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Frontiers in immunology, ISSN 1664-3224, 2015, Volume 6, p. 509
Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2574 - 2579
IL-1α, like IL-1β, possesses multiple inflammatory and immune properties. However, unlike IL-1β, the cytokine is present intracellularly in healthy tissues and... 
Myeloid cells | Chromatin | Epithelial cells | Cell nucleus | Stem cells | Neutrophils | Inflammation | Myeloid progenitor cells | Apoptosis | Necrosis | Hypoxia | Alarmin | hypoxia | INTERLEUKIN-1 | alarmin | PRECURSOR | NECROSIS-INDUCED INFLAMMATION | MULTIDISCIPLINARY SCIENCES | COMPLEXES | apoptosis | MOLECULAR-PATTERN MOLECULES | HMGB1 | IL-1-LIKE CYTOKINE IL-33 | DYING CELLS | necrosis | inflammation | IN-VIVO | EXPRESSION | Biological Sciences
Journal Article
Cellular Signalling, ISSN 0898-6568, 10/2019, Volume 62, p. 109340
Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Glrx3)) is a ubiquitously expressed protein that possesses an... 
H2AX | DNA-damage response | GLRX3 | Genotoxic stress | PICOT | OXIDATIVE STRESS | DOUBLE-STRAND BREAKS | GLUTAREDOXIN 3 PICOT | TOPOISOMERASE-I | FREE-RADICALS | CELL BIOLOGY | REACTIVE OXYGEN | HISTONE H2AX PHOSPHORYLATION | CARDIAC-HYPERTROPHY | MONOTHIOL GLUTAREDOXIN | ATM ACTIVATION
Journal Article
Journal Article
Journal Article
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 09/2019, Volume 10, Issue 10, pp. 1 - 15
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 2, pp. 469 - 475
PICOT is a ubiquitous protein that has no functional redundant ortholog and is critical for mouse embryonic development. It is involved in the regulation of... 
Grx3 | PRC2 | EED | PcG | PICOT | H3K27me3 | HISTONE METHYLTRANSFERASE ACTIVITY | COMPLEX | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENHANCER | GLUTAREDOXIN 3 PICOT | BIOPHYSICS | THIOREDOXIN | INTERACTS | CARDIAC-HYPERTROPHY | MONOTHIOL GLUTAREDOXIN | EXPRESSION
Journal Article
Aging, ISSN 1945-4589, 2015, Volume 7, Issue 9, pp. 664 - 672
Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with unknown etiology and no effective treatment. In this study, we show that primary... 
Aging | Fibroblasts | Myofibroblasts | Idiopathic pulmonary fibrosis | Cellular senescence | APOPTOSIS | TELOMERASE | LINKS | MECHANISMS | idiopathic pulmonary fibrosis | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | fibroblasts | REPAIR | cellular senescence | EPITHELIAL INJURY | IPF FIBROBLASTS | aging | MUTATIONS | myofibroblasts
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2015, Volume 132, Issue 5, p. 559
Amyloid-[beta] peptides generated by proteolysis of the [beta]-amyloid precursor protein (APP) play an important role in the pathogenesis of Alzheimer's... 
COX-2 inhibitors | Neurons | Proteolysis | Amyloid beta-protein | Cyclic adenylic acid | Phospholipases | Adenylic acid | Protein kinases | Alzheimer's disease | Protein binding
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2012, Volume 3, p. 290
During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors.... 
HIF-2 | Cytokines and inflammation | IL-1 | Alarmin | HIF-1α | Sterile inflammation | DAMPs | Sterile Inflammation | alarmin
Journal Article