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life sciences & biomedicine (9) 9
science & technology (9) 9
animals (6) 6
mice (6) 6
male (4) 4
mutation (4) 4
research (4) 4
biological and medical sciences (3) 3
cardiac & cardiovascular systems (3) 3
cardiovascular system & cardiology (3) 3
cytokines (3) 3
endocrinology & metabolism (3) 3
female (3) 3
genetics (3) 3
mice, inbred c57bl (3) 3
parathyroid hormone (3) 3
abridged index medicus (2) 2
adenoviridae - genetics (2) 2
alleles (2) 2
analysis (2) 2
biochemistry (2) 2
cell biology (2) 2
corticosterone (2) 2
cyclic amp (2) 2
fundamental and applied biological sciences. psychology (2) 2
gene expression - physiology (2) 2
gene mutations (2) 2
genes (2) 2
genetic aspects (2) 2
gnas (2) 2
immunohistochemistry (2) 2
imprinting (2) 2
medicine, research & experimental (2) 2
mice, knockout (2) 2
mice, transgenic (2) 2
myocardium - metabolism (2) 2
peripheral vascular disease (2) 2
phenotype (2) 2
physiology (2) 2
pseudohypoparathyroidism (2) 2
receptors, tumor necrosis factor - metabolism (2) 2
renal proximal tubule (2) 2
research & experimental medicine (2) 2
stimulatory g protein (2) 2
stress (2) 2
tumor necrosis factor-alpha - genetics (2) 2
vertebrates: endocrinology (2) 2
viruses (2) 2
adaptation, physiological - genetics (1) 1
adenovirus (1) 1
adrenal glands (1) 1
alkaline phosphatase (1) 1
aminopeptidasa (1) 1
aminopeptidase (1) 1
anatomy & physiology (1) 1
antigens, cd - genetics (1) 1
antigens, cd - metabolism (1) 1
antigens, cd - pharmacology (1) 1
apoptosis (1) 1
apoptosis - drug effects (1) 1
apoptosis - physiology (1) 1
bacterial diseases (1) 1
biochemistry & molecular biology (1) 1
biochimie (1) 1
bioquimica (1) 1
blindness (1) 1
brain (1) 1
calcitriol - metabolism (1) 1
calcium - blood (1) 1
calcium - metabolism (1) 1
calcium-binding proteins - metabolism (1) 1
calcium-transporting atpases - metabolism (1) 1
cardiomyopathy, dilated - drug therapy (1) 1
cardiomyopathy, dilated - etiology (1) 1
cardiomyopathy, dilated - metabolism (1) 1
care and treatment (1) 1
carrier proteins - genetics (1) 1
carrier proteins - physiology (1) 1
chemokine (1) 1
chemokine ccl2 - blood (1) 1
chemokine ccl2 - genetics (1) 1
clonacion (1) 1
clonage (1) 1
cloning (1) 1
cold (1) 1
cold temperature (1) 1
corticosterone - blood (1) 1
corticotropin-releasing hormone - genetics (1) 1
crispr (1) 1
cyclic amp - blood (1) 1
cyclic amp - physiology (1) 1
cytochemistry (1) 1
cytokines - blood (1) 1
cytokines - genetics (1) 1
cytology (1) 1
dna - biosynthesis (1) 1
dna - genetics (1) 1
dose-response relationship, drug (1) 1
down-regulation (1) 1
drug resistance (1) 1
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1. Full Text Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
by Maeder, Morgan L and Stefanidakis, Michael and Wilson, Christopher J and Baral, Reshica and Barrera, Luis Alberto and Bounoutas, George S and Bumcrot, David and Chao, Hoson and Ciulla, Dawn M and DaSilva, Jennifer A and Dass, Abhishek and Dhanapal, Vidya and Fennell, Tim J and Friedland, Ari E and Giannoukos, Georgia and Gloskowski, Sebastian W and Glucksmann, Alexandra and Gotta, Gregory M and Jayaram, Hariharan and Haskett, Scott J and Hopkins, Bei and Horng, Joy E and Joshi, Shivangi and Marco, Eugenio and Mepani, Rina and Reyon, Deepak and Ta, Terence and Tabbaa, Diana G and Samuelsson, Steven J and Shen, Shen and Skor, Maxwell N and Stetkiewicz, Pam and Wang, Tongyao and Yudkoff, Clifford and Myer, Vic E and Albright, Charles F and Jiang, Haiyan
Nature medicine, ISSN 1078-8956, 02/2019, Volume 25, Issue 2, pp. 229 - 233
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Retinal degeneration | Care and treatment | Genetic aspects | Research | Gene mutations | Staphylococcus aureus | Explants | CRISPR | Blindness | Retina | Genomes | Dystrophy | Nuclease | Mutation | Gene expression | Genetic modification | Index Medicus
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2. Full Text Postnatal Establishment of Allelic Gαs Silencing as a Plausible Explanation for Delayed Onset of Parathyroid Hormone Resistance Owing to Heterozygous Gαs Disruption
by Turan, Serap and Fernandez‐Rebollo, Eduardo and Aydin, Cumhur and Zoto, Teuta and Reyes, Monica and Bounoutas, George and Chen, Min and Weinstein, Lee S and Erben, Reinhold G and Marshansky, Vladimir and Bastepe, Murat
Journal of bone and mineral research, ISSN 0884-0431, 03/2014, Volume 29, Issue 3, pp. 749 - 760
RENAL PROXIMAL TUBULE | STIMULATORY G PROTEIN | CYCLIC AMP | PSEUDOHYPOPARATHYROIDISM | GNAS | PARATHYROID HORMONE | IMPRINTING | parathyroid hormone | pseudohypoparathyroidism | renal proximal tubule | stimulatory G protein | imprinting | cyclic AMP | GTP-Binding Protein alpha Subunits, Gs - metabolism | Gene Silencing | Parathyroid Hormone - therapeutic use | Male | GTP-Binding Protein alpha Subunits, Gs - genetics | Animals | Alleles | Kidney Tubules, Proximal - metabolism | Female | Heterozygote | Mice | Mutation | Drug Resistance | Index Medicus
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3. Full Text Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice
by Alena A. Zalutskaya and Maya Arai and George S. Bounoutas and Abdul B. Abou-Samra
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 07/2007, Volume 293, Issue 1, pp. 259 - 263
Corticosterone | Mice | Stress | Endocrinology & Metabolism | Physiology | Life Sciences & Biomedicine | Science & Technology | Urocortins | Cold Temperature | Stress, Psychological - blood | Mice, Inbred C57BL | Immobilization | Male | Sex Characteristics | Mice, Knockout | Stress, Psychological - genetics | Animals | Adaptation, Physiological - genetics | Female | Restraint, Physical | Corticotropin-Releasing Hormone - genetics | Corticosterone - blood | Brain | Peptides | Adrenal glands | Cold | Rodents | Pituitary gland | Anatomy & physiology | Index Medicus
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4. Full Text Postnatal Establishment of Allelic G[alpha]s Silencing as a Plausible Explanation for Delayed Onset of Parathyroid Hormone Resistance Owing to Heterozygous G[alpha]s Disruption
by Turan, Serap and Fernandez-Rebollo, Eduardo and Aydin, Cumhur and Zoto, Teuta and Reyes, Monica and Bounoutas, George and Chen, Min and Weinstein, Lee S and Erben, Reinhold G and Marshansky, Vladimir and Bastepe, Murat
Journal of bone and mineral research, ISSN 0884-0431, 03/2014, Volume 29, Issue 3, p. 749
Seizures (Medicine) | G proteins | RNA | Parathyroid hormone | Analysis
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5. Full Text Postnatal Establishment of Allelic Gαs Silencing as a Plausible Explanation for Delayed Onset of Parathyroid Hormone Resistance Owing to Heterozygous Gαs Disruption
: POSTNATAL ALLELIC GαS SILENCING AND PTH RESISTANCE
by Turan, Serap and Fernandez-Rebollo, Eduardo and Aydin, Cumhur and Zoto, Teuta and Reyes, Monica and Bounoutas, George and Chen, Min and Weinstein, Lee S and Erben, Reinhold G and Marshansky, Vladimir and Bastepe, Murat
Journal of bone and mineral research, ISSN 0884-0431, 03/2014, Volume 29, Issue 3, pp. 749 - 760
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6. Full Text AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice
by Choi, Vivian W and Bigelow, Chad E and McGee, Terri L and Gujar, Akshata N and Li, Hui and Hanks, Shawn M and Vrouvlianis, Joanna and Maker, Michael and Leehy, Barrett and Zhang, Yiqin and Aranda, Jorge and Bounoutas, George and Demirs, John T and Yang, Junzheng and Ornberg, Richard and Wang, Yu and Martin, Wendy and Stout, Kelly R and Argentieri, Gregory and Grosenstein, Paul and Diaz, Danielle and Turner, Oliver and Jaffee, Bruce D and Police, Seshidhar R and Dryja, Thaddeus P
Molecular therapy. Methods & clinical development, ISSN 2329-0501, 04/2015, Volume 2, pp. 15022 - 15022
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine
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7. Full Text Overexpression of Tumor Necrosis Factor- α Activates Both Anti- and Pro-Apoptotic Pathways in the Myocardium
by Kubota, Toru and Miyagishima, Masayuki and Frye, Carole S and Alber, Sean M and Bounoutas, George S and Kadokami, Toshiaki and Watkins, Simon C and McTiernan, Charles F and Feldman, Arthur M
Journal of molecular and cellular cardiology, ISSN 0022-2828, 07/2001, Volume 33, Issue 7, pp. 1331 - 1344
Heart failure | Myocardium | Cytokines | TNF-α | Apoptosis | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology | Apoptosis - drug effects | Gene Expression - genetics | Tumor Necrosis Factor-alpha - genetics | Heart Failure - physiopathology | Mice, Transgenic - genetics | Organ Size | Male | NF-kappa B - metabolism | Mice, Transgenic - metabolism | Heart Failure - pathology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Signal Transduction - drug effects | Gene Expression - physiology | Myocardium - metabolism | Up-Regulation - physiology | Female | Signal Transduction - physiology | Mice | Apoptosis - physiology | Tumor Necrosis Factor-alpha - biosynthesis | Heart Ventricles - pathology | NF-kappa B - drug effects | Index Medicus
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8. Full Text Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression
by Toshiaki Kadokami and Charles F. McTiernan and Toru Kubota and Carole S. Frye and George S. Bounoutas and Paul D. Robbins and Simon C. Watkins and Arthur M. Feldman
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2001, Volume 280, Issue 5, pp. 2281 - 2291
Chemokine | Tumor necrosis factor-α | Endotoxin shock | Adenovirus | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Interleukin-6 - analysis | Gene Expression - drug effects | Interleukin-1 - blood | Myocardium - chemistry | Recombinant Fusion Proteins - pharmacology | Interleukin-12 - genetics | Tumor Necrosis Factor-alpha - genetics | Interleukin-10 - blood | RNA, Messenger - analysis | Male | Antigens, CD - genetics | Shock, Septic - metabolism | Antigens, CD - metabolism | Interleukin-12 - blood | Interleukin-6 - blood | Gene Expression - physiology | Myocardium - metabolism | Shock, Septic - drug therapy | Adenoviridae - genetics | Cytokines - genetics | Cytokines - blood | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | Interleukin-6 - genetics | Mice, Inbred C57BL | Receptors, Tumor Necrosis Factor, Type I | Solubility | Chemokine CCL2 - genetics | Shock, Septic - physiopathology | Recombinant Proteins - pharmacology | Chemokine CCL2 - blood | Mice, Knockout | Animals | Interleukin-10 - genetics | Lipopolysaccharides - pharmacology | Antigens, CD - pharmacology | Mice | Index Medicus
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9. Full Text Impact of Impaired Receptor Internalization on Calcium Homeostasis in Knock-In Mice Expressing a Phosphorylation-Deficient Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor
by Bounoutas, George S and Tawfeek, Hesham and Fröhlich, Leopold F and Chung, Ung-il and Abou-Samra, Abdul B
Endocrinology (Philadelphia), ISSN 0013-7227, 10/2006, Volume 147, Issue 10, pp. 4674 - 4679
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vertebrates: endocrinology | Thyroid. Parathyroid. Ultimobranchial body | Hormones. Regulation | Parathyroid Hormone - physiology | Cyclic AMP - blood | Phosphorylation | Calcium - metabolism | Humans | Mice, Inbred C57BL | Osteoblasts - drug effects | Mice, Transgenic | Parathyroid Hormone - pharmacology | Receptor, Parathyroid Hormone, Type 1 - physiology | Cyclic AMP - physiology | DNA - genetics | Dose-Response Relationship, Drug | Calcium - blood | Phenotype | Phosphates - metabolism | Animals | Homeostasis - physiology | Receptor, Parathyroid Hormone, Type 1 - genetics | DNA - biosynthesis | Stem Cells - physiology | Calcitriol - metabolism | Mice | Osteoblasts - metabolism | Index Medicus | Abridged Index Medicus
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10. Full Text Postnatal Establishment of Allelic Gas Silencing as a Plausible Explanation for Delayed Onset of Parathyroid Hormone Resistance Owing to Heterozygous Gas Disruption
by Turan, Serap and Fernandez-Rebollo, Eduardo and Aydin, Cumhur and Zoto, Teuta and Reyes, Monica and Bounoutas, George and Chen, Min and Weinstein, Lee S and Erben, Reinhold G and Marshansky, Vladimir and Bastepe, Murat
Journal of bone and mineral research, ISSN 0884-0431, 03/2014, Volume 29, Issue 3, pp. 749 - 760
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology
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11. Full Text Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy
by Kubota, Toru and Bounoutas, George S and Miyagishima, Masayuki and Kadokami, Toshiaki and Sanders, Virginia J and Bruton, Christina and Robbins, Paul D and McTiernan, Charles F and Feldman, Arthur M
Circulation (New York, N.Y.), ISSN 0009-7322, 05/2000, Volume 101, Issue 21, pp. 2518 - 2525
Viruses | Genes | Hormones | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Calcium-Binding Proteins - metabolism | Immunohistochemistry | Receptors, Tumor Necrosis Factor - metabolism | Enzyme-Linked Immunosorbent Assay | Interleukin-1 - analysis | Viral Fusion Proteins - genetics | Down-Regulation | Myocarditis - drug therapy | Mice, Transgenic | Cardiomyopathy, Dilated - metabolism | Receptors, Tumor Necrosis Factor - physiology | Sarcoplasmic Reticulum - enzymology | Animals | Cardiomyopathy, Dilated - drug therapy | Cardiomyopathy, Dilated - etiology | Etanercept | Adenoviridae - genetics | Calcium-Transporting ATPases - metabolism | Mice | Genetic Vectors | Immunoglobulin G - metabolism | Intercellular Adhesion Molecule-1 - analysis | Myosin Heavy Chains - analysis | Index Medicus | Abridged Index Medicus
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12. Full Text Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone-resistance due to heterozygous Gαs disruption
by Turan, Serap and Fernandez-Rebollo, Eduardo and Aydin, Cumhur and Zoto, Teuta and Reyes, Monica and Bounoutas, George and Chen, Min and Weinstein, Lee S and Erben, Reinhold G and Marshansky, Vladimir and Bastepe, Murat
Journal of bone and mineral research, ISSN 0884-0431, 3/2014, Volume 29, Issue 3, pp. 749 - 760
pseudohypoparathyroidism | parathyroid hormone | stimulatory G protein | renal proximal tubule | imprinting | GNAS | cyclic AMP
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13. Full Text Genetic interaction with vps8-200 allows partial suppression of the vestigial vacuole phenotype caused by a pep5 mutation in Saccharomyces cerevisiae
by Woolford, C.A. (Carnegie Mellon University, Pittsburgh, PA.) and Bounoutas, G.S and Frew, S.E and Jones, E.W
Genetics (Austin), ISSN 0016-6731, 01/1998, Volume 148, Issue 1, pp. 71 - 83
PROTEINAS | HIDROLASAS | GENE INTERACTION | INTERACTION GENIQUE | VACUOLE | MUTANTS | INDUCED MUTATION | BIOCHEMISTRY | FOSFATASA ALCALINA | PRECURSEUR D'ENZYME | VACUOLA | MUTANT | MUTACION INDUCIDA | SACCHAROMYCES CEREVISIAE | GENETICA | PHOSPHATASE ALCALINE | CYTOCHEMISTRY | MUTANTES | GENE | GENETICS | CLONAGE | PLEIOTROPY | HYDROLASES | FENOTIPOS | GENETIQUE | SUPPRESSOR GENES | BIOQUIMICA | INHIBITOR GENES | ALKALINE PHOSPHATASE | HYDROLASE | PROTEASES | CLONING | GENES | BIOCHIMIE | AMINOPEPTIDASE | ENZYME PRECURSORS | METABOLISME DES PROTEINES | PROTEIN METABOLISM | CLONACION | ALLELES | AMINOPEPTIDASA | MUTATION PROVOQUEE | PHENOTYPE | VACUOLES | PHENOTYPES | PROTEINE | PROTEASAS | INTERACCION DE GENES | METABOLISMO PROTEICO | PROTEIN TRANSPORT | PRECURSORES DE ENZIMAS | PROTEINS | PROTEASE | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Carrier Proteins - physiology | Vacuoles - enzymology | Hydrolases - biosynthesis | Vacuoles - genetics | Vacuoles - ultrastructure | Genes, Suppressor - genetics | Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae - ultrastructure | Fungal Proteins - genetics | Microscopy, Electron | Carrier Proteins - genetics | Phenotype | Epistasis, Genetic | Alleles | Saccharomyces cerevisiae Proteins | Mutation | Genes, Fungal - genetics | Genes, Fungal - physiology | Suppression, Genetic | Vesicular Transport Proteins | Index Medicus
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