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Future Medicinal Chemistry, ISSN 1756-8919, 08/2013, Volume 5, Issue 12, pp. 1373 - 1376
Journal Article
Future medicinal chemistry, 08/2013, Volume 5, Issue 12, p. 1373
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7549, pp. 626 - 627
Deletion of the TP53 gene, an event seen in colorectal cancers, often occurs with co-deletion of a gene that encodes an enzyme subunit governing gene... 
VULNERABILITIES | MULTIDISCIPLINARY SCIENCES | Animals | Colorectal Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Female | Genes, p53 - genetics | Tumor Suppressor Protein p53 - deficiency | Genetic aspects | Metastasis | Health aspects | DNA damage
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 10/2015, Volume 13, Issue 10 Supplement, pp. IA27 - IA27
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. SCI-6 - SCI-6
Abstract Abstract SCI-6 In cancer, epigenetic proteins are among the most promising and intently pursued targets in drug discovery. This relates to the growing... 
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 10/2015, Volume 13, Issue 10 Supplement, pp. A41 - A41
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5824 - 5824
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 04/2017, Volume 17, Issue 4, p. 268
Journal Article
Cancer Research, ISSN 0008-5472, 07/2012, Volume 72, Issue 13 Supplement, pp. IA16 - IA16
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. SY02-03 - SY02-03
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 04/2017, Volume 17, Issue 4, p. 268
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7370, pp. 524 - 528
Journal Article
Science, ISSN 0036-8075, 06/2015, Volume 348, Issue 6241, pp. 1376 - 1381
The development of effective pharmacological inhibitors of multidomain scaffold proteins, notably transcription factors, is a particularly challenging problem.... 
SELECTIVE-INHIBITION | UBIQUITINATION | CELLS | COMPLEX | ACTIVATION | MULTIDISCIPLINARY SCIENCES | THALIDOMIDE | LEUKEMIA | CANCER | BET BROMODOMAINS | MOLECULES | Transcription factors | Identification and classification | Health aspects | Protein-protein interactions | Proteins | Molecular biology | Leukemia | Rodents | Degradation | Enzymes | Progressions | Phthalimides | Strategy | Leukemias | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 25, p. E5746
Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of... 
Cell proliferation | Tyrosine | Chromatin | Transcription factors | Immunoprecipitation | Tumor cell lines | Gene expression | Kinases | Clinical outcomes | Neoplasms | Metastases | Enhancers | Gastrointestinal diseases | Cell lines | Epigenetics | KIT protein | Mutation | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Genome Medicine, ISSN 1756-994X, 12/2014, Volume 6, Issue 12, pp. 123 - 123
Jay Bradner discusses the opportunities and challenges for the study and therapeutic targeting of the cancer epigenome, as well as innovative approaches to... 
GENETICS & HEREDITY | Medical colleges | Chromatin | Genetic research | Genetic aspects | Genetic transcription | Drug discovery | Drug therapy | Cancer
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7549, pp. 626 - 627
On page 697 of this issue, Liu et al.4 report that deletion of TP53 in many colorectal cancers is often accompanied by deletion of one copy of a subunit of the... 
Proteins | Studies | Enzymes | Cell growth | Mutation | RNA polymerase | Kinases | Gene expression | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 47, pp. 19408 - 19413
Bromodomain and extra terminal domain (BET) proteins function as epigenetic signaling factors that associate with acetylated histones and facilitate... 
Betting | Cell growth | Messenger RNA | Genes | Cell lines | Cell cycle | Histones | Small interfering RNA | Down regulation | Lung neoplasms | Drug development | Chromatin | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | drug development | C-MYC | BROMODOMAIN INHIBITION | LEUKEMIA | chromatin | TUMORIGENESIS | EXPRESSION | AP-1 | BRD4 | FAMILY | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - pathology | Molecular Targeted Therapy | Gene Knockdown Techniques | Adenocarcinoma - genetics | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Triazoles - therapeutic use | Lung Neoplasms - genetics | Proto-Oncogene Proteins c-fos - metabolism | Nuclear Proteins - metabolism | Signal Transduction - genetics | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Down-Regulation - genetics | Azepines - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Drug Screening Assays, Antitumor | Adenocarcinoma | Epigenetic inheritance | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Health aspects | Cancer | Biological Sciences
Journal Article
Analytical Chemistry, ISSN 0003-2700, 06/2015, Volume 87, Issue 12, p. 6349
  Analysis of complex mixtures of proteins by hydrogen exchange (HX) mass spectrometry (MS) is limited by one's ability to resolve the protein(s) of interest... 
Proteins | Analytical chemistry | Hydrogen | Mass spectrometry
Journal Article
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