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1. Full Text Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole
: IL-6 and voriconazole metabolism
by Vreugdenhil, Bas and van der Velden, Walter J. F. M and Feuth, Ton and Kox, Matthijs and Pickkers, Peter and van de Veerdonk, Frank L and Blijlevens, Nicole M. A and Brüggemann, Roger J. M
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2018, Volume 84, Issue 9, pp. 1980 - 1988
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2. Full Text A Population Pharmacokinetic Model Does Not Predict the Optimal Starting Dose of Tacrolimus in Pediatric Renal Transplant Recipients in a Prospective Study: Lessons Learned and Model Improvement
by Andrews, Louise M and de Winter, Brenda C. M and Cornelissen, Elisabeth A. M and de Jong, Huib and Hesselink, Dennis A and Schreuder, Michiel F and Brüggemann, Roger J. M and van Gelder, Teun and Cransberg, Karlien
Clinical Pharmacokinetics, ISSN 0312-5963, 10/2019
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3. Full Text Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial
by van den Boogaard, Mark and Slooter, Arjen J. C and Brüggemann, Roger J. M and Schoonhoven, Lisette and Beishuizen, Albertus and Vermeijden, J. Wytze and Pretorius, Danie and de Koning, Jan and Simons, Koen S and Dennesen, Paul J. W and Van der Voort, Peter H. J and Houterman, Saskia and van der Hoeven, J. G and Pickkers, Peter and van der Woude, Margaretha C. E and Besselink, Anna and Hofstra, Lieuwe S and Spronk, Peter E and van den Bergh, Walter and Donker, Dirk W and Fuchs, Malaika and Karakus, Attila and Koeman, M and van Duijnhoven, Mirella and Hannink, Gerjon and REDUCE Study Investigators and and the REDUCE Study Investigators
JAMA, ISSN 0098-7484, 02/2018, Volume 319, Issue 7, pp. 680 - 690
IMPORTANCE: Results of studies on use of prophylactic haloperidol in critically ill adults are inconclusive, especially in patients at high risk of delirium.... 
MECHANICALLY VENTILATED PATIENTS | PROPHYLAXIS | MEDICINE, GENERAL & INTERNAL | CAM-ICU | MULTICENTER | CONFUSION ASSESSMENT METHOD | INTENSIVE-CARE-UNIT | SCREENING CHECKLIST | DOUBLE-BLIND | VALIDATION | PREDICTION MODEL | Intensive Care Units | Double-Blind Method | Antipsychotic Agents - adverse effects | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Haloperidol - administration & dosage | Male | Haloperidol - adverse effects | Antipsychotic Agents - administration & dosage | Dose-Response Relationship, Drug | Critical Illness - mortality | Delirium - prevention & control | Survival Analysis | Adult | Female | Aged | Delirium | Treatment outcome | Safety and security measures | Critically ill | Analysis | Dosage and administration | Diagnosis | Haloperidol | Health aspects | Risk factors | Coma | Mental disorders | Clinical trials | Risk | Sodium chloride | Patients | Survival | Impact analysis | Incidence | Studies | Randomization | Sodium | Ventilation | Adults | Caring for the Critically Ill Patient | Original Investigation | Research
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4. Full Text Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents
by Roger J. M. Brüggemann and Jan-Willem C. Alffenaar and Nicole M. A. Blijlevens and Eliane M. Billaud and Jos G. W. Kosterink and Paul E. Verweij and David M. Burger
Clinical Infectious Diseases, ISSN 1058-4838, 5/2009, Volume 48, Issue 10, pp. 1441 - 1458
There are currently a number of licensed azole antifungal drugs; however; only 4 (namely, fluconazole, itraconazole, posaconazole, and voriconazole) are used... 
Antifungals | Enzymes | Azoles | Volunteerism | Drug interactions | Cytochromes | Reviews of Anti-Infective Agents | Bioavailability | Pharmacokinetics | Dosage | Metabolism | STEADY-STATE PHARMACOKINETICS | INFECTIOUS DISEASES | SYSTEMIC ANTIMYCOTICS KETOCONAZOLE | INCREASES PLASMA-CONCENTRATIONS | ENHANCED VINCRISTINE NEUROTOXICITY | MICROBIOLOGY | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | CELL TRANSPLANT RECIPIENTS | HEALTHY MALE-VOLUNTEERS | ITRACONAZOLE ORAL SOLUTION | ACUTE LYMPHOBLASTIC-LEUKEMIA | CYP3A4 INHIBITOR ITRACONAZOLE | Antifungal Agents - pharmacology | Azoles - pharmacokinetics | Drug Interactions | Azoles - pharmacology | Antifungal Agents - pharmacokinetics | Humans | Physiological aspects | Dosage and administration | Research | Antifungal agents | Index Medicus
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5. Full Text Cost Evaluation of Dried Blood Spot Home Sampling as Compared to Conventional Sampling for Therapeutic Drug Monitoring in Children
by Martial, L.C and Aarnoutse, R.E and Schreuder, M.F and Henriet, S.S and Bruggemann, R.J and Joore, M.A
Plos One, ISSN 1932-6203, 2016, Volume 11, Issue 12, p. e0167433
Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in... 
CREATININE | LC-MS/MS | FEASIBILITY | TACROLIMUS | MULTIDISCIPLINARY SCIENCES | Health Care Costs | Costs and Cost Analysis | Age Factors | Dried Blood Spot Testing - methods | Cost-Benefit Analysis | Humans | Child, Preschool | Home Care Services - economics | Dried Blood Spot Testing - economics | Drug Monitoring | Child | Economic aspects | Medical examination | Comparative analysis | Health aspects | Blood | Medical care, Cost of | Health care | Health sciences | Pediatrics | Costs | Nephrology | Research & development--R&D | Antimicrobial agents | Epidemiology | Patients | Chromatography | Infectious diseases | Immunology | Hospitals | Pharmacy | Children | Sampling | Drug therapy | Drug stores | Monitoring | Kidney transplantation | Research & development | R&D
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6. Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis
by Seyedmojtaba Seyedmousavi and Roger J M Brüggemann and Willem J G Melchers and Antonius J M M Rijs and Paul E Verweij and Johan W Mouton
The Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 02/2013, Volume 68, Issue 2, p. 385
  Azole resistance is an emerging problem in the treatment of Aspergillus fumigatus infections. Combination therapy may be an alternative approach to improve... 
Pharmacology | Fungal infections | Drug resistance | Drug therapy | Laboratory animals
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7. Full Text Software for Dosage Individualization of Voriconazole for Immunocompromised Patients
by William W. Hope and Michael VanGuilder and J. Peter Donnelly and Nicole M. A. Blijlevens and Roger J. M. Brüggemann and Roger W. Jelliffe and Michael N. Neely
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2013, Volume 57, Issue 4, pp. 1888 - 1894
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
TRIAL | ASPERGILLOSIS | THERAPY | EFFICACY | SAFETY | POPULATION PHARMACOKINETICS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INVASIVE FUNGAL-INFECTIONS | INTRAVENOUS VORICONAZOLE | AMPHOTERICIN-B | MULTIPLE MODEL | Models, Theoretical | Pyrimidines - therapeutic use | Humans | Voriconazole | Hematopoietic Stem Cell Transplantation | Adult | Software | Immunocompromised Host - drug effects | Triazoles - therapeutic use | Bayesian analysis | Pharmacology
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8. Full Text Understanding variability in posaconazole exposure using an integrated population pharmacokinetic analysis
by Dolton, M.J and Bruggemann, R.J.M and Burger, D.M and McLachlan, A.J
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 11, pp. 6879 - 6885
Posaconazole oral suspension is widely used for antifungal prophylaxis and treatment in immunocompromised patients, with highly variable pharmacokinetics... 
DRUG | VORICONAZOLE | ORAL POSACONAZOLE | PROPHYLAXIS | INFECTIONS | PLASMA-CONCENTRATIONS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | RESPONSE RELATIONSHIP | NASOGASTRIC TUBE | FLUCONAZOLE | RIFABUTIN | Anti-HIV Agents - pharmacology | Antifungal Agents - pharmacology | Triazoles - adverse effects | Proton Pump Inhibitors - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Biological Availability | Healthy Volunteers | Sulfonamides - pharmacology | Anticonvulsants - pharmacology | Organophosphates - pharmacology | Triazoles - pharmacology | Drug Therapy, Combination - adverse effects | Drug Interactions | Metoclopramide - pharmacology | Antifungal Agents - pharmacokinetics | Adult | Phenytoin - pharmacology | Triazoles - pharmacokinetics | Rifampin - pharmacology | Antiemetics - pharmacology | Carbamates - pharmacology | Pharmacology
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9. Full Text Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis
by Seyedmousavi, Seyedmojtaba and Brüggemann, Roger J. M and Melchers, Willem J. G and Rijs, Antonius J. M. M and Verweij, Paul E and Mouton, Johan W
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 02/2013, Volume 68, Issue 2, pp. 385 - 393
Azole resistance is an emerging problem in the treatment of Aspergillus fumigatus infections. Combination therapy may be an alternative approach to improve... 
Additivity | Echinocandins | Azoles | Synergy | Combination therapy | CASPOFUNGIN | INFECTIOUS DISEASES | synergy | MICROBIOLOGY | AMPHOTERICIN-B | ITRACONAZOLE | additivity | azoles | TRIAZOLE | echinocandins | CLINICAL-IMPLICATIONS | combination therapy | PHARMACOLOGY & PHARMACY | MUTATIONS | IN-VITRO SYNERGY | EXPERIMENTAL PULMONARY ASPERGILLOSIS | FUMIGATUS | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Triazoles - administration & dosage | Pyrimidines - administration & dosage | Echinocandins - pharmacokinetics | Treatment Outcome | Pyrimidines - pharmacology | Drug Synergism | Echinocandins - administration & dosage | Triazoles - pharmacology | Drug Therapy, Combination - methods | Animals | Antifungal Agents - pharmacokinetics | Survival Analysis | Voriconazole | Pyrimidines - pharmacokinetics | Female | Triazoles - pharmacokinetics | Mice | Antifungal Agents - administration & dosage | Drug Resistance, Fungal | Echinocandins - pharmacology | Aspergillosis - drug therapy | Disease Models, Animal | Infection | Animal models | Pharmacodynamics | Body weight | Aspergillosis | Clinical isolates | Drug interaction | Regression analysis | Survival
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10. Full Text Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model
by Seyedmousavi, Seyedmojtaba and Brüggemann, Monika and Meis, Jacques F and Melchers, Willem and Verweij, Paul and Mouton, Johan
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2015, Volume 59, Issue 5, pp. 2855 - 2866
Azole resistance is an emerging problem in Aspergillus fumigatus which translates into treatment failure. Alternative treatments with new azoles may improve... 
TARGET DETERMINATION | DOSE PHARMACOKINETICS | INVASIVE PULMONARY ASPERGILLOSIS | AZOLE RESISTANCE | NEUTROPENIC MURINE MODEL | CLINICAL-IMPLICATIONS | EUROPEAN COMMITTEE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | EPITHELIAL LINING FLUID | IN-VITRO ACTIVITY | ANTIFUNGAL TRIAZOLE BAL4815 | Aspergillus fumigatus - drug effects | Triazoles - blood | Pyridines - pharmacokinetics | Aspergillus fumigatus - pathogenicity | Nitriles - pharmacokinetics | Pyridines - blood | Animals | Nitriles - blood | Aspergillosis - metabolism | Female | Triazoles - pharmacokinetics | Mice | Aspergillosis - blood | Aspergillosis - drug therapy | Nitriles - therapeutic use | Pyridines - therapeutic use | Triazoles - therapeutic use | Pharmacology
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11. Full Text Cyclosporine A trough concentrations are associated with acute GvHD after non-myeloablative allogeneic hematopoietic cell transplantation
by de Kort, EA and de Lil, HS and Bremmers, MEJ and van Groningen, LFJ and Blijlevens, NMA and Huls, G and Bruggemann, RJM and van Dorp, S and van der Velden, WJFM
PLOS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0213913
Low plasma CsA concentrations (<300-350 ng/mL) early following allogeneic hematopoietic stem cell transplantation (HSCT) is associated with an increased risk... 
RELAPSE | TOTAL-BODY | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | RISK | TACROLIMUS | RECIPIENTS | VERSUS-HOST-DISEASE | CONSENSUS DEVELOPMENT PROJECT | MARROW TRANSPLANTATION | BLOOD | Complications and side effects | Usage | Mortality | Analysis | Stem cells | Graft versus host reaction | Transplantation | Cyclosporine | Health aspects | Risk factors | Hematopoietic stem cells | Graft-versus-host reaction | Hyponatremia | Transplants & implants | Urinalysis | Working groups | Hematology | Toxicity | Cyclosporins | Leukemia | Health risks | Stem cell transplantation | Multivariate analysis | Patients | Survival | Hemopoiesis | Incidence | Impact analysis | Lymphocytes | Bone marrow | Hypomagnesemia
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12. Full Text Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study
by Smit, Cornelis and Wasmann, Roeland E and Wiezer, Marinus J and van Dongen, Hendricus P. A and Mouton, Johan W and Brüggemann, Roger J. M and Knibbe, Catherijne A. J
Pharmaceutical Research, ISSN 0724-8741, 8/2019, Volume 36, Issue 8, pp. 1 - 12
Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with efficacy. Recently, we found that clearance of the aminoglycoside... 
Biochemistry, general | morbid obesity | Biomedicine | Pharmacy | pharmacokinetics | Medical Law | aminoglycosides | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | tobramycin | Urine | Renal function | Statistical analysis | Computer simulation | Body weight | Gentamicin | Pharmacology | Exposure | Estimates | Antibiotics | Surgery | Aminoglycoside antibiotics | Mathematical models | Gastrointestinal surgery | Tobramycin | Surface area | Nomographs | Research Paper
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13. Full Text A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation
by Andrews, Louise M and Hesselink, Dennis A and van Gelder, Teun and Koch, Birgit C. P and Cornelissen, Elisabeth A. M and Brüggemann, Roger J. M and van Schaik, Ron H. N and de Wildt, Saskia N and Cransberg, Karlien and de Winter, Brenda C. M
Clinical Pharmacokinetics, ISSN 0312-5963, 4/2018, Volume 57, Issue 4, pp. 475 - 489
Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | SOLID-ORGAN TRANSPLANTATION | UNITED-STATES | CYP3A5 GENOTYPE | LIVER-TRANSPLANTATION | KIDNEY-TRANSPLANTATION | STEROID WITHDRAWAL | PHARMACOLOGY & PHARMACY | IMMUNOSUPPRESSIVE DRUGS | CLINICAL PHARMACOKINETICS | TROUGH LEVELS | DOSAGE PREDICTION | Body Weight | Age Factors | Humans | Immunosuppressive Agents - pharmacokinetics | Child, Preschool | Male | Drug Dosage Calculations | Immunosuppressive Agents - blood | Cytochrome P-450 CYP3A - genetics | Computer Simulation | Pharmacogenomic Variants | Female | Retrospective Studies | Child | Immunosuppressive Agents - administration & dosage | Tacrolimus - administration & dosage | Drug Administration Schedule | Tacrolimus - blood | Graft Rejection - prevention & control | Genotype | Treatment Outcome | Tacrolimus - pharmacokinetics | Tacrolimus - adverse effects | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Adolescent | Immunosuppressive Agents - adverse effects | Graft Rejection - immunology | Tissue Donors | Graft Survival - drug effects | Nonlinear Dynamics | Kidney Transplantation - adverse effects | Cytochrome | Genotype & phenotype | Pediatrics | Ethnicity | Kidneys | Transplants & implants | Population | Patients | Drug dosages | Children & youth | Original
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14. Full Text Efficacy of Posaconazole against Three Clinical Aspergillus fumigatus Isolates with Mutations in the cyp51A Gene
by Eleftheria Mavridou and Roger J. M. Brüggemann and Willem J. G. Melchers and Johan W. Mouton and Paul E. Verweij
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2010, Volume 54, Issue 2, pp. 860 - 865
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
VORICONAZOLE | ORAL POSACONAZOLE | IN-VITRO | INFECTIONS | SINGLE | PHARMACOKINETICS | ITRACONAZOLE RESISTANCE | TRIAZOLE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PATIENT | IDENTIFICATION | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Triazoles - administration & dosage | Drug Administration Schedule | Administration, Oral | Area Under Curve | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Triazoles - pharmacology | Animals | Antifungal Agents - pharmacokinetics | Aspergillosis - microbiology | Aspergillus fumigatus - physiology | Cytochrome P-450 Enzyme System - genetics | Female | Triazoles - pharmacokinetics | Mice | Mutation | Antifungal Agents - administration & dosage | Aspergillosis - drug therapy | Disease Models, Animal | Triazoles - therapeutic use | Susceptibility
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15. Full Text Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters
by Smit, Cornelis and De Hoogd, Sjoerd and Brüggemann, Roger J M and Knibbe, Catherijne A J
Expert opinion on drug metabolism & toxicology, 02/2018, p. 1
The rising prevalence of obesity confronts clinicians with dosing problems in the (extreme) overweight population. Obesity has a great impact on key organs... 
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16. Full Text Moderate correlation between systemic IL‐6 responses and CRP with trough concentrations of voriconazole
by Vreugdenhil, Bas and Velden, Walter J. F. M and Feuth, Ton and Kox, Matthijs and Pickkers, Peter and Veerdonk, Frank L and Blijlevens, Nicole M. A and Brüggemann, Roger J. M
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2018, Volume 84, Issue 9, pp. 1980 - 1988
Aims Voriconazole (VCZ) exhibits wide intrapatient pharmacokinetic variability, which is disadvantageous because of its narrow therapeutic range. A... 
pharmacokinetics | voriconazole | azoles | immune response | inflammation | ANTIFUNGAL AGENT | EUROPEAN ORGANIZATION | HUMAN LIVER-MICROSOMES | INTERLEUKIN-6 | FUNGAL-INFECTIONS | PLASMA | CONCISE GUIDE | METABOLISM | PHARMACOLOGY & PHARMACY | Mycoses | C-reactive protein | Interleukins | Analysis | Original
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