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1. Full Text Professor Sebastian Brandner: the next frontiers of molecular diagnostics of brain tumours-interrogating epigenetic profiles of brain tumours
by Lu, A and Brandner, S
ANNALS OF TRANSLATIONAL MEDICINE, ISSN 2305-5839, 07/2018, Volume 6, Issue 13, pp. 273 - 273
MEDICINE, RESEARCH & EXPERIMENTAL | ONCOLOGY | Meet the Professor
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2. Full Text Invited review: Diagnostic, prognostic and predictive relevance of molecular markers in gliomas
by Brandner, Sebastian and von Deimling, Andreas
Neuropathology and Applied Neurobiology, ISSN 0305-1846, 10/2015, Volume 41, Issue 6, pp. 694 - 720
IDH mutation | Biomarker | 1p/19q codeletion | ATRX | Glioblastoma | Oligodendroglioma
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3. Full Text The pathological diagnosis of nerve biopsies: a practical approach
by Brandner, Sebastian
Diagnostic Histopathology, ISSN 1756-2317, 2016, Volume 22, Issue 9, pp. 333 - 344
Abstract The approach to the neuropathological assessment of nerve biopsies is the main focus of this review. Nerve biopsies are invasive diagnostic procedures... 
Pathology | dysproteinaemic neuropathy | axonal | inflammatory neuropathy | vasculitis | demyelination | neuropathy | genetic neuropathy | amyloid neuropathy | College teachers
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4. Full Text Nanog, Gli, and p53: a new network of stemness in development and cancer
by Brandner, Sebastian
The EMBO Journal, ISSN 0261-4189, 08/2010, Volume 29, Issue 15, pp. 2475 - 2476
EMBO J 29 15, 2646-2658 (2010); published online 25 June 2010EMBO J 29 15, 2659-2674 (2010); published online 25 June 2010Nanog and Hedgehog (HH) are both... 
CELLS | SELF-RENEWAL | MEDULLOBLASTOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRAIN | CELL BIOLOGY | Neoplasms - metabolism | Animals | Nanog Homeobox Protein | Signal Transduction | Homeodomain Proteins - metabolism | Humans | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Trans-Activators - metabolism | Mice | Zinc Finger Protein GLI1 | Stem Cells - metabolism | Cellular biology | Molecular biology | Gene expression | Brain cancer | Stem cells | Index Medicus | Have You Seen...?
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5. Full Text Transmissible human proteopathies: an expanding field
by Jaunmuktane, Zane and Brandner, Sebastian
Diagnostic Histopathology, ISSN 1756-2317, 01/2019, Volume 25, Issue 1, pp. 16 - 22
Prions are considered the prototype of transmissible proteopathies, and this property has for many decades been considered unique. More recently the... 
tauopathy | neurodegenerative disease | Parkinson's disease | prion disease | Creutzfeldt-Jakob disease | amyloid-β | neurodegeneration | tau | proteopathy | prions | CJD | Alzheimer's disease | α-synuclein
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6. Full Text Early CSF and Serum S100B Concentrations for Outcome Prediction in Traumatic Brain Injury and Subarachnoid Hemorrhage
by Kellermann, Isabel|Kleindienst, Andrea|Hore, Nirjhar|Buchfelder, Michael|Brandner, Sebastian
Clinical Neurology and Neurosurgery, ISSN 0303-8467, 2016, Volume 145, pp. 79 - 83
Highlights • Prognostic value of S100B in TBI, SAH and meningitis at 6 months following treatment. • Significant correlation between serum S100B and GOS in... 
Neurology | Neurosurgery | Biomarker | Cerebrospinal fluid | S100B | Neuroproteins | Neurotrauma | BIOMARKERS | SURGERY | S-100 PROTEIN | CEREBROSPINAL-FLUID | DAMAGE | CLINICAL NEUROLOGY | Predictive Value of Tests | Prognosis | Humans | Middle Aged | Male | Biomarkers - blood | S100 Calcium Binding Protein beta Subunit - blood | Brain Injuries, Traumatic - cerebrospinal fluid | Adult | Female | Aged | S100 Calcium Binding Protein beta Subunit - metabolism | Subarachnoid Hemorrhage - diagnosis | Biomarkers - cerebrospinal fluid | S100 Calcium Binding Protein beta Subunit - cerebrospinal fluid | Brain Injuries, Traumatic - blood | Brain Injuries, Traumatic - diagnosis | Subarachnoid Hemorrhage - cerebrospinal fluid | Subarachnoid Hemorrhage - blood | Stroke (Disease) | Brain | Injuries | Subarachnoid hemorrhage | Analysis | Mortality | Meningitis | Nerve proteins | Confidence intervals | Values | Edema | Traumatic brain injury | Statistical analysis | Hemorrhage | Index Medicus
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7. Full Text Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey
by Gill, O Noel and Spencer, Yvonne and Richard-Loendt, Angela and Kelly, Carole and Dabaghian, Reza and Boyes, Lynnette and Linehan, Jacqueline and Simmons, Marion and Webb, Paul and Bellerby, Peter and Andrews, Nick and Hilton, David A and Ironside, James W and Beck, Jon and Poulter, Mark and Mead, Simon and Brandner, Sebastian
BMJ : British Medical Journal, ISSN 0959-8138, 10/2013, Volume 347, Issue 7929, pp. 11 - 11
Objectives To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of... 
RESEARCH | Womens studies | Animal hospitals | Neurology | Reproduction | Neurodegenerative diseases | Labor force surveys | Prions | Creutzfeldt Jakob syndrome | School surveys | Health surveys | TISSUE SAMPLES | SCRAPIE | MEDICINE, GENERAL & INTERNAL | TRANSMISSION | BSE | BLOOD-TRANSFUSION | SHEEP | CREUTZFELDT-JAKOB-DISEASE | VARIANT CJD | TONSIL SPECIMENS | ACCUMULATION | Creutzfeldt-Jakob Syndrome - epidemiology | Carrier State - epidemiology | Prion Proteins | Appendix - chemistry | Genetic Testing | Prevalence | Prions - genetics | Humans | Encephalopathy, Bovine Spongiform - transmission | Prions - analysis | Male | Encephalopathy, Bovine Spongiform - epidemiology | Creutzfeldt-Jakob Syndrome - metabolism | Homozygote | Carrier State - metabolism | Animals | Encephalopathy, Bovine Spongiform - genetics | Cattle | Female | Codon - genetics | Creutzfeldt-Jakob Syndrome - genetics | United Kingdom - epidemiology | Cohort Studies | Proteins | Creutzfeldt-Jakob disease | Index Medicus | Abridged Index Medicus
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8. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Adriana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Rodriguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, Jürgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Andreas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and Driever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and Von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Gudrun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7697, pp. 469 - 474
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous... 
MOLECULAR CLASSIFICATION | MULTICENTER | ENTITY | GLIOMA | MULTIDISCIPLINARY SCIENCES | PILOCYTIC ASTROCYTOMA | CLASS PROBABILITY ESTIMATION | SUBGROUPS | MEDULLOBLASTOMA | EXPRESSION | BIOCONDUCTOR | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
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9. Full Text Diversity of prion diseases: (no) strains attached?
by Brandner, Sebastian
Acta Neuropathologica, ISSN 0001-6322, 1/2011, Volume 121, Issue 1, pp. 1 - 4
Medicine & Public Health | Pathology | Neurosciences | SCRAPIE | PROTEIN | CREUTZFELDT-JAKOB-DISEASE | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | Prion Proteins | Prions - metabolism | Genetic Predisposition to Disease - genetics | Prions - genetics | Prions - pathogenicity | Species Specificity | Humans | PrPSc Proteins - genetics | PrPSc Proteins - metabolism | Animals | Prion Diseases - transmission | Prions - isolation & purification | Prion Diseases - diagnosis | Prion Diseases - metabolism | Index Medicus
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10. Full Text Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
by Hoeck, Joerg D and Behrens, Axel and Jandke, Anett and Spencer-Dene, Bradley and Nye, Emma and Brandner, Sebastian and Blake, Sophia M
Nature Neuroscience, ISSN 1097-6256, 11/2010, Volume 13, Issue 11, pp. 1365 - 1372
Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem... 
CYCLIN-E | PROTEIN | RADIAL GLIAL-CELLS | GENE | UBIQUITIN LIGASE | INTERMEDIATE PROGENITORS | PHOSPHORYLATION | FATE SPECIFICATION | TUMOR-SUPPRESSOR | CENTRAL-NERVOUS-SYSTEM | NEUROSCIENCES | F-Box-WD Repeat-Containing Protein 7 | Brain - embryology | Nestin | Cell Proliferation | Embryo, Mammalian | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Ubiquitin-Protein Ligases - physiology | Nerve Tissue Proteins - pharmacology | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Brain - cytology | Proto-Oncogene Proteins c-jun - genetics | Cells, Cultured | Mice, Transgenic | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | F-Box Proteins - physiology | Proto-Oncogene Proteins c-jun - metabolism | Ubiquitin-Protein Ligases - deficiency | Stem Cells - physiology | Mice | Apoptosis - physiology | Intermediate Filament Proteins - metabolism | Neurons | Stem cells | Physiological aspects | Genetic aspects | Research | Cell differentiation | Apoptosis | Index Medicus
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11. Full Text An aged canid with behavioral deficits exhibits blood and cerebrospinal fluid amyloid beta oligomers
by Rusbridge, Clare and Salguero, Francisco J and David, Monique Antoinette and Faller, Kiterie M.E and Bras, Jose T and Guerreiro, Rita J and Richard-Londt, Angela C and Grainger, Duncan and Head, Elizabeth and Brandner, Sebastian G.P and Summers, Brian and Hardy, John and Tayebi, Mourad
Frontiers in Aging Neuroscience, ISSN 1663-4365, 01/2018, Volume 10, p. 7
Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated... 
Aggregation | Neurotoxicity | Neuropathology | Alzheimer | Aβ oligomers | Canine | Canine cognitive dysfunction | canine cognitive dysfunction | ANTIBODIES | ALZHEIMERS-DISEASE | canine | aggregation | MODEL | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | A beta oligomers | neurotoxicity | PATHWAY | DOGS | PROTEINS | neuropathology | BRAIN | Oligomers | Exhibitions | Canidae | Research | Behavior | Cerebrospinal fluid | Amyloid beta-protein
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12. Full Text Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis
by Giovanna Mallucci and Andrew Dickinson and Jacqueline Linehan and Peter-Christian Klöhn and Sebastian Brandner and John Collinge
Science, ISSN 0036-8075, 10/2003, Volume 302, Issue 5646, pp. 871 - 874
The mechanisms involved in prion neurotoxicity are unclear, and therapies preventing accumulation of PrP , the disease-associated form of prion protein (PrP),... 
Brain | Nervous system diseases | Neurons | Prions | Central nervous system | Central nervous system diseases | Prion diseases | Reports | Infections | Mice | Symptoms | STRAINS | SCRAPIE | RESISTANT | MULTIDISCIPLINARY SCIENCES | PROTEIN PRP | CREUTZFELDT-JAKOB-DISEASE | KNOCKOUT MICE | EXPRESSION | Neurons - pathology | Neuroglia - pathology | Astrocytes - pathology | Mice, Transgenic | Hippocampus - pathology | Scrapie - metabolism | Scrapie - therapy | Disease Progression | Brain - metabolism | PrPSc Proteins - metabolism | Hippocampus - metabolism | Scrapie - physiopathology | Animals | Recombination, Genetic | Scrapie - pathology | Brain - pathology | Neuroglia - metabolism | Brain Chemistry | Neurons - metabolism | PrPC Proteins - metabolism | PrPC Proteins - genetics | Transgenes | Astrocytes - metabolism | Pathology | Disease | Spongiform encephalopathies | Index Medicus
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13. Full Text Variant Creutzfeldt–Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129
by Joiner, Susan and Jaunmuktane, Zane and Mok, Tzehow and Morgan, Catherine and Rudge, Peter and Wakerley, Benjamin and Mead, Simon and Campbell, Tracy and Jäger, H. Rolf and Golestani, Farhad and Wadsworth, Jonathan D.F and Brandner, Sebastian and Collinge, John
The New England Journal of Medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 3, pp. 292 - 294
In this case study, variant Creutzfeldt–Jakob disease (CJD) is shown to occur in a young man with heterozygosity, rather than homozygosity, at codon 129 of the... 
MEDICINE, GENERAL & INTERNAL | Magnetic Resonance Imaging | Brain - diagnostic imaging | Humans | Fatal Outcome | Brain - pathology | Adult | Heterozygote | Male | Creutzfeldt-Jakob Syndrome - genetics | Prion Proteins - genetics | Genotype & phenotype | Brain research | Disease | BSE | Creutzfeldt-Jakob disease | Prion protein | Heterozygosity
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14. Full Text Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities
by Reuss, David E and Kratz, Annekathrin and Sahm, Felix and Capper, David and Schrimpf, Daniel and Koelsche, Christian and Hovestadt, Volker and Bewerunge-Hudler, Melanie and Jones, David T. W and Schittenhelm, Jens and Mittelbronn, Michel and Rushing, Elisabeth and Simon, Matthias and Westphal, Manfred and Unterberg, Andreas and Platten, Michael and Paulus, Werner and Reifenberger, Guido and Tonn, Joerg-Christian and Aldape, Kenneth and Pfister, Stefan M and Korshunov, Andrey and Weller, Michael and Herold-Mende, Christel and Wick, Wolfgang and Brandner, Sebastian and von Deimling, Andreas
Acta Neuropathologica, ISSN 0001-6322, 9/2015, Volume 130, Issue 3, pp. 407 - 417
IDH wild type (IDHwt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the possibilities of molecular subsets among... 
Pathology | Neurosciences | Medicine & Public Health | TERT | IDH1 | IDH2 | Glioblastoma | Classification | H3F3A | Astrocytoma | GLIOMAS | SURVIVAL | TERT PROMOTER MUTATIONS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | GRADE II | ANAPLASTIC ASTROCYTOMAS | DIFFUSE | AGE | Astrocytoma - genetics | Astrocytoma - metabolism | Immunohistochemistry | Promoter Regions, Genetic | Humans | Middle Aged | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Biomarkers, Tumor | Brain Neoplasms - metabolism | Astrocytoma - pathology | DNA Methylation | Neoplasm Grading | Telomerase - genetics | Glioblastoma - genetics | Brain Neoplasms - classification | Glioblastoma - pathology | Survival Analysis | Glioblastoma - classification | Glioblastoma - metabolism | Astrocytoma - classification | Mutation | Cohort Studies | Methylation | Telomerase | Analysis | Tumors | Index Medicus
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15. Full Text Single Treatment with RNAi against Prion Protein Rescues Early Neuronal Dysfunction and Prolongs Survival in Mice with Prion Disease
by Melanie D. White and Michael Farmer and Ilaria Mirabile and Sebastian Brandner and John Collinge and Giovanna R. Mallucci
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 29, pp. 10238 - 10243
Prion diseases are fatal neurodegenerative conditions for which there is no effective treatment. Prion propagation involves the conversion of cellular prion... 
Neurons | Prions | Medical treatment | Burrowing | Prion diseases | Viruses | Mice | Infections | T tests | Hippocampus | Gene therapy | Neurodegeneration | Behavior | PRP GENE | MULTIDISCIPLINARY SCIENCES | neurodegeneration | RATS | gene therapy | MEDIATED RNAI | MODEL | HIPPOCAMPUS | INFECTED MICE | SCRAPIE | RECOGNITION MEMORY | behavior | BRAIN | Prion Diseases - physiopathology | Prion Proteins | RNA, Small Interfering - genetics | Prion Diseases - genetics | Prions - genetics | Molecular Sequence Data | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Behavior, Animal | PrPSc Proteins - metabolism |