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1. Full Text The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics–Pharmacogenomics
by Gottesman, O and Scott, S A and Ellis, S B and Overby, C L and Ludtke, A and Hulot, J‐S and Hall, J and Chatani, K and Myers, K and Kannry, J L and Bottinger, E P
Clinical pharmacology and therapeutics, ISSN 0009-9236, 08/2013, Volume 94, Issue 2, pp. 214 - 217
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Pharmacogenetics - organization & administration | Genetic Testing | Humans | Middle Aged | Databases, Genetic | Male | Electronic Health Records - organization & administration | Outcome and Process Assessment (Health Care) | Genomics - organization & administration | Health Personnel | Female | Decision Support Systems, Clinical - organization & administration | Precision Medicine - methods | Index Medicus | Abridged Index Medicus | clinical implementation | pharmacogenomics | clinical decision support | biobank | personalized medicine
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2. Full Text Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
by Jones, G.T and Tromp, G and Kuivaniemi, H and Gretarsdottir, S and Baas, A.F and Giusti, B and Strauss, E and Hof, F.N. van 't and Webb, T.R and Erdman, R and Ritchie, M.D and Elmore, J.R and Verma, A and Pendergrass, S and Kullo, I.J and Ye, Z and Peissig, P.L and Gottesman, O and Verma, S.S and Malinowski, J and Rasmussen-Torvik, L.J and Borthwick, K.M and Smelser, D.T and Crosslin, D.R and Anade, M. de and Ryer, E.J and McCarty, C.A and Bottinger, E.P and Pacheco, J.A and Crawford, D.C and Carrell, D.S and Gerhard, G.S and Franklin, D.P and Carey, D.J and Phillips, V.L and Williams, M.J and Wei, W and Blair, R and Hill, A.A and Vasudevan, T.M and Lewis, D.R and Thomson, I.A and Krysa, J and Hill, G.B and Roake, J and Merriman, T.R and Oszkinis, G and Galora, S and Saracini, C and Abbate, R and Pulli, R and Pratesi, C and Saratzis, A and Verissimo, A.R and Bumpstead, S and Badger, S.A and Clough, R.E and Cockerill, G and Hafez, H and Scott, D.J and Futers, T.S and Romaine, S.P and Bridge, K and Griffin, K.J and Bailey, M.A and Smith, A and Thompson, M.M and Bockxmeer, F.M. van and Matthiasson, S.E and Thorleifsson, G and Thorsteinsdottir, U and Blankensteijn, J.D and Teijink, J.A and Wijmenga, C and Graaf, J. de and Kiemeney, L.A.L.M and Lindholt, J.S and Hughes, A and Bradley, D.T and Stirrups, K and Golledge, J and Norman, P.E and Powell, J.T and Humphries, S.E and Hamby, S.E and Goodall, A.H and Nelson, C.P and Sakalihasan, N and Courtois, A and Ferrell, R.E and Eriksson, P and Folkersen, L and Franco-Cereceda, A and Eicher, J.D and Johnson, A.D and Betsholtz, C and Ruusalepp, A and Franzen, O and Schadt, E.E and Bjorkegren, J.L and ... and Cardiogenics Consortium and Int Consortium Blood Pressure
Circulation research, ISSN 0009-7330, 2017, Volume 120, Issue 2, pp. 341 - 353
computational biology | meta-analysis | genetics | aortic aneurysm abdominal | matrix metalloproteinases | genome-wide association study | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Aortic Aneurysm, Abdominal - diagnosis | Genetic Predisposition to Disease - genetics | Humans | Genetic Loci - genetics | Genome-Wide Association Study - trends | Aortic Aneurysm, Abdominal - genetics | Genetic Variation - genetics | Aortic Aneurysm, Abdominal - epidemiology | Genetic Predisposition to Disease - epidemiology | Genome-Wide Association Study - methods | Diabetes mellitus | Coronary artery | Aneurysm | Aneurysms | Lipids | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Risk factors | Gelatinase B | Chromosome 1 | Interleukin 6 | Interleukin 6 receptors | Aorta | Lipoprotein (low density) receptors | Blood pressure | Chromosome 13 | Heritability | Cardiovascular diseases | Heart diseases | Index Medicus | 10082 | Clinical Track | 10084 | 10185 | 10195 | aortic aneurysm, abdominal | 10014 | Medicin och hälsovetenskap
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3. Full Text Apoptosis in podocytes induced by TGF-β and Smad7
by Schiffer, M and Bitzer, M and Roberts, I.S.D and Kopp, J.B and Dijke, P and Mundel, P and Böttinger, E.P
The Journal of clinical investigation, ISSN 0021-9738, 2001, Volume 108, Issue 6, pp. 807 - 816
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4. Full Text Implementing Algorithm‐Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive CYP2C9 and VKORC1 Genetic Testing
by Obeng, A Owusu and Kaszemacher, T and Abul‐Husn, NS and Gottesman, O and Vega, A and Waite, E and Myers, K and Cho, J and Bottinger, EP and Ellis, SB and Scott, SA
Clinical pharmacology and therapeutics, ISSN 0009-9236, 11/2016, Volume 100, Issue 5, pp. 427 - 430
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmacogenetics - methods | Genetic Testing | Anticoagulants - administration & dosage | Humans | Warfarin - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Polymorphism, Genetic | Dose-Response Relationship, Drug | Drug Dosage Calculations | Algorithms | Ethnic Groups | Electronic Health Records | Vitamin K Epoxide Reductases - genetics | Warfarin | Usage | Ethnic groups | Medical records | Dosage and administration | Research | Health aspects | Genetic screening | Index Medicus | Abridged Index Medicus
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5. Full Text Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations
by Bonnemaijer, Pieter and Iglesias, A.I and Nadkarni, G.N and Sanyiwa, A.J and Hassan, H.G and Cook, C and Simcoe, M and Taylor, Kent and Schurmann, Claudia and Belbin, G.M and Kenny, E.E and Bottinger, E.P and van de Laar, S and Wiliams, S.E.I and Akafo, S.K and Ashaye, A.O and Zangwill, Linda and Girkin, C.A and Ng, Maggie C.Y and Rotter, Jerome I and Weinreb, Robert N and Li, Z and Allingham, R Rand and Nag, Abhishek and Hysi, P.G and Meester-Smoor, Magda and Wiggs, Janey L and Hauser, M.A and Hammond, C.J and Lemij, H.G and Loos, Ruth and Duijn, Cornelia and Thiadens, Alberta and Klaver, Caroline and NEIGHBORHOOD Consortium and Eyes Africa Genetics Consortium and GIGA Study Grp and Eyes of Africa Genetics Consortium and GIGA Study Group
Human genetics, ISSN 0340-6717, 10/2018, Volume 137, Issue 10, pp. 847 - 862
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genome-Wide Association Study | Glaucoma, Open-Angle - genetics | Humans | Middle Aged | Vesicular Transport Proteins - genetics | Aged, 80 and over | Female | Male | Aged | African Continental Ancestry Group - genetics | Genetic Loci | Thioredoxin Reductase 2 - genetics | Glaucoma | Genetic research | Genomes | Comparative analysis | Genomics | Risk factors | Minority & ethnic groups | Index Medicus
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6. Full Text Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry
by Horowitz, C.R and Abul-Husn, N.S and Ellis, S and Ramos, M.A and Negron, R and Suprun, M and Zinberg, R.E and Sabin, T and Hauser, D and Calman, N and Bagiella, E and Bottinger, E.P
Contemporary clinical trials, ISSN 1551-7144, 2016, Volume 47, pp. 101 - 108
Hematology, Oncology and Palliative Medicine | Cardiovascular | African ancestry | Genetics | Chronic kidney disease | Disparities | Community-based research | Race | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Genetic Predisposition to Disease | Primary Health Care - methods | Lipoproteins, HDL - genetics | Risk Assessment | Humans | Middle Aged | Decision Support Techniques | African Americans - genetics | Genetic Counseling - methods | Genetic Testing - methods | Polymorphism, Genetic | Young Adult | Apolipoproteins - genetics | Adolescent | Apolipoprotein L1 | Renal Insufficiency, Chronic - genetics | Adult | Aged | Hypertension - genetics | Hypertension | Kidney diseases | Genomics | Genetic screening | Index Medicus | Chronic Kidney Disease | African Ancestry | Community-Based Research
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7. Full Text Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI
by Gong, J and Nishimura, K.K and Fernandez-Rhodes, L and Haessler, J and Bien, S and Graff, M and Lim, U and Lu, Y and Gross, M and Fornage, M and Yoneyama, S and Isasi, C.R and Buzkova, P and Daviglus, M and Lin, D.-Y and Tao, R and Goodloe, R and Bush, W.S and Farber-Eger, E and Boston, J and Dilks, H.H and Ehret, G and Gu, C.C and Lewis, C.E and Nguyen, K.-D.H and Cooper, R and Leppert, M and Irvin, M.R and Bottinger, E.P and Wilkens, L.R and Haiman, C.A and Park, L and Monroe, K.R and Cheng, I and Stram, D.O and Carlson, C.S and Jackson, R and Kuller, L and Houston, D and Kooperberg, C and Buyske, S and Hindorff, L.A and Crawford, D.C and Loos, R.J.F and Le Marchand, L and Matise, T.C and North, K.E and Peters, U
International Journal of Obesity, ISSN 0307-0565, 03/2018, Volume 42, Issue 3, pp. 384 - 390
Endocrinology & Metabolism | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Body Mass Index | Genome-Wide Association Study | Genomics | Humans | Polymorphism, Single Nucleotide - genetics | Continental Population Groups - genetics | Continental Population Groups - statistics & numerical data | Quantitative trait loci | Body mass index | Disease susceptibility | Genetic aspects | Health aspects | Populations | Adipose tissue | Data processing | Population studies | Single-nucleotide polymorphism | Genomes | Regression analysis | Metabolism | Minority & ethnic groups | Epidemiology | Population genetics | Loci | Ethnic factors | Chromosome 1 | Consortia | American Indians | Ethnicity | Replicating | Body mass | Body size | Race | Polygenic inheritance | Index Medicus
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8. Full Text Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations
by Bonnemaijer, P.W.M and Iglesias, A.I and Nadkarni, G.N and Sanyiwa, A.J and Hassan, H.G and Cook, C and Simcoe, M and Taylor, K.D and Schurmann, C and Belbin, G.M and Kenny, E.E and Bottinger, E.P and Laar, S. van de and Wiliams, S.E.I and Akafo, S.K and Ashaye, A.O and Zangwill, L.M and Girkin, C.A and Ng, M.C and Rotter, J.I and Weinreb, R.N and Li, Z and Allingham, R.R and Nag, A and Hysi, P.G and Meester-Smoor, M.A and Wiggs, J.L and Hauser, M.A and Hammond, C.J and Lemij, H.G and Loos, R.J and Duijn, C.M. van and Thiadens, A and Klaver, C.C.W
Human genetics, ISSN 0340-6717, 2018, Volume 137, pp. 847 - 862
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9. Full Text A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough
by Mosley, J. D and Shaffer, C. M and van est, S. L and Weeke, P. E and Wells, Q. S and Karnes, J. H and Velez Edwards, D. R and Wei, W.-Q and Teixeira, P. L and Bastarache, L and Crawford, D. C and Li, R and Manolio, T. A and Bottinger, E. P and McCarty, C. A and Linneman, J. G and Brilliant, M. H and Pacheco, J. A and Thompson, W and Chisholm, R. L and Jarvik, G. P and Crosslin, D. R and Carrell, D. S and Baldwin, E and Ralston, J and Larson, E. B and Grafton, J and Scrol, A and Jouni, H and Kullo, I. J and Tromp, G and Borthwick, K. M and Kuivaniemi, H and Carey, D. J and Ritchie, M. D and Bradford, Y and Verma, S. S and Chute, C. G and Veluchamy, A and Siddiqui, M. K and Palmer, C. N. A and Doney, A and Mahmoudpour, S. H and Maitland-van der Zee, A. H and Morris, A. D and Denny, J. C and Roden, D. M
The pharmacogenomics journal, ISSN 1470-269X, 2016, Volume 16, Issue 3, pp. 231 - 237
Pharmacology & Pharmacy | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Multivariate Analysis | Genetic Predisposition to Disease | Genome-Wide Association Study | Cough - chemically induced | Risk Assessment | Cough - genetics | United States | Gene Frequency | Humans | Risk Factors | Computational Biology | Databases, Genetic | Logistic Models | Male | Scotland | Kv Channel-Interacting Proteins - genetics | Case-Control Studies | Phenotype | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Female | Polymorphism, Single Nucleotide | Cough - ethnology | Odds Ratio | Electronic Health Records | Complications and side effects | Genome-wide association studies | Drug metabolism | Genetic aspects | Disease susceptibility | Single nucleotide polymorphisms | ACE inhibitors | Identification and classification | Methods | Index Medicus | Original
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