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1. Full Text Genetic studies of body mass index yield new insights for obesity biology
by Locke, A.E and Kahali, B and Berndt, S.I and Justice, A.E and Pers, T.H and Day, F.R and Powell, C and Vedantam, S and Buchkovich, M.L and Yang, J and Croteau-Chonka, D.C and Esko, T and Fall, T and Ferreira, T and Gustafsson, S and Kutalik, Z and Luan, J and Magi, R and Randall, J.C and Winkler, T.W and Wood, A.R and Workalemahu, T and Faul, J.D and Smith, J.A and Zhao, J and Zhao, W and Chen, J and Fehrmann, R and Hedman, A.K and Karjalainen, J and Schmidt, E.M and Absher, D and Amin, N and Anderson, D and Beekman, M and Bolton, J.L and Bragg-Gresham, J.L and Buyske, S and Demirkan, A and Deng, G and Ehret, G.B and Feenstra, B and Feitosa, M.F and Fischer, K and Goel, A and Gong, J and Jackson, A.U and Kanoni, S and Kleber, M.E and Kristiansson, K and Lim, U and Lotay, V and Mangino, M and Leach, I. Mateo and Medina-Gomez, C and Medland, S.E and Nalls, M.A and Palmer, C.D and Pasko, D and Pechlivanis, S and Peters, M.J.W and Prokopenko, I and Shungin, D and Stancakova, A and Strawbridge, R.J and Sung, Y. Ju and Tanaka, T and Teumer, A and Trompet, S and Laan, S.W. van der and Setten, J. van and Vliet-Ostaptchouk, J.V. Van and Wang, Z and Yengo, L and Zhang, W and Isaacs, A and Albrecht, E and Arnlov, J and Arscott, G.M and Attwood, A.P and Bandinelli, S and Barrett, A and Bas, I.N and Bellis, C and Bennett, A.J and Berne, C and Blagieva, R and Bluher, M and Bohringer, S and Bonnycastle, L.L and Bottcher, Y and Boyd, H.A and Bruinenberg, M and Caspersen, I.H and Chen, Y.D and Clarke, R and Daw, E.W and Craen, A.J. de and Delgado, G and Dimitriou, M and ... and ADIPOGen Consortium and PAGE Consortium and LifeLines Cohort Study and MIGen Consortium and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and CKDGen Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and AGEN-BMI Working Grp and GLGC and International Endogene Consortium and AGEN-BMI Working Group and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GLGC and The GENIE Consortium and The AGEN-BMI Working Group and The MIGen Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Medicinsk genetik och genomik and Geriatrik and Uppsala universitet and Klinisk diabetologi och metabolism and Institutionen för immunologi, genetik och patologi and Molekylär medicin and Kardiovaskulär epidemiologi and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 197 - 206
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and... 
INDIVIDUALS | PROVIDES INSIGHTS | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | GLYCEMIC TRAITS | ARCHITECTURE | TOPIRAMATE | LOCI | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Age Factors | Humans | Male | Continental Population Groups - genetics | Adiposity - genetics | Obesity - genetics | Europe - ethnology | Obesity - metabolism | Insulin - metabolism | Synapses - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Glutamic Acid - metabolism | Energy Metabolism - genetics | Adipogenesis - genetics | Insulin Secretion | Quantitative Trait Loci - genetics | Body mass index | Obesity | Genetic research | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Studies | Genomics | Genetics | Biology | Genomes | Metabolic disorders | Meta-analysis | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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2. Full Text The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics–Pharmacogenomics
by Gottesman, O and Scott, S A and Ellis, S B and Overby, C L and Ludtke, A and Hulot, J‐S and Hall, J and Chatani, K and Myers, K and Kannry, J L and Bottinger, E P
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 08/2013, Volume 94, Issue 2, pp. 214 - 217
The exponential rise in genomics research over the past decade has yielded a growing number of sequence variants associated with medication response that may... 
PHARMACOLOGY & PHARMACY | Pharmacogenetics - organization & administration | Genetic Testing | Humans | Middle Aged | Databases, Genetic | Male | Electronic Health Records - organization & administration | Outcome and Process Assessment (Health Care) | Genomics - organization & administration | Health Personnel | Female | Decision Support Systems, Clinical - organization & administration | Precision Medicine - methods | clinical implementation | pharmacogenomics | clinical decision support | biobank | personalized medicine
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3. Full Text Apoptosis in podocytes induced by TGF-β and Smad7
by Schiffer, M and Bitzer, M and Roberts, I.S.D and Kopp, J.B and Dijke, P and Mundel, P and Böttinger, E.P
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 6, pp. 807 - 816
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4. Full Text Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
by Jones, G.T and Tromp, G and Kuivaniemi, H and Gretarsdottir, S and Baas, A.F and Giusti, B and Strauss, E and Hof, F.N. van 't and Webb, T.R and Erdman, R and Ritchie, M.D and Elmore, J.R and Verma, A and Pendergrass, S and Kullo, I.J and Ye, Z and Peissig, P.L and Gottesman, O and Verma, S.S and Malinowski, J and Rasmussen-Torvik, L.J and Borthwick, K.M and Smelser, D.T and Crosslin, D.R and Anade, M. de and Ryer, E.J and McCarty, C.A and Bottinger, E.P and Pacheco, J.A and Crawford, D.C and Carrell, D.S and Gerhard, G.S and Franklin, D.P and Carey, D.J and Phillips, V.L and Williams, M.J and Wei, W and Blair, R and Hill, A.A and Vasudevan, T.M and Lewis, D.R and Thomson, I.A and Krysa, J and Hill, G.B and Roake, J and Merriman, T.R and Oszkinis, G and Galora, S and Saracini, C and Abbate, R and Pulli, R and Pratesi, C and Saratzis, A and Verissimo, A.R and Bumpstead, S and Badger, S.A and Clough, R.E and Cockerill, G and Hafez, H and Scott, D.J and Futers, T.S and Romaine, S.P and Bridge, K and Griffin, K.J and Bailey, M.A and Smith, A and Thompson, M.M and Bockxmeer, F.M. van and Matthiasson, S.E and Thorleifsson, G and Thorsteinsdottir, U and Blankensteijn, J.D and Teijink, J.A and Wijmenga, C and Graaf, J. de and Kiemeney, L.A.L.M and Lindholt, J.S and Hughes, A and Bradley, D.T and Stirrups, K and Golledge, J and Norman, P.E and Powell, J.T and Humphries, S.E and Hamby, S.E and Goodall, A.H and Nelson, C.P and Sakalihasan, N and Courtois, A and Ferrell, R.E and Eriksson, P and Folkersen, L and Franco-Cereceda, A and Eicher, J.D and Johnson, A.D and Betsholtz, C and Ruusalepp, A and Franzen, O and Schadt, E.E and Bjorkegren, J.L and ... and Cardiogenics Consortium and Int Consortium Blood Pressure and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Vaskulärbiologi
Circulation Research, ISSN 0009-7330, 2017, Volume 120, Issue 2, pp. 341 - 353
RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci... 
computational biology | meta-analysis | genetics | aortic aneurysm abdominal | matrix metalloproteinases | genome-wide association study | C-REACTIVE PROTEIN | TRANSCRIPTION FACTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | SEQUENCE VARIANT | aortic aneurysm, abdominal | SUSCEPTIBILITY LOCI | ELECTRONIC MEDICAL-RECORDS | HUMAN PREFRONTAL CORTEX | DENSITY-LIPOPROTEIN CHOLESTEROL | PERIPHERAL VASCULAR DISEASE | CANDIDATE GENE ASSOCIATION | HEMATOLOGY | RECEPTOR-RELATED PROTEIN-1 | CORONARY-ARTERY-DISEASE | Aortic Aneurysm, Abdominal - diagnosis | Genetic Predisposition to Disease - genetics | Humans | Genetic Loci - genetics | Genome-Wide Association Study - trends | Aortic Aneurysm, Abdominal - genetics | Genetic Variation - genetics | Aortic Aneurysm, Abdominal - epidemiology | Genetic Predisposition to Disease - epidemiology | Genome-Wide Association Study - methods | Diabetes mellitus | Coronary artery | Aneurysm | Aneurysms | Lipids | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Risk factors | Gelatinase B | Chromosome 1 | Interleukin 6 | Interleukin 6 receptors | Aorta | Lipoprotein (low density) receptors | Blood pressure | Chromosome 13 | Heritability | Cardiovascular diseases | Heart diseases | 10082 | Clinical Track | 10084 | 10185 | 10195 | 10014 | Medical and Health Sciences | Hematology | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | aortic aneurysm | Hematologi | abdominal
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5. Full Text Implementing Algorithm‐Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive CYP2C9 and VKORC1 Genetic Testing
by Obeng, A Owusu and Kaszemacher, T and Abul‐Husn, NS and Gottesman, O and Vega, A and Waite, E and Myers, K and Cho, J and Bottinger, EP and Ellis, SB and Scott, SA
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 11/2016, Volume 100, Issue 5, pp. 427 - 430
Implementation of pharmacogenetic‐guided warfarin dosing has been hindered by inconsistent results from reported clinical trials and a lack of available... 
PHARMACOLOGY & PHARMACY | PHARMACOGENOMICS | Pharmacogenetics - methods | Genetic Testing | Anticoagulants - administration & dosage | Humans | Warfarin - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Polymorphism, Genetic | Dose-Response Relationship, Drug | Drug Dosage Calculations | Algorithms | Ethnic Groups | Electronic Health Records | Vitamin K Epoxide Reductases - genetics | Warfarin | Usage | Ethnic groups | Medical records | Dosage and administration | Research | Health aspects | Genetic screening
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6. Full Text Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry
by Horowitz, C.R and Abul-Husn, N.S and Ellis, S and Ramos, M.A and Negron, R and Suprun, M and Zinberg, R.E and Sabin, T and Hauser, D and Calman, N and Bagiella, E and Bottinger, E.P
Contemporary Clinical Trials, ISSN 1551-7144, 2016, Volume 47, pp. 101 - 108
Abstract People of African ancestry (Blacks) have increased risk of kidney failure due to numerous socioeconomic, environmental, and clinical factors. Two... 
Hematology, Oncology and Palliative Medicine | Cardiovascular | African ancestry | Genetics | Chronic kidney disease | Disparities | Community-based research | Race | MEDICINE, RESEARCH & EXPERIMENTAL | STROKE PREVENTION | CLINICAL-TRIAL | KIDNEY-FUNCTION DECLINE | APOL1 VARIANTS | RACIAL DISPARITIES | PHARMACOLOGY & PHARMACY | HEALTH-CARE | PERSONALIZED MEDICINE | VARIANTS ASSOCIATE | RECRUITING MINORITIES | RISK-ASSESSMENT | Genetic Predisposition to Disease | Primary Health Care - methods | Lipoproteins, HDL - genetics | Risk Assessment | Humans | Middle Aged | Decision Support Techniques | African Americans - genetics | Genetic Counseling - methods | Genetic Testing - methods | Polymorphism, Genetic | Young Adult | Apolipoproteins - genetics | Adolescent | Apolipoprotein L1 | Renal Insufficiency, Chronic - genetics | Adult | Aged | Hypertension - genetics | Hypertension | Kidney diseases | Genomics | Genetic screening | Chronic Kidney Disease | African Ancestry | Community-Based Research
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7. Full Text Dietary fat and reduced levels of TGFβ1 act synergistically to promote activation of the vascular endothelium and formation of lipid lesions
by Grainger, D.J and Mosedale, D.E and Metcalfe, J.C and Bottinger, E.P
Journal of Cell Science, ISSN 0021-9533, 2000, Volume 113, Issue 13, pp. 2355 - 2361
Atherosclerosis | Inflammation | Cholesterol
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8. Full Text Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI
by Gong, J and Nishimura, K.K and Fernandez-Rhodes, L and Haessler, J and Bien, S and Graff, M and Lim, U and Lu, Y and Gross, M and Fornage, M and Yoneyama, S and Isasi, C.R and Buzkova, P and Daviglus, M and Lin, D.-Y and Tao, R and Goodloe, R and Bush, W.S and Farber-Eger, E and Boston, J and Dilks, H.H and Ehret, G and Gu, C.C and Lewis, C.E and Nguyen, K.-D.H and Cooper, R and Leppert, M and Irvin, M.R and Bottinger, E.P and Wilkens, L.R and Haiman, C.A and Park, L and Monroe, K.R and Cheng, I and Stram, D.O and Carlson, C.S and Jackson, R and Kuller, L and Houston, D and Kooperberg, C and Buyske, S and Hindorff, L.A and Crawford, D.C and Loos, R.J.F and Le Marchand, L and Matise, T.C and North, K.E and Peters, U
International Journal of Obesity, ISSN 0307-0565, 03/2018, Volume 42, Issue 3, pp. 384 - 390
OBJECTIVE: Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been... 
COMMON VARIANTS | OBESITY | NUTRITION & DIETETICS | METAANALYSIS | GENOTYPE IMPUTATION | ENDOCRINOLOGY & METABOLISM | BODY-MASS INDEX | POPULATIONS | GENETIC-LOCI | AFRICAN-AMERICANS | GENOME-WIDE ASSOCIATION | EPIDEMIOLOGY PAGE | Body Mass Index | Genome-Wide Association Study | Genomics | Humans | Polymorphism, Single Nucleotide - genetics | Continental Population Groups - genetics | Continental Population Groups - statistics & numerical data | Quantitative trait loci | Body mass index | Disease susceptibility | Genetic aspects | Health aspects | Populations | Adipose tissue | Data processing | Population studies | Genomes | Single-nucleotide polymorphism | Regression analysis | Metabolism | Minority & ethnic groups | Epidemiology | Population genetics | Loci | Ethnic factors | Chromosome 1 | Consortia | American Indians | Ethnicity | Replicating | Body mass | Body size | Race | Polygenic inheritance
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