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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 10/2019, Volume 141, Issue 40, pp. 15737 - 15741
Bioinformatic analysis of sequenced bacterial genomes has uncovered an increasing number of natural product biosynthetic gene clusters (BGCs) to which no known... 
ANTIBIOTICS | METABOLITES | RHODOCOCCUS-EQUI | POLYKETIDE | SP NOV | LOGIC | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | FAMILY
Journal Article
mBio, ISSN 2150-7511, 11/2019, Volume 10, Issue 6
ABSTRACT The effect of the microbiota on its human host is driven, at least in part, by small-molecule and protein effectors it produces. Here, we report on... 
Journal Article
by Medema, Marnix H and Kottmann, Renzo and Yilmaz, Pelin and Cummings, Matthew and Biggins, John B and Blin, Kai and de Bruijn, Irene and Chooi, Yit Heng and Claesen, Jan and Coates, R Cameron and Cruz-Morales, Pablo and Duddela, Srikanth and Düsterhus, Stephanie and Edwards, Daniel J and Fewer, David P and Garg, Neha and Geiger, Christoph and Gomez-Escribano, Juan Pablo and Greule, Anja and Hadjithomas, Michalis and Haines, Anthony S and Helfrich, Eric J N and Hillwig, Matthew L and Ishida, Keishi and Jones, Adam C and Jones, Carla S and Jungmann, Katrin and Kegler, Carsten and Kim, Hyun Uk and Kötter, Peter and Krug, Daniel and Masschelein, Joleen and Melnik, Alexey V and Mantovani, Simone M and Monroe, Emily A and Moore, Marcus and Moss, Nathan and Nützmann, Hans-Wilhelm and Pan, Guohui and Pati, Amrita and Petras, Daniel and Reen, F Jerry and Rosconi, Federico and Rui, Zhe and Tian, Zhenhua and Tobias, Nicholas J and Tsunematsu, Yuta and Wiemann, Philipp and Wyckoff, Elizabeth and Yan, Xiaohui and Yim, Grace and Yu, Fengan and Xie, Yunchang and Aigle, Bertrand and Apel, Alexander K and Balibar, Carl J and Balskus, Emily P and Barona-Gómez, Francisco and Bechthold, Aneas and Bode, Helge B and Borriss, Rainer and Brady, Sean F and Brakhage, Axel A and Caffrey, Patrick and Cheng, Yi-Qiang and Clardy, Jon and Cox, Russell J and De Mot, René and Donadio, Stefano and Donia, Mohamed S and van der Donk, Wilfred A and Dorrestein, Pieter C and Doyle, Sean and essen, Arnold J M and Ehling-Schulz, Monika and Entian, Karl-Dieter and Fischbach, Michael A and Gerwick, Lena and Gerwick, William H and Gross, Harald and Gust, Bertolt and Hertweck, Christian and Höfte, Monica and Jensen, Susan E and Ju, Jianhua and Katz, Leonard and Kaysser, Leonard and Klassen, Jonathan L and Keller, Nancy P and Kormanec, Jan and Kuipers, Oscar P and Kuzuyama, Tomohisa and Kyrpides, Nikos C and Kwon, Hyung-Jin and Lautru, Sylvie and Lavigne, Rob and Lee, Chia Y and Linquan, Bai and Liu, Xinyu and Liu, Wen and ...
Nature Chemical Biology, ISSN 1552-4469, 08/2015, Volume 11, Issue 9, pp. 625 - 631
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 44, p. 11615
Although bacterial bioactive metabolites have been one of the most prolific sources of lead structures for the development of small-molecule therapeutics, very... 
Peptides | Microbiomes | Biogeography | Environmental changes | Biosynthesis | Latitude | Environmental factors | Metabolism | Drug development | pH effects | Soils | Metabolites | Natural products | Primers | Bacteria | Adenylation | Bioactive metabolites
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2013, Volume 52, Issue 42, pp. 11174 - 11174
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 51, p. 14811
  Numerous therapeutically relevant small molecules have been identified from the screening of natural products (NPs) produced by environmental bacteria. These... 
Molecules | Peptides | Phylogenetics | Bacteria | Deoxyribonucleic acid--DNA | Biological diversity
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 07/2015, Volume 112, Issue 29, pp. 8953 - 8953
Large-scale sequencing of prokaryotic (meta)genomic DNA suggests that most bacterial natural product gene clusters are not expressed under common laboratory... 
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 07/2015, Volume 112, Issue 29, pp. 9100 - 9100
We report the discovery and characterization of a double-stranded RNA (dsRNA) mycovirus isolated from the human pathogenic fungus Aspergillus fumigatus,... 
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 09/2015, Volume 112, Issue 35, pp. E4825 - E4825
The trillions of bacteria that make up the human microbiome are believed to encode functions that are important to human health; however, little is known about... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2013, Volume 110, Issue 7, p. 2478
  Natural product discovery by random screening of broth extracts derived from cultured bacteria often suffers from high rates of redundant isolation, making... 
Antibiotics | Natural products | Phylogenetics | Bacteria | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2015, Volume 112, Issue 29, p. 9100
  We report the discovery and characterization of a double-stranded RNA (dsRNA) mycovirus isolated from the human pathogenic fungus Aspergillus fumigatus,... 
Fungi | Proteins | Viruses | Genomes | RNA polymerase | Ribonucleic acid--RNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2015, Volume 112, Issue 29, p. 8953
  Large-scale sequencing of prokaryotic (meta)genomic DNA suggests that most bacterial natural product gene clusters are not expressed under common laboratory... 
Prokaryotes | Natural products | Genomics | Biosynthesis | Genetic engineering | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Bioinformatics, ISSN 1367-4803, 09/2015, Volume 31, Issue 17, pp. 2909 - 2911
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2014, Volume 111, Issue 10, p. 3757
  In this study, we compare biosynthetic gene richness and diversity of 96 soil microbiomes from diverse environments found throughout the southwestern and... 
Soils | Metabolites | Natural products | Genetics | Biosynthesis | Metabolism | Sediments
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2014, Volume 111, Issue 10, pp. 3757 - 3762
In this study, we compare biosynthetic gene richness and diversity of 96 soil microbiomes from diverse environments found throughout the southwestern and... 
Soil samples | Sedimentary soils | Soil composition | Multigene family | Biosynthesis | Acid soils | Arid soils | Desert soils | Forest soils | Soil ecology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2015, Volume 112, Issue 35, p. E4825
  The trillions of bacteria that make up the human microbiome are believed to encode functions that are important to human health; however, little is known... 
Transcription factors | Metabolites | Genomics | Deoxyribonucleic acid--DNA
Journal Article
Angewandte Chemie, ISSN 0044-8249, 10/2013, Volume 125, Issue 42, pp. 11269 - 11273
Sequenzmarkergesteuertes Screening von DNA‐Bibiotheken in Bodenmikroben kann das Auffinden neuer Verbindungen mit verbesserten Eigenschaften ermöglichen. In... 
MDR | Anthracycline | Naturstoffe | Metagenomik | Tumortherapeutika | Anthracyclines
Journal Article
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