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1. Full Text Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
by Braissant, Olivier
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 7/2012, Volume 35, Issue 4, pp. 655 - 664
While it was thought that most of cerebral creatine is of peripheral origin, AGAT and GAMT are well expressed in CNS where brain cells synthesize creatine.... 
Human Genetics | Biochemistry, general | Pediatrics | Internal Medicine | Medicine & Public Health | Metabolic Diseases | MEDICINE, RESEARCH & EXPERIMENTAL | MENTAL-RETARDATION | METHYLTRANSFERASE DEFICIENCY | PRESYMPTOMATIC TREATMENT | AMMONIA TOXICITY | INBORN ERROR | SPATIOTEMPORAL EXPRESSION | AGAT DEFICIENCY | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | MAGNETIC-RESONANCE | RAT-BRAIN | MR SPECTROSCOPY | Creatine - cerebrospinal fluid | Glycine - analogs & derivatives | Glycine - blood | Animals | Biological Transport | Cerebrospinal Fluid - metabolism | Glycine - cerebrospinal fluid | Humans | Creatine - blood | Blood-Brain Barrier - metabolism | Taurine | Medical errors | Permeability | Creatine | Endothelium
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2. Full Text GAMT deficiency: 20years of a treatable inborn error of metabolism
by Braissant, Olivier
Molecular Genetics and Metabolism, ISSN 1096-7192, 2014, Volume 111, Issue 1, pp. 1 - 3
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3. Full Text Current concepts in the pathogenesis of urea cycle disorders
by Braissant, Olivier
Molecular Genetics and Metabolism, ISSN 1096-7192, 2010, Volume 100, pp. S3 - S12
The common feature of urea cycle diseases (UCD) is a defect in ammonium elimination in liver, leading to hyperammonemia. This excess of circulating ammonium... 
Brain | Neuroprotection | Ammonium | Toxicity | Hyperammonemia | Urea cycle diseases | MEDICINE, RESEARCH & EXPERIMENTAL | DEVELOPING BRAIN-CELLS | ACETYL-L-CARNITINE | ALTERNATIVE-PATHWAY THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL PERMEABILITY TRANSITION | ORNITHINE TRANSCARBAMYLASE DEFICIENCY | GENETICS & HEREDITY | CARBAMOYL TRANSFERASE DEFICIENCY | CENTRAL-NERVOUS-SYSTEM | SPARSE-FUR MOUSE | LONG-TERM POTENTIATION | ARGININOSUCCINATE SYNTHETASE GENE | Urea Cycle Disorders, Inborn - etiology | Animals | Quaternary Ammonium Compounds - toxicity | Hyperammonemia - complications | Humans | Central Nervous System - drug effects | Central Nervous System - pathology | Disease Models, Animal
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4. Full Text Ammonia toxicity to the brain: Effects on creatine metabolism and transport and protective roles of creatine
by Braissant, Olivier
Molecular Genetics and Metabolism, ISSN 1096-7192, 2010, Volume 100, pp. S53 - S58
Hyperammonemia can provoke irreversible damage to the developing brain, with the formation of cortical atrophy, ventricular enlargement, demyelination or gray... 
Ammonia | Brain | Neuroprotection | Creatine | Toxicity | Hyperammonemia | MEDICINE, RESEARCH & EXPERIMENTAL | DEFICIENCY SYNDROMES | UREA-CYCLE DISORDERS | SPATIOTEMPORAL EXPRESSION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | NITRIC-OXIDE | CENTRAL-NERVOUS-SYSTEM | GUANIDINOACETATE | SPARSE-FUR MOUSE | RAT-BRAIN | GABA(A) RECEPTORS | Humans | Protective Agents - metabolism | Axons - drug effects | Axons - metabolism | Brain - enzymology | Ammonia - toxicity | Brain - drug effects | Animals | Models, Biological | Creatine - metabolism | Brain - pathology | Biological Transport - drug effects | Cell Culture Techniques
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5. Full Text GAMT deficiency: 20 years of a treatable inborn error of metabolism
by Braissant, Olivier
Molecular Genetics and Metabolism, ISSN 1096-7192, 01/2014, Volume 111, Issue 1, pp. 1 - 3
GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | MEDICINE, RESEARCH & EXPERIMENTAL | CREATINE-DEFICIENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | ARGININE | BRAIN | Glycine - analogs & derivatives | Glycine - blood | Humans | Movement Disorders - diagnosis | Male | Ornithine - therapeutic use | Language Development Disorders - therapy | Intellectual Disability - therapy | Language Development Disorders - diagnosis | Movement Disorders - therapy | Guanidinoacetate N-Methyltransferase - deficiency | Movement Disorders - congenital | Creatine - metabolism | Sodium Benzoate - therapeutic use | Creatine - therapeutic use | Female | Arginine - therapeutic use | Arginine - metabolism
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6. Full Text Reply to: “Magnetic resonance spectroscopy: A surrogate marker of hepatic encephalopathy?”
by McLin, Valérie A and Braissant, Olivier and Cudalbu, Cristina
Journal of Hepatology, ISSN 0168-8278, 11/2019, Volume 71, Issue 5, p. 1057
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7. Full Text Ammonia toxicity to the brain
by Braissant, Olivier and McLin, Valérie A and Cudalbu, Cristina
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 7/2013, Volume 36, Issue 4, pp. 595 - 612
Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious... 
Human Genetics | Biochemistry, general | Pediatrics | Internal Medicine | Medicine & Public Health | Metabolic Diseases | ACUTE LIVER-FAILURE | MEDICINE, RESEARCH & EXPERIMENTAL | ALTERNATIVE-PATHWAY THERAPY | UREA CYCLE DISORDERS | VIVO H-1-NMR SPECTROSCOPY | MITOCHONDRIAL PERMEABILITY TRANSITION | MINIMAL HEPATIC-ENCEPHALOPATHY | MAGNETIC-RESONANCE-SPECTROSCOPY | ORNITHINE TRANSCARBAMYLASE DEFICIENCY | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | CEREBRAL GLUTAMINE SYNTHESIS | LONG-TERM POTENTIATION | Brain - metabolism | Hyperammonemia - pathology | Hyperammonemia - drug therapy | Animals | Hyperammonemia - metabolism | Neuroprotective Agents - pharmacology | Ammonia - metabolism | Humans | Brain Neoplasms - pathology | Brain - pathology | Brain Neoplasms - drug therapy | Brain Neoplasms - metabolism | Cerebral palsy | Urea | Ammonia | Ligases | Nitric oxide | Physiological aspects | Nuclear magnetic resonance spectroscopy | Levocarnitine | Amino acids | Seizures (Medicine) | Ciliary neurotrophic factor | Index Medicus
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8. Full Text Metabolic activity of mature biofilms of Mycobacterium tuberculosis and other non-tuberculous mycobacteria
by Solokhina, Anna and Brückner, David and Bonkat, Gernot and Braissant, Olivier
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 9225 - 7
Mycobacteria are classified into two groups, fast- and slow-growing. Often, fast-growing mycobacteria are assumed to have a higher metabolic activity than... 
HETEROGENEITY | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | LASER ABSORPTION-SPECTROSCOPY | RESISTANCE | STRESS | MICROBIAL-GROWTH | ISOTHERMAL MICROCALORIMETRY | Oxygen consumption | Biofilms | Tuberculosis | Metabolism
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9. Full Text Isothermal Microcalorimetry To Study Drugs against Schistosoma mansoni
by Theresia Manneck and Olivier Braissant and Yolanda Haggenmüller and Jennifer Keiser
Journal of Clinical Microbiology, ISSN 0095-1137, 04/2011, Volume 49, Issue 4, pp. 1217 - 1225
Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
PRAZIQUANTEL | TRANSFORMATION | MICROBIOLOGY | IN-VITRO | MEFLOQUINE | Mefloquine - pharmacology | Schistosoma mansoni - drug effects | Drug Evaluation, Preclinical - methods | Humans | Praziquantel - pharmacology | Schistosoma mansoni - anatomy & histology | Calorimetry - methods | Artemisinins - pharmacology | Animals | Parasitic Sensitivity Tests - methods | Microscopy | Anthelmintics - pharmacology | Oxamniquine - pharmacology | Parasitology
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10. Full Text Personalized Treatment Response Assessment for Rare Childhood Tumors Using Microcalorimetry–Exemplified by Use of Carbonic Anhydrase IX and Aquaporin 1 Inhibitors
by Gros, Stephanie J and Holland-Cunz, Stefan G and Supuran, Claudiu T and Braissant, Olivier
International Journal of Molecular Sciences, ISSN 1422-0067, 10/2019, Volume 20, Issue 20, p. 4984
We present a novel approach to a personalized therapeutic concept for solid tumors. We illustrate this on a rare childhood tumor for which only a generalized... 
CAIX inhibitor | drug susceptibility | rare pediatric cancer | isothermal calorimetry | AQP1 | clear cell renal carcinoma | organotypic slice culture
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11. Full Text Drug susceptibility testing of mature Mycobacterium tuberculosis H37Ra and Mycobacterium smegmatis biofilms with calorimetry and laser spectroscopy
by Solokhina, Anna and Bonkat, Gernot and Kulchavenya, Ekatherina and Braissant, Olivier
Tuberculosis, ISSN 1472-9792, 12/2018, Volume 113, pp. 91 - 98
Biofilms are more resistant to antibiotics and antimicrobial stressors than planktonic bacteria; however, only a limited number of standardized assays enable... 
Biofilm | Mycobacterium | Drug susceptibility test | Isothermal microcalorimetry | Tunable diode laser absorption spectroscopy | RESPIRATORY SYSTEM | GROWTH | RESISTANCE | MICROBIOLOGY | IMMUNOLOGY | Biofilms - drug effects | Mycobacterium smegmatis - growth & development | Isoniazid - pharmacology | Mycobacterium smegmatis - metabolism | Antitubercular Agents - pharmacology | Biofilms - growth & development | Drug Resistance, Bacterial | Mycobacterium tuberculosis - drug effects | Proof of Concept Study | Spectrum Analysis - instrumentation | Dose-Response Relationship, Drug | Lasers | Mycobacterium smegmatis - drug effects | Calorimetry | Microbial Sensitivity Tests - instrumentation | Microbial Sensitivity Tests - methods | Mycobacterium tuberculosis - metabolism | Energy Metabolism - drug effects | Mycobacterium tuberculosis - growth & development | Biomechanics | Tuberculosis | Spectrum analysis | Antitubercular agents | Biomedical engineering | Absorption spectroscopy | Differential scanning calorimetry | Spectroscopy | Change detection | Carbon dioxide | Oxygen consumption | Regrowth | Drug resistance | Antiinfectives and antibacterials | Microorganisms | Biofilms | Antibiotics | Tunable lasers | Isoniazid
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12. Full Text Synthesis and transport of creatine in the CNS: importance for cerebral functions
by Béard, Elidie and Braissant, Olivier
Journal of Neurochemistry, ISSN 0022-3042, 10/2010, Volume 115, Issue 2, pp. 297 - 313
J. Neurochem. (2010) 115, 297–313. Apart of its well known function of ‘energetic buffer’ through the creatine/phosphocreatine/creatine kinase system allowing... 
brain | creatine deficiency | creatine | guanidinoacetate | mitochondria | neuroprotection | Creatine deficiency | Brain | Neuroprotection | Mitochondria | Creatine | Guanidinoacetate | GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | PROTON MR SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-SITU HYBRIDIZATION | AMYOTROPHIC-LATERAL-SCLEROSIS | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | MITOCHONDRIAL PERMEABILITY TRANSITION | MAGNETIC-RESONANCE-SPECTROSCOPY | TRANSGENIC ANIMAL-MODEL | CENTRAL-NERVOUS-SYSTEM | ARGININE-GLYCINE AMIDINOTRANSFERASE | Central Nervous System - metabolism | Creatine - biosynthesis | Humans | Neurodegenerative Diseases - prevention & control | Protein Transport - physiology | Neurodegenerative Diseases - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Guanidinoacetate N-Methyltransferase - metabolism | Amidinotransferases - metabolism | Nerve Tissue Proteins - metabolism | Animals | Models, Biological | Cerebral Cortex - physiology | Creatine - deficiency | Enzymes | Nervous system diseases | Parkinson's disease | Huntington's chorea | Creatine kinase | Physiological aspects | Mitochondrial DNA | Glycine | Neurodegenerative diseases | Central nervous system | Data processing | Glycine amidinotransferase | Huntington's disease | Metabolism | Neuroprotective agents | Neuromodulation | Regeneration | Neurotransmitters | Arginine | Blood-brain barrier | Guanidinoacetate N-methyltransferase | ATP | Movement disorders
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