoxicity | Pain
Journal Article
Journal of Clinical Psychiatry, ISSN 0160-6689, 03/2018, Volume 79, Issue 2, p. 16
Objective: Drug-metabolizing enzymes (DMEs), such as cytochrome P450 (CYP) enzymes, and transporters have emerged as major determinants of variability in drug... 
IN-VITRO | SERUM CONCENTRATIONS | PLASMA-CONCENTRATIONS | SERTRALINE | CYP2D6 | PSYCHIATRY | MAJOR DEPRESSIVE DISORDER | HEALTHY-VOLUNTEERS | CYP2C19 | PSYCHOLOGY, CLINICAL | FLUOXETINE | VENLAFAXINE
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2015, Volume 37, Issue 8, pp. e101 - e101
  Conclusion DBS technique combined with an innovative sampling device and a sensitive analytical method can be used as a self-test for CYP and P-gp... 
Internal Medicine | Medical Education | Blood | Medical examination | Cytochrome | Metabolites | Sampling techniques
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2016, Volume 119, Issue 3, pp. 284 - 290
Cytochrome P450 ( CYP ) activity can be assessed using a ‘cocktail’ phenotyping approach. Recently, we have developed a cocktail (Geneva cocktail) which... 
2D6 | PARAXANTHINE | BUPROPION | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FLURBIPROFEN | METABOLIZING-ENZYMES | COOPERSTOWN 5+1 COCKTAIL | ORAL-CONTRACEPTIVES | P-GLYCOPROTEIN | Caffeine - administration & dosage | Humans | Midazolam - administration & dosage | Male | Genotyping Techniques | Cytochrome P-450 CYP2B6 - metabolism | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Dried Blood Spot Testing - methods | Cytochrome P-450 CYP1A2 - genetics | Flurbiprofen - administration & dosage | Adult | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 CYP2B6 - genetics | Omeprazole - administration & dosage | Cytochrome P-450 CYP2C19 - genetics | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Bupropion - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Cross-Over Studies | Phenotype | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - administration & dosage | Medical examination | Drug interactions | Analysis | Methods | Blood | Cytochrome P-450 | Confidence intervals | Cytochrome | Prescription drugs | Drug dosages | Index Medicus
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2014, Volume 96, Issue 3, pp. 349 - 359
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and... 
P4502B6 ACTIVITY | VORICONAZOLE | LC-MS/MS | SINGLE-POINT | ORAL MIDAZOLAM | VOLUNTEERS | IN-VIVO | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | KAROLINSKA COCKTAIL | BUPROPION HYDROXYLATION | Predictive Value of Tests | Pharmaceutical Preparations - blood | Caffeine - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Dried Blood Spot Testing | Humans | Omeprazole - blood | Bupropion - blood | Midazolam - administration & dosage | Substrate Specificity | Male | Chromatography, High Pressure Liquid | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Coffee | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Feasibility Studies | Enzyme Inhibitors - administration & dosage | Young Adult | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Capsules | Spectrometry, Mass, Electrospray Ionization | Flurbiprofen - administration & dosage | Adult | Dextromethorphan - pharmacokinetics | Terfenadine - blood | ATP-Binding Cassette, Sub-Family B, Member 1 - blood | Pharmaceutical Preparations - administration & dosage | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 Enzyme System - blood | Administration, Oral | Isoenzymes | Caffeine - blood | Omeprazole - administration & dosage | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Carbonated Beverages | Midazolam - pharmacokinetics | Bupropion - administration & dosage | Dextromethorphan - blood | Flurbiprofen - blood | Phenotype | Pilot Projects | Midazolam - blood | Dextromethorphan - administration & dosage | Usage | Glycoproteins | Liquid chromatography | Research | Pharmacokinetics | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
Journal Article
Metabolism, ISSN 0026-0495, 2011, Volume 60, Issue 11, pp. 1584 - 1589
Journal Article
Bioanalysis, ISSN 1757-6180, 01/2014, Volume 6, Issue 2, pp. 151 - 164
Background: An LC-MS/MS method has been developed for the simultaneous quantification of P-glycoprotein (P-gp) and cytochrome P450 (CYP) probe substrates and... 
CHEMISTRY, ANALYTICAL | HPLC-MS/MS | ENZYMES | DRIED BLOOD SPOT | IN-VIVO | BIOCHEMICAL RESEARCH METHODS | PITTSBURGH COCKTAIL | VALIDATION | HUMANS | HEALTHY-VOLUNTEERS | FLURBIPROFEN
Journal Article
DOULEUR ET ANALGESIE, ISSN 1011-288X, 12/2013, Volume 26, Issue 4, pp. 209 - 217
The physiologic changes that accompany hepatic impairment alter the disposition of many drugs, analgesics included. Furthermore, complications such as... 
CHRONIC LIVER-DISEASE | MORPHINE | Liver disease | PHARMACODYNAMICS | DISPOSITION | CLINICAL NEUROLOGY | Analgesia | Hepatic impairment | THE-COUNTER ANALGESICS | METABOLISM | ACETAMINOPHEN | ALFENTANIL PHARMACOKINETICS | CIRRHOTIC SUBJECTS | ANTIINFLAMMATORY DRUGS
Journal Article
Douleur et Analgesie, ISSN 1011-288X, 12/2013, Volume 26, Issue 4, p. 209
Les changements physiologiques survenant lors d'une insuffisance hepatique peuvent alterer la disposition de nombreux medicaments y compris les analgesiques.... 
Liver diseases | Analgesics
Journal Article
Douleur et Analgésie, ISSN 1011-288X, 12/2013, Volume 26, Issue 4, pp. 209 - 217
Les changements physiologiques survenant lors d’une insuffisance hépatique peuvent altérer la disposition de nombreux médicaments y compris les analgésiques.... 
Rheumatology | Liver disease | Intensive / Critical Care Medicine | Dentistry | Neurology | Analgesia | Pain Medicine | Atteinte du foie | Hepatic impairment | Medicine & Public Health | Analgésie | Anesthesiology | Insuffisance hépatique
Journal Article
Douleur et Analgesie, ISSN 1011-288X, 12/2013, Volume 26, Issue 4, pp. 209 - 217
Journal Article
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