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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 6, pp. 2349 - 2354
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2007, Volume 129, Issue 10, pp. 2762 - 2763
We have shown that the tris(trimethylsilyl)silyl (TTMSS) silyl enol ether of acetaldehyde undergoes aldehyde cross-aldol reactions with high selectivity and... 
ORGANIC-CHEMISTRY | CRYPTOCARYA-LATIFOLIA | TANDEM ALDOL-ALLYLATION | ENOLSILANES | DIACETATE | CHEMISTRY, MULTIDISCIPLINARY | Chemistry, Organic - methods | Organic Chemicals - chemical synthesis | Silanes - chemistry | Stereoisomerism | Aldehydes - chemistry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2014, Volume 111, Issue 6, p. 2349
  The clinical development of drug combinations is typically achieved through trial-and-error or via insight gained through a detailed molecular understanding... 
Drugs | Chemotherapy | Matrix | Lymphomas | Drug therapy | Cells
Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1278 - 1283
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute... 
Antioxidants | Oxidative stress | Medical research | Cellular metabolism | REPORTS | Erythrocytes | Cell lines | Antibodies | Oxidation | Cell membranes | Hemoglobins | CELLS | OXIDATIVE STRESS | PROTEIN | METABOLISM | MULTIDISCIPLINARY SCIENCES | ROS | TUMOR-SUPPRESSOR | ISOFORM | CANCER | Enzyme Activators - pharmacology | Neoplasm Transplantation | Protein Subunits | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Pyruvate Kinase - chemistry | Diamide - pharmacology | Transplantation, Heterologous | Neoplasms, Experimental - pathology | Mutant Proteins - antagonists & inhibitors | Cell Line | Oxidation-Reduction | Pyruvate Kinase - metabolism | Cell Survival | Mutant Proteins - genetics | Mutant Proteins - metabolism | Cysteine - chemistry | Pyruvate Kinase - antagonists & inhibitors | Animals | Mice, Nude | Mutant Proteins - chemistry | Acetylcysteine - pharmacology | Cell Line, Tumor | Glucose - metabolism | Mice | Neoplasms, Experimental - metabolism | Pentose Phosphate Pathway | Pyruvate Kinase - genetics | Amino Acid Substitution | Reactive oxygen species | Enzyme inhibitors | Pyruvate kinase | Lung cancer | Cancer cells | Physiological aspects | Oxidation-reduction reaction | Research | Health aspects | Enzymes | Biochemistry | Cellular biology | Kinases
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 08/2016, Volume 113, Issue 34, p. 9587
The aggregation of [alpha]-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson's disease (PD). Rare... 
Physiological aspects | Parkinson's disease | Health aspects | Nerve proteins
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 08/2016, Volume 113, Issue 34, pp. 9587 - 9587
The aggregation of alpha -synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson's disease (PD). Rare... 
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 10, pp. 839 - 847
Journal Article
Nature Protocols, ISSN 1754-2189, 12/2006, Volume 1, Issue 5, pp. 2434 - 2438
The synthesis of the acetaldehyde-derived tris(trimethylsilyl) silyl (super silyl) enol ether is described, as well as its use in the high-yielding aldehyde... 
CRUCIAL ROLE | CATALYSIS | ASYMMETRIC-SYNTHESIS | LEWIS-ACID | BIOCHEMICAL RESEARCH METHODS | MUKAIYAMA ALDOL | BASE | Cyclohexanones - chemistry | Trimethylsilyl Compounds - chemical synthesis | Trimethylsilyl Compounds - chemistry | Aldehydes - chemistry
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 06/2016, Volume 12, Issue 6, pp. 452 - 458
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 07/2019, Volume 25, Issue 14, pp. 4552 - 4566
Purpose: Ewing sarcoma is an aggressive solid tumor malignancy of childhood. Although current treatment regimens cure approximately 70% of patients with... 
TRIAL | BARASERTIB AZD1152 | GENOMIC LANDSCAPE | FUSION | PHARMACOKINETICS | ONCOLOGY | SAFETY | MLN8237 | PHASE-I | CANCER | MTOR
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2006, Volume 128, Issue 1, pp. 48 - 49
The use of the tris(trimethylsilyl)silyl (TTMSS) group in aldehyde-derived silyl enol ethers affords aldehyde cross-aldol products with high yields and allows... 
CARBONYL-COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY | MUKAIYAMA ALDOL | Aldehydes - chemical synthesis | Stereoisomerism | Molecular Conformation | Trimethylsilyl Compounds - chemistry | Aldehydes - chemistry
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7555, pp. 216 - 220
Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural... 
MYELIN BASIC-PROTEIN | TRANSCRIPTS | GLUCOCORTICOIDS | MULTIPLE-SCLEROSIS | LYSOLECITHIN | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION | OLIGODENDROCYTE PROGENITOR CELLS | Oligodendroglia - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Cerebellum - drug effects | Myelin Sheath - drug effects | Male | Receptors, Glucocorticoid - metabolism | Demyelinating Diseases - metabolism | MAP Kinase Signaling System | Myelin Sheath - metabolism | Oligodendroglia - drug effects | Female | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Germ Layers - drug effects | Germ Layers - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Lysophosphatidylcholines | Pluripotent Stem Cells - cytology | Germ Layers - metabolism | Tissue Culture Techniques | Cerebellum - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cerebellum - pathology | Pluripotent Stem Cells - metabolism | Phenotype | Regeneration - drug effects | Animals | Cell Differentiation - drug effects | Miconazole - pharmacology | Pluripotent Stem Cells - drug effects | Multiple Sclerosis - pathology | Mice | Clobetasol - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Multiple Sclerosis - drug therapy | Medical research | Myelination | Multiple sclerosis | Stem cells | Physiological aspects | Medicine, Experimental | Research | Drugs | Proteins | Blood-brain barrier | Laboratories | Rodents | Clinical trials | FDA approval | Gene expression
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6220
The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS) assays for drug discovery use... 
OVARIAN-CANCER METASTASIS | PLATFORM | INVASION | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | BIOLOGY | FIBROBLASTS | PROGRESSION | MESOTHELIAL CELLS | SPHEROID MODEL | STEPS | Biguanides - pharmacology | Epithelial Cells - metabolism | Escin - chemistry | High-Throughput Screening Assays - instrumentation | Coculture Techniques | Epithelial Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Extracellular Matrix - metabolism | Prochlorperazine - chemistry | Tomatine - chemistry | Tomatine - pharmacology | Isoquinolines - chemistry | Isoquinolines - pharmacology | Benzophenanthridines - chemistry | Escin - pharmacology | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Fibroblasts - metabolism | High-Throughput Screening Assays - methods | Tumor Microenvironment - drug effects | Prochlorperazine - pharmacology | Cantharidin - pharmacology | Extracellular Matrix - drug effects | Cantharidin - chemistry | Epithelial Cells - pathology | Biguanides - chemistry | Antineoplastic Agents - chemistry | Cell Adhesion - drug effects | Fibroblasts - pathology | Benzophenanthridines - pharmacology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Mice, Nude | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | Primary Cell Culture
Journal Article