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humans (4) 4
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break repair (2) 2
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devices providing patency to, or preventing collapsing of,tubular structures of the body, e.g. stents (1) 1
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1. Full Text Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage
by Zhang, Jian-Ping and Li, Xiao-Lan and Li, Guo-Hua and Chen, Wanqiu and Arakaki, Cameron and Botimer, Gary D and Baylink, David and Zhang, Lu and Wen, Wei and Fu, Ya-Wen and Xu, Jing and Chun, Noah and Yuan, Weiping and Cheng, Tao and Zhang, Xiao-Bing
Genome Biology, ISSN 1474-7596, 02/2017, Volume 18, Issue 1, p. 35
Background: Precise genome editing via homology-directed repair (HDR) after double-stranded DNA (dsDNA) cleavage facilitates functional genomic research and... 
CRISPR | Homology-directed repair (HDR) | Donor design | Human induced pluripotent stem cells | Genome editing | Knockin | 293 T | Non-homologous end joining (NHEJ) | MEDIATED TARGETED INTEGRATION | POINT MUTATION | ZINC-FINGER NUCLEASES | MAMMALIAN-CELLS | GUIDE RNAS | CAS9 RIBONUCLEOPROTEINS | PLURIPOTENT STEM-CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BREAK REPAIR | GENETICS & HEREDITY | GENE CORRECTION | HOMOLOGY-DIRECTED REPAIR | Cell Cycle - genetics | Gene Targeting - methods | Recombinational DNA Repair | DNA | Humans | CRISPR-Cas Systems | HEK293 Cells | Repressor Proteins - genetics | Genetic Loci | DNA Cleavage | beta Catenin - genetics | Induced Pluripotent Stem Cells - metabolism | Cloning | Genes | Stem cell transplantation | Homology | Genomes | Lymphocytes T | Ribonucleic acid--RNA | DNA repair | Proteins | Nocodazole | Plasmids | Lymphocytes | Efficiency | Stem cells | Cell cycle | Gene therapy | Pluripotency | Deoxyribonucleic acid--DNA | Inhibitory postsynaptic potentials
Journal Article
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2. Full Text Highly efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression
by Li, Xiao-Lan and Li, Guo-Hua and Fu, Juan and Fu, Ya-Wen and Zhang, Lu and Chen, Wanqiu and Arakaki, Cameron and Zhang, Jian-Ping and Wen, Wei and Zhao, Mei and Chen, Weisheng V and Botimer, Gary D and Baylink, David and Aranda, Leslie and Choi, Hannah and Bechar, Rachel and Talbot, Prue and Sun, Chang-Kai and Cheng, Tao and Zhang, Xiao-Bing
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 19, pp. 10195 - 10215
Abstract Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine.... 
SURVIVAL | APOPTOSIS | ELECTROPORATION | RNA | GENE | BREAK REPAIR | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENERATION | HOMOLOGOUS RECOMBINATION | P53 | Jurkat Cells | Humans | Cells, Cultured | bcl-X Protein - genetics | Up-Regulation - genetics | Genome, Human - genetics | Animals | Transfection | CRISPR-Cas Systems - physiology | HEK293 Cells | K562 Cells | Gene Editing - methods | Mice | Induced Pluripotent Stem Cells - metabolism | Molecular Biology
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3. Full Text A comparison of Staphylococcus aureus biofilm formation on cobalt-chrome and titanium-alloy spinal implants
by Patel, Shalin S and Aruni, Wilson and Inceoglu, Serkan and Akpolat, Yusuf T and Botimer, Gary D and Cheng, Wayne K and Danisa, Olumide A
Journal of Clinical Neuroscience, ISSN 0967-5868, 2016, Volume 31, pp. 219 - 223
Highlights • The use of cobalt chrome (CoCr) implants in spinal surgery has become increasingly popular. • Biofilm formation on CoCr and titanium-alloy... 
Neurology | Titanium alloy | Biofilm | Cobalt chrome | Spinal implant | Staphylococcus aureus | SITE | BACTERIAL ADHERENCE | RODS | NEUROSCIENCES | CLINICAL NEUROLOGY | STAINLESS-STEEL | BIOMATERIALS | INFECTION | EPIDERMIDIS | Chromium Alloys | Prosthesis-Related Infections - microbiology | Orthopedic Procedures - instrumentation | Staphylococcus aureus - physiology | Humans | Biofilms - growth & development | Titanium | Prostheses and Implants - microbiology | Staphylococcal Infections - microbiology | Spine - surgery | Prosthesis | Implants, Artificial | Alloys | Chromium | Comparative analysis | Cobalt
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4. Full Text Generation of integration-free induced pluripotent stem cells from human peripheral blood mononuclear cells using episomal vectors
by Wen, Wei and Zhang, Jian-Ping and Chen, Wanqiu and Arakaki, Cameron and Li, Xiaolan and Baylink, David and Botimer, Gary D and Xu, Jing and Yuan, Weiping and Cheng, Tao and Zhang, Xiao-Bing
Journal of Visualized Experiments, ISSN 1940-087X, 01/2017, Volume 2017, Issue 119
Induced Pluripotent Stem Cells (iPSCs) hold great promise for disease modeling and regenerative therapies. We previously reported the use of Episomal Vectors... 
Hematopoietic progenitor cells (HPCs) | Integration-free | Reprogramming | Developmental biology | Episomal vectors | Issue 119 | Peripheral blood mononuclear cells (PB MNC) | Induced pluripotent stem cells (iPSCs) | SYSTEM | hematopoietic progenitor cells (HPCs) | MULTIDISCIPLINARY SCIENCES | integration-free | CORD BLOOD | COMBINATION | episomal vectors | reprogramming | peripheral blood mononuclear cells (PB MNC) | induced pluripotent stem cells (iPSCs) | MUTATIONS | Developmental Biology | T-CELLS | Cell Differentiation - genetics | Epstein-Barr Virus Nuclear Antigens - genetics | Humans | Leukocytes, Mononuclear - cytology | Genetic Vectors | Induced Pluripotent Stem Cells - cytology | Plasmids - metabolism | Cellular Reprogramming
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5. Full Text High-Level Precise Knockin of iPSCs by Simultaneous Reprogramming and Genome Editing of Human Peripheral Blood Mononuclear Cells
by Wen, Wei and Cheng, Xinxin and Cheng, Tao and Fu, Yawen and Meng, Feiying and Zhang, Feng and Zhang, Lu and Zhang, Xiao-Bing and Zhang, Jian-Ping and Li, Xiao-Lan and Yang, Zhixue and Xu, Jing and Botimer, Gary D and Yuan, Weiping and Sun, Changkai
Stem Cell Reports, ISSN 2213-6711, 06/2018, Volume 10, Issue 6, pp. 1821 - 1834
We have developed an improved episomal vector system for efficient generation of integration-free induced pluripotent stem cells (iPSCs) from peripheral blood... 
reprogramming | genome editing | induced pluripotent stem cell | episomal vector | CRISPR-Cas9 | HDR | peripheral blood mononuclear cell | PLURIPOTENT STEM-CELLS | INTEGRATION | PLASMID | GENE CORRECTION | CRISPR-CAS | PATIENT | GENERATION | E-CADHERIN | INDUCTION | EFFICIENT | CELL & TISSUE ENGINEERING | CELL BIOLOGY
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6. Full Text TKA navigation using the medacta system
by Botimer, Gary D
01/2013, ISBN 3642297285
Book Chapter
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7. Limb clamp for surgery
by BOTIMER; GARY D
04/1998, 6
Embodiments of a limb clamp assembly are shown and described, each having one or more articulated arms for wrapping at least partially around a leg or other... 
TREATMENT OR PROTECTION OF EYES OR EARS | TRANSPORT OR ACCOMODATION FOR PATIENTS | HYGIENE | FILTERS IMPLANTABLE INTO BLOOD VESSELS | OPERATING TABLES OR CHAIRS | FUNERAL DEVICES | MEDICAL OR VETERINARY SCIENCE | DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS | HUMAN NECESSITIES | FIRST-AID KITS | ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES | BANDAGES, DRESSINGS OR ABSORBENT PADS | CHAIRS FOR DENTISTRY | PROSTHESES | FOMENTATION
Patent
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8. Full Text Experimental Studies of the Growth Kinetics of Methane Clathrate Hydrates & Superfluid Hydrodynamics on the Nanoscale
by Botimer, Jeffrey David
01/2016, ISBN 9781339829579
This thesis details the experimental findings of three distinct research projects. The first studies the growth kinetics of methane clathrate hydrates grown... 
Low Temperature Physics
Dissertation
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