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humans (53) 53
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1. Full Text Macrophages and their relevance in Human Immunodeficiency Virus Type I infection
by Koppensteiner, Herwig and Brack-Werner, Ruth and Schindler, Michael
Retrovirology, ISSN 1742-4690, 10/2012, Volume 9, Issue 1, pp. 82 - 82
Macrophages are important target cells for the Human Immunodeficiency Virus Type I (HIV-1) in vivo. Several studies have assessed the molecular biology of the... 
VIROLOGY | CELLULAR RESERVOIRS | ACTIVE ANTIRETROVIRAL THERAPY | MONOCYTE-DERIVED MACROPHAGES | CD4(+) T-CELLS | CENTRAL-NERVOUS-SYSTEM | HIV-1 INFECTION | RESTRICTION FACTOR SAMHD1 | BLOOD-BRAIN-BARRIER | PROTEASE INHIBITORS | MAMMARY EPITHELIAL-CELLS | Host-Pathogen Interactions | Acquired Immunodeficiency Syndrome - immunology | HIV-1 - immunology | HIV-1 - pathogenicity | Macrophages - virology | Humans | Acquired Immunodeficiency Syndrome - pathology | Macrophages - immunology | Disease transmission | Development and progression | HIV (Viruses) | T cells | Macrophages | Health aspects | HIV infection | Reviews | Acquired immune deficiency syndrome | Immunodeficiency | Chronic infection | Cytotoxicity | Cognition | Lymphocytes T | CD4 antigen
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2. Full Text Synthetic AAV/CRISPR vectors for blocking HIV‐1 expression in persistently infected astrocytes
by Kunze, Christine and Börner, Kathleen and Kienle, Eike and Orschmann, Tanja and Rusha, Ejona and Schneider, Martha and Radivojkov‐Blagojevic, Milena and Drukker, Micha and Desbordes, Sabrina and Grimm, Dirk and Brack‐Werner, Ruth
Glia, ISSN 0894-1491, 02/2018, Volume 66, Issue 2, pp. 413 - 427
Astrocytes, the most abundant cells in the mammalian brain, perform key functions and are involved in several neurodegenerative diseases. The human... 
adeno‐associated viral vector | astrocytes | CRISPR/Cas9 | HIV | adeno-associated viral vector | CELLS | HUMAN BRAIN | ADENOASSOCIATED VIRUS | NEUROLOGICAL DISORDERS | VIRAL VECTORS | NEUROSCIENCES | REPLICATION | CRISPR/CAS9 SYSTEM | GENE-EXPRESSION | CENTRAL-NERVOUS-SYSTEM | NEUROCOGNITIVE DISORDERS | Clustered Regularly Interspaced Short Palindromic Repeats - physiology | Gene Expression Regulation, Viral - physiology | Astrocytes - drug effects | Gene Expression Regulation, Viral - drug effects | Genetic Vectors - administration & dosage | HIV-1 - drug effects | Humans | Cells, Cultured | Male | Clustered Regularly Interspaced Short Palindromic Repeats - drug effects | Dependovirus - physiology | Astrocytes - physiology | HIV-1 - physiology | Foreskin - cytology | HEK293 Cells | Astrocytes - virology | Cell Line, Transformed | Medical research | Nervous system diseases | Genetic vectors | Neurons | Analysis | Medicine, Experimental | Genetic transcription | HIV (Viruses) | Health aspects | CRISPR | Brain | Deactivation | Gene transfer | Transcription | Neurodegenerative diseases | Astrocytes | Genes | Proviruses | Viruses | Cultures | Activation | Inactivation | Neurological diseases | Organoids | Human immunodeficiency virus--HIV | Mutation | Expression vectors
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3. Full Text Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis
by Brach-Werner, Ruth
AIDS, ISSN 0269-9370, 1999, Volume 13, Issue 1, pp. 1 - 22
Brain | Rev | Virus reservoirs | Astrocytes | Tat | HIV-1 neuropathogenesis | Nef | INFECTIOUS DISEASES | HUMAN GLIAL-CELLS | IN-SITU HYBRIDIZATION | HUMAN FETAL ASTROCYTES | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | brain | HUMAN-IMMUNODEFICIENCY-VIRUS | BRAIN-DERIVED CELLS | VIROLOGY | virus reservoirs | CENTRAL-NERVOUS-SYSTEM | POLYMERASE CHAIN-REACTION | CAPILLARY ENDOTHELIAL-CELLS | astrocytes | TYPE-1 TAT PROTEIN | Neurons - virology | Immune System - virology | HIV Infections - virology | Humans | Cells, Cultured | Brain - virology | HIV Infections - immunology | HIV-1 - immunology | Animals | HIV-1 - physiology | HIV Infections - pathology | Astrocytes - virology | Central Nervous System - virology
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4. Full Text A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti‐HIV Activity
by Demmer, Oliver and Frank, Andreas O and Hagn, Franz and Schottelius, Margret and Marinelli, Luciana and Cosconati, Sandro and Brack‐Werner, Ruth and Kremb, Stephan and Wester, Hans‐Jürgen and Kessler, Horst
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2012, Volume 51, Issue 32, pp. 8110 - 8113
There can be only one: Using a peptoid motif obtained by shifting the arginine side chain of a pentapeptide previously developed by Fujii et al. to the... 
peptides | peptidomimetics | biological activity | drug design | medicinal chemistry | CELLS | CHEMOKINE RECEPTOR CXCR4 | AMD3100 | LESTR/FUSIN | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | INFECTION | LIGAND | INHIBITORS | ANTAGONISTS | Anti-HIV Agents - pharmacology | Peptoids - pharmacology | HIV-1 - drug effects | Humans | Molecular Conformation | Models, Molecular | Ligands | Receptors, CXCR4 - agonists | Structure-Activity Relationship | Peptoids - chemistry | Receptors, CXCR4 - metabolism | Peptides | Universities and colleges | Pictures | Binding | Molecular conformation | Nitrogen atoms | Chains | Affinity | Frozen | Freezing | Chemokine receptors
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5. Full Text The SOLUTIONS project: Challenges and responses for present and future emerging pollutants in land and water resources management
by Brack, Werner and Altenburger, Rolf and Schüürmann, Gerrit and Krauss, Martin and López Herráez, David and van Gils, Jos and Slobodnik, Jaroslav and Munthe, John and Gawlik, Bernd Manfred and van Wezel, Annemarie and Schriks, Merijn and Hollender, Juliane and Tollefsen, Knut Erik and Mekenyan, Ovanes and Dimitrov, Saby and Bunke, Dirk and Cousins, Ian and Posthuma, Leo and van den Brink, Paul J and López de Alda, Miren and Barceló, Damià and Faust, Michael and Kortenkamp, Andreas and Scrimshaw, Mark and Ignatova, Svetlana and Engelen, Guy and Massmann, Gudrun and Lemkine, Gregory and Teodorovic, Ivana and Walz, Karl-Heinz and Dulio, Valeria and Jonker, Michiel T.O and Jäger, Felix and Chipman, Kevin and Falciani, Francesco and Liska, Igor and Rooke, David and Zhang, Xiaowei and Hollert, Henner and Vrana, Branislav and Hilscherova, Klara and Kramer, Kees and Neumann, Steffen and Hammerbacher, Ruth and Backhaus, Thomas and Mack, Juliane and Segner, Helmut and Escher, Beate and de Aragão Umbuzeiro, Gisela and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för tillämpad miljövetenskap (ITM)
Science of the Total Environment, ISSN 0048-9697, 01/2015, Volume 503-504, Issue Special issue, pp. 22 - 31
SOLUTIONS (2013 to 2018) is a European Union Seventh Framework Programme Project (EU-FP7). The project aims to deliver a conceptual framework to support the... 
Effect-based tools | Environmental risk assessment | Water policy | Exposure and risk modelling | Water Framework Directive | Mixture toxicology | Waste Management and Disposal | Pollution | Environmental Engineering | Medicine(all) | Environmental Chemistry | COMPLEX-MIXTURES | COMMUNITY TOLERANCE PICT | STRESS-RESPONSE | EFFECT-DIRECTED ANALYSIS | CHEMICAL FOOTPRINT | ENVIRONMENTAL SCIENCES | ORGANIC MICROPOLLUTANTS | TREATMENT PLANTS | WASTE-WATER | ENVIRONMENTAL CONTAMINATION | RISK-ASSESSMENT | Hazardous Substances - analysis | Conservation of Natural Resources - methods | Environmental Monitoring | Environmental Policy | Water Pollution, Chemical - prevention & control | Water Pollution, Chemical - statistics & numerical data | Risk Assessment | European Union | Ecosystem | Water Pollutants, Chemical - analysis | Water Resources - statistics & numerical data | Case studies | Water | Water pollution | Aquatic resources | Management | Pollutants | Index Medicus | Environmental Sciences | Naturvetenskap | Natural Sciences | Earth and Related Environmental Sciences | Geovetenskap och miljövetenskap | effect-directed analysis | treatment plants | community tolerance pict | environmental contamination | organic micropollutants | waste-water | complex-mixtures | stress-response | risk-assessment | chemical footprint
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6. Full Text T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV‐1 patients
by Bolduan, Sebastian and Koppensteiner, Herwig and Businger, Ramona and Rebensburg, Stephanie and Kunze, Christine and Brack‐Werner, Ruth and Draenert, Rika and Schindler, Michael
Journal of the International AIDS Society, ISSN 1758-2652, 2017, Volume 20, Issue 1, pp. 21865 - n/a
Introduction: Restriction factors (RFs) suppress HIV‐1 in cell lines and primary cell models. Hence, RFs might be attractive targets for novel antiviral... 
in vivo relevance | SerinC5 | RISP | Tetherin | HIV‐1 | restriction factors | SAMHD1 | p21 | HIV-1 | INFECTIOUS DISEASES | ACTIVATION | ANTIRETROVIRAL ACTIVITY | MACROPHAGES | ANTAGONISM | IMMUNOLOGY | NEF | REPLICATION | HEPATITIS-C VIRUS | SURFACE | VPU | HIV Infections - genetics | HIV Infections - virology | Humans | Middle Aged | Male | Leukocytes, Mononuclear - virology | T-Lymphocytes - virology | Viral Load | HIV Infections - immunology | HIV-1 - physiology | SAM Domain and HD Domain-Containing Protein 1 - immunology | Leukocytes, Mononuclear - immunology | Adult | Female | T-Lymphocytes - immunology | Aged | SAM Domain and HD Domain-Containing Protein 1 - genetics | Physiological aspects | T cells | Health aspects | HIV infection | Antiviral agents | Control | HIV patients | Dosage and administration | HIV (Viruses) | Proteins | Lymphocytes | Cloning | Viruses | Infections | Drug therapy | Patients | Experiments
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7. Full Text The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor
by Helfer, Markus and Koppensteiner, Herwig and Schneider, Martha and Rebensburg, Stephanie and Forcisi, Sara and Müller, Constanze and Schmitt-Kopplin, Philippe and Schindler, Michael and Brack-Werner, Ruth
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e87487
Global HIV-1 treatment would benefit greatly from safe herbal medicines with scientifically validated novel anti-HIV-1 activities. The root extract from the... 
ENTRY INHIBITORS | REPLICATION | PHARMACOKINETICS | SAFETY | MULTIDISCIPLINARY SCIENCES | CHEMOKINE RECEPTOR | (-)-EPIGALLOCATECHIN GALLATE | ANTIRETROVIRAL THERAPY | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | IDENTIFICATION | Anti-HIV Agents - pharmacology | Plant Extracts - chemistry | Polyphenols - isolation & purification | Plants, Medicinal - chemistry | HIV-1 - drug effects | Plant Extracts - pharmacology | Humans | Polyphenols - pharmacology | Plant Extracts - isolation & purification | Virus Attachment - drug effects | Anti-HIV Agents - chemistry | Pelargonium - chemistry | Plant Roots - chemistry | Polyphenols - chemistry | HEK293 Cells | HIV Infections - drug therapy | Anti-HIV Agents - isolation & purification | Drug Evaluation, Preclinical | Medicinal plants | Infection | Analysis | Medicine, Botanic | Medicine, Herbal | Drug therapy | HIV (Viruses) | Health aspects | Drugs | Medical research | Cell culture | Toxicity | Clinical trials | Clinical isolates | Cytotoxicity | Viruses | Leukocytes (mononuclear) | Macrophages | Plant extracts | Herbal medicine | Medicine | Acquired immune deficiency syndrome--AIDS | Infectivity | Human immunodeficiency virus--HIV | Antiviral activity | Polyphenols | Peripheral blood mononuclear cells | Safety | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
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8. Full Text Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins
by Rebensburg, Stephanie and Helfer, Markus and Schneider, Martha and Koppensteiner, Herwig and Eberle, Josef and Schindler, Michael and Gürtler, Lutz and Brack-Werner, Ruth
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 20394
Novel therapeutic options are urgently needed to improve global treatment of virus infections. Herbal products with confirmed clinical safety features are... 
ATTACHMENT | ENTRY | REPLICATION | NATURAL-PRODUCTS | PHENOLIC-COMPOUNDS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | HEPARAN-SULFATE | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | MEDICINAL-PLANTS | Cell Line | Plant Extracts - chemistry | Virus Replication - drug effects | Antiviral Agents - pharmacology | HIV-1 - drug effects | Plant Extracts - pharmacology | Humans | Cells, Cultured | Drug Resistance, Viral | Polyphenols - pharmacology | Filoviridae - drug effects | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Antiviral Agents - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Cistus - chemistry | Polyphenols - chemistry | Proteins | Disease resistance | Fractionation | Human immunodeficiency virus--HIV | Antiviral activity | Heparin | Cell surface
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9. Full Text Discovery of the Streptoketides by Direct Cloning and Rapid Heterologous Expression of a Cryptic PKS II Gene Cluster from Streptomyces sp. Tü6314
by Qian, Zhengyi and Bruhn, Torsten and D'Agostino, Paul M and Herrmann, Alexander and Haslbeck, Martin and Antal, Noemi and Fiedler, Hans-Peter and Brack-Werner, Ruth and Gulder, Tobias A. M
The Journal of Organic Chemistry, ISSN 0022-3263, 11/2019
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10. Full Text HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression
by Nehls, Julia and Koppensteiner, Herwig and Brack-Werner, Ruth and Floss, Thomas and Schindler, Michael
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e105478
The TAR DNA binding protein (TDP-43) was originally identified as a host cell factor binding to the HIV-1 LTR and thereby suppressing HIV-1 transcription and... 
RNA | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | RESTRICTION FACTORS | TRANSCRIPTION | VPU | NUCLEAR FACTOR | RELEASE | HUMAN-IMMUNODEFICIENCY-VIRUS | T-CELLS | NEF | Gene Expression | Jurkat Cells | Humans | Transcriptional Activation | HIV Long Terminal Repeat | DNA-Binding Proteins - genetics | Protein Transport | DNA-Binding Proteins - metabolism | HIV-1 - physiology | Virus Replication | Gene Expression Regulation, Viral | Genes, Viral | HEK293 Cells | Cell culture | Transcription | Environmental health | Viruses | Infections | Lymphocytes T | siRNA | Metabolism | Macrophages | Gene expression | Ribonucleic acid--RNA | Nuclei | Virology | Proteins | Lymphocytes | Human immunodeficiency virus--HIV | Replication | Nuclei (cytology) | Localization | Deoxyribonucleic acid--DNA | Immune system | Ribonucleic acid | HIV | Deoxyribonucleic acid | DNA | Human immunodeficiency virus
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11. Full Text Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential
by Sib, Anna and Milzarek, Tobias M and Herrmann, Alexander and Oubraham, Lila and Müller, Jonas I and Pichlmair, Andreas and Brack‐Werner, Ruth and Gulder, Tobias A. M
ChemBioChem, ISSN 1439-4227, 11/2019
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12. Full Text Gibt es Strategien gegen die latente Infektion?
by Kunze, Christine and Herrmann, Alexander and Bauer, Amelie and Brack-Werner, Ruth
MMW - Fortschritte der Medizin, ISSN 1438-3276, 6/2018, Volume 160, Issue S2, pp. 35 - 37
Als HIV-Reservoire können nicht nur die T-Zellen, sondern viele andere Zelltypen dienen. Bis auch diese Reservoire eliminiert oder inaktiviert werden können,... 
monocytes | macrophages | dendritic cells | Medicine & Public Health | General Practice / Family Medicine | Internal Medicine | astrocytes | HIV latency | HIV reservoir
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13. Full Text Are there strategies against latent infection?
by Kunze, Christine and Herrmann, Alexander and Bauer, Amelie and Brack-Werner, Ruth
MMW-Fortschritte der Medizin, ISSN 1438-3276, 06/2018, Volume 160, Issue 2, pp. 35 - 37
monocytes | macrophages | dendritic cells | astrocytes | HIV latency | HIV reservoir
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14. Full Text Aqueous extracts of the marine brown alga Lobophora variegata inhibit HIV-1 infection at the level of virus entry into cells
by Kremb, Stephan and Kremb, Stephan and Helfer, Markus and Helfer, Markus and Kraus, Birgit and Kraus, Birgit and Wolff, Horst and Wolff, Horst and Wild, Christian and Wild, Christian and Schneider, Martha and Schneider, Martha and Voolstra, Christian R and Voolstra, Christian R and Brack-Werner, Ruth and Brack-Werner, Ruth
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 8, p. e103895
In recent years, marine algae have emerged as a rich and promising source of molecules with potent activities against various human pathogens. The widely... 
GRIFFITHSIN | REPLICATION | MULTIDISCIPLINARY SCIENCES | POLYSACCHARIDES | Plant Extracts - chemistry | HIV-1 - drug effects | Plant Extracts - pharmacology | Humans | HEK293 Cells | HeLa Cells | Virus Internalization - drug effects | Leukocytes, Mononuclear - virology | Phaeophyta - chemistry | Antiviral agents | HIV testing | Development and progression | HIV (Viruses) | HIV infection | Health aspects | Reefs | Antibacterial agents | Coral reefs | Algae | Viruses | Infections | Biology | Ecology | Drug resistance | Virology | Acquired immune deficiency syndrome--AIDS | Filaments | Actin | Human immunodeficiency virus--HIV | Antiviral activity | Peripheral blood mononuclear cells | Replication | Viability | Binding sites | Apoptosis | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
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