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1. Full Text Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents
by Roger J. M. Brüggemann and Jan-Willem C. Alffenaar and Nicole M. A. Blijlevens and Eliane M. Billaud and Jos G. W. Kosterink and Paul E. Verweij and David M. Burger
Clinical infectious diseases, ISSN 1058-4838, 5/2009, Volume 48, Issue 10, pp. 1441 - 1458
Antifungals | Enzymes | Azoles | Volunteerism | Drug interactions | Cytochromes | Reviews of Anti-Infective Agents | Bioavailability | Pharmacokinetics | Dosage | Metabolism | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Infectious diseases | Medical sciences | Pharmacology. Drug treatments | Antifungal agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antifungal Agents - pharmacology | Azoles - pharmacokinetics | Drug Interactions | Azoles - pharmacology | Antifungal Agents - pharmacokinetics | Humans | Physiological aspects | Dosage and administration | Research | Prescription drugs | Pharmacology | Fungal infections | Medical treatment | Index Medicus
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2. Full Text Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial
by van den Boogaard, Mark and Slooter, Arjen J. C and Brüggemann, Roger J. M and Schoonhoven, Lisette and Beishuizen, Albertus and Vermeijden, J. Wytze and Pretorius, Danie and de Koning, Jan and Simons, Koen S and Dennesen, Paul J. W and Van der Voort, Peter H. J and Houterman, Saskia and van der Hoeven, J. G and Pickkers, Peter and van der Woude, Margaretha C. E and Besselink, Anna and Hofstra, Lieuwe S and Spronk, Peter E and van den Bergh, Walter and Donker, Dirk W and Fuchs, Malaika and Karakus, Attila and Koeman, M and van Duijnhoven, Mirella and Hannink, Gerjon and REDUCE Study Investigators and and the REDUCE Study Investigators
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 02/2018, Volume 319, Issue 7, pp. 680 - 690
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Intensive Care Units | Double-Blind Method | Antipsychotic Agents - adverse effects | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Haloperidol - administration & dosage | Male | Haloperidol - adverse effects | Antipsychotic Agents - administration & dosage | Dose-Response Relationship, Drug | Critical Illness - mortality | Delirium - prevention & control | Survival Analysis | Adult | Female | Aged | Delirium | Treatment outcome | Safety and security measures | Critically ill | Analysis | Dosage and administration | Diagnosis | Haloperidol | Health aspects | Risk factors | Coma | Mental disorders | Clinical trials | Risk | Sodium chloride | Patients | Survival | Impact analysis | Incidence | Studies | Sodium | Ventilation | Adults | Index Medicus | Abridged Index Medicus | Caring for the Critically Ill Patient | Original Investigation | Research
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3. Full Text Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole resistant invasive aspergillosis
by Seyedmousav, S and Bruggemann, R.J.M and Melchers, W.J.G and Verweij, P.E and Mouton, J.W and Mouton †, J.W
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 2013, Volume 68, Issue 2, pp. 385 - 393
Additivity | Echinocandins | Azoles | Synergy | Combination therapy | Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Triazoles - administration & dosage | Pyrimidines - administration & dosage | Echinocandins - pharmacokinetics | Treatment Outcome | Pyrimidines - pharmacology | Drug Synergism | Echinocandins - administration & dosage | Triazoles - pharmacology | Drug Therapy, Combination - methods | Animals | Antifungal Agents - pharmacokinetics | Survival Analysis | Voriconazole | Pyrimidines - pharmacokinetics | Female | Triazoles - pharmacokinetics | Mice | Antifungal Agents - administration & dosage | Drug Resistance, Fungal | Echinocandins - pharmacology | Aspergillosis - drug therapy | Disease Models, Animal | Pharmacology | Fungal infections | Drug resistance | Drug therapy | Laboratory animals | Index Medicus | Infection | Animal models | Pharmacodynamics | azoles | Body weight | Aspergillosis | Clinical isolates | Drug interaction | Regression analysis | Survival
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4. Full Text Software for Dosage Individualization of Voriconazole for Immunocompromised Patients
by William W. Hope and Michael VanGuilder and J. Peter Donnelly and Nicole M. A. Blijlevens and Roger J. M. Brüggemann and Roger W. Jelliffe and Michael N. Neely
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2013, Volume 57, Issue 4, pp. 1888 - 1894
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Immunopathology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Immunodeficiencies. Immunoglobulinopathies | Immunodeficiencies | Antibiotics. Antiinfectious agents. Antiparasitic agents | Models, Theoretical | Pyrimidines - therapeutic use | Humans | Voriconazole | Hematopoietic Stem Cell Transplantation | Adult | Software | Immunocompromised Host - drug effects | Triazoles - therapeutic use | Index Medicus | Bayesian analysis | Pharmacology
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5. Full Text Efficacy of Posaconazole against Three Clinical Aspergillus fumigatus Isolates with Mutations in the cyp51A Gene
by Eleftheria Mavridou and Roger J. M. Brüggemann and Willem J. G. Melchers and Johan W. Mouton and Paul E. Verweij
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2010, Volume 54, Issue 2, pp. 860 - 865
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Triazoles - administration & dosage | Drug Administration Schedule | Administration, Oral | Area Under Curve | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Triazoles - pharmacology | Animals | Antifungal Agents - pharmacokinetics | Aspergillosis - microbiology | Aspergillus fumigatus - physiology | Cytochrome P-450 Enzyme System - genetics | Female | Triazoles - pharmacokinetics | Mice | Mutation | Antifungal Agents - administration & dosage | Aspergillosis - drug therapy | Disease Models, Animal | Triazoles - therapeutic use | Index Medicus | Susceptibility
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6. Full Text A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation
by Andrews, Louise M and Andrews, Louise M and Hesselink, Dennis A and Hesselink, Dennis A and van Gelder, Teun and van Gelder, Teun and Koch, Birgit C. P and Koch, Birgit C. P and Cornelissen, Elisabeth A. M and Cornelissen, Elisabeth A. M and Brüggemann, Roger J. M and Brüggemann, Roger J. M and van Schaik, Ron H. N and van Schaik, Ron H. N and de Wildt, Saskia N and de Wildt, Saskia N and Cransberg, Karlien and Cransberg, Karlien and de Winter, Brenda C. M and de Winter, Brenda C. M
Clinical pharmacokinetics, ISSN 0312-5963, 4/2018, Volume 57, Issue 4, pp. 475 - 489
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Body Weight | Age Factors | Humans | Immunosuppressive Agents - pharmacokinetics | Child, Preschool | Male | Drug Dosage Calculations | Immunosuppressive Agents - blood | Cytochrome P-450 CYP3A - genetics | Computer Simulation | Pharmacogenomic Variants | Female | Retrospective Studies | Child | Immunosuppressive Agents - administration & dosage | Tacrolimus - administration & dosage | Drug Administration Schedule | Tacrolimus - blood | Graft Rejection - prevention & control | Genotype | Treatment Outcome | Tacrolimus - pharmacokinetics | Tacrolimus - adverse effects | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Adolescent | Immunosuppressive Agents - adverse effects | Graft Rejection - immunology | Tissue Donors | Graft Survival - drug effects | Nonlinear Dynamics | Kidney Transplantation - adverse effects
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7. Full Text Single-Dose Fluconazole versus Standard 2-Week Therapy for Oropharyngeal Candidiasis in HIV-Infected Patients: A Randomized, Double-Blind, Double-Dummy Trial
by Omar J. M. Hamza and Mecky I. N. Matee and Roger J. M. Brüggemann and Mainen J. Moshi and Elison N. M. Simon and Ferdinand Mugusi and Frans H. M. Mikx and Henrich A. L. van der Lee and Paul E. Verweij and André J. A. M. van der Ven
Clinical infectious diseases, ISSN 1058-4838, 11/2008, Volume 47, Issue 10, pp. 1270 - 1276
Highly active antiretroviral therapy | Candidiasis | Relapse | Azoles | HIV | Mycology | Articles and Commentaries | AIDS | Dosage | Lesions | Symptoms | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Immunopathology | Infectious diseases | Pharmacology. Drug treatments | Antifungal agents | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Immunodeficiencies. Immunoglobulinopathies | Immunodeficiencies | Antibiotics. Antiinfectious agents. Antiparasitic agents | Oropharynx - microbiology | Antifungal Agents - adverse effects | Prospective Studies | Double-Blind Method | Humans | Middle Aged | Fluconazole - administration & dosage | Fluconazole - adverse effects | Male | Treatment Outcome | Fluconazole - therapeutic use | Antifungal Agents - therapeutic use | HIV Infections - complications | Candidiasis, Oral - drug therapy | Adult | Female | Aged | Antifungal Agents - administration & dosage | Placebos - administration & dosage | Dosage and administration | Research | Fluconazole | Drug therapy | Patient outcomes | Thrush (Mouth disease) | Clinical trials | Antiretroviral drugs | Fungal infections | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Index Medicus
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8. Pharmacokinetics and Pharmacodynamics of Posaconazole
by Chen, Lu and Krekels, Elke H. J and Verweij, Paul E and Bui, Jochem B and Knibbe, Catherijne A. J and Bruggemann, Roger J. M
Drugs (New York, N.Y.), ISSN 0012-6667, 05/2020, Volume 80, Issue 7, pp. 671 - 695
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Triazoles - administration & dosage | Triazoles - adverse effects | Antifungal Agents - adverse effects | Animals | Injections, Intravenous | Administration, Oral | Antifungal Agents - pharmacokinetics | Humans | Drug Compounding | Triazoles - pharmacokinetics | Antifungal Agents - administration & dosage | Aspergillosis - drug therapy | Pathogens | Yeasts | Enzymes | Pharmacodynamics | Intravenous administration | Toxicity | Medical treatment | Prophylaxis | Infections | Pharmacology | Exposure | Small intestine | Patients | Absorption | Fungal diseases | Aspergillosis | Immunocompromised hosts | Mutation | Pharmacokinetics | Posaconazole | Drug dosages
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9. Full Text Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model
by Seyedmousavi, S and Bruggemann, R.J and Meis, J.F.G.M and Melchers, W.J.G and Verweij, P.E and Mouton †, J.W
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 2015, Volume 59, Issue 5, pp. 2855 - 2866
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Aspergillus fumigatus - drug effects | Triazoles - blood | Pyridines - pharmacokinetics | Aspergillus fumigatus - pathogenicity | Nitriles - pharmacokinetics | Pyridines - blood | Animals | Nitriles - blood | Aspergillosis - metabolism | Female | Triazoles - pharmacokinetics | Mice | Aspergillosis - blood | Aspergillosis - drug therapy | Nitriles - therapeutic use | Pyridines - therapeutic use | Triazoles - therapeutic use | Index Medicus | Pharmacology
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10.