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PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, p. e11552
Mutations in CuZn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) and are found in 6% of ALS patients. Non-native and aggregation-prone... 
MOTOR-NEURON DEGENERATION | IMMUNOREACTIVITY | MULTIDISCIPLINARY SCIENCES | MOLECULAR PATHOLOGY | DISEASE | CU/ZN SUPEROXIDE-DISMUTASE | LINKED SOD1 | GENE MUTATION | MUTANT SOD1 | MICE | AMYOTROPHIC-LATERAL-SCLEROSIS | Immunohistochemistry | Inclusion Bodies - immunology | Rabbits | Superoxide Dismutase - genetics | Spinal Cord - metabolism | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Ubiquitin - metabolism | Male | Blotting, Western | DNA-Binding Proteins - metabolism | Superoxide Dismutase - immunology | Animals | Chickens | Amyotrophic Lateral Sclerosis - metabolism | Aged, 80 and over | Antibodies - immunology | Female | Aged | Superoxide Dismutase-1 | Inclusion Bodies - metabolism | Microscopy, Fluorescence | Superoxide Dismutase - metabolism | Ubiquitin | Viral antibodies | Enzymes | Medical research | Peptides | Medicine, Experimental | Antibodies | Amyotrophic lateral sclerosis | Superoxide | Enzyme-linked immunosorbent assay | Protein binding | Spinal and bulbar muscular atrophy | Spinal cord | Pathogenesis | Phagosomes | Lysosomes | Confocal microscopy | Superoxide dismutase | Confocal | Inclusions | Atrophy | Cords | Mitochondria | Rodents | Deoxyribonucleic acid--DNA | Motor neurons | Markers | Patients | Microscopy | Mutation | Endoplasmic reticulum | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | amyotrophic-lateral-sclerosis; cu/zn superoxide-dismutase; motor-neuron degeneration; molecular pathology; gene mutation; linked SOD1; mutant SOD1; mice; disease; immunoreactivity | Medicinsk bioteknologi | MEDICINE | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Deoxyribonucleic acid | DNA
Journal Article
Journal of Trauma and Acute Care Surgery, ISSN 2163-0755, 10/2019, Volume 87, Issue 4, pp. 849 - 855
LEVEL OF EVIDENCE: Laboratory animal study, level IV. 
Usage | Care and treatment | Tourniquets | Emergency medicine | Hemostatic techniques | Management | Hemorrhage | Methods
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 14, pp. 4489 - 4494
Journal Article
by Brännström, Mats, M.D., Ph.D and Johannesson, Liza, M.D., Ph.D and Dahm-Kähler, Pernilla, M.D., Ph.D and Enskog, Anders, M.D., Ph.D and Mölne, Johan, M.D., Ph.D and Kvarnström, Niclas, M.D and Diaz-Garcia, Cesar, M.D and Hanafy, Ash, M.D and Lundmark, Cecilia, B.Sc and Marcickiewicz, Janusz, M.D., Ph.D and Gäbel, Markus, M.D and Groth, Klaus, M.D., Ph.D and Akouri, Randa, M.D., Ph.D and Eklind, Saskia, M.D., Ph.D and Holgersson, Jan, M.D., Ph.D and Tzakis, Andreas, M.D and Olausson, Michael, M.D., Ph.D and Institute of Biomedicine, Department of Pathology and Sahlgrenska Academy and Institute of Clinical Sciences, Section for Anesthesiology, Biomaterials and Orthopaedics. Department of Anesthesiology and Intensive care and Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi and Göteborgs universitet and Gothenburg University and Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi. Avdelningen för anestesiologi och intensivvård and Institute of Clinical Sciences, Section for Surgery and Gastrosurgical Research and Education, Department of Surgery and Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine and Institutionen för biomedicin, avdelningen för patologi and Sahlgrenska akademin and Institute of Clinical Sciences, Section for the Health of Women and Children, Department of Obstetrics and Gynecology and Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för kirurgi and Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Fertility and Sterility, ISSN 0015-0282, 2014, Volume 101, Issue 5, pp. 1228 - 1236
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2007, Volume 104, Issue 35, pp. 14157 - 14162
Journal Article
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, ISSN 2163-0755, 09/2019, Volume 87, Issue 3, pp. 741 - 741
Journal Article
Fertility and Sterility, ISSN 0015-0282, 2012, Volume 97, Issue 6, pp. 1269 - 1276
Journal Article
Experimental Cell Research, ISSN 0014-4827, 08/2015, Volume 336, Issue 1, pp. 23 - 32
Acquired resistance to cisplatin treatment is a caveat when treating patients with non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM).... 
Globotriaosylceramide (Gb3) | Multidrug resistance 1/P-glycoprotein (MDR1) | Multidrug resistance-associated protein 1 (MRP1) | DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) | Lung cancer | Malignant pleural mesothelioma (MPM) | Glucosylceramide synthase (GCS) | Cyclosporin A | Acquired drug resistance | Cisplatin | SHIGA-LIKE TOXIN | SUBCELLULAR-LOCALIZATION | DRUG-RESISTANCE | P-GLYCOPROTEIN | CLINICAL-RELEVANCE | CELL BIOLOGY | BREAST-CANCER | MDR1 | ONCOLOGY | MULTIDRUG-RESISTANCE | EXPRESSION | MOLECULAR-MECHANISMS | Lung Neoplasms - drug therapy | Mesothelioma - pathology | Apoptosis - drug effects | Cyclosporine - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Lung Neoplasms - pathology | Flow Cytometry | Cell Membrane - metabolism | Tumor Cells, Cultured | Immunosuppressive Agents - pharmacology | Cell Membrane - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Glucosyltransferases - antagonists & inhibitors | Trihexosylceramides - metabolism | Ceramides - metabolism | Lung Neoplasms - enzymology | Meperidine - pharmacology | Blotting, Western | Mesothelioma - drug therapy | Microscopy, Confocal | Mesothelioma - enzymology | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Meperidine - analogs & derivatives | Multidrug Resistance-Associated Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Mesothelioma | Development and progression | Proteins | Glycoproteins | Drug resistance | APOPTOSIS | PATIENTS | NEOPLASMS | PUMPS | BUILDUP | LUNGS | GLYCOPROTEINS | TOXINS | CELL PROLIFERATION | PROLIFERATION | TOXICITY | INDUCTION | MICROSCOPY | 60 APPLIED LIFE SCIENCES | PROPANOLS | CHEMOTHERAPY | STRESSES | BIOLOGICAL MARKERS | DRUGS | PHOSPHORUS 31 | RECEPTORS | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Medical Biotechnology
Journal Article
Neuron, ISSN 0896-6273, 2004, Volume 43, Issue 1, pp. 5 - 17
One cause of amyotrophic lateral sclerosis (ALS) is mutation in ubiquitously expressed copper/zinc superoxide dismutase (SOD1), but the mechanism of toxicity... 
COPPER CHAPERONE | DEAFNESS DYSTONIA SYNDROME | PROPOSED MECHANISM | CU,ZN-SUPEROXIDE DISMUTASE | MOTONEURON DEGENERATION | CU/ZN SUPEROXIDE-DISMUTASE | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | MOLECULAR-WEIGHT COMPLEXES | Mitochondria - enzymology | Protein Binding - genetics | Superoxide Dismutase - genetics | Intracellular Membranes - enzymology | Molecular Chaperones - metabolism | Humans | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Cytoplasm - metabolism | Intracellular Membranes - ultrastructure | Superoxide Dismutase - toxicity | Spinal Cord - chemistry | Protein Isoforms - metabolism | Mitochondria - genetics | Motor Neuron Disease - genetics | Mitochondrial Proteins - metabolism | Spinal Cord - pathology | Motor Neuron Disease - enzymology | Intracellular Membranes - pathology | Superoxide Dismutase - metabolism | Disease Models, Animal | Nerve Degeneration - enzymology | Spinal Cord - enzymology | Mice, Transgenic | Mitochondria - pathology | Microscopy, Electron | Mutation - genetics | Protein Folding | Protein Transport - genetics | Macromolecular Substances | Motor Neuron Disease - pathology | Animals | Mice | Superoxide Dismutase-1 | Aging - metabolism | Protein Isoforms - genetics | Medical research | Amyotrophic lateral sclerosis | Spinal cord | Mutation | Toxicity | Rodents | Protein Binding/genetics | Aging/metabolism | Mice; Transgenic | Protein Isoforms/genetics/metabolism | Mutation/genetics | Cytoplasm/metabolism | Nerve Degeneration/enzymology/genetics/physiopathology | Microscopy; Electron | Mitochondrial Proteins/metabolism | Spinal Cord/chemistry/enzymology/pathology | Mitochondria/enzymology/genetics/pathology | Motor Neuron Disease/enzymology/genetics/pathology | Protein Transport/genetics | Intracellular Membranes/enzymology/pathology/ultrastructure | Molecular Chaperones/metabolism | Disease Models; Animal | Superoxide Dismutase/genetics/metabolism/toxicity
Journal Article
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 12/2006, Volume 65, Issue 12, pp. 1126 - 1136
Mutant human CuZn-superoxide dismutases (hSOD1s) cause amyotrophic lateral sclerosis (ALS). The most common mutation is the wild type-like D90A and to explore... 
Amyotrophic lateral sclerosis (ALS) | Transgenic | D90A | Mice | Stereology | Inclusions | SOD1 | ALS-LINKED SOD1 | stereology | AMYOTROPHIC-LATERAL-SCLEROSIS | PATHOLOGY | amyotrophic lateral sclerosis (ALS) | mice | NEUROSCIENCES | FAMILIAL ALS | CLINICAL NEUROLOGY | MOLECULAR-WEIGHT COMPLEXES | CELL-DEATH | DEGENERATION | GENE | MOUSE MODEL | MUTATION | transgenic | inclusions | TRANSGENIC MICE | Superoxide Dismutase - genetics | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Male | Motor Neurons - pathology | Spinal Cord - pathology | Female | Amyotrophic Lateral Sclerosis - enzymology | Superoxide Dismutase - metabolism | Disease Models, Animal | Nerve Degeneration - enzymology | Amyotrophic Lateral Sclerosis - genetics | Mice, Inbred C57BL | Spinal Cord - enzymology | Mice, Transgenic | Motor Neurons - enzymology | Inclusion Bodies - enzymology | Mutation - genetics | Disease Progression | Inclusion Bodies - genetics | Phenotype | Animals | Inclusion Bodies - pathology | Spinal Cord - physiopathology | Superoxide Dismutase-1 | Mice; Transgenic | Amyotrophic Lateral Sclerosis/enzymology/genetics/physiopathology | Mutation/genetics | Spinal Cord/enzymology/pathology/physiopathology | Nerve Degeneration/enzymology/genetics/physiopathology | Mice; Inbred C57BL | Motor Neurons/enzymology/pathology | Disease Models; Animal | Superoxide Dismutase/genetics/metabolism | Inclusion Bodies/enzymology/genetics/pathology
Journal Article
Brain, ISSN 0006-8950, 02/2006, Volume 129, Issue 2, pp. 451 - 464
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153112
Journal Article