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human necessities (9) 9
hygiene (9) 9
medical or veterinary science (9) 9
preparations for medical, dental, or toilet purposes (9) 9
index medicus (8) 8
specific therapeutic activity of chemical compounds ormedicinal preparations (8) 8
viruses (6) 6
chemistry, medicinal (5) 5
hiv (5) 5
acyclic, carbocyclic or heterocyclic compounds containingelements other than carbon, hydrogen, halogen, oxygen, nitrogen,sulfur, selenium or tellurium (4) 4
chemistry (4) 4
derivatives thereof (4) 4
discovery (4) 4
heterocyclic compounds (4) 4
humans (4) 4
metallurgy (4) 4
nucleic acids (4) 4
nucleosides (4) 4
nucleotides (4) 4
organic chemistry (4) 4
sugars (4) 4
anti-hiv agents - pharmacology (3) 3
antiviral agents (3) 3
dead-box rna helicases - metabolism (3) 3
drug design (3) 3
hiv-1 - drug effects (3) 3
models, molecular (3) 3
proteins (3) 3
replication (3) 3
resistance (3) 3
virus replication - drug effects (3) 3
acyclovir (2) 2
biochemistry, genetics and molecular biology; agricultural and biological sciences (2) 2
biology and life sciences (2) 2
biotechnology (2) 2
cell survival - drug effects (2) 2
chemical synthesis (2) 2
chemistry, organic (2) 2
dead-box rna helicases - antagonists & inhibitors (2) 2
derivatives (2) 2
dosage and administration (2) 2
gels (2) 2
highly active antiretroviral therapy (2) 2
hiv infection (2) 2
identification (2) 2
infections (2) 2
laboratories (2) 2
medical research (2) 2
medicine (2) 2
medicine and health sciences (2) 2
molecular docking simulation (2) 2
molecular structure (2) 2
multidisciplinary sciences (2) 2
pathogens (2) 2
pharmacology (2) 2
pharmacy (2) 2
protein-protein interactions (2) 2
pyrimidines (2) 2
research and analysis methods (2) 2
resveratrol (2) 2
reverse transcriptase inhibitors - pharmacology (2) 2
rna helicase (2) 2
science (2) 2
small molecule libraries - chemistry (2) 2
small molecule libraries - pharmacology (2) 2
target (2) 2
usage (2) 2
viral infections (2) 2
virology (2) 2
virus diseases (2) 2
accurate docking (1) 1
acquired immune deficiency syndrome (1) 1
acquired immune deficiency syndrome--aids (1) 1
adaptor proteins, signal transducing - metabolism (1) 1
adherence (1) 1
administration, intravaginal (1) 1
administration, intravaginal; anti-hiv agents; cell survival; chemistry, pharmaceutical; dna, viral; dose-response relationship, drug; drug design; gels; hiv-1; models, molecular; molecular docking simulation; pyrimidines; reverse transcriptase inhibitors; medicine; molecular medicine; drug discovery3003 pharmaceutical science (1) 1
agents (1) 1
aids (1) 1
albumin (1) 1
albumins (1) 1
alkylation (1) 1
amination, n‐alkylation, n‐arylation (1) 1
amino-acid-polymer (1) 1
analysis (1) 1
animals (1) 1
animals; antiviral agents; cercopithecus aethiops; drug resistance, viral; female; hiv infections; hiv-1; hela cells; herpes simplex; herpesvirus 1, human; herpesvirus 2, human; humans; molecular structure; pre-exposure prophylaxis; rhodanine; simplexvirus; thiazoles; vaginal creams, foams, and jellies; vero cells; virus replication (1) 1
anti-hiv agents - administration & dosage (1) 1
anti-hiv agents - chemical synthesis (1) 1
anti-hiv agents - chemistry (1) 1
anti-hiv agents - therapeutic use (1) 1
anti-retroviral agents - chemistry (1) 1
anti-retroviral agents - metabolism (1) 1
anti-retroviral agents - pharmacology (1) 1
anti-retroviral agents - toxicity (1) 1
antimicrobials (1) 1
antiretroviral agents (1) 1
antiretrovirals (1) 1
antitumor (1) 1
antiviral activity (1) 1
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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 11/2019, Volume 10, Issue 11, pp. 1511 - 1511
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2019, Volume 10, Issue 2, pp. 142 - 142
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, p. e0198478
Although highly active antiretroviral therapies (HAART) remarkably increased life expectancy of HIV positive people, the rate of novel HIV-1 infections... 
CAPRISA 004 TRIAL | KUWANON-L | HERPES-SIMPLEX-VIRUS | PATIENTS FAILING RALTEGRAVIR | TYPE-2 INFECTION | MULTIDISCIPLINARY SCIENCES | MULTIPURPOSE PREVENTION TECHNOLOGIES | BIOLOGICAL EVALUATION | RISK | TENOFOVIR GEL | ADHERENCE | Simplexvirus - drug effects | Vaginal Creams, Foams, and Jellies - pharmacology | HIV Infections - prevention & control | Virus Replication - drug effects | Antiviral Agents - pharmacology | HIV-1 - drug effects | Humans | Cercopithecus aethiops | Herpesvirus 1, Human - drug effects | Pre-Exposure Prophylaxis | Animals | Rhodanine - analogs & derivatives | Antiviral Agents - chemistry | Vaginal Creams, Foams, and Jellies - chemistry | Drug Resistance, Viral - drug effects | Female | Herpes Simplex - prevention & control | Thiazoles - chemistry | Molecular Structure | Thiazoles - pharmacology | HeLa Cells | Herpesvirus 2, Human - drug effects | Vero Cells | Highly active antiretroviral therapy | Antiviral agents | Care and treatment | Usage | Albumin | Dosage and administration | Acyclovir | HIV infection | Health aspects | Biotechnology | Laboratories | Prophylaxis | Infections | Tenofovir | Prevention | Microbicides | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Medical research | Life expectancy | Gels | Vagina | Pharmacology | Serum albumin | Permeability | Derivatives | Virology | Pregnancy | Life span | Pharmacy | Herpes viruses | Viral infections | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, p. e0208333
Journal Article
ChemBioChem, ISSN 1439-4227, 04/2016, Volume 17, Issue 8, pp. 683 - 688
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 11/2015, Volume 55, Issue 11, p. 2443
  Targeting cellular cofactors instead of viral enzymes represents a new strategy to combat infectious diseases, which should help to overcome the problem of... 
Inhibitor drugs | Genes | Viruses | Biology | Genomes
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2333 - 2347
Increased frequency of arbovirus outbreaks in the last 10 years represents an important emergence for global health. Climate warming, extensive urbanization of... 
TARGET | CHEMISTRY, MEDICINAL | REPLICATION | BOX RNA HELICASE | DISCOVERY | SMALL-MOLECULE INHIBITOR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2016, Volume 113, Issue 19, p. 5388
  Targeting a host factor essential for the replication of different viruses but not for the cells offers a higher genetic barrier to the development of... 
Proteins | Toxicity | Viruses | Pharmacology | Kinetics | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2016, Volume 59, Issue 6, pp. 2747 - 2759
Preventing HIV transmission by the use of a vaginal microbicide is a topic of considerable interest in the fight against AIDS. Both a potent anti-HIV agent and... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2013, Volume 54, Issue 38, pp. 5204 - 5206
A versatile approach for the synthesis of 1,4-disubstituted pyrazolo[3,4- ]pyrimidines has been developed. Starting from commercially available allopurinol,... 
Microwave | Pyrazolo[3,4-d]pyrimidines | N1-functionalization | Antitumor | CELLS | POTENT | DESIGN | ALKYLATION | LEAD OPTIMIZATION | CHEMISTRY, ORGANIC | KINASE INHIBITORS | DISCOVERY | Chemical synthesis | Pyrimidines | Resveratrol | Tetrahedrons | Synthesis (chemistry) | Biological | Heating | Microwaves | Standards
Journal Article
Journal Article
09/2017
The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
04/2019
The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
01/2019
The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
10/2018
The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
ChemInform, ISSN 0931-7597, 01/2014, Volume 45, Issue 4, pp. no - no
An alternative approach for the synthesis of the title compounds is developed based on TBAF‐mediated N‐1‐functionalization of readily available chlorinated... 
fused pyrimidine derivatives | amination, N‐alkylation, N‐arylation | pyrazole derivatives | Chemical synthesis | Pyrimidines | Resveratrol
Journal Article
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