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1. Full Text A novel tool for visualizing composite endpoint associations
by Breitling, Lutz P
Circulation: Cardiovascular Quality and Outcomes, ISSN 1941-7713, 03/2018, Volume 11, Issue 3, p. e004226
Cardiovascular system | Heart | Disclosure | Follow-up studies | cardiovascular system | disclosure | follow-up studies | CARDIAC & CARDIOVASCULAR SYSTEMS | heart
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2. Full Text Evidence of non-linearity in the association of glycemic control with influenza/pneumonia mortality: a study of 19 000 adults from the US general population
: Infectious Disease Mortality & Diabetes
by Breitling, Lutz P
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 01/2016, Volume 32, Issue 1, pp. 111 - 120
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3. Full Text Current Genetics and Epigenetics of Smoking/Tobacco-Related Cardiovascular Disease
by Breitling, Lutz P
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2013, Volume 33, Issue 7, pp. 1468 - 1472
Genetic and epigenetic factors are of great importance in cardiovascular biology and disease. Tobacco-smoking, one of the most important cardiovascular risk... 
Epigenetics | Tobacco-smoking | Cardiovascular disease | Genetics | Methylation | cardiovascular disease | RISK | epigenetics | ARTERIAL-DISEASE | DIFFERENTIAL DNA METHYLATION | NICOTINE DEPENDENCE | LUNG-CANCER | genetics | HUMAN GENOME | methylation | tobacco-smoking | GENES | PERIPHERAL VASCULAR DISEASE | CIGARETTE-SMOKE | CORONARY-HEART-DISEASE | HEMATOLOGY | EXPRESSION | Smoking - adverse effects | Prognosis | Cardiovascular Diseases - prevention & control | Epigenesis, Genetic | Humans | Cardiovascular Diseases - genetics | Gene-Environment Interaction | Smoking Prevention | DNA Methylation | Cardiovascular Diseases - epidemiology | Tobacco Use Disorder - prevention & control | Tobacco Use Disorder - genetics | Genetic Predisposition to Disease | Risk Assessment | Risk Reduction Behavior | Risk Factors | Smoking - genetics | Phenotype | Animals | Receptors, Thrombin - genetics | Tobacco Smoke Pollution - adverse effects | Smoking - epidemiology | Tobacco Use Disorder - epidemiology | Smoking Cessation | Tobacco Smoke Pollution - prevention & control
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4. Full Text Evidence of non‐linearity in the association of glycemic control with influenza/pneumonia mortality: a study of 19 000 adults from the US general population
by Breitling, Lutz P
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 01/2016, Volume 32, Issue 1, pp. 111 - 120
Background Diabetes is a major public health problem and thought to be a risk factor for infectious diseases, but pertinent epidemiological evidence is... 
dose–response | CDC | non‐linearity | infectiology | impaired glucose tolerance | NHANES | glycated haemoglobin | Infectiology | Non-linearity | Dose-response | Glycated haemoglobin | Impaired glucose tolerance | Diabetes Mellitus - blood | Glycated Hemoglobin A - analysis | United States - epidemiology | Prospective Studies | Humans | Middle Aged | Male | Influenza, Human - complications | Young Adult | Pneumonia - mortality | Aged, 80 and over | Diabetes Complications - epidemiology | Influenza, Human - mortality | Adult | Female | Hyperglycemia - prevention & control | Pneumonia - epidemiology | Risk Factors | Proportional Hazards Models | Influenza, Human - epidemiology | Diabetes Complications - mortality | Health Surveys | Diabetes Mellitus - therapy | Adolescent | Pneumonia - complications | Aged | Patient Compliance | Cohort Studies | Pneumonia | Analysis | Bacterial pneumonia | Mortality | Hemoglobin | Adults | Diabetes | Glucose | Health aspects | Risk factors | Dextrose | Diabetes therapy
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5. Full Text Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and Replication
by Breitling, Lutz P and Yang, Rongxi and Korn, Bernhard and Burwinkel, Barbara and Brenner, Hermann
The American Journal of Human Genetics, ISSN 0002-9297, 04/2011, Volume 88, Issue 4, pp. 450 - 457
Tobacco smoking is responsible for substantial morbidity and mortality worldwide, in particular through cardiovascular, pulmonary, and malignant pathology. CpG... 
EPIGENETICS | HUMAN-DISEASE | MULTIPLE GENES | HYPERMETHYLATION | PROMOTER METHYLATION | SMOKERS | GENETICS & HEREDITY | MECHANISMS | CANCER | CARDIOVASCULAR RISK | GENOME-WIDE ASSOCIATION | Smoking - adverse effects | Reproducibility of Results | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Molecular Sequence Data | Male | Smoking - genetics | DNA Primers - genetics | DNA Methylation | Receptors, Thrombin - genetics | Polymerase Chain Reaction | CpG Islands | Female | Polymorphism, Single Nucleotide | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Prevention | Usage | Care and treatment | Smokers | Causes of | Biochemical assays | Cytosine | Genetic aspects | Research | Methylation | Guanine | Smoking
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6. Full Text Comparison and combination of blood DNA methylation at smoking-associated genes and at lung cancer-related genes in prediction of lung cancer mortality
: DNA methylation in prediction of lung cancer mortality
by Zhang, Yan and Breitling, Lutz P and Balavarca, Yesilda and Holleczek, Bernd and Schöttker, Ben and Brenner, Hermann
International Journal of Cancer, ISSN 0020-7136, 12/2016, Volume 139, Issue 11, pp. 2482 - 2492
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7. Full Text Smoking as an Effect Modifier of the Association of Calcium Intake With Bone Mineral Density
by Breitling, Lutz P
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 02/2015, Volume 100, Issue 2, pp. 626 - 635
Context: Data from physiological studies suggest smoking to have detrimental effects on calcium absorption, but large-scale investigations of this interaction... 
MORTALITY | POPULATION | CIGARETTE-SMOKING | METAANALYSIS | PUBLIC-HEALTH | NHANES-III | ENDOCRINOLOGY & METABOLISM | ADULTS | ABSORPTION | POSTMENOPAUSAL WOMEN | OSTEOPOROSIS | Body Mass Index | Motor Activity - physiology | Age Factors | Bone Density - physiology | Cross-Sectional Studies | Nutrition Surveys | Humans | Middle Aged | Male | Educational Status | Femur Neck - diagnostic imaging | Radiography | Young Adult | Bone Density - drug effects | Aged, 80 and over | Adult | Female | Aged | Femur Neck - drug effects | Calcium, Dietary - pharmacology | Smoking
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8. Full Text Pneumonien in der nichtinstitutionalisiertenälteren Allgemeinbevölkerung
by Breitling, Lutz P and Saum, Kai-Uwe and Schöttker, Ben and Holleczek, Bernd and Herth, Felix J and Brenner, Hermann
Deutsches Arzteblatt International, ISSN 1866-0452, 09/2016, Volume 113, Issue 37, pp. 607 - 614
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9. Full Text Vitamin D and cardiovascular disease: Systematic review and meta-analysis of prospective studies
by Grandi, Norma C and Breitling, Lutz P and Brenner, Hermann
Preventive Medicine, ISSN 0091-7435, 2010, Volume 51, Issue 3, pp. 228 - 233
Abstract Background Low serum 25-hydroxyvitamin D (25-OH-D) has recently been linked to cardiovascular diseases. This review summarizes evidence from... 
Internal Medicine | Myocardial infarction | Vitamin D deficiency | Prognosis | Vitamin D | Review | Prospective studies | Cardiovascular diseases | Coronary disease | 25-HYDROXYVITAMIN-D LEVELS | RISK-FACTORS | MYOCARDIAL-INFARCTION | D SUPPLEMENTATION | D DEFICIENCY | ALL-CAUSE | MEDICINE, GENERAL & INTERNAL | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | NUTRITION EXAMINATION SURVEY | 3RD NATIONAL-HEALTH | SERUM 25-HYDROXYVITAMIN-D | CORONARY-HEART-DISEASE | Cardiovascular Diseases - physiopathology | Prospective Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Male | Risk | Vitamins - therapeutic use | Vitamin D - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Female | Aged | Vitamins - blood | Vitamins - physiology | Vitamin D - physiology | Vitamin D - therapeutic use | Medical research | Analysis | Medicine, Experimental | Calcifediol | Alfacalcidol | Heart attack
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10. Full Text Self- or Physician-reported Diabetes, Glycemia Markers, and Cognitive Functioning in Older Adults in Germany
by Breitling, Lutz P., M.D., M.Sc and Olsen, Hutson and Müller, Heiko, Ph.D and Schöttker, Ben, Ph.D and Kliegel, Matthias, Ph.D and Brenner, Hermann, M.D., M.P.H
American Journal of Geriatric Psychiatry, ISSN 1064-7481, 2014, Volume 22, Issue 11, pp. 1105 - 1115
Objectives To assess the association of different diabetes-related variables, including self- and physician-reported information, as well as biomarkers, with... 
Internal Medicine | glycated hemoglobin | mild cognitive impairment | Fasting glucose | HEMOGLOBIN | POPULATION | DEMENTIA | PSYCHIATRY | MELLITUS | PREVALENCE | NONDIABETIC ADULTS | GERIATRICS & GERONTOLOGY | GERONTOLOGY | CARDIOVASCULAR RISK | Diabetes Mellitus - blood | Glycated Hemoglobin A - analysis | Blood Glucose - analysis | Cross-Sectional Studies | Humans | Risk Factors | Male | Cognition | Biomarkers - blood | Cognitive Dysfunction - etiology | Germany - epidemiology | Cognition Disorders - etiology | Cognitive Dysfunction - epidemiology | Diabetes Mellitus - epidemiology | Female | Aged | Cognition Disorders - epidemiology
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11. Full Text Smoking and bone mineral density: comprehensive analyses of the third National Health and Nutrition Examination Survey (NHANES III)
by Strozyk, Dominik and Gress, Thomas M and Breitling, Lutz P
Archives of Osteoporosis, ISSN 1862-3522, 12/2018, Volume 13, Issue 1, pp. 1 - 7
Some questions remain on the relationship between smoking and bone health. Detailed analyses of the relationship between smoking and BMD are presented,... 
Osteoporosis | Tobacco | Medicine & Public Health | Non-linearity | Orthopedics | Dose-response | Epidemiology | Endocrinology | RISK | CIGARETTE-SMOKING | IMPACT | ALCOHOL | ENDOCRINOLOGY & METABOLISM | CALCIUM INTAKE | ORTHOPEDICS | ASSOCIATION
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12. Full Text F2RL3 methylation as a biomarker of current and lifetime smoking exposures
by Zhang, Yan and Yang, Rongxi and Burwinkel, Barbara and Breitling, Lutz P and Brenner, Hermann
Environmental Health Perspectives, ISSN 0091-6765, 02/2014, Volume 122, Issue 2, pp. 131 - 137
Background: Recent genome-wide DNA methylation studies have found a pronounced difference in methylation of the F2RL3 gene (also known as PAR-4) in blood DNA... 
CELLS | PROTEINASE-ACTIVATED RECEPTOR-4 | MYOCARDIAL-INFARCTION | DIFFERENTIAL DNA METHYLATION | CESSATION | ALL-CAUSE MORTALITY | LUNG-CANCER | ENVIRONMENTAL SCIENCES | CIGARETTE-SMOKING | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TOXICOLOGY | EXPRESSION | CARDIOVASCULAR RISK | Biomarkers - metabolism | Humans | Middle Aged | Linear Models | Germany - epidemiology | Smoking - metabolism | DNA Methylation | Receptors, Thrombin - genetics | Smoking - epidemiology | Statistics, Nonparametric | Receptors, Thrombin - metabolism | Aged | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Cohort Studies | Physiological aspects | Genetic research | Genetic aspects | Research | Methylation | Biological markers | Health aspects | Smoking | Heart attacks | Mortality | Cardiovascular disease | Genomes | Family medical history | Blood | Studies | DNA methylation | Biomarkers | Population | Software | Recall | Genetic testing | Health risk assessment | Age | Deoxyribonucleic acid--DNA | Health | Deoxyribonucleic acid | Exposure | Active control
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13. Full Text Pneumonia in the Noninstitutionalized Older Population
by Breitling, Lutz P and Saum, Kai-Uwe and Schöttker, Ben and Holleczek, Bernd and Herth, Felix J and Brenner, Hermann
Deutsches Arzteblatt international, ISSN 1866-0452, 09/2016, Volume 113, Issue 37, p. 607
Pneumonia is a common and potentially serious disease, with an incidence of ca. 300 per 100 000 persons per year. Until now, there have been only a few... 
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14. Full Text Type II secretory phospholipase a 2 and prognosis in patients with stable coronary heart disease: Mendelian randomization study
by Breitling, Lutz P and Koenig, Wolfgang and Fischer, Marcus and Mallat, Ziad and Hengstenberg, Christian and Rothenbacher, Dietrich and Brenner, Hermann
PLoS ONE, 2011, Volume 6, Issue 7
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15. Full Text DNA methylation signatures in peripheral blood strongly predict all-cause mortality
by Zhang, Yan and Wilson, Rory and Heiss, Jonathan and Breitling, Lutz P and Saum, Kai-Uwe and Schöttker, Ben and Holleczek, Bernd and Waldenberger, Melanie and Peters, Annette and Brenner, Hermann
Nature Communications, ISSN 2041-1723, 03/2017, Volume 8, Issue 1, p. 14617
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify... 
F2RL3 METHYLATION | BREAST-CANCER CELLS | COX MODEL | EPIGENETIC CLOCK | HEALTH RESEARCH | CPG SITES | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | CARDIOVASCULAR MORTALITY | EPIGENOME-WIDE ASSOCIATION | TELOMERE LENGTH | Follow-Up Studies | Epigenesis, Genetic | Humans | Middle Aged | Mortality | Proportional Hazards Models | Male | DNA Methylation - genetics | Cause of Death | Thinness - epidemiology | Overweight - epidemiology | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Obesity - epidemiology | Cardiovascular Diseases - epidemiology | CpG Islands | Female | Aged | Hypertension - epidemiology | Neoplasms - epidemiology | Cohort Studies
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16. Full Text Theory and methods: Odd odds interactions introduced through dichotomisation of continuous outcomes
by Lutz P Breitling and Hermann Brenner
Journal of Epidemiology and Community Health (1979-), ISSN 0143-005X, 4/2010, Volume 64, Issue 4, pp. 300 - 303
Background Dichotomisation of continuous variables before analysis has frequently been criticised but, nonetheless, remains a common approach. We were... 
Statistical significance | Body mass index | Outcome variables | Obesity | Health outcomes | Sample size | Linear regression | Medical genetics | Epidemiology | Modeling
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17. Full Text Liver Enzymes: Interaction Analysis of Smoking with Alcohol Consumption or BMI, Comparing AST and ALT to [gamma]-GT
by Breitling, Lutz P and Arndt, Volker and Drath, Christoph and Brenner, Hermann
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27951
A detrimental interaction between smoking and alcohol consumption with respect serum [gamma]-glutamyltransferase ([gamma]-GT) has recently been described. The... 
Enzymes | Analysis | Liver | Aspartate | Societies | Drinking of alcoholic beverages | Associations, institutions, etc | Construction industry
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18. Full Text The Novel "Genomic Pathway Approach" to Complex Diseases: A Reason for (Over-)Optimism?
by Lutz P. Breitling and Ewout W. Steyerberg and Hermann Brenner
Epidemiology, ISSN 1044-3983, 7/2009, Volume 20, Issue 4, pp. 500 - 507
Background: Examination of the genetic structure of complex diseases by a "genomic pathway approach"—which applies stepwise model selection to sets of more... 
Datasets | Disease models | Genomics | Medical genetics | Parkinson disease | P values | Predictive modeling | Modeling | Epidemiology | METHODS | Optimism | ISSUES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MODELS | MICROARRAY | PREDICTION ERROR | LOGISTIC-REGRESSION | AXON GUIDANCE | EXTERNAL VALIDATION | VARIABLE-SELECTION | SIMULATION | Genetic Predisposition to Disease | Algorithms | Genetics, Medical | Humans | Female | Male | Polymorphism, Single Nucleotide | Odds Ratio
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19. Validated Smoking Cessation and Prognosis in Patients With Stable Coronary Heart Disease: Research Correspondence
by Breitling, Lutz P and Rothenbacher, Dietrich and Vossen, Carla Y and Hahmann, Harry and Wuesten, Bernd and Brenner, Hermann
Journal of the American College of Cardiology, ISSN 0735-1097, 07/2011, Volume 58, Issue 2, pp. 196 - 197
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20. Prognostic Usefulness of Free Fatty Acids in Patients With Stable Coronary Heart Disease
by Lutz P Breitling and Dietrich Rothenbacher and Norma C Grandi and Winfried März and Hermann Brenner
The American Journal of Cardiology, ISSN 0002-9149, 08/2011, Volume 108, Issue 4, p. 508
  Circulating nonesterified or free fatty acids (FFAs) may contribute to the development of cardiovascular pathology and correlate with ischemia in acute... 
Medical prognosis | Cardiovascular disease | Cardiology | Fatty acids | Risk factors
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