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1. Full Text Recent insights into the role of Toll‐like receptors in viral infection
by Carty, M and Bowie, A. G
Clinical & Experimental Immunology, ISSN 0009-9104, 09/2010, Volume 161, Issue 3, pp. 397 - 406
Summary Toll‐like receptors (TLRs) have a central role in innate immunity as they detect conserved pathogen‐associated molecular patterns (PAMPs) on a range of... 
viral evasion | Toll‐like receptor | innate immunity | signal transduction | human studies | Signal transduction | Viral evasion | Innate immunity | Human studies | Toll-like receptor | VACCINIA-VIRUS | IMMUNOLOGY | ADAPTER PROTEIN TRIF | PLASMACYTOID DENDRITIC CELLS | INNATE IMMUNE-RESPONSES | SINGLE-STRANDED RNA | ANTIVIRAL ACTIVITY | BETA-INTERFERON | INTERFERON-PRODUCTION | RESPIRATORY SYNCYTIAL VIRUS | IFN-ALPHA | Virus Diseases - immunology | Cytokines - metabolism | Humans | Toll-Like Receptor 1 - metabolism | Toll-Like Receptors - immunology | Virus Diseases - metabolism | Toll-Like Receptor 2 - metabolism | Immunity, Innate - immunology | Signal Transduction - immunology | Models, Immunological | Animals | Toll-Like Receptor 2 - immunology | Toll-Like Receptor 1 - immunology | Toll-Like Receptors - metabolism | Cytokines - immunology | Antiviral agents | Health aspects | Viruses | Viral infections | Immune system | Infection | Toll-like receptors | Data processing | Immune response | Immunity | Review
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2. Full Text Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
by Horan, K.A and Hansen, K and Jakobsen, M.R and Holm, C.K and Soby, S and Unterholzner, L and Thompson, M and West, J.A and Iversen, M.B and Rasmussen, S.B and Ellermann-Eriksen, S and Kurt-Jones, E and Landolfo, S and Damania, B and Melchjorsen, J and Bowie, A.G and Fitzgerald, K.A and Paludan, S.R
Journal of Immunology, ISSN 0022-1767, 2013, Volume 190, Issue 5, pp. 2311 - 2319
The innate immune system is important for control of infections, including herpesvirus infections. Intracellular DNA potently stimulates antiviral IFN... 
INTRACELLULAR DNA | DENDRITIC CELLS | VIRAL-DNA | AUTOIMMUNITY | PROTEIN IFI16 | INFLAMMASOME | INNATE IMMUNE-RESPONSE | INFECTION | HERPESVIRUSES | IMMUNOLOGY | INDEPENDENT PATHWAYS | Phosphoproteins - immunology | RNA, Small Interfering - genetics | Interferon-beta - immunology | Humans | Cercopithecus aethiops | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Ubiquitination | Cell Nucleus - metabolism | Macrophages - virology | Capsid - metabolism | Dendritic Cells - virology | Vero Cells | Dendritic Cells - metabolism | Cell Line | Cytomegalovirus - genetics | Herpesvirus 1, Human - metabolism | Cytomegalovirus - metabolism | Gene Silencing | Interferon-beta - biosynthesis | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | DNA, Viral - immunology | Macrophages - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cytosol - metabolism | Herpesvirus 1, Human - genetics | Proteasome Endopeptidase Complex - metabolism | DNA, Viral - genetics
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3. Full Text Translational Mini-Review Series on Toll-like Receptors:Recent advances in understanding the role of Toll-like receptors in anti-viral immunity
by Bowie, A. G
Clinical & Experimental Immunology, ISSN 0009-9104, 02/2007, Volume 147, Issue 2, pp. 217 - 226
ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON TOLL-LIKE RECEPTORSNetworks regulated by Toll-like receptors mediate innate and adaptive... 
viral evasion | innate immunity | interferon | inflammation | Toll-like receptor | Toll‐like receptor | Viral evasion | Innate immunity | Inflammation | Interferon | DOUBLE-STRANDED-RNA | HEPATITIS-C-VIRUS | RIG-I | IMMUNOLOGY | ADAPTER PROTEIN TRIF | PLASMACYTOID DENDRITIC CELLS | GENE INDUCTION-PROGRAM | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | RESPIRATORY SYNCYTIAL VIRUS | Antigens, Viral - immunology | Signal Transduction - immunology | Animals | Virus Diseases - immunology | Receptors, Pattern Recognition - immunology | Toll-Like Receptors - immunology | Immune Tolerance | Toll-Like Receptor 3 - immunology | Mice | Immunity, Cellular | DNA Viruses - immunology | Translational Mini-Review Series on TLRs
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4. Full Text Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase
by Bowie, A.G and O'Neill, L.A.J
Journal of Immunology, ISSN 0022-1767, 12/2000, Volume 165, Issue 12, pp. 7180 - 7188
The transcription factor NF-kappaB is a central mediator of altered gene expression during inflammation, and is implicated in a number of pathologies,... 
TUMOR-NECROSIS-FACTOR | COMPLEX | LIPID-PEROXIDATION | INDUCED APOPTOSIS | PHOSPHORYLATION | ALPHA | INFECTED-CELLS | IMMUNOLOGY | STRESS | ASCORBIC-ACID | EXPRESSION | Endothelium, Vascular - cytology | Cell Line | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | I-kappa B Proteins | Endothelium, Vascular - drug effects | NF-kappa B - metabolism | Antioxidants - pharmacology | Enzyme Activation - drug effects | I-kappa B Kinase | DNA-Binding Proteins - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Ascorbic Acid - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - physiology | Phosphorylation - drug effects | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism
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5. Full Text Novel strategies for targeting innate immune responses to influenza
by Shirey, K.A and Lai, W and Patel, M.C and Pletneva, L.M and Pang, C and Kurt-Jones, E and Lipsky, M and Roger, T and Calandra, T and Tracey, K.J and Al-Abed, Y and Bowie, A.G and Fasano, A and Dinarello, C.A and Gusovsky, F and Blanco, J.C.G and Vogel, S.N
Mucosal Immunology, ISSN 1933-0219, 09/2016, Volume 9, Issue 5, pp. 1173 - 1182
We previously reported that TLR4(-/-) mice are refractory to mouse-adapted A/PR/8/34 (PR8) influenza-induced lethality and that therapeutic administration of... 
UNITED-STATES | RESPIRATORY-TRACT | VIRUS-INFECTION | STRANDED RNA | INFLAMMATION | VACCINE EFFECTIVENESS | LIPOPOLYSACCHARIDE | ACUTE LUNG INJURY | MICE | IMMUNOLOGY | TLR4 | Interleukin-1 Receptor Accessory Protein - genetics | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Male | HMGB1 Protein - immunology | Molecular Targeted Therapy | HMGB1 Protein - genetics | Disaccharides - pharmacology | Lung - virology | Sugar Phosphates - pharmacology | Immunoglobulin G - pharmacology | Female | Acute Lung Injury - drug therapy | Orthomyxoviridae - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Interleukin-1 Receptor Accessory Protein - antagonists & inhibitors | HMGB1 Protein - antagonists & inhibitors | Orthomyxoviridae Infections - drug therapy | Oseltamivir - pharmacology | Antiviral Agents - pharmacology | Interleukin-1 Receptor Accessory Protein - immunology | Lung - pathology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Immunity, Innate | Orthomyxoviridae - growth & development | Mice, Knockout | Drug Synergism | Acute Lung Injury - mortality | Animals | Orthomyxoviridae Infections - mortality | Lung - drug effects | Survival Analysis | Toll-Like Receptor 2 - immunology | Acute Lung Injury - immunology | Mice | Acute Lung Injury - virology | Orthomyxoviridae - pathogenicity | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology
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6. Full Text Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis
by Cooke, G and Kamal, I and Strengert, M and Hams, E and Mawhinney, L and Tynan, A and O’Reilly, C and O’Dwyer, D N and Kunkel, S L and Knaus, U G and Shields, D C and Moller, D R and Bowie, A G and Fallon, P G and Hogaboam, C M and Armstrong, M E and Donnelly, S C
QJM: An International Journal of Medicine, ISSN 1460-2725, 04/2018, Volume 111, Issue 4, pp. 217 - 224
Abstract Background/Introduction Sarcoidosis is a multi-systemic disorder of unknown etiology, characterized by the presence of non-caseating granulomas in... 
NUCLEOTIDE | CELLS | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | GENE | CANCER-RISK | INFECTION | HEPATITIS-C | ASSOCIATION | EXPRESSION | TLR3 | Genetic Predisposition to Disease | Humans | Middle Aged | Logistic Models | Male | Case-Control Studies | Young Adult | Phenotype | Ireland | Adolescent | Sarcoidosis, Pulmonary - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Toll-Like Receptor 3 - genetics | Original Papers
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7. Full Text An arms race: Innate antiviral responses and counteracting viral strategies
by Schröder, M and Bowie, A.G
Biochemical Society Transactions, ISSN 0300-5127, 12/2007, Volume 35, Issue 6, pp. 1512 - 1514
Viral recognition is mediated by different classes of PRRs (pattern-recognition receptors) among which the TLRs (Toll-like receptors) and the RLHs [RIG... 
Vaccinia virus | Retinoic-acid-inducible protein I (RIG-I) | Viral immune evasion | Toll-like receptor (TLR) | Pattern-recognition receptor | Antiviral signalling | IMMUNE-RESPONSE | ACTIVATION | PROTEIN | VACCINIA-VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATITIS-C-VIRUS | RIG-I | vaccinia virus | antiviral signalling | retinoic-acid-inducible protein I (RIG-1) | pattern-fecognition receptor | PATHWAY | DNA | TARGETS | viral immune evasion | NF-KAPPA-B | Immunity, Innate - immunology | Signal Transduction - immunology | Animals | Toll-Like Receptors - immunology | Viral Proteins - immunology | Viruses - immunology | RNA Helicases - immunology
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8. Full Text Evasion of innate immunity by vaccinia virus
by HAGA, I. R and BOWIE, A. G
Parasitology, ISSN 0031-1820, 3/2005, Volume 130, Issue S1, pp. S11 - S25
Vaccinia virus, a member of the Poxviridae, expresses many proteins involved in immune evasion. In this review, we present a brief characterisation of the... 
Vaccinia virus | Toll-like receptors | Signal transduction | Immune evasion | Nuclear factor kappa B | DOUBLE-STRANDED-RNA | toll-like receptors | signal transduction | nuclear factor kappa B | HOST-RANGE | POXVIRUS PROTEIN | vaccinia virus | PROGRAMMED CELL-DEATH | INTERLEUKIN-18 BINDING-PROTEIN | immune evasion | INTERFERON-GAMMA | HAMSTER OVARY CELLS | INFECTED-CELLS | NF-KAPPA-B | PARASITOLOGY | Vaccinia - virology | Vaccinia virus - pathogenicity | Cytokines - metabolism | Signal Transduction | Humans | Vaccinia virus - immunology | Immunity, Innate - immunology | Vaccines, Attenuated - immunology | Apoptosis - immunology | Interferons - metabolism | Vaccinia - immunology | Cytokines - antagonists & inhibitors | Toll-Like Receptors - metabolism | Immunity, Cellular | Interferons - antagonists & inhibitors | Proteins | Viruses | Kinases | Apoptosis
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9. Full Text The Production of a Reactive Oxygen Intermediate during the Induction of Apoptosis by Cytotoxic Insult
by McGowan, A.J and Bowie, A.G and O'Neill, L.A.J and Cotter, T.G
Experimental Cell Research, ISSN 0014-4827, 01/1998, Volume 238, Issue 1, pp. 248 - 256
We report the protective effects of two novel anti-oxidant compounds, 3 beta-doxyl-5 alpha cholestane and 2,2,6,6-tetramethyl-piperdinoxyl, in HL-60 and U937... 
PROGRAMMED CELL-DEATH | BCL-2 | LEUKEMIA HL-60 CELLS | OXIDATIVE STRESS | ACTIVATION | INHIBITION | ANTIOXIDANTS | ONCOLOGY | HYDROGEN-PEROXIDE | THYMOCYTE APOPTOSIS | NF-KAPPA-B | CELL BIOLOGY | Consensus Sequence | Oligodeoxyribonucleotides | Cyclic N-Oxides - toxicity | Apoptosis - drug effects | Apoptosis - radiation effects | Cell Survival | Humans | Leukemia | NF-kappa B - metabolism | Antioxidants - pharmacology | Reactive Oxygen Species - physiology | Ultraviolet Rays | Cyclic N-Oxides - pharmacology | Base Sequence | HL-60 Cells | Apoptosis - physiology | Tumor Cells, Cultured | Binding Sites | Antioxidants | Analysis | Apoptosis
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10. Full Text Mal (MyD88 adapter-like) is a novel Toll IL-1 receptor (TIR) domain-containing adapter which recruits IRAK-2 during Toll-like receptor-4 signal transduction
by Fitzgerald, K.A and Bowie, A.G and Palsson-McDermott, E.M and Dunne, A and Gray, P and Harte, M.T and Jefferies, C.A and Mansell, A.S and McMurray, D and Smith, D.E and Sims, J.E and Bird, T.A and O'Neill, L.A.J
Biochemical Society Transactions, ISSN 0300-5127, 10/2001, Volume 29, Issue 5, pp. A132 - A132
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11. Necrotising fasciitis: A single centre's experience
by Rietveld, J.A and Pilmore, H.L and Jones, P.G and Theis, J.-C and Bowie, D.A and Dempster, A.G and Walker, R.J
New Zealand Medical Journal, ISSN 0028-8446, 1995, Volume 108, Issue 995, pp. 72 - 74
Necrotising fasciitis is a rare but serious soft tissue infection with high morbidity and mortality. We wished to review our 5 year experience with this... 
Fasciitis - therapy | Humans | Middle Aged | Male | Necrosis | New Zealand | Fasciitis - etiology | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Fatal Outcome | Adult | Female | Aged | Child | Fasciitis - surgery
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12. Full Text Radon and leukaemia
by Mole, R.H and Bowie, S.H.U and Alexander, FredaE and Mckinney, PatriciaA and Cartwright, RaymondA and Prentice, A.G and Copplestone, J.A and Baverstock, K.F and Butland, B.K and Muirhead, C.R and Draper, G.J and Henshaw, DenisL and Eatough, JonathanP and Richardson, RichardB and Rechavi, Gideon and Ben-Bassat, Isaac and Berkowicz, Miriam and Neumann, Yoram and Ramot, Bracha
The Lancet, ISSN 0140-6736, 1990, Volume 335, Issue 8701, pp. 1336 - 1340
MEDICINE, GENERAL & INTERNAL | Radon - adverse effects | Leukemia, Radiation-Induced - etiology | Europe | Humans | Middle Aged | Neoplasms, Radiation-Induced - etiology | Male | United Kingdom | Air Pollutants, Radioactive - analysis | Leukemia, Lymphoid - etiology | Canada | Leukemia, Myeloid - etiology | Air Pollutants, Radioactive - adverse effects | Lung Neoplasms - etiology | Adolescent | Adult | Female | Aged | Radon - analysis | Child
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13. The New Zealand Glomerulonephritis study: Introductory report
by Bowie, E.A and Collins, J.F and Doak, P.B and Gregory, M.C and North, J.D.K and Richmond, D.E and Simpson, I.J and Williams, L.C and Hatfield, P.J and Morrison, R.B.I and Neale, T.J and Bailey, R.R and Little, P.J and Lynn, K.L and Robson, R.A and Swainson, C.P and Dixon, S.R and Hocken, A.G and Herdson, P.B
Clinical Nephrology, ISSN 0301-0430, 1989, Volume 31, Issue 5, pp. 239 - 246
All patients 14 years and older seen between July 1972 and June 1983 in four of the five nephrological centers in New Zealand with biopsy-proven primary... 
UROLOGY & NEPHROLOGY | Prognosis | Prospective Studies | Age Factors | Follow-Up Studies | Humans | Middle Aged | European Continental Ancestry Group | Male | Glomerulonephritis - complications | Glomerulonephritis - ethnology | New Zealand | Biopsy | Glomerulonephritis - pathology | Adolescent | Sex Factors | Adult | Female | Aged | Glomerulonephritis - epidemiology | Kidney Failure, Chronic - etiology
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14. Full Text Lipid membrane peroxidation, vitamin E, and the generation of irreversibly sickled cells in sickle cell anemia
by Bowie, L.J and Carreathers, S.A and Wright, A.G
Clinical Chemistry, ISSN 0009-9147, 1979, Volume 25, Issue 6, p. 069
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15. Full Text Geology and health - discussion
by Alloway, B.J and Bowie, S.H.U and Shaper, A.G
Journal of the Geological Society, ISSN 0016-7649, 1980, Volume 137, Issue 5, p. 587
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16. Full Text Sudden death from occlusive disease of the atrioventricular node artery
by Anderson, Kenneth R and Bowie, J and Dempster, A.G and Gwynne, J.F
Pathology, ISSN 0031-3025, 1981, Volume 13, Issue 3, pp. 417 - 421
Non-atherosclerotic focal occlusive disease of the atrioventricular node artery was the only significant pathological lesion found at autopsy in 2 individuals... 
conducting tissue | arteries | sudden death | cardiac | Conducting tissue | Cardiac | Sudden death | Arteries | Heart Conduction System - pathology | Death, Sudden - etiology | Arterial Occlusive Diseases - pathology | Humans | Adolescent | Adult | Male | Death, Sudden - pathology | Atrioventricular Node - pathology
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17. Acute pulmonary edema following ligation of an arteriovenous fistula
by Bowie, J and Kreher, A and Graybar, G and Diethelm, A G
The Alabama journal of medical sciences, ISSN 0002-4252, 10/1986, Volume 23, Issue 4, pp. 437 - 438
Acute Disease | Ligation | Arteriovenous Shunt, Surgical - adverse effects | Humans | Middle Aged | Female | Pulmonary Edema - etiology | Renal Dialysis
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18. Full Text Vote of thanks
by Appleyard, J and Armstrong, Michael and Bassett, J. B and Bowte, J. C and Bradley, Katharine F and Brown, R. A. G and Campbell-Fergusson, J and Campbell-Smith, Simon and Dunlop, J and Enoch, B. Anthony and Fagan, David and Farewell, T and Forrest, R. D and Gordon, N. H and Hole, Roger and Hore, B. D and Lawlor, T and Low, Robert A. L and Lye, Michael and Modowal, K. K and Sheppard, Harvey and Sperryn, Peter and Stewart, A. J and Sussman, T and Tidmarsh, D and Wilson, Peter and Winwood, R. S and Woodyard, J. E
British Medical Journal, ISSN 0007-1447, 11/1969, Volume 4, Issue 5681, pp. 498 - 498
Correspondence
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19. Full Text IFI16 is an innate immune sensor for intracellular DNA
by Baran, Marcin and Unterholzner, Leonie and Fitzgerald, Katherine A and Xiao, T Sam and Latz, Eicke and Paludan, Søren R and Bowie, Andrew G and Horan, Kristy A and Sharma, Shruti and Sirois, Cherilyn M and Jin, Tengchuan and Jensen, Søren B and Keating, Sinead E
Nature Immunology, ISSN 1529-2908, 11/2010, Volume 11, Issue 11, pp. 997 - 1004
The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here... 
IFN-BETA | ACTIVATION | PROTEIN | RECOGNITION | RNA | I INTERFERONS | INFLAMMASOME | CYTOSOLIC DNA | INDUCTION | IMMUNOLOGY | CYTOPLASMIC DNA | Phosphoproteins - immunology | Cell Line | Interferon-beta - immunology | Intracellular Space - immunology | Signal Transduction | Humans | Membrane Proteins - immunology | Monocytes - immunology | Immunity, Innate | Nuclear Proteins - immunology | DNA, Viral - immunology | Animals | Interferon-beta - metabolism | Herpesvirus 1, Human - immunology | Mice | DNA-Binding Proteins | Physiological aspects | Interferon | Immune response | DNA binding proteins | Biological response modifiers | Health aspects
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