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by Thorsson, Vesteinn and Thorsson, Vésteinn and Gibbs, Richard A and Gibbs, David L and Brown, Scott D and Wolf, Gregory and Wolf, Denise and Bortone, Dante S and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Gao, Jianjiong and Plaisier, Christopher L and Eddy, James A and Ziv, Elad and Culhane, Aedin C and Paull, Evan O and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Wenbin and Liu, Jianfang and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Rader, Janet and Dhankani, Varsha and Reynolds, Sheila and Reynolds, Sheila M and Bowlby, Reanne and Califano, Andrea and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Newman, Aaron M and Rao, Arvind and Chen, Amy and Chen, Chu and Chen, Ken and Krasnitz, Alexander and Hu, Jianhong and Hu, Hai and Malta, Tathiane M and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Ojesina, Akinyemi I and Lamb, Andrew and Zhou, Wanding and Shen, Hui and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Saltz, Joel and Holt, Robert and Holt, Robert A and Rabkin, Charles S and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Jioajiao and Wang, Min and Wang, Linghua and Wang, Zhining and Wang, Timothy and Wang, Jing and Yang, Ju Dong and Yang, Hannah and Yang, Liming and Yang, Ian and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Zhang, Jiexin and Zhang, Lizhi and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Yichao and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 812 - 830.e14
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across... 
tumor immunology | immunotherapy | cancer genomics | integrative network analysis | immuno-oncology | tumor microenvironment | immune subtypes | immunomodulatory | GENOMIC ANALYSES | INFORMATION | T-CELL-RECEPTOR | REGULATORY NETWORK | CLASSIFICATION | IMMUNOLOGY | SEQUENCING DATA | SOMATIC MUTATIONS | COMPREHENSIVE ANALYSIS | PREDICTION | REVEALS | Transforming Growth Factor beta - immunology | Prognosis | Humans | Middle Aged | Th1-Th2 Balance - physiology | Male | Neoplasms - classification | Wound Healing - immunology | Young Adult | Transforming Growth Factor beta - genetics | Neoplasms - genetics | Neoplasms - immunology | Interferon-gamma - immunology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Interferon-gamma - genetics | Wound Healing - genetics | Genomics - methods | Child | Macrophages - immunology | Cell proliferation | Cluster analysis | Transcription | Copy number | p53 Protein | Lung cancer | Genomics | Aneuploidy | Lymphocytes T | Genomes | Cell interactions | Macrophages | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Immune system | Medical research | Wound healing | Immunomodulation | MiRNA | Stockholders | Inflammation | T cell receptors | Communications networks | Gene expression | White blood cells | Inventors | Medical prognosis | γ-Interferon | Mutation | Cancer | Tumors | Immune Subtypes | Integrative Network Analysis | Cancer Genomics | Immuno-oncology | Tumor immunology
Journal Article
Gut, ISSN 0017-5749, 05/2012, Volume 61, Issue 5, pp. 673 - 684
ObjectiveGastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify... 
GROWTH-FACTOR RECEPTOR | LUNG | AMPLIFICATION | COPY-NUMBER | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | TRASTUZUMAB RESISTANCE | EXPRESSION | LINEAGE-SURVIVAL ONCOGENE | GENETIC ALTERATIONS | Stomach Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Oligonucleotide Array Sequence Analysis | Receptor, ErbB-2 - genetics | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Genetic Markers | Stomach Neoplasms - drug therapy | Molecular Targeted Therapy | Proto-Oncogene Proteins c-met - genetics | Gene Amplification | Gene Deletion | Polymorphism, Single Nucleotide | Stomach Neoplasms - mortality | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Development and progression | Drug targeting | Genetic aspects | Research | Demographic aspects | Stomach cancer | Proteins | Studies | Chemotherapy | Medical prognosis | Mortality | Clinical trials | Breast cancer | Mutation | Cancer therapies | Patients | Tumors | Stomach | gastroscopy | Barrett's metaplasia | gastric cancer | targeted therapies | gene mutation | gastric pre-cancer | chemotherapy | oesophageal cancer | Barrett's carcinoma | receptor tyrosine kinases | cell signalling | gastrointestinal cancer | cancer | colorectal cancer screening | gastrointesinal endoscopy | gastric carcinoma | 1506 | molecular pathology | copy number alterations | gene expression
Journal Article
Journal Article
Journal Article
Gut, ISSN 0017-5749, 11/2015, Volume 64, Issue 11, pp. 1721 - 1731
Journal Article
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 3928 - 15
Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to characterize due to their... 
SURVIVAL | CELLS | ACTIVATION | PROGNOSIS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | SUBSETS | POLARIZATION | EXPRESSION | INFILTRATION | REVEALS | CD163 antigen | Immunohistochemistry | Multiplexing | Heterogeneity | Spatial distribution | Spatial heterogeneity | Multivariate analysis | Macrophages | Stomach cancer | Gastric cancer | Tumors | Cancer
Journal Article