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1. Full Text Noninvasive mechanical ventilation in acute respiratory failure: trends in use and outcomes
by Schnell, David and Timsit, Jean-François and Darmon, Michael and Vesin, Aurélien and Goldgran-Toledano, Dany and Dumenil, Anne-Sylvie and Garrouste-Orgeas, Maite and Adrie, Christophe and Bouadma, Lila and Planquette, Benjamin and Cohen, Yves and Schwebel, Carole and Soufir, Lila and Jamali, Samir and Souweine, Bertrand and Azoulay, Élie
Intensive Care Medicine, ISSN 0342-4642, 4/2014, Volume 40, Issue 4, pp. 582 - 591
Noninvasive ventilation (NIV) had proven benefits in clinical trials that included selected patients admitted to highly skilled centers. Whether these benefits... 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Immunocompromised | Intensive / Critical Care Medicine | Acute respiratory failure | Cardiogenic pulmonary edema | Chronic obstructive pulmonary disease | Anesthesiology | Endotracheal intubation | MORTALITY | MULTICENTER | FACE MASK | AIRWAY PRESSURE | INTENSIVE-CARE UNITS | CARDIOGENIC PULMONARY-EDEMA | RANDOMIZED CONTROLLED-TRIAL | ACUTE EXACERBATIONS | DISEASE | POSITIVE-PRESSURE VENTILATION | CRITICAL CARE MEDICINE | Acute Disease | Respiration, Artificial - methods | Follow-Up Studies | Respiratory Insufficiency - mortality | Humans | Middle Aged | Male | Treatment Outcome | Respiratory Insufficiency - therapy | Respiration, Artificial - trends | Treatment Failure | Female | Aged | Databases, Factual | Acute respiratory distress syndrome | Care and treatment | Critically ill | Patient outcomes | Artificial respiration | Life Sciences | Microbiology and Parasitology | Human health and pathology | Infectious diseases | Bacteriology | Protistology
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2. Full Text Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
by Bouadma, Lila, MD and Luyt, Charles-Edouard, MD and Tubach, Florence, MD and Cracco, Christophe, MD and Alvarez, Antonio, MD and Schwebel, Carole, MD and Schortgen, Frédérique, MD and Lasocki, Sigismond, MD and Veber, Benoît, Prof and Dehoux, Monique, MD and Bernard, Maguy, MD and Pasquet, Blandine, MS and Régnier, Bernard, Prof and Brun-Buisson, Christian, Prof and Chastre, Jean, Prof and Wolff, Michel, Prof and PRORATA Trial Grp and PRORATA trial group
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9713, pp. 463 - 474
Summary Background Reduced duration of antibiotic treatment might contain the emergence of multidrug-resistant bacteria in intensive care units. We aimed to... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | COMMUNITY-ACQUIRED PNEUMONIA | GRAM-NEGATIVE BACILLI | DISEASES-SOCIETY | THERAPY | MANAGEMENT | VENTILATOR-ASSOCIATED PNEUMONIA | GUIDELINES | SEPSIS | CRITICALLY-ILL PATIENTS | RESPIRATORY-TRACT INFECTIONS | Prospective Studies | Protein Precursors - blood | Bacterial Infections - etiology | Humans | Middle Aged | Critical Illness | Drug Resistance, Bacterial | Male | Drug Monitoring - methods | Anti-Bacterial Agents - therapeutic use | Time Factors | Adult | Female | Calcitonin Gene-Related Peptide | Length of Stay | Calcitonin - blood | France - epidemiology | Intensive Care Units | Drug Administration Schedule | Bacterial Infections - drug therapy | Decision Support Techniques | Kaplan-Meier Estimate | Treatment Outcome | Algorithms | Drug Monitoring - statistics & numerical data | Aged | Bacterial Infections - mortality | Practice Guidelines as Topic | Drug resistance in microorganisms | Usage | Research | Antibiotics | Health aspects | Calcitonin | Infections | Hospitals | Drug resistance
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3. Full Text Skin antisepsis with chlorhexidine–alcohol versus povidone iodine–alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial
by Mimoz, Olivier, Prof and Lucet, Jean-Christophe, Prof and Kerforne, Thomas, MD and Pascal, Julien, MD and Souweine, Bertrand, Prof and Goudet, Véronique, MD and Mercat, Alain, Prof and Bouadma, Lila, PhD and Lasocki, Sigismond, Prof and Alfandari, Serge, MD and Friggeri, Arnaud, MD and Wallet, Florent, MD and Allou, Nicolas, MD and Ruckly, Stéphane and Balayn, Dorothée, PhD and Lepape, Alain, MD and Timsit, Jean-François, Prof and CLEAN Trial Investigators and CLEAN trial investigators
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 10008, pp. 2069 - 2077
Summary Background Intravascular-catheter-related infections are frequent life-threatening events in health care, but incidence can be decreased by... 
Internal Medicine | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | IMPREGNATED SPONGES | INTENSIVE-CARE-UNIT | GUIDELINES | COLONIZATION | CULTURES | CRITICALLY-ILL ADULTS | BLOOD | Catheterization, Peripheral - methods | Anti-Infective Agents, Local - therapeutic use | Intensive Care Units | Humans | Middle Aged | Catheterization, Central Venous - methods | Male | Treatment Outcome | Ethanol - therapeutic use | Catheter-Related Infections - prevention & control | Chlorhexidine - therapeutic use | Povidone-Iodine - therapeutic use | Antisepsis - methods | Vascular Access Devices | Female | Aged | Drug Therapy, Combination | Catheters, Indwelling | Prevention | Care and treatment | Catheterization | Medical care | Skin | Cross infection | Nosocomial infections | Health aspects | Infection control | Quality management | Biomedical materials | Mortality | Infections | Catheters | Iodine
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4. Full Text Oral care with chlorhexidine: beware
by Bouadma, Lila and Klompas, Michael
Intensive Care Medicine, ISSN 0342-4642, 7/2018, Volume 44, Issue 7, pp. 1153 - 1155
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00134-018-5221-x 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | ALLERGY | VENTILATOR-ASSOCIATED PNEUMONIA | CRITICAL CARE MEDICINE | Prevention | Hospital patients | Usage | Aspiration pneumonia | Chlorhexidine | Dosage and administration | Research | Drug therapy | Health aspects
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5. Full Text Chlorhexidine use in adult patients on ICU
by Bouadma, Lila and Karpanen, Tarja and Elliott, Tom
Intensive Care Medicine, ISSN 0342-4642, 12/2018, Volume 44, Issue 12, pp. 2232 - 2234
Chlorhexidine (CHG) is a biguanide cationic antiseptic molecule, which has been incorporated into mouthwash solutions, dental gels, dressings, washcloths and... 
PREVENTION | CATHETER-RELATED INFECTIONS | CARE | CRITICAL CARE MEDICINE | Disease prevention | Antimicrobial agents | Intensive care | Chlorhexidine | Drug resistance | Oral hygiene
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6. Full Text Why biomarkers failed in sepsis
by Jensen, Jens-Ulrik and Bouadma, Lila
Intensive Care Medicine, ISSN 0342-4642, 12/2016, Volume 42, Issue 12, pp. 2049 - 2051
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00134-016-4531-0 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | SHOCK | RESPIRATORY-DISTRESS-SYNDROME | CRITICAL CARE MEDICINE | Severity of Illness Index | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Humans | Biomarkers - analysis | Sepsis - diagnosis | Clinical Trials as Topic | Physiological aspects | Sepsis | Research | Diagnosis | Biological markers
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7. Full Text Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
by Combes, Alain and Hajage, David and Capellier, Gilles and Demoule, Alexandre and Lavoué, Sylvain and Guervilly, Christophe and Da Silva, Daniel and Zafrani, Lara and Tirot, Patrice and Veber, Benoit and Maury, Eric and Levy, Bruno and Cohen, Yves and Richard, Christian and Kalfon, Pierre and Bouadma, Lila and Mehdaoui, Hossein and Beduneau, Gaëtan and Lebreton, Guillaume and Brochard, Laurent and Ferguson, Niall D and Fan, Eddy and Slutsky, Arthur S and Brodie, Daniel and Mercat, Alain and ECMONet and EOLIA Trial Grp and REVA and EOLIA Trial Group, REVA, and ECMONet
The New England Journal of Medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 21, pp. 1965 - 1975
This trial compared extracorporeal membrane oxygenation with non-ECMO ventilator care in patients with severe ARDS. There was no significant between-group... 
2009 INFLUENZA A(H1N1) | MORTALITY | MEDICINE, GENERAL & INTERNAL | VENTILATION | CLINICAL-TRIAL | ADULTS | LUNG INJURY | OUTCOMES | FAILURE | EPIDEMIOLOGY | ARDS | Severity of Illness Index | Thrombocytopenia - etiology | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Extracorporeal Membrane Oxygenation - adverse effects | Respiratory Distress Syndrome, Adult - mortality | Cross-Over Studies | Respiration, Artificial - adverse effects | Hemorrhage - etiology | Adult | Female | Hypoxia | Aged | Respiratory Distress Syndrome, Adult - therapy | Usage | Care and treatment | Blood oxygenation, Extracorporeal | Respiratory distress syndrome | Patient outcomes | Artificial respiration | Respiratory therapy | Thrombocytopenia | Ventilators | Oxygen | Stroke | Nutrition | Mortality | Carbon dioxide | Critical care | Patients | Medicine | Hypoxemia | Hospitals | Ischemia | Ventilation | Physiology | Blood pressure | Oxygenation
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8. Full Text Emergency craniotomy in semi-lateral position for posterior fossa hemorrhage evacuation under venoarterial extracorporeal membrane oxygenation
by Papin, Grégory and Sonneville, Romain and Nataf, Partick and Bouadma, Lila
Intensive Care Medicine, ISSN 0342-4642, 8/2019, Volume 45, Issue 8, pp. 1152 - 1153
A 38-year-old male patient (BMI=34 kg/m2 ) was admitted to the ICU for refractory post-operative cardiogenic shock requiring femoro-femoral venoarterial... 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | CRITICAL CARE MEDICINE | Life support systems | Intensive care | Neurosurgery | Oxygenation | Patient positioning | Hemorrhage
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9. Full Text Fever control using external cooling in septic shock: A randomized controlled trial
by Schortgen, Frédérique and Clabault, Karine and Katsahian, Sandrine and Devaquet, Jerome and Mercat, Alain and Deye, Nicolas and Dellamonica, Jean and Bouadma, Lila and Cook, Fabrice and Beji, Olfa and Brun-Buisson, Christian and Lemaire, François and Brochard, Laurent
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 05/2012, Volume 185, Issue 10, pp. 1088 - 1095
Rationale: Fever control may improve vascular tone and decrease oxygen consumption, but fever may contribute to combat infection. Objectives: To determine... 
Septic shock | Vasopressor agents | Fever | Intensive care unit | HYPOTHERMIA | septic shock | MANAGEMENT | NOREPINEPHRINE | fever | ANTIPYRETICS | OXYGEN | HEMOFILTRATION | ACETAMINOPHEN | INTENSIVE-CARE-UNIT | RESPIRATORY SYSTEM | intensive care unit | CRITICALLY-ILL PATIENTS | vasopressor agents | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Vasoconstrictor Agents - therapeutic use | Norepinephrine - therapeutic use | Humans | Middle Aged | Fever - therapy | Kaplan-Meier Estimate | Shock, Septic - complications | Logistic Models | Male | Treatment Outcome | Body Temperature | Shock, Septic - mortality | Epinephrine - therapeutic use | Fever - etiology | Intention to Treat Analysis | Shock, Septic - drug therapy | Critical Care | Female | Poisson Distribution | Aged | Cryotherapy
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10. Full Text Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
by Mercat, Alain and Richard, Jean-Christophe M and Vielle, Bruno and Jaber, Samir and Osman, David and Diehl, Jean-Luc and Lefrant, Jean-Yves and Prat, Gwenaël and Richecoeur, Jack and Nieszkowska, Ania and Gervais, Claude and Baudot, Jérôme and Bouadma, Lila and Brochard, Laurent and Expiratory Pressure (Express) Study Group, for the and Expiratory Pressure Express Study and Expiratory Pressure (Express) Study Group
JAMA, ISSN 0098-7484, 02/2008, Volume 299, Issue 6, pp. 646 - 655
CONTEXT The need for lung protection is universally accepted, but the optimal level of positive end-expiratory pressure (PEEP) in patients with acute lung... 
MORTALITY | MEDICINE, GENERAL & INTERNAL | TIDAL VOLUME | STRATEGY | MANEUVERS | AIRWAY PRESSURES | DERECRUITMENT | MECHANICAL VENTILATION | PROTECTIVE-VENTILATION | ALVEOLAR RECRUITMENT | PULMONARY-EDEMA | Respiratory Distress Syndrome, Adult - physiopathology | Hospital Mortality | Humans | Middle Aged | Survival Analysis | Female | Male | Aged | Tidal Volume | Positive-Pressure Respiration | Ventilator Weaning | Respiratory Distress Syndrome, Adult - therapy | Ventilators | Care and treatment | Usage | Diagnosis | Respiratory distress syndrome | Clinical trials | Airway management | Adults | Respiratory diseases | Clinical outcomes
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11. Full Text Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis
by Philipp Schuetz and Matthias Briel and Mirjam Christ-Crain and Daiana Stolz and Lila Bouadma and Michel Wolff and Charles-Edouard Luyt and Jean Chastre and Florence Tubach and Kristina B. Kristoffersen and Long Wei and Olaf Burkhardt and Tobias Welte and Stefan Schroeder and Vandack Nobre and Michael Tamm and Neera Bhatnagar and Heiner C. Bucher and Beat Mueller
Clinical Infectious Diseases, ISSN 1058-4838, 9/2012, Volume 55, Issue 5, pp. 651 - 662
Background. Procalcitonin algorithms may reduce antibiotic use for acute respiratory tract infections (ARIs). We undertook an individual patient data... 
Respiratory tract infections | Intensive care units | Medical treatment failures | Pneumonia | Antibiotics | Meta analysis | Mortality | Hospital admissions | Experimentation | Infections | ARTICLES AND COMMENTARIES | INFECTIOUS DISEASES | STEWARDSHIP | BRONCHITIS | INTENSIVE-CARE PATIENTS | ANTIMICROBIAL THERAPY | MICROBIOLOGY | GUIDANCE | SEPSIS | ALGORITHMS | IMMUNOLOGY | PNEUMONIA | TRACT INFECTIONS | REDUCTION | Calcitonin Gene-Related Peptide | Acute Disease | Protein Precursors - administration & dosage | Humans | Middle Aged | Male | Respiratory Tract Infections - drug therapy | Calcitonin - administration & dosage | Randomized Controlled Trials as Topic | Regression Analysis | Algorithms | Adult | Female | Aged | Anti-Bacterial Agents - administration & dosage | Usage | Drug therapy | and Commentaries
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12. Full Text Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis
by Schuetz, Philipp and Wirz, Yannick and Sager, Ramon and Christ-Crain, Mirjam and Stolz, Daiana and Tamm, Michael and Bouadma, Lila and Luyt, Charles E and Wolff, Michel and Chastre, Jean and Tubach, Florence and Kristoffersen, Kristina B and Burkhardt, Olaf and Welte, Tobias and Schroeder, Stefan and Nobre, Vandack and Wei, Long and Bucher, Heiner C and Annane, Djillali and Reinhart, Konrad and Falsey, Ann R and Branche, Angela and Damas, Pierre and Nijsten, Maarten and de Lange, Dylan W and Deliberato, Rodrigo O and Oliveira, Carolina F and Maravić-Stojković, Vera and Verduri, Alessia and Beghé, Bianca and Cao, Bin and Shehabi, Yahya and Jensen, Jens-Ulrik S and Corti, Caspar and van Oers, Jos A H and Beishuizen, Albertus and Girbes, Armand R J and de Jong, Evelien and Briel, Matthias and Mueller, Beat
The Lancet Infectious Diseases, ISSN 1473-3099, 01/2018, Volume 18, Issue 1, pp. 95 - 107
In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute... 
BIOMARKERS | INFECTIOUS DISEASES | COMMUNITY-ACQUIRED PNEUMONIA | CARE PATIENTS | GENE-RELATED PEPTIDE | EMPIRICAL THERAPY | GUIDANCE | DE-ESCALATION | SEPTIC PATIENTS | TRACT INFECTIONS | SEVERE SEPSIS | Length of Stay | Bacterial Infections - drug therapy | Humans | Middle Aged | Male | Respiratory Tract Infections - drug therapy | Respiratory Tract Infections - diagnosis | Drug-Related Side Effects and Adverse Reactions - epidemiology | Randomized Controlled Trials as Topic | Respiratory Tract Infections - mortality | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Anti-Bacterial Agents - adverse effects | Bacterial Infections - diagnosis | Procalcitonin - blood | Anti-Bacterial Agents - administration & dosage | Bacterial Infections - mortality | Antibiotics | Mortality | Analysis | Lung diseases | Patient outcomes | Pneumonia | Intensive care | Bacterial infections | Procalcitonin | Systematic review | Infections | FDA approval | Patients | Data bases | Clinical outcomes | Meta-analysis | Studies | Biomarkers | Sepsis | Bronchitis | Libraries | Viral infections | Ambulatory care
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13. Full Text Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure: A Randomized Clinical Trial
by Lemiale, Virginie and Mokart, Djamel and Resche-Rigon, Matthieu and Pène, Frédéric and Mayaux, Julien and Faucher, Etienne and Nyunga, Martine and Girault, Christophe and Perez, Pierre and Guitton, Christophe and Ekpe, Kenneth and Kouatchet, Achille and Théodose, Igor and Benoit, Dominique and Canet, Emmanuel and Barbier, François and Rabbat, Antoine and Bruneel, Fabrice and Vincent, Francois and Klouche, Kada and Loay, Kontar and Mariotte, Eric and Bouadma, Lila and Moreau, Anne-Sophie and Seguin, Amélie and Meert, Anne-Pascale and Reignier, Jean and Papazian, Laurent and Mehzari, Ilham and Cohen, Yves and Schenck, Maleka and Hamidfar, Rebecca and Darmon, Michael and Demoule, Alexandre and Chevret, Sylvie and Azoulay, Elie and Grp Rech Reanimation Resp Patient and Groupe de Recherche en Réanimation Respiratoire du patient d’Onco-Hématologie (GRRR-OH)
JAMA, ISSN 0098-7484, 10/2015, Volume 314, Issue 16, pp. 1711 - 1719
IMPORTANCE: Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure.... 
SURVIVAL | MEDICINE, GENERAL & INTERNAL | ADMISSION | MECHANICAL VENTILATION | ONCOLOGY PATIENTS | HEMATOLOGY | CRITICALLY-ILL PATIENTS | CANCER | Acute Disease | Intensive Care Units | Respiratory Insufficiency - mortality | Humans | Middle Aged | Cross Infection | Hypoxia - mortality | Male | Respiratory Insufficiency - therapy | Hypoxia - therapy | Cause of Death | Belgium | Time Factors | Female | Intubation - utilization | Aged | Immunocompromised Host | France | Oxygen Inhalation Therapy - mortality | Noninvasive Ventilation - mortality | Acute respiratory distress syndrome | Usage | Care and treatment | Oxygen therapy | Immunocompromised host | Clinical trials | Comparative analysis | Health aspects | Artificial respiration | Ventilation | Intensive care | Respiration | Mortality | Life Sciences | Human health and pathology
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