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Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Genome Integrity, ISSN 2041-9414, 11/2012, Volume 3, Issue 1, pp. 9 - 9
Proper repair of DNA double strand breaks (DSBs) is vital for the preservation of genomic integrity. There are two main pathways that repair DSBs, Homologous... 
DSB repair | NHEJ | DNA repair assays | PARP inhibitors
Journal Article
Nature, ISSN 0028-0836, 2018, Volume 560, Issue 7716, pp. 117 - 121
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1849 - 14
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2017, Volume 117, Issue 1, pp. 113 - 123
Background: Elevated APOBEC3B expression in tumours correlates with a kataegic pattern of localised hypermutation. We assessed the cellular phenotypes... 
drug sensitivity | cell cycle | DNA damage | mutation signature | APOBEC3B | 21 BREAST CANCERS | PHOSPHORYLATION | DNA-DAMAGE | MECHANISMS | STRAND | IN-VITRO | ONCOLOGY | MULTIPLE HUMAN CANCERS | PARP INHIBITORS | UP-REGULATION | ATR | Humans | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | RNA Interference | HEK293 Cells | Minor Histocompatibility Antigens - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | DNA Damage - genetics | Cell Cycle Checkpoints - genetics | DNA Damage - drug effects | Cell Line | Cytidine Deaminase - genetics | Checkpoint Kinase 1 - antagonists & inhibitors | Cisplatin - pharmacology | Gene Knockout Techniques | Blotting, Western | G2 Phase Cell Cycle Checkpoints | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Minor Histocompatibility Antigens - metabolism | Cell Cycle Checkpoints - drug effects | Cytidine Deaminase - metabolism | Nuclear Proteins - antagonists & inhibitors | CRISPR-Cas Systems | Checkpoint Kinase 2 - antagonists & inhibitors | Uracil - metabolism | Mutation | Protein-Tyrosine Kinases - antagonists & inhibitors | Profiling | p53 Protein | Reversing | Genomes | Inactivation | Gene sequencing | Cell cycle | Deoxyribonucleic acid--DNA | Damage assessment | Sensitivity analysis | Deactivation | RNA-mediated interference | Hypersensitivity | Interference | Poly(ADP-ribose) polymerase | Gene expression | Ribonucleic acid--RNA | Cisplatin | Sensitivity | Inhibitors | Biomarkers | Replication | Uracil | In vitro methods and tests | Tumors | Genetics & Genomics
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 2022 - 2034
Journal Article
Reproductive Toxicology, ISSN 0890-6238, 09/2019, Volume 88, pp. 18 - 19
Journal Article
Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 13, pp. 3790 - 3798.e7
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We... 
spermatogenesis | HSF2BP | meiosis | homologous recombination | BRCA2 | REPAIR | PROTEIN | RAD51 | GENE | CHROMOSOME SYNAPSIS | DNA-DAMAGE | GENOME-WIDE | HOMOLOGOUS RECOMBINATION | FANCONI-ANEMIA | CANCER | CELL BIOLOGY
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0126029
Journal Article
Cancers, ISSN 2072-6694, 01/2019, Volume 11, Issue 1
textabstractThe DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the... 
HSP90 | hyperthermia | RAD51 | homologous recombination | reactive oxygen species | SILAC mass spectrometry | BRCA2 | ubiquitin | protein degradation
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2016, Volume 126, Issue 8, pp. 2903 - 2918
markdownabstractHeterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA... 
MEDICINE, RESEARCH & EXPERIMENTAL | POLY(ADP-RIBOSE) POLYMERASE | MAMMARY-TUMORS | BREAST-CANCER SUSCEPTIBILITY | POLYMERASE-II HOLOENZYME | MUTATION CARRIERS | EMBRYONIC STEM-CELLS | STRANDED-DNA OLIGONUCLEOTIDES | MESSENGER-RNA DECAY | OVARIAN-CANCER | CHEMOTHERAPY RESISTANCE
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2016, Volume 126, Issue 8, p. 2903
  Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand... 
Genes | Rodents | Breast cancer | Mutation
Journal Article