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FEBS Journal, ISSN 1742-464X, 11/2013, Volume 280, Issue 21, pp. 5237 - 5257
Acquired resistance to the anti‐estrogen tamoxifen remains a significant challenge in breast cancer management. In this study, we used an integrative approach... 
phosphoproteomics | MCF | MARCKS | Yes kinase | endocrine resistance | MCF7 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RNA, Small Interfering - genetics | Receptors, Estrogen - metabolism | Cell Proliferation | Myristoylated Alanine-Rich C Kinase Substrate | Tissue Array Analysis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Immunoenzyme Techniques | Breast Neoplasms - metabolism | Protein Interaction Maps | Carcinoma, Ductal, Breast - drug therapy | Carcinoma, Ductal, Breast - pathology | Female | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Phosphorylation - drug effects | Tumor Cells, Cultured | Carcinoma, Ductal, Breast - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Antineoplastic Agents, Hormonal - pharmacology | Membrane Proteins - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Cell Adhesion | Blotting, Western | Cell Cycle | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Breast Neoplasms - pathology | Proteomics | Tamoxifen - pharmacology | Apoptosis | Cell Movement | Analysis | Estrogen | Physiological aspects | Breast cancer | Chemical properties | Binding proteins | Tamoxifen | Muscle proteins | Mass spectrometry | Protein binding | Drug resistance | Chemotherapy
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 274 - 288
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing,... 
pancreatic cancer | actin | development | cell biology | FLIM-FRET | breast cancer | small GTPase RhoA | biosensors | intravital imaging | immunology | CELLS | PANCREATIC DUCTAL ADENOCARCINOMA | ACTIVATION | FAMILY GTPASES | DYNAMICS | DRIVEN | RAC1 | CANCER | EGF RECEPTOR | REVEALS | CELL BIOLOGY | Intestine, Small - ultrastructure | Mammary Neoplasms, Experimental - ultrastructure | Fluorescence Resonance Energy Transfer - instrumentation | Pancreatic Neoplasms - blood supply | Neutrophils - ultrastructure | Intravital Microscopy - methods | Mammary Glands, Animal - blood supply | Mammary Neoplasms, Experimental - genetics | Osteocytes - ultrastructure | Pancreatic Neoplasms - drug therapy | Time-Lapse Imaging - instrumentation | Bone and Bones - metabolism | Intravital Microscopy - instrumentation | Female | Mammary Neoplasms, Experimental - blood supply | Time-Lapse Imaging - methods | Antineoplastic Agents - pharmacology | Neutrophils - metabolism | Bone and Bones - cytology | Mammary Neoplasms, Experimental - drug therapy | Osteocytes - metabolism | rho GTP-Binding Proteins - genetics | Gene Expression Regulation | Pancreatic Neoplasms - ultrastructure | Mice, Transgenic | Pancreatic Neoplasms - genetics | Mammary Glands, Animal - drug effects | Dasatinib - pharmacology | Cell Movement - drug effects | Mammary Glands, Animal - ultrastructure | Mechanotransduction, Cellular | Animals | Erlotinib Hydrochloride - pharmacology | rho GTP-Binding Proteins - metabolism | Biosensing Techniques | Fluorescence Resonance Energy Transfer - methods | Mice | Intestine, Small - metabolism
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2017, Volume 9, Issue 384, pp. eaai8504 - eaai8504
The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | DUCTAL ADENOCARCINOMA | CELL INVASION | RHO-KINASE/ROCK | TUMOR | TENSION | EXTRACELLULAR-MATRIX | CLEAVAGE FURROW | REVEALS | CELL BIOLOGY | Liver - pathology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Extracellular Matrix - metabolism | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | rho-Associated Kinases - antagonists & inhibitors | CDC2 Protein Kinase - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Neoplasm Metastasis | rho-Associated Kinases - metabolism | Actin Cytoskeleton - drug effects | src-Family Kinases - metabolism | Albumin-Bound Paclitaxel - therapeutic use | Antineoplastic Agents - pharmacology | Actin Cytoskeleton - metabolism | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Albumin-Bound Paclitaxel - pharmacology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Treatment Outcome | Disease Progression | Collagen - metabolism | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Biosensing Techniques | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Deoxycytidine - analogs & derivatives
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 22, pp. 9391 - 9401
Journal Article
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