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1. Full Text Regulation of leukocyte recruitment by the long pentraxin PTX3
by Doni, Andrea and Constantin, Gabriela and Salvatori, Giovanni and Sironi, Marina and Deban, Livija and Valentino, Sonia and Laudanna, Carlo and Garlanda, Cecilia and Moalli, Federica and Zambelli, Vanessa and Sassano, Marica and Danese, Silvio and Cuccovillo, Ivan and Bottazzi, Barbara and Bastone, Antonio and Scanziani, Margherita and Rossi, Barbara and Evangelista, Virgilio and Mantovani, Alberto and Zenaro, Elena and Russo, Remo Castro and Gobbi, Marco
Nature Immunology, ISSN 1529-2908, 04/2010, Volume 11, Issue 4, pp. 328 - 334
Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the... 
C-REACTIVE PROTEIN | HUMORAL INNATE IMMUNITY | ADHESION | SELECTIN GLYCOPROTEIN LIGAND-1 | AMYLOID-P COMPONENT | RECOGNITION | COMPLEMENT ACTIVATION | IN-VIVO | ACUTE LUNG INJURY | IMMUNOLOGY | TRANSGENIC MICE | Cricetinae | Serum Amyloid P-Component - immunology | Cricetulus | Cell Separation | Immunity, Humoral - immunology | Electrophoresis, Polyacrylamide Gel | Humans | Mice, Inbred C57BL | Inflammation - immunology | Leukocyte Rolling - immunology | Mice, Knockout | Animals | Flow Cytometry | Recombinant Proteins - immunology | Acute Lung Injury - immunology | Mice | C-Reactive Protein - immunology | CHO Cells | Neutrophil Infiltration - immunology | Physiological aspects | Development and progression | Natural immunity | Genetic aspects | Inflammation | Research | Leukocytes | Immunity
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2. Full Text Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
by Garlanda, Cecilia and Bottazzi, Barbara and Bastone, Antonio and Mantovani, Alberto
Annual Review of Immunology, ISSN 0732-0582, 2005, Volume 23, Issue 1, pp. 337 - 366
C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long... 
Extracellular matrix | Inflammatory response | Immune response | Fertility | Neurodegeneration | C-REACTIVE PROTEIN | REGULATES TISSUE FACTOR | FC-GAMMA RECEPTORS | fertility | inflammatory response | neurodegeneration | IMMUNOLOGY | ACUTE-PHASE PROTEINS | immune response | ACUTE MYOCARDIAL-INFARCTION | GROWTH-DIFFERENTIATION FACTOR-9 | LONG PENTRAXIN | CENTRAL-NERVOUS-SYSTEM | SERUM-AMYLOID-P | extracellular matrix | TRANSGENIC MICE | Serum Amyloid P-Component - immunology | Humans | Serum Amyloid P-Component - chemistry | Extracellular Matrix - metabolism | Serum Amyloid P-Component - physiology | C-Reactive Protein - genetics | Phylogeny | C-Reactive Protein - chemistry | C-Reactive Protein - physiology | Immunity, Innate | Inflammation - etiology | Fertility - physiology | Serum Amyloid P-Component - genetics | Models, Immunological | Animals | Female | Ligands | Nerve Degeneration - etiology | C-Reactive Protein - immunology
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3. Full Text Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3
by Mantovani, Alberto and Garlanda, Cecilia and Doni, Andrea and Bottazzi, Barbara
Journal of Clinical Immunology, ISSN 0271-9142, 1/2008, Volume 28, Issue 1, pp. 1 - 13
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in evolution. Based on the primary structure of the subunit, the pentraxins... 
Medical Microbiology | cardiovascular disease | Biomedicine | Immunology | innate immunity | inflammation | fertility | Internal Medicine | Infectious Diseases | Pentraxin | extracellular matrix | Cardiovascular disease | Extracellular matrix | Innate immunity | Inflammation | Fertility | NEURONAL PENTRAXIN | SERUM AMYLOID-P | REGULATES TISSUE FACTOR | DENDRITIC CELLS | pentraxin | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | ACUTE-PHASE PROTEINS | RECOGNITION RECEPTOR PTX3 | ACUTE MYOCARDIAL-INFARCTION | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | Serum Amyloid P-Component - immunology | Cytokines - metabolism | Receptors, Pattern Recognition - immunology | Humans | Receptors, Pattern Recognition - physiology | Gene Expression Regulation | Neutrophils - immunology | Serum Amyloid P-Component - chemistry | Complement System Proteins - immunology | Immune Tolerance | Serum Amyloid P-Component - physiology | Inflammation - immunology | C-Reactive Protein - chemistry | C-Reactive Protein - physiology | Immunity, Innate | Animals | Complement System Proteins - physiology | Female | Ligands | Neutrophils - metabolism | C-Reactive Protein - immunology | Cytokines - immunology | C-reactive protein
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4. Full Text An integrated view of humoral innate immunity: Pentraxins as a paradigm
by Bottazzi, Barbara and Doni, Andrea and Garlanda, Cecilia and Mantovani, Alberto
Annual Review of Immunology, ISSN 0732-0582, 04/2010, Volume 28, Issue 1, pp. 157 - 183
The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are... 
Phagocytes | Serum amyloid P component | Complement | Collectins | C reactive protein | Ficolins | C-REACTIVE PROTEIN | L-FICOLIN | serum amyloid P component | AMYLOID-P COMPONENT | phagocytes | MANNOSE-BINDING LECTIN | COMPLEMENT ACTIVATION | IMMUNOLOGY | SURFACTANT PROTEINS | collectins | CELLS IN-VIVO | GRAM-NEGATIVE BACTERIA | ficolins | APOPTOTIC CELLS | PATTERN-RECOGNITION MOLECULE | complement | Animals | Immunity, Humoral | Humans | Antibodies - immunology | Ligands | Immunity, Innate | C-Reactive Protein - immunology | Proteins | Physiological aspects | Properties | Immune system | Immunological research
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5. Full Text Pentraxins in innate immunity: lessons from PTX3
by Deban, Livija and Jaillon, Sebastien and Garlanda, Cecilia and Bottazzi, Barbara and Mantovani, Alberto
Cell and Tissue Research, ISSN 0302-766X, 1/2011, Volume 343, Issue 1, pp. 237 - 249
The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive... 
Human Genetics | Biomedicine | Proteomics | Innate immunity | Molecular Medicine | Inflammation | PTX3 | Pattern recognition | Pentraxins | C-REACTIVE PROTEIN | SERUM AMYLOID-P | DENDRITIC CELLS | COMPLEMENT ACTIVATION | FACTOR-H | CELL BIOLOGY | EPITHELIAL-CELLS | APOPTOTIC CELLS | ACUTE MYOCARDIAL-INFARCTION | RECOGNITION RECEPTOR PTX3 | LONG PENTRAXIN | Immunity, Innate - immunology | Serum Amyloid P-Component - immunology | Animals | Humans | Biomarkers | Complement System Proteins - immunology | Inflammation - immunology | Protein Isoforms - immunology | C-Reactive Protein - immunology | Microorganisms | Cells | Immune system
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6. Full Text The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules
by Mantovani, Alberto and Valentino, Sonia and Gentile, Stefania and Inforzato, Antonio and Bottazzi, Barbara and Garlanda, Cecilia
Annals of the New York Academy of Sciences, ISSN 0077-8923, 05/2013, Volume 1285, Issue 1, pp. 1 - 14
Pattern recognition molecules (PRMs) are components of the humoral arm of innate immunity; they recognize pathogen‐associated molecular patterns (PAMP) and are... 
pattern recognition molecules | PTX3 | innate immunity | pentraxins | Innate immunity | Pattern recognition molecules | Pentraxins | C-REACTIVE PROTEIN | CHRONIC HEART-FAILURE | FC-GAMMA RECEPTORS | COMPLEMENT ACTIVATION | INNATE IMMUNE-RESPONSE | IMMUNOLOGY | APOPTOTIC CELLS | ACUTE MYOCARDIAL-INFARCTION | SERUM-AMYLOID-P | CHRONIC KIDNEY-DISEASE | STREPTOCOCCUS-PNEUMONIAE INFECTION | Serum Amyloid P-Component - genetics | Serum Amyloid P-Component - immunology | Animals | Immunity, Humoral | Humans | Translational Medical Research | Serum Amyloid P-Component - chemistry | C-Reactive Protein - genetics | C-Reactive Protein - chemistry | C-Reactive Protein - immunology | Genes | Product development | Immune system | Proteins | Molecular structure | Prototypes | Activation | Complement | Pattern recognition | Recognition | Stimuli
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7. Full Text PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
by Antonietta Salustri and Cecilia Garlanda and Emilio Hirsch and Marika De Acetis and Alessia Maccagno and Barbara Bottazzi and Andrea Doni and Antonio Bastone and Giovanna Mantovani and Paolo Beck Peccoz and Giovanni Salvatori and David J. Mahoney and Anthony J. Day and Gregorio Siracusa and Luigina Romani and Alberto Mantovani
Development, ISSN 0950-1991, 04/2004, Volume 131, Issue 7, pp. 1577 - 1586
PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity against selected pathogens and in female fertility. Here, we report that... 
Extracellular matrix | Cumulus oophorus | Mouse | Fertility | Pentraxins | C-REACTIVE PROTEIN | AMYLOID-P COMPONENT | fertility | DEVELOPMENTAL BIOLOGY | pentraxins | cumulus oophorus | LONG PENTRAXIN PTX3 | mouse | FACTOR-STIMULATED GENE-6 | HYALURONIC-ACID SYNTHESIS | ACUTE-PHASE PROTEINS | MOUSE OOCYTES | CELL-OOCYTE COMPLEX | GROWTH-DIFFERENTIATION FACTOR-9 | MURAL GRANULOSA-CELLS | extracellular matrix | Spermatocytes - metabolism | Culture Techniques | Humans | Extracellular Matrix - metabolism | Male | Fertility - physiology | Oocytes - cytology | Fertility - genetics | C-Reactive Protein - metabolism | Female | Ovarian Follicle - cytology | Ovarian Follicle - metabolism | Cytokines - metabolism | Fertilization | C-Reactive Protein - genetics | Mice, Inbred Strains | Mice, Knockout | Serum Amyloid P-Component - genetics | Phenotype | Animals | Fertilization in Vitro | Oocytes - physiology | Hyaluronic Acid - metabolism | Mice | Serum Amyloid P-Component - metabolism
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8. PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer
by Cecilia Garlanda and Barbara Bottazzi and Elena Magrini and Antonio Inforzato and Alberto Mantovani
Physiological Reviews, ISSN 0031-9333, 04/2018, Volume 98, Issue 2, p. 623
Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern recognition molecule conserved in evolution which acts as a key component... 
Microbiology | Tissue engineering | Innate immunity | Inflammation | Pattern recognition | Proteins | Reperfusion | Ischemia | Immunity (humoral) | Extracellular matrix | Phagocytosis | Immune system | Cancer | Tumors
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9. Full Text Aging, inflammation and cancer
by Bottazzi, Barbara and Riboli, Elio and Mantovani, Alberto
Seminars in Immunology, ISSN 1044-5323, 12/2018, Volume 40, Issue C, pp. 74 - 82
Aging is a key aspect of neoplasia at the level of cells, individuals and populations. Unrestrained expression and production of inflammatory mediators is a... 
Inflammaging | Immunosenescence | Cancer | C-REACTIVE PROTEIN | PENTRAXIN 3 | DENDRITIC CELLS | IMMUNOLOGY | COLORECTAL-CANCER | CLONAL HEMATOPOIESIS | FUNCTIONAL-CHANGES | CARDIOVASCULAR-DISEASE | EPIGENETIC REGULATION | TUMOR-ASSOCIATED MACROPHAGES | INNATE IMMUNITY | Development and progression | Inflammation | Research institutes
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10. Full Text PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer
by Garlanda, Cecilia and Bottazzi, Barbara and Magrini, Elena and Inforzato, Antonio and Mantovani, Alberto
Physiological Reviews, ISSN 0031-9333, 04/2018, Volume 98, Issue 2, pp. 623 - 639
Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern recognition molecule conserved in evolution which acts as a key component... 
C-REACTIVE PROTEIN | COMPLEMENT FACTOR-H | AMYLOID-P COMPONENT | PHYSIOLOGY | PLASMA-LEVELS | PSEUDOMONAS-AERUGINOSA | ACUTE MYOCARDIAL-INFARCTION | CARDIOVASCULAR-DISEASE | INFLUENZA-A VIRUSES | EXTRACELLULAR-MATRIX | LONG PENTRAXIN PTX3 | Neoplasms - metabolism | Immunity, Innate - immunology | Animals | C-Reactive Protein - metabolism | Immunity, Humoral - immunology | Neoplasms - immunology | Humans | Inflammation - immunology | Serum Amyloid P-Component - metabolism | Wound Healing - immunology | Analysis | Homeostasis | Genetic aspects | Diagnosis | Research | Tissues | Immunity | Health aspects | Cancer | complement activation | cancer-related inflammation | PTX3 | innate immunity | pentraxins | inflammation
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11. Full Text The Long Pentraxin PTX3 in Bone Homeostasis and Pathology
by Parente, Raffaella and Sobacchi, Cristina and Bottazzi, Barbara and Mantovani, Alberto and Grčevic, Danka and Inforzato, Antonio
Frontiers in Immunology, ISSN 1664-3224, 11/2019, Volume 10
The innate immune system is equipped with a number of germ-line encoded soluble pattern recognition molecules (PRMs) that collectively mediate the humoral host... 
PTX3 | osteoblasts | pentraxins | periodontitis | osteoimmunology
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