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Cell Stem Cell, ISSN 1934-5909, 03/2009, Volume 4, Issue 3, pp. 226 - 235
In normal brain, the side population (SP) phenotype is generated by ABC transporter activity and identifies stem cell and endothelial cell subpopulations by... 
STEMCELL | CANCER-CELLS | SURVIVAL | GLIOBLASTOMA | TRANSPORTER | IN-VIVO | DISTINCT | DRUG-RESISTANCE | MULTIDRUG-RESISTANCE | EXPRESSION | TEMOZOLOMIDE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplastic Stem Cells - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Glioma - metabolism | Brain - metabolism | Neoplastic Stem Cells - metabolism | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | ATP-Binding Cassette Transporters - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | PTEN Phosphohydrolase - genetics | Cells, Cultured | Dacarbazine - metabolism | Enzyme Inhibitors - pharmacology | Glioma - chemically induced | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Platelet-Derived Growth Factor - pharmacology | Blood-Brain Barrier - metabolism | Animals | Mice, Nude | Brain - pathology | Mice | Mitoxantrone - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Antineoplastic Agents, Alkylating - metabolism | Index Medicus | PTEN | Akt | Glioma | Side Population | ABCG2
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 626 - 630
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One... 
Enzymes | Cell growth | Glioma | RNA | Neurons | REPORTS | Methylation | Cellular differentiation | Genetic mutation | Heterologous transplantation | Tumors | TRANSFORMATION | GLIOBLASTOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BRAIN | Benzeneacetamides - toxicity | Protein Multimerization | Imidazoles - administration & dosage | Gene Expression Profiling | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - genetics | RNA Interference | Enzyme Inhibitors - toxicity | Glioma - pathology | Imidazoles - toxicity | Gene Expression Regulation, Neoplastic - drug effects | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Glioma - enzymology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Imidazoles - pharmacology | Mice, SCID | Benzeneacetamides - administration & dosage | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic | Isocitrate Dehydrogenase - chemistry | Mutant Proteins - chemistry | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Histones - metabolism | Glioma - drug therapy | Cell proliferation | Gene mutations | Gliomas | Growth | Cancer cells | Physiological aspects | Genetic aspects | Research | Cancer | Genes | Cells | Mutation | Index Medicus | Drugs | Binding | Mutations | Inhibitors | Online | Delay
Journal Article
by Brennan, Cameron W and Verhaak, Roel G.W and McKenna, Aaron and Campos, Benito and Noushmehr, Houtan and Salama, Sofie R and Zheng, Siyuan and Chakravarty, Debyani and Sanborn, J. Zachary and Berman, Samuel H and Beroukhim, Rameen and Bernard, Brady and Wu, Junyuan and Wu, Chang-Jiun and Genovese, Giannicola and Shmulevich, Ilya and Barnholtz-Sloan, Jill and Zou, Lihua and Vegesna, Rahulsimham and Shukla, Sachet A and Ciriello, Giovanni and Yung, W.K and Yung, W.K. Alfred and Zhang, Zhaobin and Zhang, Wei and Zhang, Jianhua and Zhang, Hailei and Sougnez, Carrie and Mikkelsen, Tom and Aldape, Kenneth and Bigner, Darell D and Bigner, Darell and Van Meir, Erwin G and Prados, Michael and Sloan, Andrew and Sloan, Andrew E and Black, Keith L and Eschbacher, Jennifer and Finocchiaro, Gaetano and Friedman, William and Andrews, David W and Guha, Abhijit and Iacocca, Mary and O’Neill, Brian P and Foltz, Greg and Myers, Jerome and Weisenberger, Daniel J and Penny, Robert and Kucherlapati, Raju and Perou, Charles M and Hayes, D. Neil and Gibbs, Richard and Marra, Marco and Mills, Gordon and Mills, Gordon B and Lander, Eric S and Lander, Eric and Spellman, Paul and Wilson, Richard K and Wilson, Richard and Sander, Chris and Weinstein, John N and Weinstein, John and Meyerson, Matthew and Gabriel, Stacey B and Gabriel, Stacey and Laird, Peter W and Haussler, David and Getz, Gad and Chin, Lynda and Benz, Christopher and Barrett, Wendi and Ostrom, Quinn and Wolinsky, Yingli and Bose, Bikash and Boulos, Madgy and Boulos, Paul T and Brown, Jenn and Czerinski, Christine and Eppley, Matthew and Kempista, Thelma and Kitko, Teresa and Koyfman, Yakov and Rabeno, Brenda and Rastogi, Pawan and Sugarman, Michael and Swanson, Patricia and Yalamanchii, Kennedy and Otey, Ilana P and Liu, Yuexin and Liu, Yingchun Spring and Liu, Wenbin and Xiao, Yonghong and Auman, J.Todd and Chen, Qing-Rong and Chen, Peng-Chieh and Chen, Ken and Hadjipanayis, Angela and Lee, Eunjung and Lee, Semin and ... and TCGA Res Network and TCGA Research Network
Cell, ISSN 0092-8674, 10/2013, Volume 155, Issue 2, pp. 462 - 477
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 3041 - 3046
Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor... 
Tumor cell line | Glioma | Glioblastoma | Cell lines | Cell separation | Genetic mutation | Genotypes | Tumors | Cancer | Daughter cells | Mosaicism | Amplicon | Glioblastoma genetics | MULTIDISCIPLINARY SCIENCES | RECURRENT GLIOBLASTOMA | TUMORIGENICITY | CANCER | MULTIFORME | PHASE-II TRIAL | THERAPY | mosaicism | COPY NUMBER | glioma | GENE AMPLIFICATION | MALIGNANT GLIOMAS | amplicon | MEDULLOBLASTOMA | glioblastoma genetics | Receptor, Epidermal Growth Factor - genetics | Glioblastoma - enzymology | Cell Proliferation | Humans | In Situ Hybridization, Fluorescence | Genetic Heterogeneity | Genome, Human - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Gene Amplification | Glioblastoma - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Computer Simulation | Glioblastoma - pathology | Chromosome Segregation - genetics | Tyrosine | Receptors | Blood platelets | Physiological aspects | Development and progression | Genetic aspects | Health aspects | Phosphotransferases | Glioblastoma multiforme | Molecules | Kinases | Cells | Deoxyribonucleic acid--DNA | Fluorescence in situ hybridization | Platelet-derived growth factor receptors | Epidermal growth factor receptors | Hepatocyte growth factor | Tumor cells | Clinical trials | Genomes | 1-Phosphatidylinositol 3-kinase | c-Met protein | Protein-tyrosine kinase receptors | Atlases | DNA sequencing | Index Medicus | Biological Sciences
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2017, Volume 32, Issue 4, pp. 506 - 519.e5
Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with