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Cell, ISSN 0092-8674, 06/2017, Volume 169, Issue 7, pp. 1177 - 1186
Journal Article
Bioinformatics, ISSN 1367-4803, 2014, Volume 30, Issue 18, pp. 2670 - 2672
A Summary Molecular inversion probes (MIPs) enable cost-effective multiplex targeted gene resequencing in large cohorts. However, the design of individual MIPs... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Computational Biology - methods | Algorithms | Sequence Analysis - methods | Computer Simulation | Humans | DNA Probes - genetics | Models, Statistical | Applications Notes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 21, pp. 5461 - 5466
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2017, Volume 49, Issue 11, pp. 1602 - 1612
The challenge of linking intergenic mutations to target genes has limited molecular understanding of human diseases. Here we show that H3K27ac HiChIP generates... 
HUMAN GENOME | VARIANTS | SPECIFICITY | PROMOTERS | HI-C | RESOLUTION | TRANSCRIPTION | GENETICS & HEREDITY | LOCI | DIFFERENTIATION | CHROMATIN ARCHITECTURE | Chromatin | Humans | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | T-Lymphocytes, Helper-Inducer - immunology | DNA, Intergenic - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes, Regulatory - cytology | Chromatin Immunoprecipitation - methods | Cell Differentiation | Autoimmune Diseases - pathology | Myocytes, Smooth Muscle - cytology | Promoter Regions, Genetic | Cardiovascular Diseases - metabolism | Autoimmune Diseases - immunology | DNA, Intergenic - genetics | Histones - genetics | Enhancer Elements, Genetic | Alleles | K562 Cells | Myocytes, Smooth Muscle - immunology | Histones - metabolism | Mutation | Primary Cell Culture | Genome, Human | Quantitative Trait Loci | Molecular targeted therapy | Disease susceptibility | Genetic aspects | Gene mutations | Health aspects | Innovations | CRISPR | Target recognition | Immunoregulation | Genes | Genomics | Coronary artery | Health risks | Smooth muscle | Cardiovascular disease | Genomes | Lymphocytes T | Gene expression | Quantitative trait loci | Enhancers | Maps | Lymphocytes | Coronary vessels | Gene mapping | Cardiovascular diseases | Alzheimers disease | Chromosomes | Deoxyribonucleic acid--DNA
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 12/2018, Volume 14, Issue 12, pp. e8594 - n/a
Powerful new technologies for perturbing genetic elements have recently expanded the study of genetic interactions in model systems ranging from yeast to human... 
CRISPR | functional genomics | genome‐wide perturbation | network topology | genetic interactions | genome-wide perturbation | PATHWAYS | SET | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRISPR SCREEN | GENE ONTOLOGY | YEAST | INHIBITORS | MAP | TOOL | Networks | Yeast | Communities | Genes | Genomes | Mapping | Genetic screening | Proteins | Artifacts | Screening | Pathways | Cell lines | New technology | Gene mapping | Genotypes | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 21, p. 5461
The bacterial adaptive immune system CRISPR-Cas9 has been appropriated as a versatile tool for editing genomes, controlling gene expression, and visualizing... 
Adaptive systems | Profiling | Editing | Genomes | Time | Biochemistry | Nucleotides | gRNA | Gene sequencing | Proteins | Thermodynamics | Bacteria | Libraries | Mathematical models | Nuclease | Deoxyribonucleic acid--DNA | Immune system | Binding | CRISPR | Gene expression | Ribonucleic acid--RNA | Loci | Flow | Determinants | Kinetics | Thermodynamic properties | Combinatorial analysis | DNA sequencing
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 8, pp. 1074 - 1087