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1. Full Text Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm
by Cannon, Daniel T and Rodewohl, Lukas and Adams, Volker and Breen, Ellen C and Bowen, T Scott
Journal of applied physiology (Bethesda, Md. : 1985), ISSN 8750-7587, 09/2019, Volume 127, Issue 5, pp. 1360 - 1369
Diaphragm dysfunction accompanies cardiopulmonary disease and impaired oxygen delivery. Vascular endothelial growth factor (VEGF) regulates oxygen delivery... 
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2. Full Text Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training
by Bowen, T. Scott and Schuler, Gerhard and Adams, Volker
Journal of Cachexia, Sarcopenia and Muscle, ISSN 2190-5991, 09/2015, Volume 6, Issue 3, pp. 197 - 207
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and respiration. Transmission of external stimuli to intracellular... 
Sarcopenia | Molecular analysis | Cachexia | Exercise training | Muscle wasting | CHRONIC HEART-FAILURE | CANCER CACHEXIA | GERIATRICS & GERONTOLOGY | MEDICINE, GENERAL & INTERNAL | LEFT-VENTRICULAR DYSFUNCTION | CELL SELF-RENEWAL | AGE-RELATED-CHANGES | GENE-EXPRESSION | PROTEIN BREAKDOWN | GROWTH-FACTOR-I | UBIQUITIN-PROTEASOME PATHWAY | MITOCHONDRIAL-DNA-DELETION | Intervention | Disease | Authorship | Mortality | Cancer therapies | Autophagy | Insulin | Quality of life | Proteins | Musculoskeletal system | Physical fitness | Scholarships & fellowships | Exercise | Protein synthesis | Older people | Aging | Growth factors | Fitness training programs | Chronic illnesses | Reviews
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3. Full Text Abstract 13344: Murf1 and Murf2 Independently Mediate Muscle Wasting in Mice With Cardiac Cachexia
by Adams, Volker and Nguyen, Thanh and Bowen, T Scott and Werner, Sarah and Labeit, Siegfried and Linke, Axel
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A13344 - A13344
BackgroundPatients with cardiac cachexia (CC) are characterized by a severe loss of muscle mass limiting mobility and quality of life. The mechanisms mediating... 
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4. Data collection, handling, and fitting strategies to optimize accuracy and precision of oxygen uptake kinetics estimation from breath-by-breath measurements
by Alan P Benson and T Scott Bowen and Carrie Ferguson and Scott R Murgatroyd and Harry B Rossiter
Journal of Applied Physiology, ISSN 8750-7587, 07/2017, Volume 123, Issue 1, p. 227
Phase 2 pulmonary oxygen uptake kinetics (...) reflect muscle oxygen consumption dynamics and are sensitive to changes in state of training or health. This... 
Oxygen | Statistical analysis | Computer simulation | Transitions | Stacking | Muscles | Oxygen consumption | Statistical methods | Oxygen uptake | Optimization | Studies | Confidence intervals | Interpolation | Accuracy | Computer applications | Data collection | Comparative studies | Collection | Oxidation | Kinetics
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5. Full Text Data collection, handling, and fitting strategies to optimize accuracy and precision of oxygen uptake kinetics estimation from breath-by-breath measurements
by Benson, Alan P and Bowen, T Scott and Ferguson, Carrie and Murgatroyd, Scott R and Rossiter, Harry B
Journal of applied physiology (Bethesda, Md. : 1985), ISSN 8750-7587, 07/2017, Volume 123, Issue 1, pp. 227 - 242
Phase 2 pulmonary oxygen uptake kinetics (phi 2 tau Vo(2P)) reflect muscle oxygen consumption dynamics and are sensitive to changes in state of training or... 
data handling | computational modeling | oxygen uptake kinetics | accuracy and precision | CHRONIC HEART-FAILURE | EXERCISE TRANSIENTS | SPORT SCIENCES | PULMONARY O-2 UPTAKE | PHYSIOLOGY | CONFIDENCE-INTERVALS | MODEL PARAMETERS | GAS-EXCHANGE KINETICS | PHASE-I | MODERATE EXERCISE | HISTORICAL-PERSPECTIVE | INTENSITY EXERCISE | Pulmonary Gas Exchange - physiology | Models, Biological | Humans | Kinetics | Data Collection - methods | Monte Carlo Method | Oxygen Consumption - physiology | Respiratory Mechanics - physiology
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6. Full Text Respiratory Muscle Weakness in Patients with Heart Failure: Time to Make It a Standard Clinical Marker and a Need for Novel Therapeutic Interventions?
by Taylor, Bryan J and Bowen, T. Scott
Journal of Cardiac Failure, ISSN 1071-9164, 04/2018, Volume 24, Issue 4, pp. 217 - 218
DIAPHRAGM | LIMB | CARDIAC & CARDIOVASCULAR SYSTEMS | PRESERVED EJECTION FRACTION | STRENGTH | VALUES | DYSFUNCTION
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7. Full Text High-intensity interval training prevents oxidantmediated diaphragm muscle weakness in hypertensive mice
by Bowen, T. Scott and Eisenkolb, Sophia and Drobner, Juliane and Fischer, Tina and Werner, Sarah and Linke, Axel and Mangner, Norman and Schuler, Gerhard and Adams, Volker
FASEB Journal, ISSN 0892-6638, 01/2017, Volume 31, Issue 1, pp. 60 - 71
Heart failure | Skeletal muscle | Exercise
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8. Full Text Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training
: Muscle wasting and exercise training
by Bowen, T. Scott and Schuler, Gerhard and Adams, Volker
Journal of Cachexia, Sarcopenia and Muscle, ISSN 2190-5991, 09/2015, Volume 6, Issue 3, pp. 197 - 207
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9. Full Text Reply to Francescato et al.: Interpreting the averaging methods to estimate oxygen uptake kinetics parameters
by Benson, Alan P and Scott Bowen, T and Ferguson, Carrie and Murgatroyd, Scott R and Rossiter, Harry B
Journal of Applied Physiology, ISSN 8750-7587, 10/2017, Volume 123, Issue 4, pp. 1019 - 1019
SPORT SCIENCES | PHYSIOLOGY
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10. Full Text Skeletal muscle ATP turnover by 31P magnetic resonance spectroscopy during moderate and heavy bilateral knee extension
by Cannon, Daniel T and Bimson, William E and Hampson, Sophie A and Bowen, T. Scott and Murgatroyd, Scott R and Marwood, Simon and Kemp, Graham J and Rossiter, Harry B
The Journal of Physiology, ISSN 0022-3751, 12/2014, Volume 592, Issue 23, pp. 5287 - 5300
Key points Heavy‐intensity exercise causes a progressive increase in energy demand that contributes to exercise limitation. This inefficiency arises within the... 
Anaerobiosis | Magnetic Resonance Spectroscopy | Oxygen - physiology | Humans | Mitochondria, Muscle - metabolism | Oxidative Phosphorylation | Male | Muscle, Skeletal - metabolism | Oxygen Consumption - physiology | Young Adult | Pulmonary Gas Exchange - physiology | Adenosine Triphosphate - metabolism | Muscle Contraction - physiology | Glycolysis | Adult | Female | Exercise - physiology | Phosphocreatine - metabolism | Muscles | Nuclear magnetic resonance spectroscopy | Exercise | Muscle
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11. Full Text Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model
by Vinke, Paulien and Bowen, T.S and Boekschoten, Mark V and Witkamp, Renger F and Adams, Volker and Norren, van, Klaske
Scientific Reports, ISSN 2045-2322, 2019, Volume 9, Issue 1, pp. 10160 - 11
Pulmonary arterial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricle (RV), which leads to functional decline of... 
HNE Nutrition and Pharmacology | Sensoriek en eetgedrag | Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | Voeding, Metabolisme en Genomica | Chair Sensory Science and Eating Behaviour | Sensory Science and Eating Behaviour | Chair Nutrition and Pharmacology (HNE) | VLAG | Voedingsbiologie en Gezondheid | Nutritional Biology and Health | HNE Voeding en Farmacologie | HNE Sensoriek en Eetgedrag | HNE Sensory Science and Eating Behaviour | HNE Nutrition, Metabolism and Genomics | PATHOGENESIS | CACHEXIA | METABOLISM | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | CHAIN AMINO-ACIDS | MECHANISMS | DYSFUNCTION | COMBINATION | EXPRESSION | Hypertension | Cardiac muscle | Fish oils | Pulmonary arteries | Monocrotaline | Inflammation | Oligosaccharides | Leucine | Skeletal muscle | Pulmonary artery | Atrophy | Musculoskeletal system | Fibrosis | Ventricle
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12. Full Text Endothelial function is disturbed in a hypertensive diabetic animal model of HFpEF: Moderate continuous vs. high intensity interval training
by Schmederer, Zelia and Rolim, Natale and Bowen, T. Scott and Linke, Axel and Wisloff, Ulrik and Adams, Volker and OptimEx Study Grp and OptimEx study group
International Journal of Cardiology, ISSN 0167-5273, 12/2018, Volume 273, pp. 147 - 154
Heart failure with preserved ejection fraction (HFpEF) is associated with endothelial dysfunction, but the molecular mechanisms still remain unclear. Whether... 
SINGLE-BLIND TRIAL | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | OLDER PATIENTS | RATS | PRESERVED EJECTION FRACTION | MEDIATED ARTERIAL DILATION | EXERCISE CAPACITY | RANDOMIZED CONTROLLED-TRIAL | DYSFUNCTION | DIASTOLIC HEART-FAILURE | High-Intensity Interval Training - methods | Physical Conditioning, Animal - methods | Heart Failure - physiopathology | Endothelium, Vascular - drug effects | Male | Diabetes Mellitus, Experimental - therapy | Endothelium, Vascular - physiology | Heart Failure - therapy | Heart Failure - diagnostic imaging | Hypertension - therapy | Vasodilation - physiology | Obesity - diagnostic imaging | Diabetes Mellitus, Experimental - physiopathology | Vasoconstrictor Agents - pharmacology | Stroke Volume - physiology | Rats | Obesity - physiopathology | Physical Conditioning, Animal - physiology | Hypertension - physiopathology | Animals | Endothelium, Vascular - diagnostic imaging | Obesity - therapy | Hypertension - diagnostic imaging | Vasodilation - drug effects | Diabetes Mellitus, Experimental - diagnostic imaging | Oxidases | Hypertension | Collagen | Nitric oxide | Endothelium
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13. Full Text Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle
by Bowen, T. Scott and Rolim, Natale P. L and Fischer, Tina and Bækkerud, Fredrik H and Medeiros, Alessandra and Werner, Sarah and Brønstad, Eivind and Rognmo, Oivind and Mangner, Norman and Linke, Axel and Schuler, Gerhard and Silva, Gustavo J. J and Wisløff, Ulrik and Adams, Volker and Optimex Study Grp and Optimex Study Group
European Journal of Heart Failure, ISSN 1388-9842, 03/2015, Volume 17, Issue 3, pp. 263 - 272
Aims Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with... 
Mitochondrial respiration | Diastolic dysfunction | Soleus | Diaphragm | Exercise training | CARDIAC & CARDIOVASCULAR SYSTEMS | DETERMINANTS | EXERCISE CAPACITY | INTOLERANCE | WEAKNESS | TRIAL | OLDER PATIENTS | ENDURANCE EXERCISE | DIAPHRAGM DYSFUNCTION | Mitochondria, Muscle - metabolism | Oxidative Stress - physiology | Heart Failure - physiopathology | NADPH Oxidases - metabolism | Stroke Volume - physiology | Rats | Muscle, Skeletal - metabolism | Heart Failure - metabolism | Troponin C - metabolism | Catalase - metabolism | Animals | Exercise Tolerance - physiology | Muscle, Skeletal - physiopathology | Female | Models, Animal | Myosin Light Chains - metabolism | Rats, Inbred Dahl | Diaphragm - metabolism | Superoxide Dismutase - metabolism | Diaphragm - physiopathology
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14. Full Text Optimising Oxygen Uptake Kinetic Fitting Methods in Healthy Humans Ranging in Anatomical and Physiological Characteristics
: 366 Board #204 May 28, 11
by Benson, Alan P and Bowen, T. Scott and Ferguson, Carrie and Murgatroyd, Scott R and Rossiter, Harry B
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 05/2014, Volume 46, p. 93
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15. Full Text Optimising oxygen uptake kinetic fitting methods in healthy humans ranging in anatomical and physiological characteristics
by Rossiter, Harry B and Murgatroyd, Scott R and Ferguson, Carrie and Bowen, T. Scott and Benson, Alan P
Medicine and Science in Sports and Exercise, ISSN 0195-9131, 05/2014, Volume 46, Issue 5
Oxygen consumption | Research
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16. Full Text Diaphragm muscle weakness in mice is early-onset post-myocardial infarction and associated with elevated protein oxidation
by Bowen, T. Scott and Mangner, Norman and Werner, Sarah and Glaser, Stefanie and Kullnick, Yvonne and Schrepper, Andrea and Doenst, Torsten and Oberbach, Andreas and Linke, Axel and Steil, Leif and Schuler, Gerhard and Adams, Volker
Journal of Applied Physiology, ISSN 8750-7587, 01/2015, Volume 118, Issue 1, pp. 11 - 19
Heart failure induced by myocardial infarction (MI) causes diaphragm muscle weakness, with elevated oxidants implicated. We aimed to determine whether... 
MI: protein carbonylation | Skeletal muscle | Chronic heart failure | SPORT SCIENCES | ACTIVATION | PHYSIOLOGY | MYOCARDIAL-INFARCTION | RATS | REPERFUSION | chronic heart failure | MODEL | CALCIUM SENSITIVITY | SKELETAL-MUSCLE | DYSFUNCTION | skeletal muscle | CONGESTIVE-HEART-FAILURE | STRESS | Muscle Weakness - etiology | Protein Carbonylation | Xanthine Oxidase - metabolism | Oxidation-Reduction | Actins - metabolism | NADPH Oxidases - metabolism | Myocardial Infarction - metabolism | Carbonic Anhydrases - metabolism | Myocardial Infarction - complications | Animals | Muscle Weakness - metabolism | Female | Myocardial Infarction - physiopathology | Mice | Muscle Weakness - physiopathology | Diaphragm - physiopathology
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